CN205434010U - Can implant intracavity false body - Google Patents
Can implant intracavity false body Download PDFInfo
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- CN205434010U CN205434010U CN201520920225.9U CN201520920225U CN205434010U CN 205434010 U CN205434010 U CN 205434010U CN 201520920225 U CN201520920225 U CN 201520920225U CN 205434010 U CN205434010 U CN 205434010U
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- intraluminal prosthesis
- filament
- implantable intraluminal
- diameter
- frame
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Abstract
The utility model discloses a can implant intracavity false body who has the multilayer configuration, the false body includes that at least one weaves frame (braided framework) from the inflation. Weave the frame can the radial compression state when carrying expand to the radial expansion state along axis extend. Weave 196 filament constitutions at the most that the frame adopted preset diameter (img file='DDA0000850162960000011. TIF'wi='75'he='69' /). Weave the wall that the frame does not have the overburden of any permeable and has formed the intracavity false body. Weave the lumen that the frame includes the drum shape, have circular cross section and invariable diameter. During the radial expansion state, the the?thickness?of the?wall T1 of intracavity false body is greater than 2.0 with filament's diameter (img file='DDA0000850162960000012. TIF'wi='70'he='70' /) than (img file='DDA0000850162960000013. TIF'wi='144'he='71' /), it is preferred at least 2.5, it is more preferably at least 3.0, it is even more preferably at least 3.5, still or even more preferably 4.0. Under the radial expansion state, the surface covering rate of intracavity false body be greater than 30% with be less than 70%, preferred be greater than 35% with be less than 50%.
Description
Technical field
This utility model relates to implantable intraluminal prosthesis.Particularly, this utility model relates to treating the aneurysmal intraluminal prosthesis including branch.
Background technology
Ink vessel transfusing reparation is considered as a kind of newer less invasive techniques for the treatment of aortic aneurysm.This technology is the implantable pipe (graft) using metal or plastic stent (intravascular stent) to support via the conveying of remote blood vessel.But, because its impermeability, this technology cannot be used for aneurysm repair, in this reparation, aneurysm relates to important branch (such as, coronary artery, bow top set, kidney and middle suprarenal artery, Visceral artery and internal iliac artery), otherwise, this can cause severe complication because of branch block.
Utility model content
First purpose of the present utility model is to provide a kind of aneurysmal apparatus treated by endovascular procedure and relate to branch.
Further object of the present utility model is aneurysmal to guarantee that branch is unobstructed in treatment simultaneously.
Theme of the present utility model is determined by accompanying independent claim.Preferred implementation is then determined by dependent claims.
Theme of the present utility model is the implantable intraluminal prosthesis with multilamellar configuration, and described prosthese includes at least one self-expanding weave frame (braidedframework).Described weave frame the radial compression when conveying can expand into extending along axis of radial expanded state.Weave frame uses given diameterAt most 196 filaments constitute.Described weave frame is without any cover layer that can be saturating the wall that defines intraluminal prosthesis.Weave frame includes the tube chamber of drum, with circular cross section and constant diameter.During radial expanded state, the thickness T of the wall of described intraluminal prosthesis1Diameter with filamentRatioMore than 2.0, preferably at least 2.5, more preferably at least 3.0, even more desirably at least 3.5, even more preferably still 4.0.Under radial expanded state, the surface coverage of described intraluminal prosthesis is more than 30% with less than 70%, preferably greater than 35% with less than 50%.
Self-expanding weave frame preferably includes at least 90 filaments and at most 130 filaments；With wire diameter at least 120 μm, preferably at least 200 μm and at most 220 μm.
In another preferred embodiment, under radial expanded state, self-expanding framework constitutes the multilamellar filament made by bio-compatible material；Every layer constitutes one grid；Described grid protocol is with the grating frame (lattice) of multiple filaments of described layer；Described grid mutually locks, and described filament is integrated in the grid of at least one of which adjacent layer.
