CN205964235U - Novel weave vascular support - Google Patents

Abstract

The utility model provides a novel weave vascular support, includes support and medicine carrying coating, its characterized in that: the passive film that the support surface has the one deck to handle, medicine carrying coating coat on the surface of passive film, the diamond mesh form body that the support formed for use metal filament weaves in succession, all diamond crossing put and are the moving point that lives, the rhombus grid density of support open end is less than the rhombus grid density of interlude, the surface of silk is woven to the passive film at the support metal, the medicine carrying coating comprises carrier and medicine, and the medicine passes through the carrier peridium on the surface of support passive film, the medicine is rapamycin or taxol, the metal filament cross sectional shape can be for circular, also can be for the deltiod. The utility model discloses a different and the surface coating drug coating of support net braiding density in the axial can effectively reduce the stimulation that normal blood vessel received, reduces the incidence of reangiostenosis, reduces thrombosis, improves support adherence nature and compliance.

Description

A kind of novel weaved intravascular stent

Technical field

The utility model is related to a kind of blood vessel insertion type medicine equipment of medical instruments field, more particularly, to a kind of new volume Knit intravascular stent.

Background technology

PCI is a kind of new diagnostic and treatment angiocardiopathy technology, through puncturing peripheral vascular, subtracts in numeral Under the continuous throwing of shadow is shone, send into vessel catheter, by specific vessel catheter operating technology, vascular diseases are made a definite diagnosis and control Treat, such method is little to the wound of patient, its high security and validity have been subject to the affirmative of doctor and patient, it has also become blood The critical treatment method of pipe disease.

Intravascular stent implantation refers to, on the basis of tube chamber balloon expandable shapes, prop up to reach in lesion Stent Implantation Hold stenosis occlusion section blood vessel, reduce blood vessel elasticity retraction and moulding again, the unimpeded purpose of holding tube chamber blood flow, also there is prevention again Narrow effect.Wherein, the braided support of close mesh due to its good compliance, stronger support force, good adherence quality, Excellent fatigue resistance and its blood vessel minor impact is widely paid close attention to.

In prior art, braided support generally includes the netted body being knitted to form by least metal monofilament, this net Shape body has uniform count structure.However, after braided support implantation human body, the openend at two ends is just generally attached at Normal blood vessel, support intermediate body portion attaches vascular lesion region, for guaranteeing effectively to strut lesion blood vessel, support Need there is larger radial support power to provide enough supports, but simultaneously larger radial support power can be produced to normal blood vessels The larger stimulation of life, and during human motion, the friction to this position can be increased with angiokinesis in carrier openings end, Carrier openings end reangiostenosis rate is led to increase, increase.For to sum up, the support of integral weaving even structure can not be fine Ground is applied to actual implantation.

Clinically widely used intravascular stent mainly has bare metal stent and the bracket for eluting medicament of laser cutting at present. Laser cut metal bare bracket achieves, after entering clinical treatment, the curative effect attracting people's attention, but the application through more than ten years Gradually expose some shortcomings and disadvantage, such as compliance deficiency is pliable, easy fracture；In addition there is also thrombosis rate at a specified future date High, restenosis rate is high, the problems such as cause vascular damaged.Clinical research shows that bare metal stent is implanted in latter 6 months supports again Narrow incidence up to 20%～30%.Bracket for eluting medicament, is in the one layer of prevention of laser cut metal bare bracket surface spraying The medicine of reangiostenosis, the application of this technology so that in postoperative 1 year of metallic support restenosis rate fall below less than 10%.

Chinese patent literature CN105250058A discloses a kind of tube chamber braided support, is knitted to form including by metal monofilament Netted body, netted body includes Part I and Part II vertically；Netted body also includes multiple first and hooks around knot, The often metal monofilament of at least two one end being derived from Part II axially mutually hooking around formation one first along netted body Hook after knot separately, the metal monofilament that all compositions first hook around knot is knitted to form Part I；The mesh density of Part I Mesh density less than Part II.Above-mentioned tube chamber braided support, the mesh density due to Part I is less than Part II Mesh density, so that the radial support power of Part I reduces, reduces the stimulation to normal wall of the lumen for the Part I, thus dropping The risk of low ISR.This support is bare metal stent, and surface does not have coated medicament coating.

