CN206431088U - A kind of biology sensor - Google Patents
A kind of biology sensor Download PDFInfo
- Publication number
- CN206431088U CN206431088U CN201621309579.0U CN201621309579U CN206431088U CN 206431088 U CN206431088 U CN 206431088U CN 201621309579 U CN201621309579 U CN 201621309579U CN 206431088 U CN206431088 U CN 206431088U
- Authority
- CN
- China
- Prior art keywords
- electrode
- diffusion
- biology sensor
- diffused component
- sensor according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model is related to technical field of biological, and in particular to a kind of biology sensor.Substrate layer, diffusion-controlled layer, space including being sequentially overlapped setting from the bottom to top manufacture layer and cover layer；Substrate layer is provided with electrode system, and electrode system includes spaced working electrode, to electrode and reference electrode, is located at the both sides of working electrode respectively to electrode and reference electrode, and auxiliary diffusion electrode is provided with reference electrode or to the outside of electrode.By setting auxiliary diffusion electrode, not only overcome the surface tension effects of substrate layer so that reagent can the smooth uniform diffusion on electrode system, and reach position set in advance, and interelectrode weak electromagnetic sensing, raising detection accuracy can be eliminated.
Description
Technical field
The utility model is related to technical field of biological, and in particular to a kind of biology sensor.
Background technology
In recent years, from initially with clinical labororatory's pattern detection to only need at one's side can be real in doctor's office or patient
Existing quick detection, medical health care detection field there occurs great variety.Disposable biological sensor with electrode system is frequent
It is used among quick detection.By taking the daily glucose detection of diabetic as an example, present patient need to only utilize one at home
Secondary property biology sensor is detected, so that it may is obtained the tested glucose level of patient at that time, is helped patient to understand itself in time
Health and adjust the dietary structure of oneself accordingly, or allow doctor according to the data of daily monitoring to dosage to hospital
It is adjusted.Therefore the accuracy of this kind of disposable biological sensor is particularly important in the daily monitoring of disease.
This kind of biology sensor with electrode system can be used for the detection of various materials, according to analyte not
Together, the reaction reagent added on electrode system is also different.The biology sensor of Glucose in Blood by Cyclic is for example determined, first
It is to add the reaction reagents such as glucose oxidase on the working electrode (s, when blood sample drops are added in working electrode, due to enzyme
Reaction reagent dissolves in blood, and the glucose in blood will react with the oxidizing ferment on working electrode, electron acceptor
Reduce therewith.After enzyme reaction terminates, the electron acceptor electrochemical oxidation of reduction is worth in sample by calculating oxidation current
The content of glucose.
The basic structure of this kind of biology sensor includes：One insulating base；There is electrode system on the insulating base,
The electrode system at least includes working electrode and to electrode；Containing according to measured matter content in sample, signal can be surveyed by producing
Reaction reagent is covered at least one working electrode；One detection sample channel for being formed by separation layer, sample channel position
On in working electrode and to electrode, detection sample reacts and produced with the reaction reagent in passage when passing through the call can be by
The signal detected.Instrument draws testing result according to the signal.
Participate in and detect that the amount of the reaction reagent of example reaction has a very big impact to testing result in passage.Therefore,
The amount for how accurately controlling the reaction reagent for participating in reaction is a big technical barrier of this area.Participate in the reaction reagent of reaction
Amount be equal to the area of sample channel and be multiplied by the thickness of reaction reagent layer, therefore, accurately control the difference of same batch production
The size and control reaction reagent caliper uniformity of sample channel between product are the problem of mainly needing to solve.
When being tested with biology sensor sample, the sample size of very little is generally only needed to, for example, only needs to 0.5 micro-
It is raised to 1 microlitre of amount of liquid.Biology sensor is also made into the structure of very little, is covered in reaction reagent on electrode just more
It is small.In the research for improving test accuracy, people do not notice that reaction reagent expands on the electrode of so small area
Diversity, and influence of these diversity to test result is presented in the situation of dissipating.People's structure often from electrode, the material of electrode
Make a search to improve the detection accuracy of biology sensor on material selection, test methodology and tester.And it was noted that
When using the distribution that rectangle diffusion of reagents control zone controls reaction reagent on electrode, the area of rectangle control zone is very thin
Small, reagent can cause electrode because surface tension effects form a hemispherical droplet-like in the groove of rectangle control zone
On reagent it is in uneven thickness, form thin result around thick middle, there is uneven or reaction examination at the edge of particularly coating area
Agent concentrates on the phenomenon in the centre of electrode activity region.And the presence of hemispherical droplet-like edge surface tension force is prevented
Reagent is further to around spreading, so as to occur reserving reagent blank area phenomenon, i.e., four between reagent edge and four drift angles
It can not be filled up at drift angle by reaction reagent.The biology sensor produced in this way occurs on the sensor having
Electrode activity region is uniformly covered full by reaction reagent, and the drift angle of some electrode activity regions does not have reaction reagent or covering
Became uneven one.The some positions of electrode do not have reaction reagent that sample segment can be caused to be not engaged in what is covered on reaction, electrode
The change that reaction reagent became uneven for a moment occurs reaction rate does not meet mode set in advance, and these can all cause detection
As a result inaccurate.
