CN206463540U - It is a kind of can wash cycles regeneration in situ chromatographic apparatus - Google Patents
It is a kind of can wash cycles regeneration in situ chromatographic apparatus Download PDFInfo
- Publication number
- CN206463540U CN206463540U CN201720109452.2U CN201720109452U CN206463540U CN 206463540 U CN206463540 U CN 206463540U CN 201720109452 U CN201720109452 U CN 201720109452U CN 206463540 U CN206463540 U CN 206463540U
- Authority
- CN
- China
- Prior art keywords
- cleaning
- reserve tank
- liquid reserve
- discharge pipe
- flange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model be related to it is a kind of can wash cycles regeneration in situ chromatographic apparatus, it is characterised in that：Described device includes cleaning expansion post, upper flange, chromatographic column, upper sieve plate, lower sieve plate, lower flange, cleaning flange, cleaning pipeline, discharge pipe line, circulating pump, liquid reserve tank and circulation line, the top of the chromatographic column is set together by upper flange with close be connected the in the bottom for cleaning expansion post, and the bottom of chromatographic column output end respectively with cleaning pipeline, the input of discharge pipe line are connected setting.The present apparatus is when in use, open the circulation pump is pumped directly into chromatographic column by cleaning pipeline by acid or alkali or deionization clear water, soaking and washing is carried out, waste liquid can be released by discharge pipe line, liquid reserve tank, and the chromatography column apparatus, which sets back, to come into operation again, effect is good, resin loss late is low, and labor intensity is low, facilitates feasible, industrialized production is especially suitable for, to using bringing facility.
Description
Technical field
The utility model belongs to chromatographic column equipment technical field, especially it is a kind of can wash cycles regeneration in situ chromatography dress
Put.
Background technology
At present, in Chromatographic purification ciclosporin A, tacrolimus, double hydrogen tacrolimus, ascosin, sirolimus, the white bacterium of spine
All need to be chromatographed with normal pressure chromatographic column during the antibiotic such as plain B, often need to use class when particularly once chromatographing upper hectogram level sample
Like 220*2200mm pilot scale chromatographic column, chromatographic column is after 5-6 Reusability, post effect meeting degradation, it is necessary to by chromatographic column
Ring flange and sieve plate are pulled down, the hz-816 macroreticular resins that removal is loaded, by macroreticular resin with moving in 150L Plastic Drums first with 3%
Hydrochloric acid or nitric acid dousing a few hours, then with agitator stirring mixing cleaning macroreticular resin a few hours, need to use high mesh number Buddhist nun after pickling
Imperial sock filtration, then discarded pickle is removed, cleans macroreticular resin until pH is neutral with deionization clear water repeatedly, then by neutrality
Macroreticular resin was put into 150L Plastic Drums with 3% soaking with sodium hydroxide a few hours, opened agitating device mixing cleaning a few hours, alkali
Filtered, then discarded alkali wash water removed with high mesh number nylon filter bag after washing, cleaned repeatedly with deionization clear water macroreticular resin up to
PH is neutral, replace and soaked with 80% or anhydrous propanone and fills post on request again again, and process is complicated, and resin loss late is big, works
Intensity is high, to using bringing inconvenience.
The content of the invention
The purpose of this utility model is to overcome the deficiencies in the prior art part can wash cycles regeneration in situ there is provided one kind
Chromatographic apparatus, when in use, acid or alkali or deionization clear water are pumped directly into the device by open the circulation pump by cleaning pipeline
Chromatographic column, carries out soaking and washing, and waste liquid can be released by discharge pipe line, liquid reserve tank, and the chromatography column apparatus sets back can be again
Secondary to come into operation, effect is good, and resin loss late is low, and labor intensity is low, facilitates feasible, is especially suitable for industrialized production, to using
Bring facility.
The utility model solves its technical problem and takes following technical scheme to realize：
It is a kind of can wash cycles regeneration in situ chromatographic apparatus, described device includes cleaning expansion post, upper flange, chromatography
Post, upper sieve plate, lower sieve plate, lower flange, cleaning flange, cleaning pipeline, discharge pipe line, circulating pump, liquid reserve tank and circulation line, institute
The top for stating chromatographic column is set together by upper flange with close be connected in the bottom for cleaning expansion post, and the bottom of the chromatographic column leads to
Cross the lower sieve plate being closely connected, lower flange and cleaning flange respectively with clean the output end of pipeline, discharge pipe line input
Be connected setting, is respectively provided with valve on the cleaning pipeline, discharge pipe line, the output end of the discharge pipe line can be discharged
Waste liquid；
Coaxial close connection sets upper sieve plate in the middle and upper part of the cleaning expansion post, and the input of the cleaning pipeline leads to
Cross circulating pump with liquid reserve tank to be connected setting, cleaning fluid can be stored in the liquid reserve tank；
The input of the circulation line is connected in the cleaning expansion post being arranged above upper sieve plate, the circulation line
Output end is connected setting with liquid reserve tank, and the bottom of the liquid reserve tank, which is provided with a blow-off pipe, the blow-off pipe, also is provided with a valve.