Chinese patent literature CN201150578Y discloses a kind of braided blood vessel stent, woven by single elastic metallic yarn and Become, including a tubular network body and an outer layer ring network skirt being connected in the middle part of this body, tubular is netted Multiple deformable units being surrounded by netting twine are all comprised, at the two ends of network body in rack body and outer layer ring network skirt And the free end of net skirt forms multiple arcs line and turns, each netting twine is that slidably contact connects in intersection, described volume The surface knitting intravascular stent is uniformly coated with one layer of medication coat that can prevent reangiostenosis.This support grid vertically Count is identical.

Braided support in above-mentioned patent document, or the braided metal bare bracket that mesh-density is different, but do not apply Cover medication coat, or the carried stent of coated medicament coating, but open weave density is identical in the axial direction, two kinds of supports are not Can pre- preventing restenosis of blood vessel well generation, reduce the formation of thrombus.

Further, since the continuous development of minimally invasive medical technology, intervention apparatus also develop toward microminiaturization direction.Apparatus Profile is less, and the wound that patient is caused is also less.The metal monofilament of braided support, cross sectional shape is generally circular in cross section, though energy Ensure enough mechanical strengths, but the radial dimension of radial dimension, particularly supporting conveyer is also restricted it is impossible to be made more Little.

Utility model content

In view of the deficiency of the above-mentioned braided support of prior art, the purpose of this utility model is to develop a kind of axially surfs the Net Lattice count difference and the novel weaved intravascular stent of surface coating combination drug coating, it can effectively reduce in normal blood vessels What wall was subject to stimulates, and reduces the incidence of reangiostenosis, reduces thrombosis, improves support adherence quality and compliance；Simultaneously Apparatus can realize less profile, reduces the damage to patient.

The purpose of this utility model to be realized especially by following technical scheme：

A kind of novel weaved intravascular stent, including support and drug-carried coat.Rack surface has one layer of passivating film processing. On the surface of backbone metal monofilament, drug-carried coat is coated in the surface of passivating film to passivating film.Passivating film is so that stenter to implant Blood vessel long term stenosis rate reduces afterwards, and further, the medication coat for preventing blood vessel hyperplasia purposes is coated in passivation Film surface.Support is the diamond-mesh body using metal monofilament continuous weaving, and support is in straight tube-like or band taper.Support The network density of openend is less than the network density of interlude, and all diamond crossing points are moving point.Rhombus net Lattice density is different, then produced support force is also different.Above-mentioned design makes support both ends open part support force compare pars intermedia Divide slightly weak, thus reducing the risk that carrier openings end causes blood vessel hyperplasia to vascular wall repetitious stimulation.Diamond crossing point can Activity variable-length so that rhombus is diagonally played, so that support possesses and good has compliance and good bend resistance ability. Drug-carried coat is made up of carrier and medicine, and medicine is coated on the surface of support passivating film by carrier.Described medicine is that thunder handkerchief is mould Element or taxol, this is through Long-term clinical, is proved safely and effectively medicine.Metal monofilament cross sectional shape can be circle, It can also be deltiod.Circular monofilaments mechanical strength is preferable；Deltiod monofilament, in addition to enough mechanical properties are provided, Ke Yibang Conveyer is helped to accomplish less Profile, thus reducing the damage to patient.

Further, described support is to be formed using metal monofilament continuous weaving, profile straight tube-like or taper, and has whole The netted body of the continuous network of body.

Further, network catercorner length in the axial direction in described carrier openings end is 1.71～2.50mm, in Between section network catercorner length in the axial direction be 0.80～1.70mm.Prop up in peripheral vascular Weaving type for applying Frame, above-mentioned parameter can ensure that support provides enough support forces for blood vessel.

