CN205339560U - Single needle mixer , hard dual interface and infusion soft bag - Google Patents
Single needle mixer , hard dual interface and infusion soft bag Download PDFInfo
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- CN205339560U CN205339560U CN201520908421.4U CN201520908421U CN205339560U CN 205339560 U CN205339560 U CN 205339560U CN 201520908421 U CN201520908421 U CN 201520908421U CN 205339560 U CN205339560 U CN 205339560U
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Abstract
The utility model provides a single needle mixer, include integrated into one piece the base, mix the medicine passageway, mix the medicine glass, mix the medicine glass and constitute by wall of cup and bottom of cup, the pjncture needle, its characterized in that: it passes to mix medicine passageway lower extreme the base, the upper end is passed the bottom of cup, mix the upper end of medicine passageway, be provided with the pjncture needle that possesses the cavity passageway, the lower extreme of pjncture needle with mix medicine passageway upper end sealing connection just the cavity passageway with mix medicine passageway intercommunication, mix the lower extreme of medicine passageway, be provided with yi zhebing, and pass through it is right easily to roll over the handle the lower extreme that mixes the medicine passageway seals, open on the syringe needle of pjncture needle have with the hole of cavity passageway intercommunication, the pjncture needle does not extend mix the rim of a cup of medicine glass, mixer still includes the seal membrane, the seal membrane is in with the mode welding of pressure welding mix the rim of a cup of medicine glass, it is right it forms sealedly to mix the medicine glass, the seal membrane still can keep easy dyestripping smooth basically after the sterilization of damp and hot method terminal. The utility model also discloses a hard dual interface and infusion soft bag.
Description
Technical field
The present invention relates to a kind of medicine mixer, particularly to a kind of medicine mixer with mixed medicine glass.
Background technology
When the injectable powder using cillin bottle to contain, lyophilized injectable powder or aqueous injection, it is necessary to by syringe, the liquid medicine in transfusion flexible bag or water for injection are extracted out in injection cillin bottle, repeat above-mentioned work, until having enough medicinal liquids in cillin bottle；Then again cillin bottle is shaken repeatedly until the medicament mix homogeneously in bottle, then with syringe, cillin bottle inner liquid medicine is extracted out in injection transfusion flexible bag, so repeatedly, until the medicinal liquid in bottle is exhausted.
First, above-mentioned mixed medicine operating process is relatively time-consuming, require great effort, take consumptive material such as syringe, more seriously, in above-mentioned mixed medicine process, it is very easy to be injected in cillin bottle and transfusion flexible bag by the air of outside, much air exists under generic condition more various dust, pathogenic bacteria, enters back into human body after being mixed into liquid medicine injection, very serious malpractice can be brought.
Secondly, traditional dosing mode, it is first make up a prescription to inject again, in advance the medicine in cillin bottle is pumped in transfusion flexible bag, then the transfusion flexible bag preparing medicine is brought to ward to patient fluid infusion.After having joined medicine, vacant cillin bottle is placed, and what medicine what patient protected that medical personnel do not know to join in transfusion flexible bag completely is, does not possess trackability.Slightly not noting going wrong once medical personnel in dosing, medicinal liquid mismatch is wrong, and consequence is by hardly imaginable.
Again, for the medicine that some are special, such as needing namely to join medicine namely, traditional dispensing method is very inconvenient, and the various medicine mixer structures disclosed before this patent, not can solve this problem.
Finally, the various medicine mixer structures disclosed before making the present invention, fail to solve the problem of Drug leakage after mixed medicine always.For the needs to higher medical service level, in the urgent need to a kind of easy to use, safe and reliable, infusion products without potential safety hazard.
It addition, medicine mixer is welded on transfusion flexible bag, after transfusion flexible bag fill, it is necessary to transfusion flexible bag entirety carries out high temperature sterilize, high temperature sterilize environment is usually the high temperature of 115-121 degree Celsius, sterilization time 30-15 minute, and sterilization pressure is 0.15MPa.Although the material polypropylene used by medicine mixer and transfusion flexible bag can withstand the temperature of 120 degrees Celsius, but inevitably soften, add the high pressure of 0.15MPa, be equivalent to every square centimeter of pressure bearing 150N this for the mixed medicine glass being in sealing state, be fatal.First-selection, mixed medicine glass and diaphragm seal are at the temperature of 120 degrees Celsius, and mechanical strength can decrease；Secondly, the pressure of every square centimeter of 150N, the cup deformation of mixed medicine glass can be directly resulted in, diaphragm seal is stretched, and fold occurs, sealing is destroyed, and causes that mixed medicine glass structure is completely damaged and cannot use.
Before making the present invention, the medicine mixer of sealed mixed medicine cup structure, its terminal sterilization, is the individual obstacle being difficult to and overcoming；And mixed medicine glass blow-by, again it cannot be guaranteed that meet sterility requirements when using, whether from policies and regulations still from the consideration of actual security standpoint, the terminal sterilization of transfusion flexible bag, be all must and also be very necessary.
