CN205122533U - Be suitable for high voltage pulse generator of mass spectrograph - Google Patents
Be suitable for high voltage pulse generator of mass spectrograph Download PDFInfo
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- CN205122533U CN205122533U CN201520939722.3U CN201520939722U CN205122533U CN 205122533 U CN205122533 U CN 205122533U CN 201520939722 U CN201520939722 U CN 201520939722U CN 205122533 U CN205122533 U CN 205122533U
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Abstract
The utility model discloses a be suitable for time -of -flight mass spectrometer's high voltage pulse generator, including the high voltage DC fast switch, voltage input wiring end IN1, the 2nd voltage input wiring end IN2, pulse voltage outlet terminal OUT1, metacoxal plate voltage output wiring end OUT2. The utility model discloses the advantage lies in adopting the circuit design of low complexity, stack 10KV's pulse voltage on 30KV's base plate voltage to with pulse voltage's trailing edge along the width control about 200ns, the pulse voltage width is less than 10us, the needs actual demand of several nanoseconds of stewing after having satisfied the ion and obtaining the laser energy and spill over, the sensitivity that has improved ionic transmission and system greatly, time -of -flight mass spectrometer's manufacturing cost has effectively been reduced to the while.
Description
Technical field
The utility model relates to high-voltage pulse generator, especially relates to the high-voltage pulse generator being suitable for time-of-flight mass spectrometer.
Background technology
Time-of-flight mass spectrometer (TOF:TimeofFlightMassSpectrometer), Matrix Assisted Laser Desorption ionization time of flight mass spectrometry, is made up of Matrix Assisted Laser Desorption ion source and time of flight mass analyzer.Matrix Assisted Laser Desorption ion source uses laser to irradiate sample and substrate formed mixture, in a narrow and small region, make matrix obtain sufficiently high energy in very short time, matrix absorbing energy transferring to sample molecule, thus makes sample molecule produce ionization.The effect of time of flight mass analyzer makes ion obtain kinetic energy under electric field action, accelerates to fly over dirft tube, according to the difference of ion flight time, identifies ion mass-to-charge ratio.Laser bombardment mixture needs a high voltage electric field and laser pulse to be used in combination.Bombard mixture generation ion fast at laser and enter electric field after time delay, provide certain kinetic energy by the high voltage electric field suddenlyd change to ion, then ion flies into vacuum cavity.
At present, time-of-flight mass spectrometer is switched by high-speed switch, a high-voltage pulse is exported through capacitive coupling, but the actual demand of Matrix Assisted Laser Desorption ionization time of flight mass spectrometry is not analyzed, also cannot to realize high-voltage pulse trailing edge along width control system at about 200ns, also high-pressure installation fail safe is not considered simultaneously, just simple circuit is piled up, therefore can not meet ion obtain laser energy overflow after the actual demand of needs standing hundreds of nanosecond, had a strong impact on ion transfer and system sensitivity.
Summary of the invention
The utility model object is to provide a kind of high-voltage pulse generator being suitable for time-of-flight mass spectrometer.
For achieving the above object, the utility model takes following technical proposals:
The high-voltage pulse generator being suitable for time-of-flight mass spectrometer described in the utility model, comprise high direct voltage high-speed switch, the first voltage input terminal IN1, the second voltage input terminal IN2, pulse voltage outlet terminal OUT1, metacoxal plate voltage outlet terminal OUT2; Described first voltage input terminal IN1 is connected with the parallel branch hot end be made up of voltage-stabiliser tube D3 and resistance R3 through resistance R2, the described parallel branch cold end be made up of voltage-stabiliser tube D3 and resistance R3 is divided into two-way to export, one tunnel is connected with the high potential contact lug end HV+ of described high direct voltage high-speed switch, separately leading up to series capacitance C3, C4 is connected with resistance R5 hot end, described resistance R5 cold end ground connection; Described second voltage input terminal IN2 is connected with resistance R5 hot end by resistance R4; One end of described pulse voltage outlet terminal OUT1 is connected with resistance R5 hot end by resistance R8, and the other end of pulse voltage outlet terminal OUT1 is connected with high-pressure coaxial cable; Described metacoxal plate voltage outlet terminal OUT2 is connected with resistance R5 hot end by resistance R7, R6; The tie point of resistance R7 and resistance R6 is by electric capacity C9 ground connection; The electronegative potential contact lug end HV-ground connection of described high direct voltage high-speed switch, the parallel branch ground connection of control signal input terminal TRI by being made up of voltage-stabiliser tube D2 and resistance R1 of high direct voltage high-speed switch, the supply terminals of high direct voltage high-speed switch is connected with described control signal input terminal TRI by voltage-stabiliser tube D1.