Further, network length in the axial direction in described carrier openings end is 5～15mm.This partial-length needs Moderate, too short then carrier openings end support force is too strong, and this still can be made partly vascular wall to be caused transition to stimulate；Long, affect Rack body section expanding and supporting role to hemadostewnosis part.

Further, there is one layer of passivating film on the metal monofilament surface of described support.There is chemistry with material surface in passivating film It is reacted to a material surface part.

Further, described carrier is polymer.

Further, when the section of described metal monofilament is deltiod, fitted with vascular wall in the long side in deltiod silk section.

Further, each grid of the metal monofilament of described support is that slidably contact connects in intersection.

Further, the head end of described metal monofilament and end can be welded together by the connecting tube of NiTi material. Connection bore big 0.02～0.05mm than metal monofilament external diameter.Aforesaid way can avoid exposed wire head to pierce through blood vessel The risk of wall.

Further, the head end of described metal monofilament and end, by overlap mode coincidence one segment distance, form closed loop.On The mode of stating operates relatively simply, and cost is relatively low.

Further, described metal monofilament material is Nitinol, or platinum core nitinol alloy wire.Material requirements possesses Certain mechanical strength, elastic recovery, and possess certain developability.

Further, described stent diameter is 3.5-12mm, and length is 10-250mm.

Further, when the section of described metal monofilament is circular, a diameter of 0.12～0.20mm of silk.Propped up according to different Frame diameter, and braiding difficulty, select suitable filament diameter.

Further, when the section of described metal monofilament is deltiod, the long side of silk is 0.10～0.40mm, and minor face is 0.05～0.20mm.

Compared with prior art, during the openend open weave density of novel weaved intravascular stent of the present utility model is less than Between section mesh-density, thus reducing the radial load making openend, the stimulation to normal vascular wall for the openend can be reduced, from And reduce the risk of ISR；And support is passivated processing, and it is coated with composite drug-loaded coating on surface, blood can be reduced The formation of bolt, reduces the incidence of ISR.Bracket conveyer can accomplish less Profile, thus reducing to patient's Damage.

Brief description

In order to be illustrated more clearly that the technical scheme of the utility model embodiment, below will be to required in embodiment description The accompanying drawing using is briefly described.It is readily apparent that drawings in the following description are only some described in the application Specific embodiment, it is not the restriction to protection domain of the present utility model.For those of ordinary skill in the art, not On the premise of paying creative work, certainly can also obtain some its according to these embodiments of the present utility model and its accompanying drawing Its embodiment and accompanying drawing.

Fig. 1 is the structural representation of the utility model novel weaved intravascular stent.

Fig. 2 is support section mplifying structure schematic diagram of the present utility model.

Fig. 3 is the structural representation of drug-carried coat of the present utility model.

Fig. 4 is the structural representation of openend of the present utility model grid.

Fig. 5 is the structural representation of middle segment mesh of the present utility model.

Fig. 6 is the structural representation of circular connecting pipe of the present utility model.

Fig. 7 is the structural representation of deltiod connecting tube of the present utility model.

Fig. 8 is metal monofilament head end of the present utility model and end welded structure schematic diagram.

Fig. 9 is metal monofilament head end of the present utility model and end overlaps coincidence schematic diagram.

The cross section structure schematic diagram of Figure 10 deltiod monofilament.

Figure 11 is the a-a cross-sectional view that in Fig. 1, metal monofilament section is during circle.

Figure 12 is the a-a cross-sectional view that in Fig. 1, metal monofilament section is during deltiod.

In figure：100th, support, 1, metal monofilament, 11, openend, 12, interlude, 110, openend grid, 120, middle Segment mesh, 1a, monofilament head end, 1b, monofilament end, 2, passivating film, 3, drug-carried coat, 31, carrier, 32, medicine, 4, connecting tube, 41st, circular connecting pipe, 42, deltiod connecting tube.