Summary of the invention
Based on the problems referred to above, the present invention proposes a kind of easy to use reliable and transfusion flexible bag without potential safety hazard and associated medicine mixer, interface.
The medicine mixer that the present invention proposes, including integrated pedestal, mixed medicine passage, mixed medicine glass, described mixed medicine glass is constituted by the bottom of wall of cup and cup, puncture needle, it is characterised in that:
Described mixed medicine passage lower end is through described pedestal, and upper end is at the bottom of described cup；
In the upper end of described mixed medicine passage, being provided with the puncture needle possessing hollow channel, the lower end of described puncture needle and described mixed medicine passage upper end are tightly connected and described hollow channel and described mixed medicine channel connection；
Having the hole connected with described hollow channel on the syringe needle of described puncture needle, described puncture needle does not extend the rim of a cup of described mixed medicine glass；
Described medicine mixer also includes diaphragm seal, and described diaphragm seal is welded on the rim of a cup of described mixed medicine glass in the way of pressure welding, described mixed medicine glass is formed and seals；
Described diaphragm seal is still to keep substantially smooth easily tore film after wet heating terminal sterilization.
Medicine mixer as above, it is characterised in that:
Described diaphragm seal is breathability easily tore film.
Medicine mixer as above, it is characterised in that:
The air penetrability of described diaphragm seal is 5% to 35%.
Medicine mixer as above, it is characterised in that:
Described diaphragm seal upper surface metal-plated membrane layer.
As above arbitrary described medicine mixer, it is characterised in that:
Also include a cover plate；
Described cover plate is positioned at described rim of a cup edge, and is covered by described diaphragm seal.
Medicine mixer as above, it is characterised in that:
Described cover plate is polygon, and center is provided with through hole, and the needle portion of described puncture needle is positioned at described through hole but is not passed through described hole；
The internal diameter of described through hole is less than the external diameter of described puncture needle but more than the needle point of described syringe needle so that described needle point can stretch in described through hole but cannot pass through described through hole, supports so that described cover plate to be formed；
Described cover plate is provided with reinforcement.
As above arbitrary described medicine mixer, it is characterised in that:
Described mixed medicine glass, before being sealed by described diaphragm seal, pre-installs a certain amount of liquid.
Medicine mixer as above, it is characterised in that:
Described liquid be can under high temperature sterilize environment the liquid of rapid vaporization.
As above arbitrary described medicine mixer, it is characterised in that:
The described certain quantity of fluid of prepackage is vaporized the gas formed under high temperature sterilize environment, and the described inside and outside air pressure of mixed medicine glass can be allowed in a basic balance.
As above arbitrary described medicine mixer, it is characterised in that:
Being provided with restriction protrusion on the inwall of described wall of cup, after described cross needle is installed into described mixed medicine glass, described needle plate is limited to and can not be removed between at the bottom of described restriction protrusion and described cup by described restriction protrusion.
Medicine mixer as above, it is characterised in that:
Described restriction protrusion is elastic card claw, the inwall week of wall of cup described in described elastic card claw upper end edge is along being evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely；
The free end of described elastic card claw is basically identical with the thickness of XiLin bottle cap to the distance between at the bottom of described cup or thickness slightly larger than described XiLin bottle cap, after making cillin bottle be assembled on described medicine mixer, the bottle cap of described cillin bottle is stuck in by described elastic card claw between at the bottom of described free end and described cup.
Medicine mixer as above, it is characterised in that:
Described restriction protrusion is elastic clamp seat, described elastic clamp seat includes a snap ring, it is provided with elastic card claw on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely；
The free end of described elastic card claw is basically identical with the thickness of XiLin bottle cap to the distance between at the bottom of described cup or thickness slightly larger than described XiLin bottle cap, after making cillin bottle be assembled on described medicine mixer, the bottle cap of described cillin bottle is stuck in by described elastic card claw between at the bottom of described free end and described cup；
Being provided with position limiting structure on the inwall of described wall of cup, described elastic clamp seat is installed on and is limited by described position limiting structure in described mixed medicine glass.
Medicine mixer as above, it is characterised in that:
Described elastic clamp seat has integrated base plate, support column, described snap ring and described elastic card claw, and described base plate periphery is provided with support column and supports fixing to the formation of described snap ring；
Described base plate is provided with centre bore, described puncture needle match through described centre bore.
As above arbitrary described medicine mixer, it is characterised in that:
Described mixed medicine passage lower end, is provided with foldable handle, and by described foldable handle, the lower end of described mixed medicine passage is sealed.
The invention also discloses a kind of medicine mixer with reinforcement structure, it is characterised in that: include as above arbitrary described medicine mixer；
On the described wall of cup of described mixed medicine glass, it is provided with reinforcing rib structure to strengthen the comprcssive strength of described wall of cup.
Medicine mixer as above, it is characterised in that:
Described reinforcement is arranged on inside described wall of cup along the vertical direction and/or horizontal direction one is arranged.
