CN206492518U - The blood shunt device of dark dike formula - Google Patents
The blood shunt device of dark dike formula Download PDFInfo
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- CN206492518U CN206492518U CN201720111262.4U CN201720111262U CN206492518U CN 206492518 U CN206492518 U CN 206492518U CN 201720111262 U CN201720111262 U CN 201720111262U CN 206492518 U CN206492518 U CN 206492518U
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Abstract
The utility model provides a kind of blood shunt device of dark dike formula, is mainly made up of main body and divided fluid stream passage.It is characterized in that：Main body is in the form of annular discs, at the edge of disk to the center of circle, be machined with the shape of a spiral, up and down closing, the unequal divided fluid stream passage of width.Divided fluid stream passage >=3 layer of main body.On the channel centerline at every layer of split channel beginning, all it is machined with one section of drainage dike, drainage dike Downstream processing has the shunting island wall of quantity >=3, it is inner flow passage and outer flow passage to shunt island wall and punish split channel from diffluence pass, mouth is sorted between two shunting island walls, inner flow passage is connected with outer flow passage, resistance in the dark gear dike is machined with each diffluence pass, the sorting dark dike of mouth is machined with each sorting mouth.The utility model beneficial effect there is provided one kind can be with quick separating cell, cell separation apparatus that is easy to operate, not easily causing cellular damage, the cell device can one side feed liquor, side separated, and can repeatedly, multi-cycle separation, improve the efficiency of separation.
Description
Technical field
The utility model is related to a kind of blood separating mechanism, from using being that a kind of suitable general medical mechanism is carried out
Blood cell is separatory, the blood shunt device for having the dark dike formula of embankment wall in passage under liquid level.
Background technology
At present, blood cell separation substantially has two kinds of technical methods to realize, i.e. membrane separation technique and centrifugation is separated
Technology.Membrane separation technique is to utilize the film with selection through ability to do separating medium, and stoste passes through film under a certain pressure
Side, solvent and small molecule solute are permeate through membranous wall, and bigger molecule solute is rejected by, so as to reach material point
From and concentration purpose.Membrane separation technique, which exists, uses non-cross-flow filtration, and film is easily blocked, using cross-flow filtration, though film is difficult
It is blocked, but, cost increase high to the performance requirement of film.Centrifugal separation technology is by blood components by centrifuge separation equipment
It is separated from each other by difference of specific gravity, to obtain required blood component, but easily causes cell mechanical injuries and easily pollution, carefully
Born of the same parents have phase-state change, so as to influence cell quality；Meanwhile, the environmental requirement to laboratory is very strict, adds cell separation
Cost.
Therefore, the utility model solves this problem there is provided a kind of loss cell is minimum, acellular phase-state change, just
In the technical scheme of simple, the efficient blood shunt device of subsequent analysis.