Auxiliary diffusion electrode is and for example disclosed in Chinese 2013101065210 patent come to being applied on feature electrode
Liquid reagent be diffused, but in fact, effect is not notable, it is impossible to improve the actual effect of diffusion.
Because the biology sensor size of the concentration of glucose in blood for detecting the mankind is very small, testing mechanism is very
Complexity, and the blood sample amount used is generally between 0.3-1.0 microlitre, therefore current technology level can only be obtained
To relatively accurate testing result.U.S.'s food and drug surveilance office（FDA）To for detecting that the glucose in blood of the mankind is dense
The legal requirements of the biology sensor of degree are：As long as the positive and negative deviation of more than 95% testing result and standard glucose concentration exists
Within 20%, product is to be considered as qualified.As can be seen here, lifting detects that concentration of glucose is accurate in human blood with biology sensor
The technical difficulty of true property is very high.
IDF（IDF）Statistics in 2011 show that global diabetic has increased to 3.66 at present
Hundred million people, it is contemplated that nearly 600,000,000 people was up in 20 years.In China, the illness rate of diabetes was turned over nearly twice at nearly 10 years.
2010, Chinese Adult diabetes prevalence was 9.7%, and diabetic is up to people more than 100,000,000 4 thousand.Because radix is huge, i.e.,
Test accuracy rate is set only to improve 1%, then, it will reduce by 3,600,000 person-times of mistaken diagnosis in the whole world, the whole world will have 3,600,000 people therefrom
Benefit, this will bring sizable economic benefit and social benefit.
Medical expert reminds, and diabetes are the important component of NCD, if do not monitored rationally and being controlled
Treat, the long term hyperglycemia state of diabetic can cause the infringement of whole body multisystem, cause various acute and chronic complication, such as heart
Vascular diseases, diabetic nephropathy, diabetic neuropathic pathology, diabetic retinopathy etc..Therefore, the accuracy of test is very
Important, patient can be effectively ensured in it and doctor has found change of illness state early, in time revision dosage and eating habit, prevent from suffering from
Person is chronically at hyperglycemia state, it is to avoid the generation of dire complications.Correctly whether distribution is one to reaction reagent on electrode
Ignored by people but be to ensure one of whole accurate key factor of test result.
The content of the invention
There is provided a kind of biological biography for the problem of the purpose of this utility model is to solve current biology sensor Shortcomings
Sensor.
In order to reach above-mentioned utility model purpose, the utility model uses following technical scheme：
A kind of biology sensor, it is characterised in that the substrate layer of insulating properties is set including being sequentially overlapped from the bottom to top, contained
Diffusion-controlled layer, space manufacture layer and the cover layer of diffusion of reagents control zone；Substrate layer is provided with electrode system, electrode system bag
Functional electrode is included, the outside of functional electrode is provided with auxiliary diffused component.
Preferably, functional electrode includes spaced working electrode, to electrode and/or reference electrode, to electricity
Pole and/or reference electrode are located at the both sides of working electrode respectively, are spread in reference electrode and/or to the outside of electrode provided with auxiliary
Element.
Preferably, the auxiliary diffused component is set for single or multistage.
Preferably, the region matching for opening up area and electrode system of the diffusion of reagents control zone.
Preferably, the working electrode, auxiliary diffused component, linearly arranged side by side to electrode and/or reference electrode
Set or the concentric circles at interval is set.
Preferably, described auxiliary diffused component is set for the form of bending.
Preferably, the area to electrode or reference electrode partly positioned at diffusion of reagents control zone is less than part position
Working electrode in diffusion of reagents control zone.
Preferably, partly it is located at reagent than part to electrode or reference electrode positioned at diffusion of reagents control zone to expand
The working electrode for dissipating control zone is thin.
Preferably, auxiliary diffused component is set with relative arc, and described opposing arcuate sets what is formed
Shape and the shape in the region set by diffusion-controlled layer are roughly equal.