Invention further discloses a kind of hard double nip with medicine mixer, including as above arbitrary described medicine mixer, it is characterised in that:
Relative to the opposite side of described mixed medicine passage on the described pedestal of described medicine mixer, it is provided with an infusion channel.
A kind of transfusion flexible bag with hard double nip, it is characterised in that:
Described hard double nip is described above hard double nip.
A kind of transfusion flexible bag with medicine mixer, it is characterised in that: described medicine mixer is as above arbitrary described medicine mixer；
Described medicine mixer is bonded together by described pedestal and described soft bag.
Transfusion flexible bag as above, it is characterised in that:
Also including an infusion connector, described infusion connector is arranged on and on the transfusion flexible bag of described medicine mixer homonymy, or is arranged on the transfusion flexible bag of the opposite side relative with described medicine mixer.
As above arbitrary described transfusion flexible bag, it is characterised in that:
What described transfusion flexible bag adopted is non-PVC multi-layer co-extruded film；
What described integrated pedestal and mixed medicine glass, barrier film adopted is medical polypropylene material, it is preferred that polypropylene R530C material；
Described cross needle, described restriction protrusion are polypropylene material, it is preferred that polypropylene P17 material.
Accompanying drawing explanation
Fig. 1 single needle medicine mixer schematic diagram
Fig. 2 single needle syringe needle partial, detailed view
Fig. 3 single needle partial, detailed view
Fig. 4 mixes medicine glass partial, detailed view
Fig. 5 elastic clamp seat
Fig. 6 cover plate
The Fig. 7 transfusion flexible bag with single needle medicine mixer
Single needle medicine mixer transfusion flexible bag under Fig. 8 use state
Fig. 9 infuses and mixes the single needle medicine mixer transfusion flexible bag that medicine is discrete
The single needle medicine mixer transfusion flexible bag discrete with mixed medicine of infusing under Figure 10 use state
Description of reference numerals: 1 transfusion flexible bag, 2 pedestals, 3 mixed medicine glasses, 3-1 wall of cup, at the bottom of 3-2 cup, 3-3 reinforcement, 4 restriction protrusion/elastic clamp seat, 4-1 elastic card claw, 4-2 snap ring, 4-3 centre bore, 4-4 support column, 4-5 base plate, 5 puncture needles, 5-1 side opening, 5-2 needle point, 5-3 elastic contraction film, 6 foldable handles, 7 mixed medicine passage, 8 cover plates, 9 diaphragm seals, 10 cillin bottles, 11 infusion channel, 12 inner caps easy to break, 13 plugs, 14 enclosing covers easy to break
Detailed description of the invention
Below, in conjunction with Figure of description, the present invention is further detailed.
First embodiment
As it is shown in figure 1, include pedestal 2, mixed medicine glass 3, restriction protrusion 4, puncture needle 5, mixed medicine passage 7, foldable handle 6, the above-mentioned medicine mixer body construction being made up of pedestal 2, mixed medicine glass 3, mixed medicine passage 7 is formed in integrated mode.The lower end of mixed medicine passage 7 is formed and closes by foldable handle 6, under use state as shown in Figure 8, breaks disconnected foldable handle 6 so that mixed medicine passage 7 connects with cillin bottle 10 through puncture needle 5, thus completing mixed medicine.
Medicine mixer as shown in Figure 1, except mixed medicine passage, it is also possible to integrated arrange infusion channel 11, with being arranged side by side on the base 2 of mixed medicine passage 7 competition.Infusion channel 11 upper end is provided with easy fold, including inner cap 12, plug 13 and easy fold 14.
At the opening of mixed medicine glass upper end, it is provided with cover plate 8 and diaphragm seal 9, mixed medicine glass is formed and seals completely.
As for restriction protrusion 4, it is preferred that elastic card claw；It is further preferred that elastic card claw and described mixed medicine glass 3 as restriction protrusion 4 are one-body molded.
The inwall week of wall of cup 31 described in elastic card claw 4 upper end edge, described elastic card claw lower end was free end along being evenly arranged and fixing, and described elastic card claw 4 is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely, as shown in Figure 1.
Medicine mixer under use state as shown in Figure 8, loading after cillin bottle 10, cillin bottle 10 is pushed into mixed medicine glass 3, and its bottle cap is punctured pin 5 and punctures and then blocked by the free end of elastic card claw 4 and can not extract.It is understandable that, the bottle cap thickness of cillin bottle 10 should and the free end of elastic card claw 4 basically identical to distance between 32 at the bottom of mixed medicine glass cup, make cillin bottle 10 pass right through bottle cap to be stuck at the bottom of the free end of elastic card claw 4 and cup between 32, and can not move up and down.