The content of the invention
To solve the above problems, the technical solution of the utility model is：A kind of blood shunt device of dark dike formula, mainly by leading
Body and divided fluid stream passage composition.It is characterized in that：Main body is in the form of annular discs, at the edge of disk to the center of circle, is machined with helically
Shape, up and down closing, the unequal divided fluid stream passage of width.Divided fluid stream passage >=3 layer of main body.First layer split channel from
Total injection port of the edge processing of disk starts, and terminates to the outlet of first layer outer flow passage.Every layer of split channel beginning it is logical
On road center line, one section of drainage dike is all machined with；Drainage dike Downstream processing has the shunting island wall of quantity >=3, and shunting island wall will
It is inner flow passage and outer flow passage that split channel is punished from diffluence pass；Wall is hit in the convolution that a protrusion is machined with each inner flow passage,
Convolution hits wall downstream and is close to a sorting mouth；Mouth is sorted between two shunting island walls, inner flow passage is connected with outer flow passage.With
Wall is hit in upper 1 convolution and 2 shunting island walls constitute a separation unit.Sort the entrance of the inner flow passage by mouth turns into next again
The diffluence pass of separation unit.Design repeats layering sorting really in units of separation unit.Second layer split channel is from second
The drainage dike of layer starts, and terminates to the outlet of second layer outer flow passage.Third layer split channel is since the drainage dike of third layer, to
Terminate three layers of outer flow passage outlet.Layers below divided fluid stream passage the like, finally, inner flow passage always goes out sample the main body center of circle
Mouth terminates.The main body can be machined with resistance in the dark gear dike at the diffluence pass of separation unit；Resistance in the dark gear dike is blocked in lateral direction penetrating
Cut in inner flow passage, embankment wall of the height dimension less than 2mm ~ 5mm at the top of inner flow passage.This design is that increasing fluid enters inner flow passage
Initial velocity.The shunting island wall of the main body can be machined with the sorting dark dike of mouth at sorting mouth；The sorting dark dike of mouth is in shunting
Island wall is processed one section of protrusion, sorted in laterally interception at mouth back to fluid and flow direction identical one end, but incomplete
Embankment wall of the height dimension less than 2mm ~ 5mm at the top of sorting mouth of portion's insertion sorting mouth.This design is to increase the separation of sorting mouth
Efficiency, further controls size of separation.
In above-mentioned technical proposal, the drainage dike is wide 0.5mm ~ 1mm, and height dimension is less than divided fluid stream channel roof
2mm ~ 5mm band.The width per layer fluid split channel is consistent, width dimensions >=5mm, or the divided fluid stream of each layer leads to
The width in road successively increases or successively reduced.Shunting island wall is moved towards in fish shape, waveform, rhombus along divided fluid stream passage,
This design makes the arcuate directions of the inner flow passage of a separation unit inconsistent in passage leading portion and back segment；Or in fan-shaped, cattle horn shape,
This design makes the arcuate directions of the inner flow passage of a separation unit consistent with back segment in passage leading portion.The height for stating shunting island wall is same
The top of divided fluid stream passage is concordant, i.e., above and below sealing fluid split channel.
In above-mentioned technical proposal, the outer flow passage is the smooth smooth-going of two side walls along the smooth transition in the same direction of main body circular arc
Curved channel；The outer flow passage width of each layer is consistent, the divided fluid stream channel width dimension of width dimensions≤1/4, or each layer outflow
The width dimensions in road are gradually reduced or gradually increased.
In above-mentioned technical proposal, the width dimensions of the inner flow passage each section of passage before, during and after a separation unit are not
Unanimously, the inner flow passage width dimensions of each layer are inconsistent.The shape of the inner flow passage：Because shunting island wall is in inner flow passage side first half
Section is in the arc of reverse main body circular arc radian, the second half section on wall convex surface is hit in correspondence convolution, again in main body circular arc radian in the same direction
Arc；Again because the protruding parts that wall is hit in the convolution is the circular arc radian direction of reverse main body.That is shunting island wall is hit with convolution
Wall corresponding matching, by arc convolution bend of the front half section of inner flow passage in reverse main body circular arc radian, after wall is hit by convolution
It is in the passage of main body circular arc radian in the same direction again.Or the shape of inner flow passage：Because shunting island wall is hit in inner flow passage side with convolution
Wall is all the circular arc radian direction of reverse main body, is in the passage of reverse main body circular arc radian by inner flow passage.
In above-mentioned technical proposal, total injection port is consistent with the diameter of general sample outlet, and both greater than each layer outer flow passage
Outlet diameter.Design ensures that inner flow passage has enough flow velocitys.The outlet diameter of each layer outer flow passage needs the shape by master-plan
And size, calculate with fluid simulation software.The height dimension of the outer flow passage bottom of the outer flow passage is higher than the interior stream of inner flow passage
Height 0.5mm ~ 2mm of road bottom.The outer flow passage bottom is by raised point of circular arc at sorting mouth with inner flow passage bottom
Mouth bottom is selected to connect transition；In the ramped bottom surface that transition position is high, outside is low after the connection transition of outer flow passage bottom.
