CN206359455U - Liquaemin device is produced in a kind of multistage resin dedicated concentration - Google Patents
Liquaemin device is produced in a kind of multistage resin dedicated concentration Download PDFInfo
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- CN206359455U CN206359455U CN201621225297.2U CN201621225297U CN206359455U CN 206359455 U CN206359455 U CN 206359455U CN 201621225297 U CN201621225297 U CN 201621225297U CN 206359455 U CN206359455 U CN 206359455U
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Abstract
The utility model is related to a kind of multistage resin dedicated concentration and produces liquaemin device, and its innovative point is：Including enzymolysis mechanism, the first thickening filtration mechanism, adsorption and desorption by resin mechanism, the second thickening filtration mechanism, Alcohol-settling tank and drying tower；Enzymolysis mechanism, the first thickening filtration mechanism, adsorption and desorption by resin mechanism, the second thickening filtration mechanism, Alcohol-settling tank and drying tower are set step by step；Realize that enzymolysis, ceramic membrane filter, resin adsorption, ethanol elution, the concentration of sodium filter membrane, alcohol precipitation and drying can significantly improve the purity and yield of liquaemin finished product from raw material, the service life of ion exchange resin can also be extended.
Description
Technical field
The utility model is related to a kind of liquaemin device for making, more particularly to heparin is produced in a kind of multistage resin dedicated concentration
Sodium device.
Background technology
Liquaemin mostlys come from the mucous membrane of chitterlings, is a kind of acid mucopolysaccharide containing sulfate, is typical anti-
Coagulant, can tissue blood condensation process, the formation of anti-tampon, wide clinical application and anti-tampon shape before and after surgical operation
Into and blood embolization, prevented during transfusion blood clotting and preserve new blood anti-coagulants, be widely used in prevent thrombus disease, control
The treatment of miocardial infarction and nephrosis is treated, China is the maximum country of heparin yield, during the heparin 70% of international market comes from
State, as the production of the increase in demand liquaemin in market is increasingly taken seriously.
The extracting method of liquaemin is mainly saltoutd extraction method and zymohydrolysis extracting method.Salting out method is domestic conventional heparin
Extracting method, its general principle is to utilize the protein phenomenon that solubility is reduced and precipitated in the salting liquid of high concentration.First use
Alkaline solution separates heparin from heparin-albumen composition, then removes protein using salting out method, through adsorbing, eluting,
Ethanol precipitation, dry after etc. obtain heparin product after conventional processes.This method is simple to operate, with low cost, but its shortcoming is egg
White matter can not be removed completely.Enzymatic Extraction is that the impurity protein in heparin is degraded into small-molecular peptides using protease, so that
Heparin molecule departs from, then by adjusting pH, thermal denaturation and the obtained heparin production of protein for removing zymoprotein and being degraded of saltouing
Product.
Extraction and purification process for liquaemin, there are reports for patent document.Publication No. CN102746421A,
It is entitled《The impurity removal process of crude heparin sodium》Patent document disclose a kind of method of purification of crude heparin sodium, mainly to thick
Product liquaemin is dissolved, adsorbed, being eluted, being precipitated and drying process, finally gives heparin sodium product.Publication No.
It is CN103588902A, entitled《The isolation and purification method of refined heparin sodium》Patent document disclose a kind of using absorption, alcohol
The method that heavy and two-step penetration method is purified to crude heparin sodium.It is Publication No. CN102993336A, entitled《It is a kind of thick
The purifying technique of product liquaemin》Patent document disclose using adding diatomite, after polyaluminium aluminium salt through centrifuging removal of impurities, then
Heparin sodium product is obtained after alcohol precipitation, hydrogen peroxide oxidation, alcohol precipitation and filtering, freeze-drying.Based on these above-mentioned patents
Document, is all mainly that liquaemin is purified by traditional method, technique is more complicated, and the production cycle of product is longer,
And medicament addition can be related in purification process, and alcohol precipitation need to expend substantial amounts of alcohol, and processing cost is higher, refines
Journey is complicated, and product purity is difficult to be lifted.