For puncture needle 5, it is arranged on the upper end of mixed medicine passage, it is possible to dismountable with mixed medicine passage be tightly connected, it is preferred that one-body molded with medicine mixer body construction.Needle head structure for puncture needle 5, the structure of side opening 51 is added than the needle point 52 even more preferably adopted as described in Figure 2, so arrange, be in order to avoid when puncturing plug, bottle stopper, stopper is formed directly cutting and produces substantial amounts of chip by the edge of puncture needle 5 outlet.By outlet being arranged on the sidewall of syringe needle and form side opening 51 as shown in Figure 2, needle point 52 can directly thrust in plug, will not form direct dissection, reduces the generation of chip.
Additionally, after bottle cap is pierced through for puncture needle 5, in order to prevent medicinal liquid along the gap leakage between puncture needle 5 and cillin bottle bottle cap, can be as shown in Figure 3, outer surface at puncture needle 5 is coated with one layer of elastic contraction film 53, elastic contraction film 53 is compressed after piercing, is deposited in around puncturing hole, such that it is able to effectively prevent medicinal liquid along puncturing hole gap leakage out.
For the restriction protrusion 4 in mixed medicine glass 3, an alternative scheme is, adopts independent elastic clamp seat 4 as shown in Figure 5, is fitted in mixed medicine glass 3, to play the position-limiting action to cillin bottle.
Structure for elastic clamp seat 4, one can concrete design be: as shown in Figure 5, elastic clamp seat 4, including a snap ring 42, it is provided with elastic card claw 41 on the downside of described snap ring 42, snap ring 42 described in described elastic card 41 upper end edge is evenly arranged and fixing, and described elastic card claw 41 lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely.Described elastic clamp seat has integrated base plate 45, support column 44, snap ring 42 and elastic card claw 41, and described base plate 45 periphery is provided with support column 44 pairs described snap ring 46 formation and supports fixing.
Described base plate 45 is provided with centre bore 43, the described puncture needle 5 described centre bore of traverse.
What elastic clamp seat 4 independent with it matched is, the inwall of described wall of cup 31 is provided with position limiting structure (not shown), described elastic clamp seat 4 is installed on and is limited by described position limiting structure in described mixed medicine glass so that elastic clamp seat 4 will not skid off mixed medicine glass after placing.Especially, the medicine mixer under use state as shown in Figure 8, after cillin bottle 10 is pushed into puncture, the complete limited structure of elastic clamp seat 4 is limited can not be exited at the bottom of cup.
By above-mentioned setting, it is possible to conveniently, safely, make up a prescription efficiently, dosing, completely solve the secondary pollution problem in link of making up a prescription.Also can guarantee that transfusion can be reviewed, because being fixed to mixed medicine glass 3 from cillin bottle 10 docking, after being blocked by elastic card claw 4/4 1, cillin bottle 10 cannot nondestructive take out simultaneously.It is to say, from making up a prescription, complete to transfusion, until reclaiming link, can trace back to added, which kind of medicine what inject is.
And above-mentioned medicine mixer, a class is needed to the medicine of special preservation, for example need namely to join i.e. note type, after can also taking out, from pharmacy, the medicine that cillin bottle 10 fills, it is assembled on the mixed medicine glass 3 of transfusion flexible bag 1 to take to ward, then completes mixed medicine after breaking disconnected foldable handle 6, it is achieved namely join and namely use.
Shape and structure about pedestal 2, after being welded in soft bag in order to avoid medicine mixer, infusion channel or the hard double nip with medicine mixer and infusion channel, the transfusion flexible bag with medicine mixer as shown in Figure 7 is storing, is transporting and in use procedure, the damage that transfusion flexible bag is caused by pedestal welding position, pedestal is designed as dumb-bell shape or ship shape, shown in pedestal 2 in Fig. 1, and the lower end of mixed medicine passage 7, infusion channel 11 is concordant with the lower end of pedestal 2.Uniform welding lines on the surrounding sidewall of pedestal 2, so can well ensure to be in that in the welding process of transfusion flexible bag, even pedestal 2 also can well fuse welding with soft bag 2 at a lower temperature.And, the pedestal of ship shape or dumb-bell shape, streamlined good, improve the mechanical property of welding not to the utmost, and there is no sharp angle, it is possible to make hard double nip and transfusion flexible bag 2 in conjunction with smoother, be hardly damaged soft bag.
For the selection of medicine mixer and transfusion flexible bag material, what transfusion flexible bag adopted is the non-PVC multi-layer co-extruded film commonly used at present, including the PP TYPE of three layers, five layers.
And medicine mixer, then what adopt is and the transfusion flexible bag good medical polypropylene material of the non-PVC material compatibility, pedestal, mixed medicine glass, cover plate preferably polypropylene R530C material；And puncture needle, elastic clamp seat, position limiting structure, it is contemplated that its puncture and mechanical property, it is preferred that the P17 material in pp material system.
Finally, in the medicine mixer sealing structure crucial some sealed mixed medicine devices terminal sterilization after being welded in soft bag.Considering from the angle of policies and regulations and actual injection safety at present, all of drug packaging, before fill is dispatched from the factory, it is necessary to carries out terminal sterilization, or adopts injection Sterility Assurance technique.
