CN205949080U - Rich blood platelet plasma separation extraction element - Google Patents

Rich blood platelet plasma separation extraction element Download PDF

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Publication number
CN205949080U
CN205949080U CN201620924869.XU CN201620924869U CN205949080U CN 205949080 U CN205949080 U CN 205949080U CN 201620924869 U CN201620924869 U CN 201620924869U CN 205949080 U CN205949080 U CN 205949080U
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China
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blood
extraction device
rich plasma
platelet rich
upper lid
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CN201620924869.XU
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宋东范
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GUANGZHOU PAILI BIOTECHNOLOGY Co.,Ltd.
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Guangzhou Li Biological Technology Co Ltd
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Abstract

The utility model provides a rich blood platelet plasma separation extraction element, including main part pipe, upper cover and lower cover. The utility model discloses can realize that blood only through once the centrifugation is back, only can separate and draw the separating layer of blood through a container to shorten the activity duration by a wide margin, PRP's loss in can preventing to transfer, the convenience and the efficiency of operation improve, to the overall process of blood specimen operation all in a container, avoid with contacts such as outside air or operator, instrument, effectively avoided operation process in the blood sample receive the pollution to and avoid the pollution of blood specimen to operator and environment, not only can still can and draw red blood cell and leucocyte separation once with separating and drawing out rich blood platelet plasma (PRP), further improve work efficiency.