Specific embodiment

In order that those skilled in the art more fully understand the technical scheme in the application, new below in conjunction with this practicality Accompanying drawing in type embodiment, is clearly and completely described to the technical scheme in the utility model embodiment.Obviously, retouched The embodiment stated is only some embodiments of the present application, rather than whole embodiments.Based on concrete reality described herein Apply example, all other embodiment that those of ordinary skill in the art are obtained on the premise of not making creative work, all Should fall within the utility model concept.

Referring now to accompanying drawing, the utility model is described in further detail.

Referring to Fig. 1 and Fig. 2, a kind of new braided blood vessel stent, include support 100 and drug-carried coat 3.

As shown in figure 1, described support 100 is to be risen to other end spiral woven in special dies from metal monofilament 1 from one end On, intersect both axially and radially around and circulate braiding network netted body, be then passed through 450 DEG C～ 550 DEG C of high-temperature shapings 8～15 minutes, then obtain one layer of passivating film 2 through chemical treatment on metal monofilament 1 surface again.Passivation Film 2 becomes a part for metal monofilament 1 material surface, and dependent exists.

The netted body of described support 100 is formed by least metal monofilament 1 braiding, for example, can be a metal Monofilament 1 reciprocal knitting forms or many metal monofilament 1 cooperate, and the braiding that crosses forms, follow-up illustrate in no longer bright Really distinguish, all can be described as many metal monofilament；Described metal monofilament 1 can be nickel-iron wire or platinum core Nitinol Silk；The section of described metal monofilament 1 can be circular or deltiod, when the section of metal monofilament 1 is circular, silk A diameter of 0.12～0.20mm, when the section of metal monofilament 1 is deltiod, the long side w value of silk is 0.10～0.40mm, minor face T value is 0.05～0.20mm, such as Figure 10.

In described novel weaved intravascular stent 100, described special dies can be designed as needed, so that support Openend 11 and the braided parameter of support interlude 12（Such as braiding helical pitch and length）Independently of one another, mutually not limited peace treaty Bundle, changes described special dies structure it is possible to the braided parameter of separately adjustable openend 11 or intermediate ends 12, therefore openend 11 and interlude 12 can have different braided parameter, the mesh-density of corresponding openend 11 and interlude 12 differs. Mesh-density herein refers to the number of weave mesh in unit area；If the mesh-density of knitted body is less, this part Knitted body has preferable compliance, and radial load support force is less, and vice versa.

Referring to Fig. 1, after support 100 implantation human body, openend 11 is attached at normal blood vessel, and interlude 12 attaches In lesion vesselses inwall.Openend 11 interlude 12 relatively has more sparse mesh-density, the therefore radial direction of openend 11 Support force is relatively small, and such that it is able to relatively reduce the stimulation to normal vascular wall, the body weakening body foreign matter to external world is anti- Should, reduce ISR risk, simultaneously the larger interlude of mesh-density 12 be still provided that enough radial support power it is ensured that Support fixation in intravascular.

Referring to Fig. 2 and Fig. 3, described drug-carried coat 3 is coated in the surface of the passivating film 2 of support 100, and drug-carried coat 3 is by carrying Body 31 and medicine 32 form, and the surface coating one layer of polymeric carrier 31 of the passivating film 2 of support 100, outside this polymer support 31 It has been coated with medicine 32, described medicine 32 is rapamycin or taxol, drug-carried coat 3 can reduce the endometrial hyperplasia of blood vessel, The generation of preventing in-stent restenosis.

Referring to Fig. 4 and Fig. 5, the catercorner length in the axial direction of openend grid 110 is a, its value is 1.71～ 2.50mm, the catercorner length on axial mountain for the middle segment mesh 120 is b, and its value is 0.80～1.70mm.

Referring to Fig. 6, Fig. 7 and Fig. 8, described connecting tube 4 can be hollow circular connecting pipe 41 or hollow flat Square connecting tube 42, the effect of connecting tube 4 is to be welded on one by 4 monofilament head end 1a of connecting tube and monofilament end 1b three Rise.During welding, monofilament head end 1a and monofilament end 1b is respectively penetrated in connecting tube 4, by monofilament head end 1a and monofilament end 1b Contact and be placed in the centre of connecting tube 4, then carry out laser welding, the shadow region in Fig. 8 is weld seam.Described connecting tube 4 Material be niti material.