At present, the Sterility Assurance technique of injection mainly has two kinds:
1. terminal sterilization technique: controlling on the basis of microorganism contaminant capacity, after medicine embedding, degerming by moist heat sterilization mode.In general, this method cost is low, and sterility assurance level is high, is suitable for the sterilizing of bulk capacity injection and small-volume injection.
2. sterile production technique: under sterile system environment, by aseptic filtration method or aseptic manipulation, to prevent for the purpose of pollution, eliminates the various probabilities causing polluting to ensure aseptic level.Typically, since this method is high to the requirement of environmental system, and the factor that affects sterile working is many and make sterility assurance level lower than terminal sterilization technique.Sterile production technique is generally applicable to injectable powder, also can be suitable for clinical needs but can not carry out the small-volume injection of terminal sterilization.Thus, terminal sterilization technique and sterile production technique have different system requirements, different degerming methods and different Sterility Assurance results
For infusion solutions, it is cost exquisite sensitivity, so, the terminal sterilization in infusion solutions, it is only possible to employing low cost and efficient moist heat sterilization sterilization procedure condition is usually under the high temperature of 115 121 degrees Celsius, the steam of 0.15MPa pressure, keep 30 15 minutes.
Although medicine mixer and transfusion flexible bag, it is all the polypropylene material resistant to 120 celsius temperatures selected, but, the medicine mixer under sealing state, at such high temperatures, its mechanical performance can reduce, and is very easy under the pressure of 0.15MPa and deforms；And diaphragm seal also can occur deformation, fold losing sealing effectiveness at this temperature and pressure.
We carried out the experiment of up to a hundred times up to 4 years from 2011 to 2014, solved the medicine mixer under sealing state and transfusion flexible bag terminal sterilization problem.
Firstly, for the structure of mixed medicine glass, as shown in Figure 4, it is provided with reinforcement 33 in the lower half of cup.The setting of reinforcement is the wall of cup to mixed medicine glass, and preferential is carry out in wall of cup lower half.
Reinforcement can be provided in the vertical bar integrated with mixed medicine glass of the equally distributed projection in inside wall of cup and/or outside or horizontal stripe or crisscross network structure.Preferably along the equally distributed perpendicular list structure in lower half inside wall of cup；At the bottom of more preferably the vertical bar of projection extends to glass from lower half inside wall of cup, it is most preferred that to be that the thickness of vertical bar projection is smooth gradually from top to bottom increase continuously.
It is provided with the mixed medicine glass of reinforcement, suitable degree improves the mechanical resistance of cup.Experiment is compared, it does not have arrange the mixed medicine glass of reinforcement, after adopting wet heating sterilization process, and circular mixed medicine glass cup, it is compressed into square, can not use completely.
After being provided with reinforcement, after wet heating sterilization process, circular mixed medicine glass cup, there is slight compression, have no substantial effect on and use function normally.
Secondly, for diaphragm seal 9, itself is a very thin easily tore film simply, is easy to the effect torn when playing the sealing to mixed medicine glass 3 and use.Diaphragm seal 9 is more weaker than the cup of mixed medicine glass 3, because the thin film of diaphragm seal 9 simply one layer of micron dimension thickness itself, holds and can't stand the pressure of 0.15MPa in wet heating sterilization process.
To this, have passed through substantial amounts of experiment, it is found that installing a cover plate 8 as shown in Figure 6 under diaphragm seal 9 additional, diaphragm seal 9 covers cover plate 8 so that diaphragm seal 9 is formed effective support by cover plate 8, it is prevented that diaphragm seal 9 when sterilizing by compression.It is step-like interior along upper that cover plate 8 is then shelved on described mixed medicine glass rim of a cup, make the upper surface being arranged on the cover plate at rim of a cup place concordant with rim of a cup or slightly below described rim of a cup, and such setting of cover plate 8, diaphragm seal 9 pressure welding is not resulted in impact at the sealing technology of described wall of cup upper end face.
For the shape of cover plate, with the circle of the shape substantially match that of mixed medicine glass rim of a cup, it is preferred that the shape of cover plate 8 is cross section is polygon, such as pentagon, hexagon, octagon, 12 deformation.The benefit of polygonal cover plate 8 one aspect is taken out when being and use eaily；And cover plate 8 is set to polygonal other beyond thought acting on and can mention below.
Additionally, for the comprcssive strength strengthening cover plate, it is preferred that cover plate 8 and puncture needle are coaxially disposed, and needle point 52 is just to cover plate central and to cover plate formation support.More have preferably, cover plate 8 center is provided with a through hole 81, and through hole 81 internal diameter is less than the external diameter of puncture needle 5, and needle point 52 part is positioned at through hole but cannot pass through described through hole, namely needle point 52 embeds in the through hole 81 of cover plate 8, so that puncture needle 5 is more notable to the support effect of cover plate 8.