In above-mentioned technical proposal, point that shunting island metope is tapered in fluid, one end opposite with flow direction
Flow island wall point.The conical points of shunting island wall point are sharpened the end face for being processed into a width dimensions >=1mm, and end face is from inner flow passage one
Side starts to be machined with the irregular convex surface of projection；To outer flow passage side, gradually upper lower bifurcation reduces the area on irregular convex surface, high
Degree is gradually lowered, and is finally combined together with the irregular concave surface on irregular convex surface in the middle of the fork of lower bifurcation.The convolution is hit
Metope is not of uniform size on fluid, the side wall opposite with flow direction, being machined with, irregular convex surface pockety and not
Regular concave surface.This design is to increase the laminar flow phenomenon in fluid convolution, increase fluid mixing and vortex, reduction microchannel.With
Beneficial to separation blood constituent and cell.
The utility model has used " blown sand " separation principle of Dujiang weir water conservancy, that is, has used theory and the centrifugation of swirling flow
Power is acted on, in the design that this is applied to blood separation.At present, both at home and abroad, there is the blood point of numerous studies micro-channel chip
From still, microchannel is laminar flow mostly, and Common fluids are theoretical not to be applied to more.The utility model is by conventional water conservancy fluid and blood
Fluid is combined, in the separation for being used in the blood constituent of non-micro scale channel and cell.The albumen and cell of big quality, are dividing
Mouth is selected to isolate.By circulation repeatedly sorting, the separation purpose of blood cell is reached.
The purpose of this utility model be to provide one kind can with quick separating cell, it is easy to operate, do not easily cause it is thin
The cell separation apparatus of cellular damage, the cell device can one side feed liquor, side separated, and can repeatedly, multi-cycle separation,
Improve the efficiency of separation.The knockout causes cell separation and the operation collected, and becomes simple and easy to apply.
Brief description of the drawings
Fig. 1 is schematic top plan view of the present utility model.
Fig. 2 is a separation unit schematic diagram of the present utility model.
Fig. 3 is the A end views of shunting island of the present utility model wall point.
Fig. 4 is the D-D schematic cross-sections of shunting island of the present utility model wall point A end faces.
Fig. 5 hits the B end views of wall for of the present utility model circle round.
Fig. 6 is the cross-sectional view of drainage dike of the present utility model.
Fig. 7 is a kind of three separation unit schematic diagrames of sector diffuence island wall of the present utility model.
Fig. 8 is the section B-B schematic diagram that resistance in the dark of the present utility model keeps off dike.
Fig. 9 is the sorting dark dike of mouth of the present utility model and the C-C schematic cross-sections of outer flow passage bottom angled bottom surface.
In figure：1. total injection port；2. first layer split channel；3. drainage dike；4. diffluence pass；5. shunt island wall；6. interior flow
Road；7. outer flow passage；8. sort mouth；9. wall is hit in convolution；10. general sample outlet；11. main body；12. third layer split channel；13. the 3rd
The outlet of layer outer flow passage；14. second layer outer flow passage is exported；15. second layer split channel；16. first layer outer flow passage is exported；17. time
Revolve bend；18. resistance in the dark keeps off dike；19. sort the dark dike of mouth；20. shunt island wall point；21. irregular convex surface；22. irregular concave surface；
23. inner flow passage bottom；24. sort mouth bottom；25. outer flow passage bottom.
Embodiment
Further the utility model is illustrated with reference to the accompanying drawings and examples.
Embodiment one
Referring to figs. 1 to Fig. 9 shape and structure, a kind of blood shunt device of dark dike formula, divided fluid stream passage=3 of main body 11
Layer, the shunting island wall 5 of 9 every layer constitutes 8 separation units, that is, has 8 sorting mouths 8.