Description

A kind of platelet rich plasma separating extraction device
Technical field
The utility model is related to technical field of medical instruments, particularly to a kind of platelet rich plasma separating extraction device.
Background technology
The blood execution such as inferior several functions of the blood vessel interior circulation in human body or animal body:The oxygen that will be sucked by lung It is transported to histocyte, to pulmonary delivery carbon dioxide and be discharged into outside from tissue, will be defeated for the nutrient being absorbed by alimentary canal Deliver to internal organs or histocyte, as the catabolite of tissue, unnecessary material for organism is transported to kidney simultaneously It is discharged to external, the hormone secreted from incretory (hormone) is transported to effect organ, tissue, is uniformly dispersed body Heat and regularly keep body temperature, in addition, to invade biological internal bacterium, foreign matter etc. carry out destroying, Non-toxic.
Though this blood also serves as the leading indicator judging various diseases or health status, in blood rich in growth because The blood platelet of sub (Growth factor) and white blood cell are used with therapeutic purposes.
Blood comprises red blood cell, white blood cell, blood platelet etc., and wherein, blood platelet is primarily present in blood plasma, and blood plasma is divided into rich blood Platelet-poor plasma (Platelet Rich Plasma, PRP) layer and platelet poor plasma (Platelet Poor Plasma, PPP) Layer.
Referred to as PRP (Platelet Rich Plasma:Blood platelet concentrate blood plasma) rich in hematoblastic blood plasma be located at blood Slurry relatively under position, comprise cell factor (cytokine), platelet derived growth factor (Platelet Derived Growth Factor, PDGF), transforming growth factor-beta 1 (Transforming Growth Factor-BETA1, TGF- BETA1), the growth factor such as VEGF (Vascular Endothelial Growth Factor, VEGP), It has been illustrated especially effective to disease of skin and Wound healing in the data such as paper.
In addition, referred to as PPP (Platelet Poor Plasma:Blood platelet poor plasma) almost without hematoblastic blood plasma As autoblood filler or autologous plasma cosmetics.
Wherein, PRP layer only accounts for the 1% about of gathered blood, and viscosity is higher and be attached to red blood cell, therefore difficult To gather.If by described PRP be transplanted to affected part, particularly inside the knee, ligament, muscle etc., play dry around stimulating Cell and contribute to the effect of Hemapoiesis, therefore used with therapeutic purposes always, but because its amount is few and is attached to red blood cell And be difficult to gather, if red blood cell enters into the human body, very big misery can be caused, and also can therefore produce inflammation, therefore And focus on that collection removes the technology of erythrocytic PRP.
However, currently in order to extracting Platelet Concentrate layer, having and being separated by centrifugal separation processes, a secondary centrifuging The process that Cheng Jinhang concentrates, described process is that blood is being injected into the first separation container with top, lower liquid room Behind lower liquid interior, the first separation container being injected with blood is carried out with a centrifugation, promote in a centrifugation During separated white blood cell and buffy (Buffy coat) layer and so that its etc. is moved to top liquid chamber.
Hereafter, there is following process:Serve white blood cell and the buffy coat of portion's liquid chamber to secondary separation container sidesway, Carry out secondary centrifuging to separate again and so that its grade is concentrated, thus extracting Platelet Concentrate.
Now, there is following problem:Not only dividing in the blood to a secondary separation container centrifugation of the sidesway warp let-off Produce loss during absciss layer, and a centrifugation operation, secondary centrifuging detached job be relatively complicated and the activity duration Longer.
Utility model content
In view of the above-mentioned problems in the prior art, main purpose of the present utility model is to provide a kind of rich platelet Blood plasma-separating extraction device, this device can be utilized a container to carry out separating, concentrate PRP, reduces the loss of PRP, simplifies centrifugation Detached process.
In order to reach above-mentioned purpose, the utility model provides a kind of platelet rich plasma-separating extraction device, including master Body pipe 100, upper lid 300 and lower cover 200.
Described main body tube 100 be internally provided with receiving space portion 102 and separated space portion 104, described receiving space portion 102 and described separated space portion 104 separated by passage portion 105, the upper/lower terminal of described passage portion 105 is respectively equipped with opening, And the diameter of lower ending opening is gradually increased, until being connected with the inwall of described main body tube 100 and forming rake 110;Described receipts Hold the slide block 106 that the bottom setting of spatial portion 102 can be slided in tube chamber, described slide block 106 includes collet 107 and rubber sleeve 109, described rubber sleeve 109 surrounds downwards described collet 107, and described collet 107 is provided with inlet 108;
The joint portion 311 being combined with the upper end open of described passage portion 105, institute are formed at the bottom of described upper lid 300 The lateral lower end stating joint portion 311 extends formation storage unit 312, when described joint portion 311 is incorporated into described passage portion 105 Behind upper end, then described storage unit 312 is connected with described receiving space portion 102;
Described upper lid 300 is provided with the first flow export 302 and the second flow export 303, described first flow export 302 with described Storage unit 312 connects;Described second flow export 303 is connected with described separated space portion 104;
