CN205720119U - Semi-preparative supercritical fluid chromatograph - Google Patents
Semi-preparative supercritical fluid chromatograph Download PDFInfo
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- CN205720119U CN205720119U CN201620657741.1U CN201620657741U CN205720119U CN 205720119 U CN205720119 U CN 205720119U CN 201620657741 U CN201620657741 U CN 201620657741U CN 205720119 U CN205720119 U CN 205720119U
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Abstract
The utility model discloses a kind of semi-preparative supercritical fluid chromatograph, by three joint group parts, two-stage refrigeration cooling device, liquid CO2Delivery pump, entrainer delivery pump, static mixer, post position switching valve, column oven, chromatographic column, UV detector, pressure transducer, two-stage back pressure regulator device, component collection device and host computer composition.This instrument may be used for pilot scale stage and the batch production of the products such as biological medicine.
Description
Technical field
This utility model relates to a kind of supercritical fluid chromatograph, belongs to chromatographic field.
Background technology
Supercritical fluid chromatography (supercritical fluid chromatography is called for short SFC) is with supercritical
Fluid (material a kind of state when higher than critical pressure and critical temperature, have the low viscosity of gas, liquid high density with
And between air-liquid the feature such as higher diffusion coefficient) for flowing phase, solid absorbent or the high polymer being bonded on carrier
Chromatograph for fixing phase.Compared with common liquid chromatograph, flowing is generally carbon dioxide and the mixture of organic solvent mutually, surpasses and faces
Boundary's Fluid Chromatography uses carbon dioxide and the mixture of organic solvent (methanol etc.).It not only can segregation gas chromatography difficulty separate
Thermally labile, relative molecular mass be higher, highly polar or non-volatile compounds, and can separate high performance liquid chromatography and be difficult to
The high-molecular weight compounds separated, can keep the activity of target compound in separating preparation process simultaneously well, compared with it
It is carbon dioxide that his separation method has unrivaled advantage, especially its supercritical fluid used, with Traditional liquid phase ratio
Relatively, the Discarded organic solvent of generation is few, pollutes little, more environmentally friendly.
Although supercritical fluid chromatograph device is with a wide range of applications at chromatographic field, but supercritical fluid at present
Chromatographic apparatus, mainly based on analytical type instrument, is applied to the separating-purifying of laboratory low dose sample and opening of experimental technique
Send out, lack and be applied to the supercritical fluid chromatograph device of pilot scale stage and batch production, therefore, develop a kind of efficiently, environmental protection and
The semi-preparative supercritical fluid chromatograph device of safety, becomes the target pursued in Supercritical fluid chromatography research.
Summary of the invention
The purpose of this utility model is: develops a kind of semi-preparative supercritical fluid chromatograph device, is applied to pilot scale rank
Section and batch production.
The technical solution of the utility model is as follows:
A kind of semi-preparative supercritical fluid chromatograph is by three joint group parts 1, two-stage refrigeration cooling device 2, liquid CO2Conveying
Pump 3, entrainer delivery pump 4, static mixer 5, the switching of post position valve 6, column oven 7, chromatographic column 8, UV detector 9, pressure sensing
Device 10, two-stage back pressure regulator device 11, component collection device 12 and host computer 13 form；Three joint group parts 1, two-stage refrigeration cool-down fill
Put 2 and liquid CO2Delivery pump 3 is linked in sequence by pipeline, and entrainer delivery pump 4 is by pipeline and liquid CO2Delivery pump 3 phase is also
Connection, static mixer 5, post position switching valve 6, column oven 7, chromatographic column 8, UV detector 9, pressure transducer 10, two-stage back pressure are adjusted
Regulating device 11 and component collection device 12 are connected by pipeline order；It is characterized in that the diameter range of chromatographic column be 10cm ~
100cm；Two-stage back pressure regulator device 11 is made up of the automatic back pressure regulating valve of one-level 14 and two-stage hand back pressure regulating valve 15.
Three linked piece 1 is used for showing CO2Pressure of storage tank, adjust tolerance and filter gaseous impurity, dual unit device for cooling 2 is used for
By CO2It is cooled to liquid；CO2Delivery pump 3 is used for carrying CO2Liquid, entrainer delivery pump 4 is for conveyer gripping belt agent, static
Blender 5 is for by liquid CO2Phase is closed with entrainer；Post position switching valve 6 is used for injecting in chromatographic column 8 by product to be separated,
UV detector 9 flows through the material in the flowing mutually of chromatographic column for detection；Pressure transducer 10 is used for measuring loine pressure, two-stage
Back pressure regulator device 11 is for the pressure regulation of instrument, and component collection device 12 is used for collecting separation component, and host computer 13 is used for
Control semi-preparative supercritical fluid chromatograph device.