Accompanying drawing explanation
Introducing other characteristic of the present utility model and advantage with reference to the accompanying drawings, accompanying drawing is as follows:
Fig. 1 is the front schematic view according to intraluminal prosthesis of the present utility model；
Fig. 1 a is the close-up schematic view of front elevation shown in Fig. 1；
Fig. 2 is the side view of intraluminal prosthesis shown in Fig. 1；
Fig. 3 is the profile of intraluminal prosthesis shown in Fig. 1, Fig. 1 a and Fig. 2, shown cuts open by plane III-III；
Fig. 3 a is the zoomed-in view of the part section embodiment shown in Fig. 3；
Fig. 3 b is the zoomed-in view of the part section another embodiment shown in Fig. 3；
Fig. 4 is the zoomed-in view of the another part according to intraluminal prosthesis of the present utility model；
Fig. 5 and Fig. 6 is two stages of aneurysm agglutination, wherein, implants intraluminal prosthesis of the present utility model；
Fig. 7 and Fig. 8 is respectively prior art support and the simulated view of this utility model intraluminal prosthesis blood flow rate at aortic branch mouth；
Fig. 9 a and 9b is respectively prior art (not belt supporting frame) and the simulated view of this utility model intraluminal prosthesis blood flow rate on aorta model；
Figure 10 a and 10b is respectively the enlarged detail at the bow top set mouth of simulation shown in Fig. 9 a and 9b；
Figure 11 a and 11b is respectively the enlarged detail at the coronary ostium of simulation shown in Fig. 9 a and Fig. 9 b；
Figure 12 is the profile of aorta, it is shown that aortic arch width and the measuring method of height；
Figure 13 (a-d) shows the different phase of saccular aneurysm agglutination, relates to branch and uses intraluminal prosthesis of the present utility model；
Figure 14 (a-d) is the different phase of netraneurysm agglutination, relates to branch and uses intraluminal prosthesis of the present utility model.
Detailed description of the invention
In introducing herein below, the term " implantable " used refers to that medical apparatus and instruments can be seated in the internal a certain position of body vessel.Implantable medical device can be arranged to during medical treatment gets involved temporarily be seated in inside body vessel (such as, several seconds, several minutes, a few hours), or is held permanently in body vessel.
Term " intracavity " or " through chamber " prosthese mean and fit through the apparatus that operation is seated in health bending or Vasa recta, and wherein, described prosthese pushes from distant site and passes body vessel chamber to the targeting moiety within body vessel.In vascular surgery, generally, medical apparatus and instruments uses conduit to be placed into " Ink vessel transfusing " via filament guider under fluoroscopic guidance.Conduit and filament guider can be introduced in vascular system by tradition implanting.
Term " conduit " means and inserts endovascular pipe for entering targeting moiety.In this utility model description, " conduit " would indicate that conduit itself or the conduit with adnexa, i.e. pin, filament, catheter sheath and other general suitable medical apparatus and instruments well known to the skilled artisan.
Term " forever " mean medical apparatus and instruments be seated in Ink vessel transfusing and will over a long time (such as, several months, several years) and may with patient all one's life.
Intraluminal prosthesis 1 is compression shape, time in induction system, diameter less and uniform (i.e. " compressive state "), and expansion shape can be formed naturally in the delivery site of such as body lumen, radially swell diameter (i.e. " deployed condition ").In this article, term " inflated configuration " or " swelling state " refer to from resilient body (such as, weave frame 20) shape caused by (that is, non-compressed state) its self-expanding characteristic or state when not allowed by any external compressive force to expand.In addition to these define, term " nominal diameter " refers to the implantable intraluminal prosthesis diameter when being placed in target vascular therapy.Generally, it is designed to forever to insert the nominal diameter of the self-expanding apparatus in body lumenThan described apparatus not by external compressive forceAnd the outer dia little 10 to 25% when launching.
Include that at least one can expand into the self-expanding weave frame 20 of radial expanded state from the radial compression of transporting pattern according to implantable intraluminal prosthesis 1 of the present utility model.Implantable intraluminal prosthesis 1 uses multilamellar configuration, and including at least two of which self-expanding weave frame 20 or include at least one self-expanding weave frame 20, the latter is with the multiple interlocked layers (interlocked multi-layers configuration) using many filaments of braiding to be formed.Weave frame 20 includes columnar tube chamber, with the circular cross-section shown in Fig. 1,1a and 2 and constant diameter.
With wall be orthogonal lower observation with the intraluminal prosthesis 1 of multilamellar configuration time, the grid of weave frame 20 constitutes the grating frame with multiple horizontal wire 21.Fig. 3 shows the cross sectional representation according to intraluminal prosthesis 1 of the present utility model.Fig. 3 a shows the detailed partial view of the intraluminal prosthesis 1 being made up of self-expanding framework 20, and Fig. 3 b shows the partial schematic diagram of the intraluminal prosthesis 1 being made up of two self-expanding frameworks 20.The thickness T of the wall of intraluminal prosthesis 11Diameter with filament 21RatioShould be greater than 2.0.It is characterized in that, described intraluminal prosthesis 1 is with more than one layer of grid, i.e. multilamellar configuration.Weave frame 20 preferably employs thickness T20Multilayer braided fabric make.Term " interlocked multi-layers " has referred to the framework of multilamellar, and its synusia is not that it is obvious that such as the synusia to the filament of determined number with the second layer 23 and/or other layer of the synusia of ground floor 22 mutually locks, as shown in Figure 4 when braiding.Such as, the braider that described interlocked multi-layers can use EP1248372 patent to be introduced is made.