The bottom of described lower cover 200 is provided with through hole 201, and described through hole 201 is right against described collet 107.
Preferably, wherein said upper lid 300 is attached to the upper end of described main body tube 100 in removably mode, thus logical Crossing lifting makes joint portion 311 connect with passage portion 105 or separate.
Preferably, wherein said joint portion 311 integration is connected to described upper lid 300.
Preferably, wherein said joint portion 311 is removably attachable to described upper lid 300.
Preferably, the top edge of wherein said storage unit 312 is provided with raised 314, and described upper lid 300 is provided with circular hole, Described raised 314 are combined with described circular hole in nested fashion.
Preferably, the lower end of wherein said joint portion 311 is provided with outside the upper end for being engaged to described passage portion 105 The combined hole 313 of side face.
Preferably, wherein said storage unit 312 bottom is provided with circular groove 306, described circular groove 306 forms institute State the bottom surface of storage unit 312.
Preferably, wherein said upper lid is 300 to be threadedly connected to described main body tube 100.
Preferably, wherein said lower cover 200 is to be threadedly connected to described main body tube 100.
Preferably, wherein said first flow export 302 is provided with the first rubber stopper 304;On described second flow export 303 It is provided with the second rubber stopper 305.
The utility model has the advantages that:
Platelet rich plasma separating extraction device provided by the utility model, its being internally formed with centre in main body tube The separated space portion that divides for medium of passage portion and receiving space portion, and the storage connecting with passage portion when covering in combination Portion is configured at the bottom of lid, therefore has the effect that:Can separate and extract the rich platelet blood of blood by a container Slurry (PRP) and the separating layer of other blood, thus the loss in can preventing from transferring, and significantly shorten the activity duration;
Platelet rich plasma separating extraction device provided by the utility model, it is by centrifugal separation processes Realize separation and the extraction of blood in a container, the convenience therefore with operation improves, and can improve the efficiency of operation Advantage;
Platelet rich plasma separating extraction device provided by the utility model, the overall process of its operation is all in a container Inside carry out, it is to avoid contact with outside air or operator, instrument etc., effectively prevent blood sample in operating process and be subject to dirt Dye, and avoid blood sample to situations such as the pollution of operator and environment;
Platelet rich plasma separating extraction device provided by the utility model, it not only can disposably will be enriched in growing The blood platelet of the factor is isolated, and also can separate red blood cell and white blood cell, further increase operating efficiency.
Brief description
The structural representation of the platelet rich plasma separating extraction device that Fig. 1 provides for the utility model embodiment;
The front view of the decomposition of the platelet rich plasma separating extraction device that Fig. 2 provides for the utility model embodiment;
The joint portion of the platelet rich plasma separating extraction device that Fig. 3 provides for the utility model embodiment and storage unit Stereogram;
Fig. 4 is to show the platelet rich plasma separating extraction device use state reference that embodiment of the present utility model provides One of figure;
Fig. 5 is to show the platelet rich plasma separating extraction device use state reference that embodiment of the present utility model provides The two of figure;
Fig. 6 is to show the platelet rich plasma separating extraction device use state reference that embodiment of the present utility model provides The three of figure.
In figure description of symbols:
100- main body tube;102- receiving space portion;104- separated space portion;105- passage portion;
106- slide block;107- collet;108- inlet;109- rubber sleeve;110- rake;
200- lower cover;201- through hole;
Cover on 300-;302- first flow export;303- second flow export;304- first rubber stopper;305- second rubber stopper; 306- circular groove;311- joint portion;312- storage unit;313- combined hole;314- is raised;
P- Platelet Concentrate layer;R- layer of red blood cells;W- white blood cell layer.
Specific embodiment
Purpose, technical scheme and advantage for making the utility model embodiment are clearer, new below in conjunction with this practicality Accompanying drawing in type embodiment, is clearly and completely described it is clear that being retouched to the technical scheme in the utility model embodiment The embodiment stated is a part of embodiment of the utility model, rather than whole embodiments.Generally described in accompanying drawing herein and The assembly of the utility model embodiment illustrating can be arranged with various different configurations and design.Therefore, below to attached The detailed description of the embodiment of the present utility model that in figure provides is not intended to limit claimed scope of the present utility model, But it is merely representative of selected embodiment of the present utility model.Based on the embodiment in the utility model, ordinary skill people The every other embodiment that member is obtained under the premise of not making creative work, broadly falls into the model of the utility model protection Enclose.
Embodiment of the present utility model is described below in detail, the example of described embodiment is shown in the drawings, wherein ad initio To the element that same or similar label represents same or similar element or has same or like function eventually.Below by ginseng The embodiment examining Description of Drawings is exemplary it is intended to be used for explaining the utility model, and it is not intended that to the utility model Restriction.