Advantage of the present utility model and good effect are：
The present apparatus includes cleaning expansion post, upper flange, chromatographic column, upper sieve plate, lower sieve plate, lower flange, cleaning flange, cleaning
Pipeline, discharge pipe line, circulating pump, liquid reserve tank and circulation line, when in use, open the circulation pump will by cleaning pipeline for the device
Acid or alkali or deionization clear water are pumped directly into chromatographic column, carry out soaking and washing, and waste liquid can be released by discharge pipe line, liquid reserve tank,
The chromatography column apparatus, which sets back, to come into operation again, and effect is good, and resin loss late is low, and labor intensity is low, facilitate feasible,
Industrialized production is especially suitable for, to using bringing facility.
Brief description of the drawings
Fig. 1 is structure connection diagram of the present utility model.
Embodiment：
Below by specific embodiment, the utility model is described in further detail, following examples be it is descriptive, no
It is limited, it is impossible to which protection domain of the present utility model is limited with this.
Structure, annexation and the method not being described in detail in the utility model, can be understood as public affairs in the art
Know general knowledge.
It is a kind of can wash cycles regeneration in situ chromatographic apparatus, as shown in figure 1, described device include cleaning expansion post 1, on
Flange 2, chromatographic column 3, upper sieve plate 13, lower sieve plate 4, lower flange 5, cleaning flange 6, cleaning pipeline 8, discharge pipe line 9, circulating pump
10th, liquid reserve tank 11 and circulation line 12, the top of the chromatographic column are closely connected by upper flange with cleaning the bottom of expansion post
It is set together, the bottom of the chromatographic column is managed with cleaning respectively by the closely coupled lower sieve plate connect, lower flange and cleaning flange
The output end of line, the input of discharge pipe line are connected setting, and valve 7 is respectively provided with the cleaning pipeline, discharge pipe line,
The output end of the discharge pipe line can discharge waste liquid；
Coaxial close connection sets upper sieve plate in the middle and upper part of the cleaning expansion post, and the upper sieve plate can be used in stopping tree
Fat is escaped, wash cycles regeneration, and the input of the cleaning pipeline is connected setting, the liquid reserve tank by circulating pump with liquid reserve tank
It is interior to store cleaning fluid, such as acid, alkali or deionized water；
The input of the circulation line is connected in the cleaning expansion post being arranged above upper sieve plate, the circulation line
Output end is connected setting with liquid reserve tank, and the bottom of the liquid reserve tank, which is provided with a blow-off pipe 14, the blow-off pipe, also is provided with a valve
Door.
The present apparatus includes cleaning expansion post, upper flange, chromatographic column, upper sieve plate, lower sieve plate, lower flange, cleaning flange, cleaning
Pipeline, discharge pipe line, circulating pump, liquid reserve tank and circulation line, when in use, open the circulation pump will by cleaning pipeline for the device
Acid or alkali or deionization clear water are pumped directly into chromatographic column, carry out soaking and washing, and waste liquid can be released by discharge pipe line, liquid reserve tank,
The chromatography column apparatus, which sets back, to come into operation again, and effect is good, and resin loss late is low, and labor intensity is low, facilitate feasible,
Industrialized production is especially suitable for, to using bringing facility.
A kind of application method of this chromatographic apparatus is as follows：
On-line cleaning method：3% hydrochloric acid or salpeter solution are first pumped into liquid reserve tank 11, open the circulation pump 10 opens valve
Door, controls flow, carries out wash cycles pollution resin 2-5 hours, and cleaning is finished, and the valve on circulating pump is closed with circulating pump 10
Close, discharge pipe line 9 and the blow-off pipe 14 of the bottom of liquid reserve tank 11 are opened, by discharging of waste liquid.In the liquid reserve tank 11 of waste liquid is racked up
Deionized water is pumped into, circulating pump 10 is then turned on, valve is opened, the resin in flow, circulation flushing chromatographic column, 10 minutes is controlled
Afterwards, waste liquid is discharged, deionized water rinsing is pumped into liquid reserve tank 11 again, it is repeated multiple times, until pH is neutral.By 3% hydrogen-oxygen
Change sodium solution and be pumped into liquid reserve tank, open the circulation pump 10 opens valve, controls flow, carry out wash cycles pollution resin 2-5 small
When, cleaning is finished, and the valve on circulating pump is closed with circulating pump 10, opens the blowdown of discharge pipe line 9 and the bottom of liquid reserve tank 11
Pipe, by discharging of waste liquid.Deionized water is pumped into the liquid reserve tank 11 racked up, circulating pump 10 is then turned on, valve, controlling stream is opened
Resin in amount, circulation flushing chromatographic column, after 10 minutes, discharges waste liquid, is pumped into deionized water rinsing in liquid reserve tank 11 again,
It is repeated multiple times, until pH is neutral.Chromatography column apparatus is set back and can be come into operation again, effect is good, resin loss late is low,
Labor intensity is low, facilitates feasible, is especially suitable for industrialized production, to using bringing facility.