Utility model content
The technical problems to be solved in the utility model is to provide a kind of multistage resin dedicated concentration and produces liquaemin device, energy
The purity and yield of liquaemin finished product are significantly improved, the service life of ion exchange resin can also be extended.
In order to solve the above technical problems, the technical solution of the utility model is：Liver is produced in a kind of multistage resin dedicated concentration
Plain sodium device, its innovative point is：Including enzymolysis mechanism, the first thickening filtration mechanism, adsorption and desorption by resin mechanism, the second concentration
Filter mechanism, Alcohol-settling tank and drying tower；Digest mechanism, it is the first thickening filtration mechanism, adsorption and desorption by resin mechanism, second concentrated
Filter structure, Alcohol-settling tank and drying tower are set step by step；
The enzymolysis mechanism includes flash column, thermal source, enzymatic vessel, material source, condenser and vavuum pump a, the flash distillation
Tower includes first interface, second interface, the 3rd interface and discharging opening a, and material source is connected by first interface with flash column, digests
Tank is connected with the discharging opening a of flash column, and vavuum pump a is connected with the second interface of flash column, and thermal source passes through linker and flash column
The 3rd orifice, and the top of the linker is higher than the liquid level of material to be digested in flash column, condenser and flash column
Top be connected；
The first thickening filtration mechanism includes filtering tank a, ceramic membrane, the first sodium filter membrane and vavuum pump b；The filtering tank
A includes the 4th interface, the 5th interface and discharging opening b；Ceramic membrane and the first NF membrane are disposed with filtering tank a；Filtering tank a
The 4th interface be connected with the bottom of enzymatic vessel, vavuum pump b is connected with filtering tank a the 5th interface；
The adsorption and desorption by resin mechanism includes reactor, feeding mouth a, discharging opening c, resin addition mouth and ethanol addition
Mouthful；The reactor includes resin adsorption room and ethanol elution room；Feeding mouth a, resin addition mouth are arranged at reactor resin
The top of adsorption chamber, ethanol addition mouth is arranged on the top of ethanol elution room；The feeding mouth a and the first thickening filtration mechanism
Discharging opening b is connected；Discharging opening c is arranged on the bottom of ethanol elution room；
The second thickening filtration mechanism includes filtering tank b, the second sodium filter membrane, vavuum pump c；The filtering tank b includes the
Six interfaces, the 7th interface and discharging opening d；Second sodium filter membrane is arranged in filtering tank b；Filtering tank b the 6th interface and reactor
Discharging opening c be connected；Vavuum pump c is connected with the 7th interface on filtering tank b；
The Alcohol-settling tank includes feeding mouth b and discharging opening e；The feeding mouth b and filtering tank b of Alcohol-settling tank discharging opening d are connected,
The discharging opening e of Alcohol-settling tank is connected with drying tower.
Further, the enzymatic vessel is the container with agitating device.
Further, the average pore size of the ceramic membrane is 50-500nm.
The utility model has the advantage of：1）By digesting mechanism, the first thickening filtration mechanism, adsorption and desorption by resin machine
Structure, the second thickening filtration mechanism, Alcohol-settling tank and drying tower；Realize that enzymolysis, ceramic membrane filter, resin adsorption, ethanol are washed from raw material
De-, sodium filter membrane concentration, alcohol precipitation and drying can significantly improve the purity and yield of liquaemin finished product, can also extend ion friendship
Change the service life of resin.
Brief description of the drawings
The utility model is described in further detail with reference to the accompanying drawings and detailed description.
Fig. 1 is that liquaemin schematic device is produced in the resin dedicated concentration of multistage of the present utility model.
Fig. 2 is that liquaemin device flow chart is produced in the resin dedicated concentration of multistage of the present utility model.
Embodiment
The following examples can make professional and technical personnel that the utility model is more fully understood, but therefore will not
The utility model is limited among described scope of embodiments.