Per layer fluid split channel depth 8mm, width 10mm.The width of drainage dike 3 1mm, high 6mm.Island wall 5 is shunted along fluid point
Circulation road trend is in fish shape, and high 8mm is concordant with the top of fluid split channel；Shunt the wide 2mm of end face of island wall point 20.Each layer
Two loudspeaker opening of inner flow passage 6, front half section is in the arc convolution bend 17 of the reverse circular arc radian of main body 11, and convolution bend 17 terminates
Locate width most narrow；Inner flow passage 6 is after wall 9 is hit by convolution and in the passage of the circular arc radian of main body 11 in the same direction.The outer flow passage 7 of each layer
Wide 2.5mm.The height dimension of the outer flow passage bottom 25 of each layer is higher than the height 2mm of inner flow passage bottom 23；Outer flow passage bottom 25 connects
Take over after crossing in the ramped bottom surface that transition position is high, outside is low.Total injection port 1 consistent with the diameter of general sample outlet 10 is 2mm, first
A diameter of 0.8mm of layer outer flow passage outlet 16, second layer outer flow passage outlet 14 and third layer outer flow passage outlet 13.
Resistance in the dark of the height dimension less than the top 2mm of inner flow passage 6, which is machined with, in the diffluence pass 4 of each separation unit keeps off dike 18.
Shunting island wall 5 is machined with the dark dike 19 of sorting mouthful of the height dimension less than sorting mouth 8 top 3mm at each sorting mouth 8.
Embodiment two
Referring to figs. 1 to Fig. 9 shape and structure, a kind of blood shunt device of dark dike formula, divided fluid stream passage=5 of main body 11
Layer, the shunting island wall 5 of 6 every layer constitutes 5 separation units, that is, has 5 sorting mouths 8.
First layer divided fluid stream channel depth 10mm, width 12mm；Second layer divided fluid stream channel depth 10mm, width
11mm；Third layer divided fluid stream channel depth 10mm, width 10mm；4th layer fluid split channel depth 10mm, width 9mm；
Layer 5 divided fluid stream channel depth 10mm, width 8mm.The width of drainage dike 3 0.5mm, high 5mm.Shunt island wall 5 logical along divided fluid stream
Road trend is in sector, and high 10mm is concordant with the top of fluid split channel；Shunt the wide 1mm of end face of island wall point 20.Outside first layer
The width of runner 7 3mm；The width of second layer outer flow passage 7 2.5mm；The width of third layer outer flow passage 7 2mm；The 4th layer of width of outer flow passage 7 1.5mm；5th
The layer width of outer flow passage 7 1.5mm.The height dimension of the outer flow passage bottom 25 of each layer is higher than the height 1mm of inner flow passage bottom 23；Outer flow passage
In the ramped bottom surface that transition position is high, outside is low after the connection transition of bottom 25.Two loudspeaker opening of inner flow passage 6 of each layer, in reverse
Width is most narrow at the arc convolution bend 17 of the circular arc radian of main body 11, the convolution end of bend 17.Total injection port 1 and general sample outlet 10
Diameter unanimously be 3mm, the diameter that first layer is exported to layer 5 outer flow passage is 1.5mm.
Resistance in the dark of the height dimension less than the top 5mm of inner flow passage 6, which is machined with, in the diffluence pass 4 of each separation unit keeps off dike 18.
Shunting island wall 5 is machined with the dark dike 19 of sorting mouthful of the height dimension less than sorting mouth 8 top 2mm at each sorting mouth 8.
Embodiment three
Referring to figs. 1 to Fig. 9 shape and structure, a kind of blood shunt device of dark dike formula, divided fluid stream passage=4 of main body 11
Layer, the shunting island wall 5 of 7 every layer constitutes 6 separation units, that is, has 6 sorting mouths 8.