With specific embodiment, the utility model is further described below with reference to accompanying drawings.
Embodiment 1
As Figure 1-3, a kind of platelet rich plasma separating extraction device providing for the utility model, including main body tube 100th, upper lid 300 and lower cover 200.
Main body tube 100 be internally provided with receiving space portion 102 and separated space portion 104, receiving space portion 102 and separating Spatial portion 104 is separated by passage portion 105, and the upper/lower terminal of passage portion 105 is respectively equipped with opening, the diameter of lower ending opening by Cumulative big, until being connected with the inwall of main body tube 100 and forming rake 110;In the bottom in receiving space portion 102, slide block is set 106, slide block 106 includes collet 107 and rubber sleeve 109, and rubber sleeve 109 surrounds collet 107 downwards, plays the effect of sealing, bottom Inlet 108 is arranged on support 107;
The joint portion 311 that the bottom formation of upper lid 300 is combined with the upper end open of passage portion 105, the side of joint portion 311 Extend to lower end and form storage unit 312, after joint portion 311 is incorporated into the upper end of passage portion 105, then storage unit 312 and collecting Spatial portion 102 connects;
First flow export 302 and the second flow export 303, the first flow export 302 and storage unit 312 are provided with upper lid 300 Connection;Second flow export 303 is connected with separated space portion 104;
The bottom of lower cover 200 is provided with through hole 201, and through hole 201 is right against collet 107.
As the preferred embodiment of above-described embodiment, upper lid 300 is attached to described main body tube 100 in removably mode Upper end, thus making joint portion 311 connect with passage portion 105 by lifting or separating.
As the preferred embodiment of above-described embodiment, joint portion 311 is integrated with upper lid 300 to be connected.
As the preferred embodiment of above-described embodiment, joint portion 311 is removably connected with upper lid 300.
As the preferred embodiment of above-described embodiment, the top edge setting raised 314 of storage unit 312, the setting of upper lid 300 Circular hole, raised 314 are combined with circular hole in nested fashion.
As the preferred embodiment of above-described embodiment, the lower end of joint portion 311 is provided with for being engaged to passage portion 105 Upper end outer peripheral face combined hole 313.
As the preferred embodiment of above-described embodiment, storage unit 312 is provided with circular groove 306, circular groove 306 Form the bottom surface of storage unit 312.
As the preferred embodiment of above-described embodiment, to threaded between upper lid 300 and main body tube.
As the preferred embodiment of above-described embodiment, lower cover 200 is threadedly connected to main body tube 100.
As the preferred embodiment of above-described embodiment, through hole 201 is configured with internal thread.
As the preferred embodiment of above-described embodiment, the outside setting rubber sleeve 109 of slide block 106;First flow export It is provided with the first rubber stopper 304 on 302;Second rubber stopper 305 is provided with the second flow export 303.
Specifically:The receiving space portion 102 of accommodating blood is formed at the bottom of main body tube 100, in receiving space portion 102 Passage portion 105 is formed at top, and the lower inner diameter of passage portion 105 is gradually increased, until being connected to the inwall of main body tube 100 and being formed Rake 110, rake 110 makes the more downward space in separated space portion 104 narrower, is easy to extract content therein;Path The upper end open in portion 105, passage portion 105 surrounds separated space portion 104 with the inwall of main body tube 100.After centrifugal blood layering, Separated space portion 104 houses blood plasma and the white blood cell layer W of the superiors passing through via passage portion 105.
In the bottom of main body tube 100, lower cover 200 is combined in removably mode, the anti-limited slip block 106 of lower cover 200 comes off, and It is right against collet 107 and forms the female through hole 201 of configuration, to be available for promoting slide block 106 to make it increase to upside Lifting tool turnover (not shown) or finger turnover.
Slide block 106, it is slidably coupled to the bottom in receiving space portion 102, and it can be along main body tube Inwall upward sliding, thus the blood in receiving space portion 102 is pushed passage portion 105.Slide block 106 is elastic slide block, including Collet 107 and rubber sleeve 109, rubber sleeve 109 is the seal member combining multiple ring-types in outer peripheral face periphery, so that gas can be kept Close, and reduce the volume in receiving space portion 102 with uniform pressure when carrying out vertical motion, collet 107 is incorporated into rubber The bottom of set 109, when the rubber sleeve 109 making slide block 106 top using lifting tool carries out vertical motion, can protect slide block The rubber sleeve 109 on 106 tops.Collet 107 is provided with inlet 108, and inlet 108 is available for injection and needs detached blood.
Upper lid 300, it is attached to the upper end of main body tube 100 in removably mode, is formed at and master in central lower The joint portion 311 that body pipe 100 is combined with the upper end of passage portion 105 when combining, and there is storage unit 312, storage unit 312 is with to knot The mode that one side lower part in conjunction portion 311 extends is formed, the Platelet Concentrate layer P when slide block 106 rises, in the separating layer of blood Flow into and be housed in storage unit 312.