Claims (1)
1. it is a kind of can wash cycles regeneration in situ chromatographic apparatus, it is characterised in that：Described device includes cleaning expansion post, upper method
Orchid, chromatographic column, upper sieve plate, lower sieve plate, lower flange, cleaning flange, cleaning pipeline, discharge pipe line, circulating pump, liquid reserve tank and circulation
Pipeline, the top of the chromatographic column is set together by upper flange with close be connected in the bottom for cleaning expansion post, the chromatographic column
Bottom by the closely coupled lower sieve plate connect, lower flange and cleaning flange respectively with cleaning the output end of pipeline, discharge pipe line
Input be connected setting, be respectively provided with valve, the output end of the discharge pipe line on the cleaning pipeline, discharge pipe line
Waste liquid can be discharged；
Coaxial close connection sets upper sieve plate in the middle and upper part of the cleaning expansion post, and the input of the cleaning pipeline is by following
Ring pump is connected setting with liquid reserve tank, and cleaning fluid can be stored in the liquid reserve tank；
The input of the circulation line is connected in the cleaning expansion post being arranged above upper sieve plate, the output of the circulation line
The setting that is connected with liquid reserve tank is held, the bottom of the liquid reserve tank, which is provided with a blow-off pipe, the blow-off pipe, also is provided with a valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720109452.2U CN206463540U (en) | 2017-02-06 | 2017-02-06 | It is a kind of can wash cycles regeneration in situ chromatographic apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720109452.2U CN206463540U (en) | 2017-02-06 | 2017-02-06 | It is a kind of can wash cycles regeneration in situ chromatographic apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206463540U true CN206463540U (en) | 2017-09-05 |
Family
ID=59703174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720109452.2U Expired - Fee Related CN206463540U (en) | 2017-02-06 | 2017-02-06 | It is a kind of can wash cycles regeneration in situ chromatographic apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206463540U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481962A (en) * | 2018-12-28 | 2019-03-19 | 大连大学 | A kind of automatic filling of chromatographic column and elution multifunctional combined apparatus |
-
2017
- 2017-02-06 CN CN201720109452.2U patent/CN206463540U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481962A (en) * | 2018-12-28 | 2019-03-19 | 大连大学 | A kind of automatic filling of chromatographic column and elution multifunctional combined apparatus |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203200824U (en) | Automatic washing water tank | |
| CN104548747A (en) | Intelligent filter control method | |
| CN104562165B (en) | Intelligent filter control system | |
| CN203400542U (en) | Filter cloth online soaking and pickling system of filter press in sludge dewatering work | |
| CN206463540U (en) | It is a kind of can wash cycles regeneration in situ chromatographic apparatus | |
| CN208927720U (en) | Automatic backwash basket filter | |
| CN104674517B (en) | A kind of filter and washing machine | |
| DE102013100859A1 (en) | Dishwasher and method for the introduction of fresh water in a dishwasher | |
| JP2011241867A (en) | Valve which can be cleaned and valve cleaning system | |
| CN105817060B (en) | It is rotary to wash filter by rubbing with the hands certainly | |
| CN109925743A (en) | A kind of column tomographic system of external closed cycle cleaning and regeneration | |
| CN204645169U (en) | A kind of Mousehold water saving toilet-flushing apparatus | |
| CN209077358U (en) | A kind of novel pulse cleaning machine | |
| CN206463541U (en) | It is a kind of can situ cleaning regeneration chromatographic apparatus | |
| CN206204071U (en) | A kind of bottle-washing water circulating purifying device | |
| CN204455343U (en) | A kind of intelligently filters Controlling System | |
| CN104436774A (en) | Mechanical filter | |
| DE10100163A1 (en) | Descaling apparatus for household appliances, e.g. dishwashers and washing machines, comprises a housing containing a descaling agent which is connected via the water inlet for the appliance | |
| CN203408517U (en) | On-line soaking and cleaning plate-and-frame filter press system | |
| CN203569631U (en) | Water tank with automatic cleaning function | |
| CN202762315U (en) | Ultrafiltration system | |
| CN106745975A (en) | Laundrywastes purification circulating device | |
| CN206549253U (en) | Sewage treatment filter with automatic pollution discharge and cleaning filter-screen function | |
| CN208610791U (en) | One key apparatus for eliminating sludge of covering type commercial dish-washing machine | |
| CN207076214U (en) | A kind of filter plant of wash cycles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170905 Termination date: 20200206 |