Meanwhile, consider the huge downward pressure that cover plate 8 bears, except cover plate 8 is formed support by design puncture needle 5, also carried out cover plate 8 strengthening arranging, the reinforcement 82 radially arranged with ring-type as shown in Figure 6, enhances the mechanical strength of cover plate 8.
The diaphragm seal 9 of pressure welding and rim of a cup upper end, tightly be pasted on cover plate 9 upper surface so that diaphragm seal 9, substantially without bearing high pressure, alleviates diaphragm seal 9 greatly and deforms the phenomenon of fold.
And for fold, owing to diaphragm seal 9 is too thin, slightly pressure may result in the appearance of fold, have a strong impact on the visual effect of product.
Through contrast experiment repeatedly, at the metal film that the plating of diaphragm seal 9 upper surface is a layer thin, the diaphragm seal such as aluminized, it is possible to the effective problem alleviating diaphragm seal fold.
The sealed mixed medicine device so arranged, although also substantially can normally use after withstanding the high temperature and high pressure of wet heating sterilization process, but, the profile as product is still difficult to be maintained at good state, consider from the angle of infusion products, remain underproof product.
After structurally medicine mixer having been carried out above-mentioned design, can only ensure to use function, in order to thoroughly solve the terminal sterilization problem of sealed mixed medicine device, in addition it is also necessary to from root, solve the mixed medicine glass inside and outside air pressure balance when wet heating sterilizing sealed.
After mixed medicine glass is completed, installs cover plate 8 and diaphragm seal 9 additional to before its sealing, in cup, pre-install a certain amount of liquid, then install cover plate again additional, seal.
The sealed mixed medicine cup of contained liquid, when carrying out terminal sterilization with transfusion flexible bag, liquid fast vaporizing under high temperature, such that it is able to the air pressure inside and outside cup that allows quickly reaches a balance.
For preloaded with liquid, it is preferred that thermal capacity is less, the liquid that saturated vapor pressure is higher.We have studied various liquid at 120 degrees Celsius, the state under 0.15MPa, including the harmless liquid that water, ethanol etc. are conventional, our demand all can be met.Consider cost and safety, it is preferred that preloaded with liquid is water.
As for vital pre-installation of water V0, it is possible to confirmed by below equation:
PV=nRT, wherein P is that external and internal pressure during wet heating sterilizing is poor, and V is mixed medicine glass volume, and n is the molal quantity of preloaded with liquid/water, and R is gas constant, and T is absolute temperature during wet heating sterilizing.
V0=n*M/ ρ, wherein M is the molal weight of fluid/water, and ρ is the density of fluid/water.
Can well the balanced seal medicine mixer inner and outer air pressure when terminal sterilization according to above-mentioned equation.
In the way of preloaded with liquid, balance inner and outer air pressure, be a ratio more preferably solution.
But, the problem that said method can solve the problem that air pressure balance, then in actual use, still there is certain problem, most typically, the finished product transfusion flexible bag that sterilizing is over, in mixed medicine glass, there is water droplet or liquid after cooling, very affect perception, and such product generally also less can be accepted by hospital and patient.
On this basis, one scheme being more highly preferred to is, we have studied the diaphragm seal with certain air permeability based on pp material system especially, ensure after vaporizing liquid, sufficient gas exchange can be carried out by gas-permeable seal film and outside, so after sterilizing completes, in mixed medicine glass, do not have the liquid of residual.
The air penetrability of gas-permeable seal film, through long many experiments, 5% 35% air penetrabilities, are highly preferred.
For the medicine mixer adopting the gas-permeable seal film that we study to seal, after wet heating high temperature sterilize, mixed medicine glass does not have a bit deformation, diaphragm seal also smooth as before, it does not have fold occur.
Certainly, one modified model scheme is, at not preloaded with liquid, the gas-permeable seal film with appropriate air permeability is directly adopted to carry out sealed mixed medicine device, many experiments through us, select breathability between 25% 35%, it is preferred that the diaphragm seal of about 30%, substantially can guarantee that the integrity of medicine mixer structure after sterilizing.
And the structure of the cover plate shape-polygonal of decision design and middle with hole, experiments show that, after have employed air pressure balance means, this decision design, the air pressure inside and outside mixed medicine glass can be allowed faster to reach balance, thus in wet heating sterilization process, showing more outstanding diaphragm seal smooth as before, mixed medicine glass does not at all deform.This is because the cover plate of polygon and middle with hole, can add under large cover and the atmosphere exchange rate in region on cover plate, can allow the air pressure equalisation in mixed medicine glass faster, allow mixed medicine glass other balances inside and outside.
Second embodiment
As it is shown in figure 9, mixed medicine glass 3 is provided separately with infusion channel 11, and it is positioned at the upper and lower both sides of transfusion flexible bag.It is, of course, understood that medicine mixer can separate with infusion channel be arranged on transfusion flexible bag homonymy.Medicine mixer in medicine mixer in this embodiment, infusion channel and interface and embodiment 1 is just the same, the difference is that in this embodiment medicine mixer and infusion channel 11 and the interface that is made up of inner cap 12, enclosing cover easy to break 14, plug be provided separately.