Compared with the wall thickness of conventional stent, due to thickness wall T of multilamellar intraluminal prosthesis 11, intraluminal prosthesis 1 presents three-dimensional (3D) porosity.This wall is the thickest (shows alignment filament diameter), three-dimension hole porosity effect is the biggest.
One of them technical effect that the 3D porosity of intraluminal prosthesis 1 is provided is, intraluminal prosthesis 1 of the present utility model can make the blood stream of entrance aneurysmal sack less desirable in aneurysmal sack will damage turbulent flow due to its multilamellar configuration, be converted to smooth laminar flow 11 (as shown in Figure 5), and unlike as conventional stent implanted prosthetics is used, machinery/physically discharge blood stream from aneurysm.By forming protectiveness organized thrombus, layer (layersofZhan) (see Fig. 6) of referred to as standing, and get rid of aneurysm, make branch and subbranch keep unimpeded simultaneously.Due to the Permeability multiple structure of intraluminal prosthesis 1, thus it is no longer necessary to additional repairing, the open debranching enzyme by-pass operation such as the used and/branch stent configuration of windowing of customization for keeping blood flowing.
Under radial expanded state, the surface coverage (SCR) of intraluminal prosthesis 1 between 30% and 70%, preferably greater than 35% and less than 50%, more preferably less than 45%.The SCR of intraluminal prosthesis defines as the following formula:
SCR=Sw/St
In formula, " Sw" it is the actual surface covered with the filament 21 constituting intraluminal prosthesis 1, and " St" total surface area of wall of intraluminal prosthesis 1 when being then viewing orthogonal relative to wall.
Research and experiment that this utility model person is carried out have drawn wondrous and beyond thought conclusion.According to intraluminal prosthesis SCR ratioIncreasing between 30% and 70%, the blood perfusion in branch improves, without blocking these branches.In a physiologically, the process of the capillary bed conveying blood being health in biological tissue " is irrigated ".Term " hypoperfusion " and " hyperperfusion " are to measure the perfusion degree relative to tissue current needs, to meet its metabolism needs.Such as, intraluminal prosthesis of the present utility model increases the perfusion of bow top set 30 when it covers branch, so that bow top set 30 improves to the organ dysfunction of its conveying blood.As shown in Fig. 7 simulates, at the 34 of branch, form heavily concussion (heavyturbulence).On the contrary, when intraluminal prosthesis is placed in mouth 34 front, eliminate chaotic flow because flowing through the wall of intraluminal prosthesis, and be converted to regular Laminar Flow.This accelerates the flowing in the branch that intraluminal prosthesis 1 is covered.To this end, the ratio that intraluminal prosthesis 1 of the present utility model is under radial expanded stateShould more than 2.0, preferably at least 2.5, more preferably at least 3.0, even more desirably at least 3.5, even more preferably still 4.0, and SCR is maintained between 30% and 70%, preferably between 35% and 50%.Blood flow simulating comparable situation in and without the aorta model of intraluminal prosthesis is respectively illustrated at Fig. 9 a and Fig. 9 b.Aorta model creates based on the actual pathology of patient.In Fig. 9 b, put intraluminal prosthesis, in order to cover from coronary artery 31 to the blood vessel wall of bow top set 30.Surprisingly, after so processing, when compared with the flow velocity without apparatus shown in Figure 10 a (enlarged detail of Fig. 9 a), the blood flow rate entering bow top set 30 dramatically increases 21% and 24%, as shown in Figure 10 b (enlarged detail of Fig. 9 b) at the mouth 34 of bow top set 30.IC flowing velocity is also added to 20%, as shown in figures 11a and 11b.
Use this interlocked multi-layers configuration, it can be seen that another to significantly improve be " perfusion " in the branch that covered of intraluminal prosthesis 1.The weave frame 20 of intraluminal prosthesis 1 uses at most 196 filaments 21 to make, preferably at least 90 filaments and at most 130 filaments.The preferred diameter of filamentIt is at least 120 μm, preferably at least 150 μm, more preferably at least 180 μm, even more desirably at least 200 μm and at most 220 μm.
