CN205691602U - A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer - Google Patents
A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer Download PDFInfo
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- CN205691602U CN205691602U CN201620427750.1U CN201620427750U CN205691602U CN 205691602 U CN205691602 U CN 205691602U CN 201620427750 U CN201620427750 U CN 201620427750U CN 205691602 U CN205691602 U CN 205691602U
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- Prior art keywords
- plasma resonance
- surface plasma
- miniaturization
- sample
- optical system
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- 238000002347 injection Methods 0.000 title claims abstract description 22
- 239000007924 injection Substances 0.000 title claims abstract description 22
- 230000003287 optical effect Effects 0.000 claims abstract description 25
- 230000033228 biological regulation Effects 0.000 claims abstract description 9
- 238000010030 laminating Methods 0.000 claims abstract description 8
- 238000005070 sampling Methods 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 23
- 239000002699 waste material Substances 0.000 claims description 20
- 238000005406 washing Methods 0.000 claims description 19
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 14
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 claims description 14
- 229920002530 polyetherether ketone Polymers 0.000 claims description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 13
- 239000000741 silica gel Substances 0.000 claims description 13
- 229910002027 silica gel Inorganic materials 0.000 claims description 13
- 230000002572 peristaltic effect Effects 0.000 claims description 12
- 239000000872 buffer Substances 0.000 claims description 9
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 238000001514 detection method Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer, is included on light source and is equipped with the surface plasma resonance optical system of regulation platform and sample measuring cell that the laminating of surface plasma resonance optical system uses, the automatic sample handling system that provides sample source for described sample measuring cell.
Description
Technical field
This utility model relates to detection technique field, particularly relates to a kind of miniaturization auto injection surface plasma resonance raw
Fractional analysis instrument.
Background technology
Surface plasma resonance (Surface Plasmon Resonance, SPR) sensing technology is an emerging biology
Chemical detection technique.Since Nylander and Liedberg uses it for gas detecting and biosensor first in nineteen eighty-two
In, over 30 years, SPR sensorgram technology all obtains development at full speed on implementation, instrument development and application extend.
At present existing multiple import SPR analyser listing, but the instrument of only Sweden BIACORE company becomes the most
Ripe, its price is also much more expensive (ten thousand yuan/platform of 200-300) and bulky certainly, applies in general to lab analysis and grinds
Study carefully, it is impossible to meet the needs of Site Detection.And domestic auto injection SPR biochemistry analyzer also exists transducer sensitivity not
Height, structure are the compactest, sample measuring cell is tight with optical system laminating, and easy leakage, sampling needle are cleaned not thorough thus made
Become the drawbacks such as sample contamination, limit its application to a certain extent.
Miniaturization, high sensitivity, sample measuring cell are easy for installation, sampling needle cleans thoroughly, with automatic sample handling system
Surface plasma resonance biochemistry analyzer can make its application be greatly expanded, and is especially suitable for field quick detection.
Summary of the invention
For the deficiencies in the prior art, the purpose of this utility model is to provide a miniaturization, high sensitivity, sample measurement
Pond is easy for installation, sampling needle cleans auto injection surface plasma resonance biochemistry analyzer thoroughly.
For reaching above-mentioned purpose, technical solution of the present utility model is:
A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer, is included on light source and is equipped with regulation platform
Surface plasma resonance optical system and the laminating of surface plasma resonance optical system use sample measuring cell, for sample
Measuring cell provides the automatic sample handling system of sample source.
Described miniaturization auto injection surface plasma resonance biochemistry analyzer, its described regulation platform is X-axis and Z axis
Twocouese slidably regulates platform；Described light source is connected with regulation platform by fixture.
Described miniaturization auto injection surface plasma resonance biochemistry analyzer, its described sample measuring cell is fixed on pendulum
One end of arm, the other end of swing arm uses rotating shaft to be fixed on the upper surface of surface plasma resonance optical system；Swing arm is put down
After, measuring cell is fitted in surface plasma resonance optical system directly over prism；Spring knob is assemblied in the center of swing arm
Between, it is equipped with knob buckle in the relevant position of surface plasma resonance optical system upper surface, rotating spring knob by it
Measuring cell can be made to fit tightly with the prism in surface plasma resonance optical system in being stuck in buckle.