Multistage resin dedicated concentrate of one kind as shown in Fig. 1 Fig. 2 produces liquaemin device, including enzymolysis mechanism 1, first is dense
Contracting filter mechanism 2, adsorption and desorption by resin mechanism 3, the second thickening filtration mechanism 4, Alcohol-settling tank 5 and drying tower 6；Digest mechanism 1, the
One thickening filtration mechanism 2, adsorption and desorption by resin mechanism 3, the second thickening filtration mechanism 4, Alcohol-settling tank 5 and drying tower 6 are set step by step.
Digesting mechanism 1 includes flash column 11, thermal source 12, enzymatic vessel 13, material source 14, condenser 15 and vavuum pump a16,
The flash column 11 includes first interface 111, second interface 112, the 3rd interface 113 and discharging opening a114, and material source 14 passes through
First interface 111 is connected with flash column 11, and enzymatic vessel 13 is connected with the discharging opening a114 of flash column 11, vavuum pump a16 and flash distillation
The second interface 112 of tower 11 is connected, and thermal source 12 is connected by linker 17 with the 3rd interface 113 of flash column 11, and the company
The top of logical device 17 is higher than the liquid level of material to be digested in flash column 11, and condenser 15 is connected with the top of flash column 11.
First thickening filtration mechanism 2 includes filtering tank a21, ceramic membrane 22, the first sodium filter membrane 23 and vavuum pump b24；It is described
Filtering tank a21 includes the 4th interface 211, the 5th interface 212 and discharging opening b213；Ceramic membrane is disposed with filtering tank a21
22 and first NF membrane 23；Filtering tank a21 the 4th interface 211 is connected with the bottom of enzymatic vessel 13, vavuum pump b24 and filtering tank
A21 the 5th interface 212 is connected.
Adsorption and desorption by resin mechanism 3 includes reactor 31, feeding mouth a32, discharging opening c33, resin addition mouth 34 and ethanol
Add mouth 35；The reactor 31 includes resin adsorption room 311 and ethanol elution room 312；Feeding mouth a32, resin addition mouth 34
The top of the resin adsorption room 311 of reactor 31 is arranged at, ethanol addition mouth 34 is arranged on the top of ethanol elution room 35；It is described
Feeding mouth a32 is connected with the discharging opening b213 of the first thickening filtration mechanism 2；Discharging opening c33 is arranged on the bottom of ethanol elution room 312
End.
Second thickening filtration mechanism 4 includes filtering tank b41, the second sodium filter membrane 42, vavuum pump c43；The filtering tank b41 bags
Include the 6th interface 411, the 7th interface 412 and discharging opening d413；Second sodium filter membrane 42 is arranged in filtering tank b41；Filtering tank b41
The 6th interface 411 be connected with the discharging opening c33 of reactor 31；Vavuum pump c43 and the phase of the 7th interface 412 on filtering tank b41
Even.
Alcohol-settling tank 5 includes feeding mouth b51 and discharging opening e52；The feeding mouth b51 and filtering tank b41 of Alcohol-settling tank 5 discharging opening
D413 is connected, and the discharging opening e51 of Alcohol-settling tank 5 is connected with drying tower 6.
Enzymatic vessel 12 is the container with agitating device.
The average pore size of ceramic membrane 22 is 50-500nm.
The operation principle that the multistage resin dedicated agriculture speed produces liquaemin is：By by what is smashing, chitling being cleaned, twisted
It is broken, after the mixing that adds water, digested, gained enzymolysis liquid obtains ceramic membrane clear liquid by ceramic membrane cross-flow filtration；Gained ceramics
Film clear liquid is concentrated with the first NF membrane, obtains the first concentrate；The first concentrate of gained resin adsorption, elution, are eluted
Liquid；Gained eluent is concentrated with the second NF membrane, obtains the second concentrate；The concentrate of gained second passes through ethanol alcohol precipitation, done
Liquaemin finished product is obtained after dry.