First layer divided fluid stream channel depth 10mm, width 9mm；Second layer divided fluid stream channel depth 10mm, width
10mm；Third layer divided fluid stream channel depth 10mm, width 11mm；4th layer fluid split channel depth 10mm, width 12mm.
The width of drainage dike 3 0.5mm, high 7mm.It is in fish shape that island wall 5, which is shunted, along divided fluid stream passage trend, and high 10mm is with fluid split channel
Top is concordant；Shunt the wide 1mm of end face of island wall point 20.The width of first layer outer flow passage 7 1.5mm；The width of second layer outer flow passage 7 2mm；3rd
The layer width of outer flow passage 7 2.5mm；The 4th layer of width of outer flow passage 7 3mm.The height dimension of the outer flow passage bottom 25 of each layer is higher than inner flow passage bottom
The height 1.5mm in portion 23；In the ramped bottom surface that transition position is high, outside is low after the connection transition of outer flow passage bottom 25.The interior stream of each layer
Two loudspeaker opening of road 6, in the reverse circular arc radian of main body 11 arc circle round bend 17, convolution the end of bend 17 at width most
It is narrow；Inner flow passage 6 is after wall 9 is hit by convolution and in the passage of the circular arc radian of main body 11 in the same direction.Total injection port 1 and general sample outlet 10
Diameter unanimously be 2.5mm, the diameter that first layer is exported to the 4th layer of outer flow passage is 1mm.
Resistance in the dark of the height dimension less than the top 3mm of inner flow passage 6, which is machined with, in the diffluence pass 4 of each separation unit keeps off dike 18.
Shunting island wall 5 is machined with the dark dike 19 of sorting mouthful of the height dimension less than sorting mouth 8 top 3mm at each sorting mouth 8.
Claims (6)
1. a kind of blood shunt device of dark dike formula, mainly by main body（11）With divided fluid stream passage composition, it is characterised in that：Main body
（11）It is in the form of annular discs, at the edge of disk to the center of circle, be machined with the shape of a spiral, up and down closing, the unequal divided fluid stream of width
Passage；Main body（11）Divided fluid stream passage >=3 layer；First layer split channel（2）The total injection port processed from the edge of disk
（1）Start, to the outlet of first layer outer flow passage（16）Terminate；On the channel centerline at every layer of split channel beginning, all process
There is one section of drainage dike（3）；Drainage dike（3）Downstream processing has the shunting island wall of quantity >=3（5）, shunt island wall（5）Shunting is logical
Road is from diffluence pass（4）Punish as inner flow passage（6）And outer flow passage（7）；Each inner flow passage（6）Place is all machined with the convolution of a protrusion
Hit wall（9）, circle round and hit wall（9）Downstream is close to a sorting mouth（8）；Sort mouth（8）Island wall is shunted at two（5）Between, will
Inner flow passage（6）With outer flow passage（7）Connection；Wall is hit in 1 convolution of the above（9）With 2 shunting island walls（5）Constitute a separation unit；
Sort mouth（8）Other inner flow passage（6）Entrance again turn into next separation unit diffluence pass（4）；Second layer split channel
（15）From the drainage dike of the second layer（3）Start, to the outlet of second layer outer flow passage（14）Terminate；Third layer split channel（12）From
Three layers of drainage dike（3）Start, to the outlet of third layer outer flow passage（13）Terminate；Layers below divided fluid stream passage the like,
Finally, inner flow passage（6）In main body（11）The general sample outlet in the center of circle（10）Terminate；The main body（11）In the diffluence pass of separation unit
（4）Place is machined with resistance in the dark gear dike（18）；Resistance in the dark keeps off dike（18）It is to be intercepted in lateral direction penetrating in inner flow passage（6）In, height dimension is low
In inner flow passage（6）Top 2mm ~ 5mm embankment wall；The main body（11）Shunting island wall（5）In sorting mouth（8）Place is machined with sorting
The dark dike of mouth（19）；Sort the dark dike of mouth（19）It is in shunting island wall（5）Back to fluid and flow direction identical one end, process convex
Go out one section, in laterally intercepting in sorting mouth（8）Place, but inwhole insertion sorting mouths（8）Height dimension less than sorting mouth（8）
Top 2mm ~ 5mm embankment wall.