Described miniaturization auto injection surface plasma resonance biochemistry analyzer, its described automatic sample handling system includes cutting
Change subsystem and sampled subsystem；Wherein switching subsystem and sampled subsystem are connected by pipeline, and one end of pipeline connects cuts
Changing No. 1 port of subsystem midplane six-way valve, the other end connects the sampling needle in sampled subsystem；Described pipeline is FEP pipe, silicon
Sebific duct or PEEK pipe.
Described miniaturization auto injection surface plasma resonance biochemistry analyzer, its described switching subsystem includes two
Peristaltic pump, a six-way valve；Wherein one end of the first peristaltic pump connects buffer bottle by pipeline, and the other end connects flat
No. 2 ports of face six-way valve；One end of second peristaltic pump connects buffer bottle by pipeline, and the other end connects the 4 of six-way valve
Number port；Described pipeline is FEP pipe, silica gel tube or PEEK pipe.
Described miniaturization auto injection surface plasma resonance biochemistry analyzer, its described sampled subsystem includes one
The circular rotatable sample frame being fixed on pedestal, a liftable sampling needle and a micro air pump；The most circular rotatable
Position, two test tube holes in specimen holder is used for installing sampling needle outer wall washing mouth and sampling needle inner wall washing mouth；In sampling on pedestal
The underface of pin is provided with washes pin waste liquid outlet；Micro air pump is arranged on below pedestal, and wherein one end is washed by pipeline connection
Pin waste liquid outlet, the other end connects waste liquid bottle；Described pipeline is FEP pipe, silica gel tube or PEEK pipe.
Described miniaturized surface plasma resonance biochemistry analyzer, its described sampling needle inner wall washing mouth is fixed on
On any one test tube position of specimen holder, it is shaped as end face and the hollow cylindrical of the equal open-ended of bottom surface；Sampling needle outer wall
Butterworth Hatch is fixed on another test tube position any of specimen holder, is shaped as the circular cone of end face open-ended, bottom seal
Shape, conical side has an opening near the position on top 1/4.
The beneficial effects of the utility model are: in this miniaturization auto injection surface plasma resonance biochemistry analyzer
On light source in optical system, it is mounted with that x-axis and z-axis twocouese slidably regulate platform, can be made up by fine adjustment stage
Machining and the error of assembling, it is ensured that light source is on the optimal location that can excite SPR phenomenon, thus ensure that the detection of system
Sensitivity；Sample measuring cell and optical system use the laminating type of spring compression, simple to operation, and laminating closely, is difficult to
Leakage；Automatic sample handling system uses the peristaltic pump of compact so that the overall volume miniaturization of instrument；In auto injection mistake
Cheng Zhong, is not only carried out the inwall of sampling needle, is also carried out its outer wall, decreases the probability of sample contamination, really
Protect the accuracy of detection, not available for general auto injection surface plasma resonance biochemistry analyzer.
Accompanying drawing explanation
With embodiment, this utility model is further illustrated below in conjunction with the accompanying drawings.
Fig. 1 is overall structure schematic diagram of the present utility model.
Fig. 2 is surface plasma resonance optical system and the sample measuring cell structure used of fitting therewith in this utility model
Schematic diagram.
Fig. 3 is automatic sample handling system structural representation in this utility model.
Fig. 4 is the shape and structure schematic diagram of sampling needle inner wall washing mouth in automatic sample handling system in this utility model.
Fig. 5 is the shape and structure schematic diagram of sampling needle outer wall washing mouth in automatic sample handling system in this utility model.
Detailed description of the invention
As it is shown in figure 1, be overall structure schematic diagram of the present utility model.Automatic sample handling system includes switching subsystem and adopting
Subsystem, two subsystems use silica gel tube, FEP pipe or PEEK pipe to connect.Sample measuring cell and surface plasma resonance light
System laminating uses.Switching subsystem is managed by silica gel tube, FEP or PEEK pipe is connected with sample measuring cell.Buffer bottle leads to
Cross silica gel tube, FEP pipe or PEEK pipe to be connected with switching subsystem.Waste liquid bottle is managed by silica gel tube, FEP or PEEK pipe is surveyed with sample
Amount pond and sampled subsystem connect.This design makes the maximum miniaturization of whole instrument and integration.
As in figure 2 it is shown, be that in this utility model, surface plasma resonance optical system and the sample used of fitting therewith are surveyed
Amount pool structure schematic diagram.The left surface of surface plasma resonance optical system is fixed with X-axis and Z axis twocouese is slidably adjusted
Joint platform, light source is connected with regulation platform by fixture.By regulation platform adjustment light source in X-axis and the displacement of Z-direction,
Can effectively make up machining and rigging error, it is ensured that light source incides prism exciting the optimum position of SPR phenomenon
The upper surface i.e. position of sample measuring cell, so that it is guaranteed that the detection sensitivity of instrument.