It should be understood by those skilled in the art that, the utility model is not restricted to the described embodiments, above-described embodiment and
Simply illustrate principle of the present utility model described in specification, on the premise of the utility model spirit and scope are not departed from,
The utility model also has various changes and modifications, and these changes and improvements both fall within claimed the utility model scope
It is interior.Scope is claimed by appended claims and its equivalent thereof in the utility model.
Claims (3)
1. liquaemin device is produced in a kind of multistage resin dedicated concentration, it is characterised in that：Including enzymolysis mechanism, the first thickening filtration
Mechanism, adsorption and desorption by resin mechanism, the second thickening filtration mechanism, Alcohol-settling tank and drying tower；Digest mechanism, the first concentrated filter
Structure, adsorption and desorption by resin mechanism, the second thickening filtration mechanism, Alcohol-settling tank and drying tower are set step by step；
The enzymolysis mechanism includes flash column, thermal source, enzymatic vessel, material source, condenser and vavuum pump a, the flash column bag
Include first interface, second interface, the 3rd interface and discharging opening a, material source is connected by first interface with flash column, enzymatic vessel with
The discharging opening a connections of flash column, vavuum pump a connects with the second interface of flash column, thermal source pass through linker and flash column the
The top of three orifices, and liquid level of the top higher than material to be digested in flash column of the linker, condenser and flash column
End is connected；
The first thickening filtration mechanism includes filtering tank a, ceramic membrane, the first sodium filter membrane and vavuum pump b；The filtering tank a bags
Include the 4th interface, the 5th interface and discharging opening b；Ceramic membrane and the first NF membrane are disposed with filtering tank a；Filtering tank a's
4th interface is connected with the bottom of enzymatic vessel, and vavuum pump b is connected with filtering tank a the 5th interface；
The adsorption and desorption by resin mechanism includes reactor, feeding mouth a, discharging opening c, resin addition mouth and ethanol addition mouth；Institute
Stating reactor includes resin adsorption room and ethanol elution room；Feeding mouth a, resin addition mouth are arranged at reactor resin adsorption room
Top, ethanol addition mouth is arranged on the top of ethanol elution room；The feeding mouth a and the first thickening filtration mechanism discharging opening
B is connected；Discharging opening c is arranged on the bottom of ethanol elution room；
The second thickening filtration mechanism includes filtering tank b, the second sodium filter membrane, vavuum pump c；The filtering tank b connects including the 6th
Mouth, the 7th interface and discharging opening d；Second sodium filter membrane is arranged in filtering tank b；Filtering tank b the 6th interface and going out for reactor
Material mouth c is connected；Vavuum pump c is connected with the 7th interface on filtering tank b；
The Alcohol-settling tank includes feeding mouth b and discharging opening e；The feeding mouth b and filtering tank b of Alcohol-settling tank discharging opening d are connected, alcohol precipitation
The discharging opening e of tank is connected with drying tower.
2. liquaemin device is produced in a kind of multistage resin dedicated concentration according to claim 1, it is characterised in that：The enzyme
Solution tank is the container with agitating device.
3. liquaemin device is produced in a kind of multistage resin dedicated concentration according to claim 1, it is characterised in that：The pottery
The average pore size of porcelain film is 50-500nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621225297.2U CN206359455U (en) | 2016-11-15 | 2016-11-15 | Liquaemin device is produced in a kind of multistage resin dedicated concentration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621225297.2U CN206359455U (en) | 2016-11-15 | 2016-11-15 | Liquaemin device is produced in a kind of multistage resin dedicated concentration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206359455U true CN206359455U (en) | 2017-07-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621225297.2U Active CN206359455U (en) | 2016-11-15 | 2016-11-15 | Liquaemin device is produced in a kind of multistage resin dedicated concentration |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106380527A (en) * | 2016-11-15 | 2017-02-08 | 如皋市坝新肠衣有限公司 | Device for preparing heparin sodium by concentrating multilevel special resin |
-
2016
- 2016-11-15 CN CN201621225297.2U patent/CN206359455U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106380527A (en) * | 2016-11-15 | 2017-02-08 | 如皋市坝新肠衣有限公司 | Device for preparing heparin sodium by concentrating multilevel special resin |
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