2. a kind of blood shunt device of dark dike formula according to claim 1, it is characterised in that：The drainage dike（3）It is wide
0.5mm ~ 1mm, height dimension is less than divided fluid stream channel roof 2mm ~ 5mm band；The width per layer fluid split channel
Degree is consistent, and width dimensions >=5mm, or the width of the divided fluid stream passage of each layer successively increase or successively reduced；The shunting island
Wall（5）It is in fish shape, waveform, rhombus along divided fluid stream passage trend, or in fan-shaped, cattle horn shape, highly with fluid split channel
Top it is concordant, i.e., above and below sealing fluid split channel.
3. a kind of blood shunt device of dark dike formula according to claim 1, it is characterised in that：The outer flow passage（7）It is two
The smooth smooth-going of side wall along main body（11）The curved channel of circular arc smooth transition in the same direction；The outer flow passage of each layer（7）Width is consistent,
The divided fluid stream channel width dimension of width dimensions≤1/4, or each layer outer flow passage（7）Width dimensions be gradually reduced or gradually increase
Plus.
4. a kind of blood shunt device of dark dike formula according to claim 1, it is characterised in that：The inner flow passage（6）One
The width dimensions of each section of passage are inconsistent before, during and after individual separation unit, the inner flow passage of each layer（6）Width dimensions are inconsistent；Institute
State inner flow passage（6）Shape, the inner flow passage（6）Shape, front half section be in reverse main body（11）The arc convolution of circular arc radian
Bend（17）, wall is being hit by convolution（9）Afterwards again in main body in the same direction（11）The passage of circular arc radian；Or inner flow passage（6）Shape
Shape, is all reverse main body（11）Circular arc radian direction passage.
5. a kind of blood shunt device of dark dike formula according to claim 1, it is characterised in that：Total injection port（1）With
General sample outlet（10）Diameter it is consistent, and both greater than each layer outer flow passage（7）Outlet diameter；The outer flow passage（7）Outer flow passage
Bottom（25）Height dimension be higher than inner flow passage（6）Inner flow passage bottom（23）Height 0.5mm ~ 2mm；The outer flow passage bottom
（25）With inner flow passage bottom（23）In sorting mouth（8）Place, is by circular arc raised sorting mouthful bottom（24）Connect transition；Outflow
Road bottom（25）Connect after transition in the ramped bottom surface that transition position is high, outside is low.
6. a kind of blood shunt device of dark dike formula according to claim 1, it is characterised in that：Shunting island wall（5）Face
The shunting island wall point being tapered in fluid, one end opposite with flow direction（20）, shunting island wall point（20）Conical points quilt
Fine away and be processed into width dimensions >=1mm end face, end face is from inner flow passage（6）Side starts to be machined with the irregular convex of projection
Face（21）；Irregular convex surface（21）Area to outer flow passage（7）Gradually upper lower bifurcation reduces for side, is highly gradually lowered, most
Afterwards with irregular convex surface（21）Irregular concave surface in the middle of the fork of upper lower bifurcation（22）Combine together；Wall is hit in the convolution（9）Face
To on fluid, the side wall opposite with flow direction, being machined with not of uniform size, irregular convex surface pockety（21）No
Regular concave surface（22）.
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| CN201720111262.4U CN206492518U (en) | 2017-02-07 | 2017-02-07 | The blood shunt device of dark dike formula |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106823475A (en) * | 2017-02-07 | 2017-06-13 | 重庆科技学院 | A kind of blood shunt device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106823475A (en) * | 2017-02-07 | 2017-06-13 | 重庆科技学院 | A kind of blood shunt device |
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