Figure 10 is the transfusion flexible bag with medicine mixer under use state, and cillin bottle 10 assembles and is pushed in mixed medicine glass 3, and its bottle cap is punctured pin 5 and punctures, and cillin bottle 10 is then blocked the bottleneck position under bottle cap by elastic card claw 4 simultaneously, it is impossible to nondestructive exit.
It should be understood that it is above only in order to illustrative not limiting technical scheme, although the present invention being described in detail with reference to above-described embodiment, it will be understood by those within the art that: still the present invention can be modified or equivalent replacement, without deviating from any modification or partial replacement of the spirit and scope of the present invention, all should be encompassed in the middle of scope of the presently claimed invention.
Claims (20)
1. a single needle medicine mixer, including integrated pedestal, mixed medicine passage, mixed medicine glass, described mixed medicine glass is constituted by the bottom of wall of cup and cup, puncture needle, it is characterised in that:
Described mixed medicine passage lower end is through described pedestal, and upper end is at the bottom of described cup；
In the upper end of described mixed medicine passage, being provided with the puncture needle possessing hollow channel, the lower end of described puncture needle and described mixed medicine passage upper end are tightly connected and described hollow channel and described mixed medicine channel connection；
The lower end of described mixed medicine passage, is provided with foldable handle, and by described foldable handle, the lower end of described mixed medicine passage is sealed；
The syringe needle of described puncture needle has the hole connected with described hollow channel；
Described medicine mixer also includes diaphragm seal, and described diaphragm seal is welded on the rim of a cup of described mixed medicine glass in the way of pressure welding, described mixed medicine glass is formed and seals；
Described diaphragm seal is still to keep substantially smooth easily tore film after wet heating terminal sterilization.
2. medicine mixer as claimed in claim 1, it is characterised in that:
Described diaphragm seal is breathability easily tore film.
3. medicine mixer as claimed in claim 2, it is characterised in that:
The air penetrability of described diaphragm seal is 5% to 35%.
4. medicine mixer as claimed in claim 3, it is characterised in that:
Described diaphragm seal upper surface metal-plated membrane layer.
5. the medicine mixer as described in as arbitrary in claim 14, it is characterised in that:
Also include a cover plate；
Described cover plate is positioned at described rim of a cup edge, and is covered by described diaphragm seal.
6. medicine mixer as claimed in claim 5, it is characterised in that:
Described cover plate is polygon, and center is provided with through hole, and the needle portion of described puncture needle is positioned at described through hole but is not passed through described hole；
The internal diameter of described through hole is less than the external diameter of described puncture needle but more than the needle point of described syringe needle so that described needle point can stretch in described through hole but cannot pass through described through hole, supports so that described cover plate to be formed；
Described cover plate is provided with reinforcement.
7. the medicine mixer as described in as arbitrary in claim 14,6, it is characterised in that:
Described mixed medicine glass by described diaphragm seal seal before, pre-install a certain amount of can under high temperature sterilize environment the liquid of rapid vaporization；
The gas formed after vaporization makes the described inside and outside air pressure of mixed medicine glass in a basic balance.
8. medicine mixer as claimed in claim 5, it is characterised in that:
Described mixed medicine glass by described diaphragm seal seal before, pre-install a certain amount of can under high temperature sterilize environment the liquid of rapid vaporization；
The gas formed after vaporization makes the described inside and outside air pressure of mixed medicine glass in a basic balance.
9. the medicine mixer as described in as arbitrary in claim 14,6,8, it is characterised in that:
Being provided with restriction protrusion on the inwall of described wall of cup so that after cillin bottle is assembled on described medicine mixer, the bottle cap of described cillin bottle is limited in by described restriction protrusion between at the bottom of the free end of described restriction protrusion and described cup.
10. medicine mixer as claimed in claim 5, it is characterised in that:
Being provided with restriction protrusion on the inwall of described wall of cup so that after cillin bottle is assembled on described medicine mixer, the bottle cap of described cillin bottle is limited in by described restriction protrusion between at the bottom of the free end of described restriction protrusion and described cup.
11. medicine mixer as claimed in claim 7, it is characterised in that:
Being provided with restriction protrusion on the inwall of described wall of cup so that after cillin bottle is assembled on described medicine mixer, the bottle cap of described cillin bottle is limited in by described restriction protrusion between at the bottom of the free end of described restriction protrusion and described cup.
12. medicine mixer as claimed in claim 9, it is characterised in that:
Described restriction protrusion is elastic card claw, the inwall week of wall of cup described in described elastic card claw upper end edge is along being evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely；
The free end of described elastic card claw is basically identical with the thickness of XiLin bottle cap to the distance between at the bottom of described cup or thickness slightly larger than described XiLin bottle cap, after making cillin bottle be assembled on described medicine mixer, the bottle cap of described cillin bottle is stuck in by described elastic card claw between at the bottom of described free end and described cup.