Prism in sample measuring cell and surface plasma resonance optical system uses the laminating type of spring compression.Sample
Product measuring cell is arranged on the left end of swing arm, and swing arm right-hand member axle is fixed on the upper surface of surface plasma resonance optical system.Pendulum
After arm puts down, measuring cell is fitted in surface plasma resonance optical system directly over prism；Spring knob is assemblied in swing arm
Middle, be equipped with knob buckle, rotating spring knob in the relevant position of surface plasma resonance optical system upper surface
And measuring cell can be made to fit tightly with the prism in surface plasma resonance optical system in being stuck in buckle.This set
Meter makes the assembling simple and fast of sample measuring cell, and sample measuring cell and prism fit tightly, not easy-to-leak liquid.
As it is shown on figure 3, be automatic sample handling system structural representation in this utility model.This automatic sample handling system includes switching
Subsystem and sampled subsystem；Wherein switching subsystem and sampled subsystem are connected by FEP pipe, silica gel tube or PEEK pipeline,
One end of pipeline connects switching No. 1 port of subsystem midplane six-way valve, and the other end connects the sampling needle in sampled subsystem.
Switching subsystem includes two peristaltic pumps, a six-way valve；Wherein FEP is passed through in one end of the first peristaltic pump
Pipe, silica gel tube or PEEK pipeline connect buffer bottle, and the other end connects No. 2 ports of six-way valve；One end of second peristaltic pump
Connecting buffer bottle by FEP pipe, silica gel tube or PEEK pipeline, the other end connects No. 4 ports of six-way valve.
Sampled subsystem includes the circular rotatable sample frame being fixed on pedestal, a liftable sampling needle and
Individual micro air pump；Wherein the position, two reserved test tube holes in circular rotatable sample frame be used for installing sampling needle outer wall washing mouth and
Sampling needle inner wall washing mouth；On pedestal, underface at sampling needle is provided with and washes pin waste liquid outlet；Micro air pump is arranged on pedestal
Below, wherein pin waste liquid outlet is washed by FEP pipe, silica gel tube or the connection of PEEK pipeline in one end, and the other end connects waste liquid bottle.This
Planting design makes the inwall of sampling needle and outer wall all be cleaned, thus avoids sample contamination, it is ensured that the accuracy of detection.
As shown in Figure 4, it is sampling needle inner wall washing mouth structure schematic shapes in this utility model.It is fixed on circle can
On any one test tube position of Rotary Specimen Rack.
Sampling needle inner wall washing mouth-shaped is upper end face and the hollow cylindrical of the equal open-ended of bottom surface, the chamber of hollow space
Body volume both can make that sampling needle is the most clog-free to be moved up and down, and the most sufficiently small tries into sample without being misplaced by user
Pipe.After cleaning sampling needle inwall process starts, circular sample frame rotates also washes pin waste liquid by sampling needle inner wall washing mouth alignment
Outlet, now host computer procedure can control peristaltic pump work, ceaselessly draws buffer and from washing pin mouth inwall from buffer bottle
Being discharged to wash pin waste liquid port, micro air pump is started working simultaneously, being drawn into waste liquid bottle from the waste liquid washing the outflow of pin waste liquid outlet
In, thus realize cleaning the purpose of sampling needle inwall.
As it is shown in figure 5, be sampling needle outer wall washing mouth structure schematic shapes in this utility model.It is fixed on circle can
On any one test tube position of Rotary Specimen Rack.
Sampling needle outer wall washing mouth-shaped is upper end face open-ended, the cone of bottom seal, and conical side is near upper
There is an opening position in portion 1/4.After cleaning sampling needle outer wall process starts, circular sample frame rotates and by clear for sampling needle outer wall
Washing mouth alignment and wash pin waste liquid outlet, now host computer procedure can control peristaltic pump work, and extraction buffer is also stored in cone
In cavity, sampling needle the most ceaselessly moves simultaneously, and increasing buffer arrival opening part will spill into washes pin waste liquid
Outlet, micro air pump is started working simultaneously, being drawn in waste liquid bottle from the waste liquid washing the outflow of pin waste liquid outlet.If the most repeatedly
Dry time, it is sampled the liquid that pin outer wall polluted in conical cavity body and is repeatedly replaced, thus realize cleaning sampling needle outer wall
Purpose.