The upper surface of upper lid 300 is provided with the first flow export 302 and the second flow export 303, the first flow export 302 and second Flow export 303 is respectively arranged with the first rubber stopper 304 and the second rubber stopper 305.It is contained in the Platelet Concentrate in storage unit 312 Layer P can be extracted by the first flow export 302;It is contained in the blood plasma in separated space portion 104 and white blood cell layer W can pass through second Outlet 304 extracts.
The joint portion 311 of upper lid 300 is formed with the combined hole 313 of lower openings, to be engaged to the upper end of passage portion 105 Portion's outer peripheral face.
Storage unit 312 has the structure being formed in the way of the position that bottom face is located at less than the bottom of joint portion 311 Make.That is, storage unit 312 has the construction housing the Platelet Concentrate layer P flowing into by passage portion 105.
On the other hand, storage unit 312 and joint portion 311 can also be integral under upper lid 300 with a main body Portion face, or it is attached to the bottom of upper lid 300 in removably mode by raised 314.
Working theory and processing of the present utility model is as follows:
First, with reference to Fig. 4 platelet rich plasma of the present utility model separating extraction device, using syringe or other injections Device injects blood by inlet 108 into receiving space portion 102, the injection rate of blood can according to 30~60cc about note Enter, wait to be centrifuged.Now, upper lid 300 keeps being incorporated into the state on the top of main body tube 100, so that close in centrifugal separation processes Envelope separated space portion 104.
Using centrifuge separate, according to difference of specific gravity formed separating layer, wherein blood plasma and white blood cell layer W in the superiors, in Interbed is Platelet Concentrate layer P, and orlop is layer of red blood cells R.
As shown in figure 5, first, before slide block 106 is moved upwards, joint portion 311 is moved up, makes joint portion 311 are separated with passage portion 105.Now, passage portion 105 is connected with separated space portion 104.
Secondly, lifting tool is entered into the inside of the through hole 201 of lower cover 200 and screw ejection slide block 106 upwards, then slide Block 106 carries out stable vertical motion and reduces the volume in receiving space portion 102 in the inside in receiving space portion 102.
Slide block 106 makes blood plasma and white blood cell in the separating layer of blood being stored in receiving space portion 102 when rising Layer W is injected in separated space portion 104 by passage portion 105.
When blood plasma and white blood cell layer W are all injected in separated space portion 104, slide block 106 stops.
Hereafter, as shown in fig. 6, upper lid 300 is moved down, joint portion 313 is made to be engaged to the upper end of passage portion 105 Mouthful, then passage portion 105 is connected with storage unit 312.
Promote slide block 106 to move up again, be then filled with the appearance in the receiving space portion 102 of a separating layer part of blood Amass and reduce further, Platelet Concentrate layer P is flowed in storage unit 312 by passage portion 105.When Platelet Concentrate layer P is whole When being flowed in storage unit 312, slide block 106 stops again.
The capacity being stored into the Platelet Concentrate layer P of storage unit 312 can according to the injection rate of blood and the property of blood Become, substantially concentration storage 1.5~3.0cc about.
The blood plasma being stored in separated space portion 104 by the second flow export 303 using syringe or other samplers Take out with white blood cell layer W;Or blood plasma and white blood cell layer W can be taken off when separating.
Will be little for the deshydremia being stored in storage unit 312 by the first flow export 302 using syringe or other samplers Flaggy P, takes out and obtains final product platelet rich plasma (PRP).
Finally can as needed layer of red blood cells R be taken out:1. can be by slide block 106 after the taking-up of bottom, then will be red Blood cell layer R takes out from the lower end of main body tube 100;
Or 2. continue to press on slide block 106 to move up, so that layer of red blood cells R is entered in the storage unit 312 having emptied;
Or 3. upper lid 300 is moved up, so that joint portion 313 is separated from each other with passage portion 105, then passage portion 105 and Separated space portion 104 connects.Continue to press on slide block 106 to move up, make layer of red blood cells R enter the separated space portion having emptied In 104.
Thus, layer of red blood cells R in blood, Platelet Concentrate layer P and blood plasma and white blood cell layer W are separated.
Therefore, platelet rich plasma (PRP) separating extraction device of the present utility model, can by a container and once from Heart separation process is realized the centrifugation by blood and is concentrated operation, therefore has and can prevent from producing during existing transfer Raw loss, and improve the convenience of operation and the effect of efficiency, shortening activity duration, and can effectively anti-Hemostatic Oral Liquid quilt The pollution and blood pollution to operator or link.
Finally it should be noted that:Above-described each embodiment is merely to illustrate the technical solution of the utility model, rather than It is limited;Although being described in detail to the utility model with reference to the foregoing embodiments, those of ordinary skill in the art It should be understood that:It still can be modified to the technical scheme described in previous embodiment, or to wherein part or all of Technical characteristic carries out equivalent;And these modifications or replacement, do not make the essence of appropriate technical solution depart from the utility model The scope of each embodiment technical scheme.