Preferably, auxiliary diffused component is arranged at intervals to form ellipse with multistage, wherein including in ellipse
Working electrode, to one or more of electrode or reference electrode electrode.
Preferably, functional electrode includes spaced working electrode, to electrode and/or reference electrode, to electricity
Pole and/or reference electrode are located at the both sides of working electrode respectively.When only setting one to electrode/or reference electrode, wherein
This is located at the side of working electrode, when setting two simultaneously, respectively positioned at the both sides of working electrode.
Preferably, the auxiliary diffused component is located at the outside to electrode.
Preferably, the auxiliary diffused component is located at the outside of reference electrode.
Preferably, the diffusion-controlled layer is included on body, body above and below electrode system corresponding position is offered
Penetrating diffusion of reagents control zone.
Preferably, space manufacture layer offers open sample addition mouth positioned at electrode system corresponding position.
Preferably, passage is offered in electrode system corresponding position in cover layer, passage is added positioned at sample
The inside front of mouth.
Preferably, working electrode, electrode, reference electrode and auxiliary diffused component are linearly set up in parallel or together
Heart circle is set.
When being set for concentric circles, the diffusion of reagents control of auxiliary diffused component one similar half elliptic of formation
Area, when liquid reagent apply on the working electrode (s when, due to the hydrophobicity of insulating properties bottom plate, liquid solution into drops,
When being spread to surrounding, liquid can be allowed to contact the two ends of the auxiliary diffused component of bending in advance, so as to guide liquid fast
The diffusion of speed.In addition, the degree of the bending when auxiliary diffused component, such as curvature and the bending curvature one of diffusion of reagents control zone
When sample, whole diffusion of reagents control zone can be sprawled with accelerating liquid.
Preferably, diffusion-controlled layer size and electrode system match, space manufacture layer and cover layer with diffusion
Key-course matches.
Preferably, auxiliary diffused component to electrode with being smaller than working electrode and the spacing to electrode.
Preferably, auxiliary diffused component and reference electrode are smaller than between working electrode and reference electrode
Away from.
As preferred technical scheme, auxiliary diffused component is carbon coating, the screen printing work electrode on insulating base
Carbon-coating when, while silk-screen printing aid in diffused component.I.e. the material of auxiliary diffused component is with working electrode, to electrode
Material can be the same, can also be different, in order to convenient for production, using the same material.
Compared with prior art, beneficial effect is the utility model：This case is not only with the diffusion of reagents control for not having wedge angle
The sample-adding pattern in area processed, effectively overcomes the edge effect of reaction reagent, reaction reagent is uniformly distributed in electrode
Respective regions, so as to control exactly same batch produce biology sensor reaction reagent thickness homogeneity, enter
And improve the accuracy of testing result.In the production process of biology sensor, the reaction reagent filling added is expired and it
Shape identical reaction reagent adds area, it is to avoid the phenomenon that reaction reagent addition four, area drift angle is not filled up by reaction reagent.
Meanwhile, the biology sensor preparation technology of this case is simple, and the electrode system tool of the biology sensor of this programme
There is an auxiliary diffused component, the auxiliary diffused component can not only overcome the surface tension effects of insulating properties bottom plate so that examination
Agent can the smooth uniform diffusion on electrode system, and reach position set in advance, and the auxiliary diffused component of this case is set
In the outside to electrode or reference electrode, eliminate in the outside setting presence simultaneously to electrode and reference electrode to examining
The influence that data are caused, while set auxiliary diffused component working electrode relative with the spacing to electrode or reference electrode small,
Auxiliary diffused component is enabled to eliminate the influence of electromagnetic induction.
Brief description of the drawings
Fig. 1 is the structural representation of biology sensor of the present utility model；
Fig. 2 is the structural representation of substrate layer of the present utility model；
Fig. 3 is another structural representation of substrate layer of the present utility model；
Fig. 4 is another structural representation of substrate layer of the present utility model；
Fig. 5 is another structural representation of substrate layer of the present utility model；
Fig. 6 is the structural representation of diffusion-controlled layer of the present utility model；
Fig. 7 is the structural representation that space of the present utility model manufactures layer；
Fig. 8 is the structural representation of cover layer of the present utility model；
Fig. 9 is a kind of improved structure schematic diagram of substrate layer of the present utility model；
Figure 10 is another improved structure schematic diagram of substrate layer of the present utility model；
Figure 11 is the schematic layout pattern of electrode system of the present utility model；
Figure 12 is another schematic layout pattern of electrode system of the present utility model；
Figure 13 is another structural representation of the auxiliary diffused component of electrode system of the present utility model.