Claims (7)
1. a miniaturization auto injection surface plasma resonance biochemistry analyzer, it is characterised in that including:
Light source is equipped with the surface plasma resonance optical system of regulation platform；
The sample measuring cell used with the laminating of surface plasma resonance optical system；
The automatic sample handling system in sample introduction source is provided for described sample measuring cell.
Miniaturization auto injection surface plasma resonance biochemistry analyzer the most according to claim 1, it is characterised in that institute
The regulation platform stated is X-axis and Z axis twocouese slidably regulates platform；
Described light source is connected with regulation platform by fixture.
Miniaturization auto injection surface plasma resonance biochemistry analyzer the most according to claim 1, it is characterised in that institute
The sample measuring cell stated is fixed on one end of swing arm, and the other end of swing arm uses rotating shaft to be fixed on surface plasma resonance optical system
On the upper surface of system；After swing arm is put down, measuring cell is fitted in surface plasma resonance optical system directly over prism；Spring
Knob is assemblied in the middle of swing arm, is equipped with knob card in the relevant position of surface plasma resonance optical system upper surface
Button, rotating spring knob also can make measuring cell and the prism in surface plasma resonance optical system in being stuck in buckle
Fit tightly.
Miniaturization auto injection surface plasma resonance biochemistry analyzer the most according to claim 1, it is characterised in that institute
The automatic sample handling system stated includes switching subsystem and sampled subsystem；Wherein switching subsystem and sampled subsystem pass through pipeline
Connecting, one end of pipeline connects switching No. 1 port of subsystem midplane six-way valve, and the other end connects the sampling in sampled subsystem
Pin；Described pipeline is FEP pipe, silica gel tube or PEEK pipe.
Miniaturization auto injection surface plasma resonance biochemistry analyzer the most according to claim 4, it is characterised in that institute
State switching subsystem and include two peristaltic pumps, a six-way valve；Wherein one end of the first peristaltic pump connects slow by pipeline
Rushing liquid bottle, the other end connects No. 2 ports of six-way valve；One end of second peristaltic pump connects buffer bottle by pipeline, another
End connects No. 4 ports of six-way valve；Described pipeline is FEP pipe, silica gel tube or PEEK pipe.
Miniaturization auto injection surface plasma resonance biochemistry analyzer the most according to claim 4, it is characterised in that institute
State sampled subsystem and include that a circular rotatable sample frame being fixed on pedestal, a liftable sampling needle and one are miniature
Air pump；Wherein the position, two test tube holes in circular rotatable sample frame is used for installing sampling needle outer wall washing mouth and sampling needle inwall
Butterworth Hatch；On pedestal, underface at sampling needle is provided with and washes pin waste liquid outlet；Micro air pump is arranged on below pedestal, wherein
One end is connected by pipeline washes pin waste liquid outlet, and the other end connects waste liquid bottle；Described pipeline is FEP pipe, silica gel tube or PEEK pipe.
Miniaturization auto injection surface plasma resonance biochemistry analyzer the most according to claim 6, it is characterised in that adopt
Sample pin inner wall washing mouth is fixed on any one test tube position of specimen holder, is shaped as end face and the equal open-ended of bottom surface
Hollow cylindrical；Sampling needle outer wall washing mouth is fixed on another test tube position any of specimen holder, is shaped as top
Face open-ended, the cone of bottom seal, conical side has an opening near the position on top 1/4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620427750.1U CN205691602U (en) | 2016-05-13 | 2016-05-13 | A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620427750.1U CN205691602U (en) | 2016-05-13 | 2016-05-13 | A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205691602U true CN205691602U (en) | 2016-11-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620427750.1U Expired - Fee Related CN205691602U (en) | 2016-05-13 | 2016-05-13 | A kind of miniaturization auto injection surface plasma resonance biochemistry analyzer |
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| Country | Link |
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| CN (1) | CN205691602U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021027393A1 (en) * | 2019-08-13 | 2021-02-18 | 深圳市康立生物医疗有限公司 | High-speed electrolyte analyzer |
-
2016
- 2016-05-13 CN CN201620427750.1U patent/CN205691602U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021027393A1 (en) * | 2019-08-13 | 2021-02-18 | 深圳市康立生物医疗有限公司 | High-speed electrolyte analyzer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161116 |
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| CF01 | Termination of patent right due to non-payment of annual fee |