13. the medicine mixer as described in as arbitrary in claim 10-11, it is characterised in that:
Described restriction protrusion is elastic card claw, the inwall week of wall of cup described in described elastic card claw upper end edge is along being evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely；
The free end of described elastic card claw is basically identical with the thickness of XiLin bottle cap to the distance between at the bottom of described cup or thickness slightly larger than described XiLin bottle cap, after making cillin bottle be assembled on described medicine mixer, the bottle cap of described cillin bottle is stuck in by described elastic card claw between at the bottom of described free end and described cup.
14. medicine mixer as claimed in claim 9, it is characterised in that:
Described restriction protrusion is elastic clamp seat, described elastic clamp seat includes a snap ring, it is provided with elastic card claw on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely；
The free end of described elastic card claw is basically identical with the thickness of XiLin bottle cap to the distance between at the bottom of described cup or thickness slightly larger than described XiLin bottle cap, after making cillin bottle be assembled on described medicine mixer, the bottle cap of described cillin bottle is stuck in by described elastic card claw between at the bottom of described free end and described cup；
Being provided with position limiting structure on the inwall of described wall of cup, described elastic clamp seat is installed on and is limited by described position limiting structure in described mixed medicine glass.
15. the medicine mixer as described in as arbitrary in claim 10-11, it is characterised in that:
Described restriction protrusion is elastic clamp seat, described elastic clamp seat includes a snap ring, it is provided with elastic card claw on the downside of described snap ring, snap ring described in described elastic card claw upper end edge is evenly arranged and fixing, described elastic card claw lower end is free end, and described elastic card claw is to the described centroclinal structure of mixed medicine glass from fixing described upper end to described lower end freely；
The free end of described elastic card claw is basically identical with the thickness of XiLin bottle cap to the distance between at the bottom of described cup or thickness slightly larger than described XiLin bottle cap, after making cillin bottle be assembled on described medicine mixer, the bottle cap of described cillin bottle is stuck in by described elastic card claw between at the bottom of described free end and described cup；
Being provided with position limiting structure on the inwall of described wall of cup, described elastic clamp seat is installed on and is limited by described position limiting structure in described mixed medicine glass.
16. medicine mixer as claimed in claim 14, it is characterised in that:
Described elastic clamp seat has integrated base plate, support column, described snap ring and described elastic card claw, and described base plate periphery is provided with support column and supports fixing to the formation of described snap ring；
Described base plate is provided with centre bore, described puncture needle match through described centre bore.
17. medicine mixer as claimed in claim 15, it is characterised in that:
Described elastic clamp seat has integrated base plate, support column, described snap ring and described elastic card claw, and described base plate periphery is provided with support column and supports fixing to the formation of described snap ring；
Described base plate is provided with centre bore, described puncture needle match through described centre bore.
18. a medicine mixer with reinforcement structure, it is characterised in that: include as arbitrary in claim 1 17 as described in medicine mixer；
On the described wall of cup of described mixed medicine glass, it is provided with reinforcing rib structure to strengthen the comprcssive strength of described wall of cup；
Described reinforcement is arranged on inside described wall of cup along the vertical direction and/or horizontal direction one is arranged.
19. with a hard double nip for medicine mixer, including the medicine mixer as described in as arbitrary in claim 1 12, it is characterised in that:
Relative to the opposite side of described mixed medicine passage on the described pedestal of described medicine mixer, it is provided with an infusion channel.
20. a transfusion flexible bag, it is characterised in that: described transfusion flexible bag include as arbitrary in claim 1 18 as described in medicine mixer；
Or hard double nip as claimed in claim 19；
Described medicine mixer or described hard double nip are bonded together by described pedestal and described soft bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520908421.4U CN205339560U (en) | 2015-11-13 | 2015-11-13 | Single needle mixer , hard dual interface and infusion soft bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520908421.4U CN205339560U (en) | 2015-11-13 | 2015-11-13 | Single needle mixer , hard dual interface and infusion soft bag |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205339560U true CN205339560U (en) | 2016-06-29 |
Family
ID=56167309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520908421.4U Withdrawn - After Issue CN205339560U (en) | 2015-11-13 | 2015-11-13 | Single needle mixer , hard dual interface and infusion soft bag |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205339560U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342850A (en) * | 2015-11-13 | 2016-02-24 | 重庆莱美药业股份有限公司 | Single-needle medicine mixing device, hard dual joint and infusion soft bag |
-
2015
- 2015-11-13 CN CN201520908421.4U patent/CN205339560U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342850A (en) * | 2015-11-13 | 2016-02-24 | 重庆莱美药业股份有限公司 | Single-needle medicine mixing device, hard dual joint and infusion soft bag |
| WO2017080521A1 (en) * | 2015-11-13 | 2017-05-18 | 重庆莱美药业股份有限公司 | Single-needle medicine mixer, dual hard ports, and soft infusion bag |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160629 Effective date of abandoning: 20191018 |