In figure：1 substrate layer, 2 diffusion-controlled layers, 3 spaces manufacture layer, 4 cover layers, 5 working electrodes, 6 pairs of electrodes, 7 references
Electrode, 8 auxiliary diffused components, 9 bodies, 10 diffusion of reagents control zones, 11 samples addition mouth, 12 passages, 13 electrode systems.
Embodiment
Explanation is further described to the technical solution of the utility model below by specific embodiment.
Embodiment 1：
A kind of biology sensor, as shown in figure 1, substrate layer 1, diffusion-controlled layer including being sequentially overlapped setting from the bottom to top
2nd, space manufacture layer 3 and cover layer 4；As shown in Fig. 2 substrate layer 1 is provided with electrode system, electrode system includes spaced
Working electrode 5, to electrode 6 and reference electrode 7, be located at the both sides of working electrode 5 respectively to electrode 6 and reference electrode 7, in reference
Electrode 7 or to the outside of electrode 6 provided with auxiliary diffused component 8.
As shown in Figure 3 and Figure 5, auxiliary diffused component 8 is located at the outside to electrode 6.Or as shown in Figure 2 and Figure 4, auxiliary
Diffused component 8 is located at the outside of reference electrode 7.As shown in Figures 2 and 3, working electrode 5, to electrode 6, reference electrode 7 and auxiliary
Diffused component 8 is linearly set up in parallel, as shown in Figure 4 and Figure 5, and each electrode is set for concentric circles.And, it is preferred that auxiliary expands
Dissipate element and working electrode and the spacing to electrode are smaller than to electrode；Aid in the spacing of diffused component and reference electrode small
In the spacing of working electrode and reference electrode.Outside, auxiliary diffused component 8 is set to be single or multiple, i.e., to electrode 6 or reference
The outside of electrode 7 sets the auxiliary diffused component 8 of two or 3 simultaneously, specifically as shown in fig. 9 or 10；
As shown in fig. 6, the diffusion-controlled layer 2 is included on body 9, body 9 above and below electrode system corresponding position is offered
Penetrating diffusion of reagents control zone 10, the region matching for opening up area and electrode system of diffusion of reagents control zone 10.
As shown in fig. 7, space manufacture layer 3, which is located at electrode system corresponding position, offers open sample addition mouth 11.
As shown in figure 8, offering passage 12 in electrode system corresponding position in cover layer 4, passage 12 adds positioned at sample
Plus the inside front of mouth 11.
In all of above embodiment, auxiliary diffused component is carbon coating, the screen printing work on insulating base
When the carbon-coating of electrode, while silk-screen printing aids in diffused component.
Embodiment 2：
It is arranged on the both sides of working electrode 5 simultaneously to electrode 6 and reference electrode 7, the setting quantity of auxiliary diffused component 8 is two
It is individual, i.e., auxiliary diffused component 8 is set simultaneously in the outside to electrode 6 and reference electrode 7；Auxiliary a kind of situation of diffused component 8 be
Linear pattern, another is circular arc, and when it is circular arc, the opening of two circular arcs is relative, forms symmetrical structure.
Meanwhile, auxiliary diffused component 8 can be single linear pattern or single hop arc, or the linear pattern of multistage or
The arc of multistage.
Embodiment 3：
When one of them is arranged on the outside of working electrode 5 to electrode 6 or reference electrode 7, now, diffused component 8 is aided in
One can be set, two can also be set；
Can be the linear pattern of single hop or the opening of single hop towards inner side when aiding in diffused component 8 to be set to one
Arc, or the multistage arc of the linear pattern of multistage or opening towards inner side.
The part-structure schematic diagram of embodiment 2 and 3 is shown in Figure 11-Figure 13.
Claims (10)
1. a kind of biology sensor, it is characterised in that the substrate layer of insulating properties is set including being sequentially overlapped from the bottom to top（1）, contain
There is diffusion of reagents control zone（10）Diffusion-controlled layer（2）, space manufacture layer（3）And cover layer（4）；Substrate layer（1）It is provided with
Electrode system（13）, electrode system（13）Including functional electrode, the outside of functional electrode is provided with auxiliary diffused component（8）.
2. biology sensor according to claim 1, it is characterised in that functional electrode includes spaced working electrode
（5）, to electrode（6）And/or reference electrode（7）, to electrode（6）And/or reference electrode（7）It is located at working electrode respectively（5）'s
Both sides, in reference electrode（7）And/or to electrode（6）Outside provided with auxiliary diffused component（8）.