Another advantage of the present utility model is, implantable intraluminal prosthesis 1 has higher ratioValue, with relatively low-ratioWeave frame compare, aneurysmal sack is effectively formed thrombosis.The wall thickness T of intraluminal prosthesis 11Wire diameter with filament 21RatioMore than 2.0, it is characterized in that, intraluminal prosthesis 1 has more than one layer of grid.RatioThe biggest, the number of plies included by intraluminal prosthesis 1 is the most.Every filament forms multilamellar so that blood flowing forms laminar flow, through the wall of intraluminal prosthesis 1.
The width W that the bending of aortic arch 32 is generally bent by measurement32With height H32Determine, if Ou et al. was at " cardiothoracic surgery magazine " (J.Thrac.Cardiovasc.Surg.2006 in 2006；132:1105-1111) upper described.Width W32Measure by the maximum horizontal range between ascending aorta and descending aorta 32 midpoint 35, near the axial plane through right pulmonary artery；And the height H of aortic arch32It is then to measure W32With aortic arch W32Maximum normal distance between peak 35, as shown in figure 12.
There are at least 2.5 ratiosInterlocked multi-layers configuration can bring important Advantageous techniques characteristic.When aneurysm is positioned at curved outside; it is highly important that; optimal SCR and grid optimal aperture size are set in the outside of flexibility; with thrombosis in forming protection machine at aneurysmal sack; by the laminar flow 36 being converted to smooth by unwanted damage concussion 33; meanwhile, keeping each branch, such as bow top set 30 is unobstructed.The filament of interlocked multi-layers configuration of the present utility model moves to keep adjacent, parallel rule distance, thus keeps the most consistent at case of bending with the chien shih SCR of straight configuration.On the contrary, use in curved lumenDuring the latticed pipe of conventional monolayers less than 2.0, the SCR outside knee is more much lower than the SCR of straight configuration.Therefore, the ratio of intraluminal prosthesis 1 of the present utility modelShould be even more preferably still at least 4.0 more than 2.0, preferably at least 2.5, more preferably at least 3.0, even more desirably at least 3.5.
Owing to another wonderful effect is that intraluminal prosthesis 1 of the present utility model has interlocked multi-layers configuration, do not have " common " expection situation, i.e. space between aneurysm wall and intraluminal prosthesis can be blocked by thrombosis, as shown in Figure 6, aneurysm including branch can directly be shunk, without forming thrombosis in aneurysmal sack, meanwhile, blood is still kept to flow into branch, as shown in Figure 13 and Figure 14.This utility model person think, by sealing, the unwanted concussion 33 that the opening part of aorta increases is eliminated, and then forms desired smooth flow 11 in this region.So, accelerate non-oscillating blood and flow into branch, decrease the pressure under Venturi effect simultaneously, cause the contraction of aneurysmal sack.
Preferably a kind of metal substrate of the bio-compatible material used in this utility model, it is chosen in the race including rustless steel (such as, 316,316L or 304)；Including shape memory or super-elasticity type tweezer titanium alloy (such as, Nitinol,)；Cochrome (such as, elgiloy)；Cobalt chrome-nickel (such as, phynox)；Cobalt, nickel, chromium and molybdenum alloy (such as, MP35N or MP20N)；Cobalt chrome alum alloy；Cobalt-chromium-tungsten alloy；Magnesium alloy；Titanium alloy (such as, TiC, TiN)；Tantalum alloy (such as, TaC, TaN)；L605.Described metal substrate is preferably chosen in the race being made up of following metal, titanium alloy, Nitinol (such as nitinol and), any kind of rustless steel, or such asCobalt chrome-nickel.
Claims (14)
- The most implantable intraluminal prosthesis (1), it is with multilamellar configuration, including at least one self-expanding weave frame (20), along the axis extension that can expand into radial expanded state from the radial compression of conveying configuration；Described self-expanding weave frame (20) uses at most 196 and has given wire diameterFilament (21) formed；This self-expanding weave frame (20) is without any impermeable cover layer, and defines the wall of described intraluminal prosthesis (1)；Described self-expanding weave frame (20) includes cylindrical shape tube chamber, with circular cross section and constant diameter；It is characterized in that, when radial expanded state, the thickness (T of the wall under described implantable intraluminal prosthesis (1) radial expanded state1) and the diameter of filament (21)RatioMore than 2.0；And the surface coverage (SCR) at least 30% and at most 70% of described weave frame (20).