This utility model, by the design of semi-preparative supercritical fluid chromatograph device, can reach from multicomponent system one
The acquisition one of which target compound of secondary property batch, this instrument purifies for the lot splitting of compound, can bring substantially
Economic and social benefit.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
As shown in the figure:
1, three joint group part
2, two-stage refrigeration cooling device
3, liquid CO2Delivery pump
4, entrainer delivery pump
5, static mixer
6, post position switching valve
7, column oven
8, chromatographic column
9, UV detector
10, pressure transducer
11, two-stage back pressure regulator device
12, component collection device
13, host computer
14, the automatic back pressure regulating valve of one-level
15, two-stage hand back pressure regulating valve.
Detailed description of the invention
In conjunction with accompanying drawing 1, detailed description of the invention of the present utility model is described.
CO2Gas is after storage tank flows out, and through three linked piece 1, three linked piece 1 demonstrates mouth pressure, regulates CO2Go out gas velocity, with
Time filter objectionable impurities, pure CO2Gas is after the cooling down of the two-stage refrigeration cooling device 2 controlled by host computer 13
Become CO2Liquid, by CO2Delivery pump 3 carries, and closes in static mixer 5 with the modifying agent of entrainer delivery pump 4 conveying
Phase, the gas-liquid mixed material after closing mutually, through the distribution of post position switching valve 6, enters column oven 7, forms supercritical after heating up
State, chromatographic column 8 carries out eluting to above-critical state material, the component materials that obtains after eluting enter UV detector 9 carry out separating and
Detection, the inlet pressure level of above-critical state component materials is fed back to host computer 13 by pressure transducer 10, in the control of host computer 13
Under system, the component after separation, through the regulation of two-stage back pressure apparatus 11 and stable, is collected by component collection device 12.
Above example only illustrates technological thought of the present utility model, it is impossible to limit protection model of the present utility model with this
Enclose, every according to the technological thought that the utility model proposes, any change done on the basis of technical scheme, each fall within this reality
Within the scope of novel protected.
Claims (1)
1. a semi-preparative supercritical fluid chromatograph, by three joint group parts (1), two-stage refrigeration cooling device (2), liquid CO2Defeated
Send pump (3), entrainer delivery pump (4), static mixer (5), post position switching valve (6), column oven (7), chromatographic column (8), UV inspection
Survey device (9), pressure transducer (10), two-stage back pressure regulator device (11), component collection device (12) and host computer (13) composition；
Three joint group parts (1), two-stage refrigeration cooling device (2) and liquid CO2Delivery pump (3) is linked in sequence by pipeline, and entrainer carries
Pump (4) is by pipeline and liquid CO2Delivery pump (3) is in parallel, static mixer (5), post position switching valve (6), column oven (7),
Chromatographic column (8), UV detector (9), pressure transducer (10), two-stage back pressure regulator device (11) and component collection device (12) are logical
Piping order is connected；The diameter range that it is characterized in that chromatographic column is 10cm ~ 100cm；Two-stage back pressure regulator device (11)
It is made up of the automatic back pressure regulating valve of one-level (14) and two-stage hand back pressure regulating valve (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620657741.1U CN205720119U (en) | 2016-06-29 | 2016-06-29 | Semi-preparative supercritical fluid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620657741.1U CN205720119U (en) | 2016-06-29 | 2016-06-29 | Semi-preparative supercritical fluid chromatograph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205720119U true CN205720119U (en) | 2016-11-23 |
Family
ID=57317160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620657741.1U Active CN205720119U (en) | 2016-06-29 | 2016-06-29 | Semi-preparative supercritical fluid chromatograph |
Country Status (1)
| Country | Link |
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| CN (1) | CN205720119U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107121504A (en) * | 2017-04-12 | 2017-09-01 | 岛津企业管理（中国）有限公司 | Multi-functional temperature-pressure extraction trapping chromatographic isolation on-line coupling equipment |
| CN107543870A (en) * | 2016-06-29 | 2018-01-05 | 江苏汉邦科技有限公司 | Semi-preparative supercritical fluid chromatograph |
-
2016
- 2016-06-29 CN CN201620657741.1U patent/CN205720119U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107543870A (en) * | 2016-06-29 | 2018-01-05 | 江苏汉邦科技有限公司 | Semi-preparative supercritical fluid chromatograph |
| CN107121504A (en) * | 2017-04-12 | 2017-09-01 | 岛津企业管理（中国）有限公司 | Multi-functional temperature-pressure extraction trapping chromatographic isolation on-line coupling equipment |
| CN107121504B (en) * | 2017-04-12 | 2019-08-20 | 岛津企业管理（中国）有限公司 | Multi-functional temperature-pressure extraction-trapping-chromatographic isolation on-line coupling equipment |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 223005 no.1-9 Jixian Road, Huaian Economic and Technological Development Zone, Jiangsu Province Patentee after: Jiangsu Hanbang Technology Co.,Ltd. Address before: 223005 no.1-9 Jixian Road, Huaian Economic and Technological Development Zone, Jiangsu Province Patentee before: JIANGSU HANBON SCIENCE & TECHNOLOGY Co.,Ltd. |