3. biology sensor according to claim 1 or 2, it is characterised in that the auxiliary diffused component（8）To be single or
Multistage is set.
4. biology sensor according to claim 1 or 2, it is characterised in that the diffusion of reagents control zone（10）Open
If area and electrode system（13）Region match.
5. biology sensor according to claim 2, it is characterised in that the working electrode（5）, auxiliary diffused component
（8）, to electrode（6）And/or reference electrode（7）The concentric circles for being linearly set up in parallel or being spaced is set.
6. biology sensor according to claim 1, it is characterised in that described auxiliary diffused component（8）For bending
Form is set.
7. biology sensor according to claim 1 or 2, it is characterised in that partly positioned at pair of diffusion of reagents control zone
Electrode（6）Or reference electrode（7）Area be less than part be located at diffusion of reagents control zone working electrode（5）.
8. biology sensor according to claim 7, it is characterised in that partly positioned at diffusion of reagents control zone to electrode
（6）Or reference electrode（7）Than the working electrode that part is located at diffusion of reagents control zone（5）It is thin.
9. biology sensor according to claim 1 or 2, it is characterised in that the auxiliary diffused component（8）With relative
Arc is set, the region set by the formed shape of described opposing arcuate setting and diffusion-controlled layer（10）Shape phase
Match somebody with somebody.
10. biology sensor according to claim 1 or 2, it is characterised in that the auxiliary diffused component（8）With multistage
It is arranged at intervals and forms ellipse, wherein includes working electrode in ellipse（5）, to electrode（6）Or reference electrode（7）In one
Individual or multiple electrodes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621309579.0U CN206431088U (en) | 2016-12-01 | 2016-12-01 | A kind of biology sensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621309579.0U CN206431088U (en) | 2016-12-01 | 2016-12-01 | A kind of biology sensor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206431088U true CN206431088U (en) | 2017-08-22 |
Family
ID=59586186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621309579.0U Ceased CN206431088U (en) | 2016-12-01 | 2016-12-01 | A kind of biology sensor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206431088U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023222078A1 (en) * | 2022-05-18 | 2023-11-23 | 利多(香港)有限公司 | Biosensor and method for preparing biosensor |
-
2016
- 2016-12-01 CN CN201621309579.0U patent/CN206431088U/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023222078A1 (en) * | 2022-05-18 | 2023-11-23 | 利多(香港)有限公司 | Biosensor and method for preparing biosensor |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101173884B (en) | Electrochemical sensor and method for analyzing liquid sample | |
| TWI295372B (en) | Method and apparatus for electrochemical detection | |
| Moon et al. | Non‐Invasive Sweat‐Based Tracking of L‐Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration | |
| US10209214B2 (en) | Biosensor | |
| WO2018201931A1 (en) | Analyte monitoring and automatic medication delivery system | |
| JP5020641B2 (en) | Analyte testing apparatus and method | |
| CN101900701A (en) | Biosensor | |
| Ming et al. | Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study | |
| Kost et al. | Evaluation of point-of-care glucose testing accuracy using locally-smoothed median absolute difference curves | |
| CN206431088U (en) | A kind of biology sensor | |
| WO2021216614A1 (en) | A wearable patch for continuous analysis of sweat at a naturally secreting rate | |
| EP2980572B1 (en) | Biosensor and method for manufacturing a biosensor | |
| CN206431093U (en) | A kind of open diffusion control zone biology sensor | |
| Davis et al. | The challenges and promise of sweat sensing | |
| CN203324219U (en) | Biosensor | |
| Zhang et al. | Biosensor | |
| KR20170084310A (en) | Test element for electrochemically detecting at least one analyte | |
| CN104181291A (en) | Diagnostic method for assessing state of atopic dermatitis by TARC/CCL17 | |
| JP6436985B2 (en) | Analyte measuring instrument with operable range setting technology | |
| CN209086257U (en) | A kind of biosensor improving sample introduction speed | |
| CN203551502U (en) | Biosensor | |
| Fu et al. | Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids. Chemosensors 2023, 11, 467. htps | |
| Georgiou et al. | Semiconductors for early detection and therapy | |
| CN109115854A (en) | The test strips of joint test and the preparation method and application thereof that are a kind of while measuring two kinds of blood parameters | |
| JP2012220291A (en) | Biological specimen measuring apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| IW01 | Full invalidation of patent right | ||
| IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 20190301 Decision number of declaring invalidation: 39161 Granted publication date: 20170822 |