- Implantable intraluminal prosthesis (1) the most according to claim 1, it is characterised in that: when radial expanded state, described self-expanding framework (20) includes the multilamellar filament (21) that multiple employing bio-compatible material is made；Every layer forms grid；Described grid forms grating frame with many filaments (21) of described layer；Described grid is interlocked, and described filament is integrated on the grid of adjacent layer described at least one of which.
- Implantable intraluminal prosthesis (1) the most according to claim 1 and 2, it is characterised in that: described ratioAt least 2.5.
- Implantable intraluminal prosthesis (1) the most according to claim 3, it is characterised in that: described ratioAt least 3.0.
- Implantable intraluminal prosthesis (1) the most according to claim 4, it is characterised in that: described ratioAt least 3.5.
- Implantable intraluminal prosthesis (1) the most according to claim 5, it is characterised in that: described ratioAt least 4.0.
- Implantable intraluminal prosthesis (1) the most according to claim 1, it is characterised in that: the surface coverage (SCR) of described weave frame (20) is more than 35% with less than 50%.
- Implantable intraluminal prosthesis (1) the most according to claim 1, it is characterised in that: described self-expanding weave frame (20) includes at least 90 filaments and at most 130 filaments.
- Implantable intraluminal prosthesis (1) the most according to claim 1, it is characterised in that: diameter at least 120 μm of described filament (21).
- Implantable intraluminal prosthesis (1) the most according to claim 9, it is characterised in that: diameter at least 150 μm of described filament (21).
- 11. implantable intraluminal prosthesis (1) according to claim 10, it is characterised in that: diameter at least 180 μm of described filament (21).
- 12. implantable intraluminal prosthesis (1) according to claim 11, it is characterised in that: diameter at least 200 μm of described filament (21) and at most 220 μm.
- 13. implantable intraluminal prosthesis according to claim 2, it is characterised in that: described bio-compatible material is a kind of metal substrate chosen in the race that following metal forms, titanium alloy, Nitinol；Any kind of rustless steel, or cobalt chrome-nickel.
- 14. implantable intraluminal prosthesis according to claim 13, it is characterised in that: described Nitinol is: nitinol andDescribed cobalt chrome-nickel is
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520920225.9U CN205434010U (en) | 2015-11-18 | 2015-11-18 | Can implant intracavity false body |
| TW105136898A TW201722373A (en) | 2015-11-13 | 2016-11-11 | Implantable endoluminal prosthesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520920225.9U CN205434010U (en) | 2015-11-18 | 2015-11-18 | Can implant intracavity false body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205434010U true CN205434010U (en) | 2016-08-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520920225.9U Expired - Fee Related CN205434010U (en) | 2015-11-13 | 2015-11-18 | Can implant intracavity false body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205434010U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110520083A (en) * | 2017-03-06 | 2019-11-29 | 心血管实验室股份公司和布雷维蒙特 Cv 实验室股份公司 | Multilayer endoluminal prosthesis and its manufacturing method |
| US11065136B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US11065009B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| CN114287989A (en) * | 2021-12-24 | 2022-04-08 | 珠海通桥医疗科技有限公司 | Blood flow guider support |
-
2015
- 2015-11-18 CN CN201520920225.9U patent/CN205434010U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110520083A (en) * | 2017-03-06 | 2019-11-29 | 心血管实验室股份公司和布雷维蒙特 Cv 实验室股份公司 | Multilayer endoluminal prosthesis and its manufacturing method |
| CN110520082A (en) * | 2017-03-06 | 2019-11-29 | 心血管实验室股份公司和布雷维蒙特 Cv 实验室股份公司 | Multilayer endoluminal prosthesis component and its manufacturing method |
| CN110520082B (en) * | 2017-03-06 | 2022-02-18 | 心血管实验室股份公司和布雷维蒙特 Cv 实验室股份公司 | Multi-layer intraluminal prosthetic assembly and method of making same |
| CN110520083B (en) * | 2017-03-06 | 2022-03-29 | 心血管实验室股份公司和布雷维蒙特 Cv 实验室股份公司 | Multi-layer intraluminal prosthesis and method of making same |
| US11065136B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US11065009B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US11759342B2 (en) | 2018-02-08 | 2023-09-19 | Covidien Lp | Vascular expandable devices |
| US11957357B2 (en) | 2018-02-08 | 2024-04-16 | Covidien Lp | Vascular expandable devices |
| CN114287989A (en) * | 2021-12-24 | 2022-04-08 | 珠海通桥医疗科技有限公司 | Blood flow guider support |
| CN114287989B (en) * | 2021-12-24 | 2023-12-08 | 珠海通桥医疗科技有限公司 | Blood flow guiding device bracket |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160810 Termination date: 20191118 |