Claims (10)

1. a kind of platelet rich plasma separating extraction device, including main body tube (100), upper lid (300) and lower cover (200), it is special Levy and be:
Described main body tube (100) be internally provided with receiving space portion (102) and separated space portion (104), described receiving space Portion (102) and described separated space portion (104) pass through passage portion (105) and separate, and the upper/lower terminal of described passage portion (105) divides It is not provided with opening, and the diameter of lower ending opening is gradually increased, until being connected with the inwall of described main body tube (100) and forming inclination Portion (110);The slide block (106) that the bottom setting of described receiving space portion (102) can be slided in tube chamber, described slide block (106) collet (107) and rubber sleeve (109) are included, described rubber sleeve (109) surrounds downwards described collet (107), described collet (107) it is provided with inlet (108) on;The bottom of described upper lid (300) is formed can be opened with the upper end of described passage portion (105) The joint portion (311) that mouth combines, a lateral lower end of described joint portion (311) extends and forms storage unit (312), when described combination After portion (311) is incorporated into the upper end of described passage portion (105), then described storage unit (312) and described receiving space portion (102) connect Logical;
Described upper lid (300) is provided with the first flow export (302) and the second flow export (303), described first flow export (302) with Described storage unit (312) connection;Described second flow export (303) is connected with described separated space portion (104);
The bottom of described lower cover (200) is provided with through hole (201), and described through hole (201) is right against described collet (107).
2. platelet rich plasma separating extraction device according to claim 1 it is characterised in that described upper lid (300) with Removably mode is attached to the upper end of described main body tube (100).
3. platelet rich plasma separating extraction device according to claim 1 is it is characterised in that described joint portion (311) Integration is connected to described upper lid (300).
4. platelet rich plasma separating extraction device according to claim 1 is it is characterised in that described joint portion (311) It is removably attachable to described upper lid (300).
5. platelet rich plasma separating extraction device according to claim 4 is it is characterised in that described storage unit (312) Top edge be provided with raised (314), described upper lid (300) is provided with circular hole, described projection (314) in nested fashion with institute State circular hole to combine.
6. platelet rich plasma separating extraction device according to claim 1 is it is characterised in that described joint portion (311) Lower end be provided with the combined hole (313) of the upper end outer peripheral face for being engaged to described passage portion (105).
7. platelet rich plasma separating extraction device according to claim 1 is it is characterised in that described storage unit (312) Bottom is provided with circular groove (306), and described circular groove (306) forms the bottom surface of described storage unit (312).
8. platelet rich plasma separating extraction device according to claim 1 it is characterised in that described upper lid (300) with It is threadedly connected to described main body tube (100).
9. platelet rich plasma separating extraction device according to claim 1 it is characterised in that described lower cover (200) with It is threadedly connected to described main body tube (100).
10. the platelet rich plasma separating extraction device according to any one of claim 1-9 is it is characterised in that described First rubber stopper (304) is provided with the first flow export (302);It is provided with the second rubber stopper on described second flow export (303) (305).
CN201620924869.XU 2016-08-23 2016-08-23 Rich blood platelet plasma separation extraction element Active CN205949080U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111254045A (en) * 2018-11-30 2020-06-09 瑞崴制造股份有限公司 Kit for separating and concentrating humoral cells containing stem cells

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111254045A (en) * 2018-11-30 2020-06-09 瑞崴制造股份有限公司 Kit for separating and concentrating humoral cells containing stem cells
CN111254045B (en) * 2018-11-30 2023-07-11 瑞崴制造股份有限公司 Body fluid cell separation and concentration kit containing stem cells

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Effective date of registration: 20200803

Address after: 510530 A2 fourth layer, No. 11 Kaiyuan Road, Whampoa District, Guangzhou, Guangdong.

Patentee after: GUANGZHOU PAILI BIOTECHNOLOGY Co.,Ltd.

Address before: 510613, room 233, 7106 Tianhe North Road, Guangzhou, Tianhe District, Guangdong

Co-patentee before: GUANGZHOU PAILI BIOTECHNOLOGY Co.,Ltd.

Patentee before: Song Dongfan

TR01 Transfer of patent right