Referring to Fig. 6, Fig. 7 and Figure 10, when the metal monofilament 1 used by when braided support 100 is circular monofilaments, connected with circular Monofilament head end 1a and monofilament end 1b is welded together by pipe 41, and the internal diameter d of circular connecting pipe 41 is bigger than the external diameter of circular monofilaments 0.001～0.02mm；When metal monofilament 1 used by when braided support 100 is deltiod monofilament, will be single with deltiod connecting tube 42 Silk head end 1a and monofilament end 1b welds together, and the long edge lengths of inner chamber of deltiod connecting tube 42 are e, and bond length is f, e Bigger 0.01～0.05mm than w, f 0.01～0.05mm bigger than t.

Referring to Fig. 1 and Fig. 9, described metal monofilament head end 1a and monofilament end 1b by overlap mode overlap a segment distance C, Form closed loop, the length of C is（0.5～1）π D, wherein D are the diameter of support.

Referring to Fig. 1 and Figure 11, when the section of metal monofilament 1 is circular, a-a cross-section structure such as Figure 11, Tu11Zhong in Fig. 1 Shadow region be monofilament section.

Referring to Fig. 1 and Figure 12, when the section of metal monofilament 1 is deltiod, a-a cross-section structure such as Figure 12, Figure 12 in Fig. 1 In shadow region be monofilament section, the long side w of deltiod monofilament fits in the inwall of blood vessel.

The utility model is mainly used in the angiostenosis problem that vascular lesion leads to, and is particularly suited for ilium, stock, artery narrow Narrow.

Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or new using this practicality Type.Multiple modifications to these embodiments will be apparent from for those skilled in the art, is determined herein The General Principle of justice can be realized in the case of without departing from spirit or scope of the present utility model in other embodiments.Cause This, the utility model will not be limited to the embodiments shown herein, and be to fit to principles disclosed herein and The consistent scope the widest of features of novelty.

Claims (14)

1. a kind of novel weaved intravascular stent, including support and drug-carried coat it is characterised in that：Described rack surface has at one layer The passivating film managed, drug-carried coat is coated in the surface of passivating film, and described support is formed using metal monofilament continuous weaving Diamond-mesh body, all diamond crossing points are moving point, and the network density at described carrier openings end is less than interlude Network density, described passivating film is made up of carrier and medicine in the surface of backbone metal braided wires, described drug-carried coat, Medicine is coated on the surface of support passivating film by carrier, and described medicine is rapamycin or taxol, and described metal monofilament cuts Face shape can be circular or deltiod.

2. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described support is to use metal monofilament Continuous weaving forms, profile straight tube-like or taper, and has the netted body of overall continuous network.

3. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described carrier openings end network Catercorner length in the axial direction be 1.71～2.50mm, interlude network catercorner length in the axial direction be 0.80～ 1.70mm.

4. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described carrier openings end network Length in the axial direction is 5～15mm.

5. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that the braided wires surface of described support has Passivating film, passivating film and material surface occur chemical reaction to become a material surface part.

6. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described carrier be polymer.

7. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described metal monofilament section be flat When square, fitted with vascular wall in the long side in deltiod silk section.

8. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that the metal monofilament of described support each Grid is that slidably contact connects in intersection.

9. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that the head end of described metal monofilament and end End can be welded together by the connecting tube of NiTi material.

10. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that the head end of described metal monofilament and End, by overlap mode coincidence one segment distance, forms closed loop.

11. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described metal monofilament material be nickel Titanium alloy, or platinum core nitinol alloy wire.

12. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that described stent diameter be 3.5～ 12mm, length is 10～250mm.

13. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that the section of described metal monofilament is When circular, a diameter of 0.12～0.20mm of silk.

14. as claimed in claim 1 a kind of novel weaved intravascular stent it is characterised in that the section of described metal monofilament is During deltiod, the long side of silk is 0.10～0.40mm, and minor face is 0.05～0.20mm.