The bare wire capacitance of described high-pressure coaxial cable is 100PF, withstand voltage is 30KV; Described resistance R6 is variable resistor.
The parallel branch ground connection that the cold end of described resistance R2 forms via electric capacity C1, C2.
The utility model advantage is the circuit design adopting low complex degree, the substrate voltage of 30KV superposes the pulse voltage of 10KV, and by the trailing edge of pulse voltage along width control system at about 200ns, pulse voltage width is less than 10us, meet ion and obtain the actual demand needing standing hundreds of nanosecond after laser energy overflows, substantially increase the transmission of ion and the sensitivity of system, effectively reduce the manufacturing cost of time-of-flight mass spectrometer simultaneously.
Accompanying drawing explanation
Fig. 1 is the circuit theory diagrams of high-voltage pulse generator described in the utility model.
Fig. 2 is the circuit structure reference diagram that the utility model is applied to time-of-flight mass spectrometer.
Embodiment
As shown in Figure 1, 2, the high-voltage pulse generator being suitable for time-of-flight mass spectrometer described in the utility model, comprise high direct voltage high-speed switch 1, first voltage input terminal IN1, the second voltage input terminal IN2, pulse voltage outlet terminal OUT1, metacoxal plate voltage outlet terminal OUT2.The input voltage of the first voltage input terminal IN1 is 0 ~+10KV, the input voltage of the second voltage input terminal IN2 is 0 ~+30KV, pulse voltage outlet terminal OUT1 is used for providing pulse voltage to the prebasal plate 2 of time-of-flight mass spectrometer, the output voltage of metacoxal plate voltage outlet terminal OUT2 is 0 ~+30KV, provides voltage for giving the metacoxal plate 3 of time-of-flight mass spectrometer.First voltage input terminal IN1, the second voltage input terminal IN2, pulse voltage outlet terminal OUT1, metacoxal plate voltage outlet terminal OUT2 all select 40KV high-tension connector, the model that high direct voltage high-speed switch 1 selects German Bake (Behlke) company to produce is the high direct voltage high-speed switch of HTS150, the effective closing time of this high direct voltage high-speed switch is less than 10us, transient current can carry 30A, maximum carrying voltage is 15KV, and reverse breakdown voltage is greater than 18KV.
First voltage input terminal IN1 is connected with the parallel branch hot end be made up of voltage-stabiliser tube D3 and resistance R3 through resistance R2, the parallel branch ground connection that the cold end of resistance R2 forms via electric capacity C1, C2.The parallel branch cold end be made up of voltage-stabiliser tube D3 and resistance R3 is divided into two-way to export, one tunnel is connected with the high potential contact lug end HV+ of high direct voltage high-speed switch 1, separately leading up to series capacitance C3, C4 is connected with resistance R5 hot end, resistance R5 cold end ground connection; Second voltage input terminal IN2 is connected with resistance R5 hot end by resistance R4; One end of pulse voltage outlet terminal OUT1 is connected with resistance R5 hot end by resistance R8, and the other end of pulse voltage outlet terminal OUT1 is connected with high-pressure coaxial cable 4, and the bare wire capacitance of high-pressure coaxial cable 4 is 100PF, withstand voltage is 30KV; Resistance R6 is variable resistor.Metacoxal plate voltage outlet terminal OUT2 is connected with resistance R5 hot end by resistance R7, variable resistor R6; The tie point of resistance R7 and variable resistor R6 is by electric capacity C9 ground connection; The electronegative potential contact lug end HV-ground connection of high direct voltage high-speed switch 1, the parallel branch ground connection of control signal input terminal TRI by being made up of voltage-stabiliser tube D2 and resistance R1 of high direct voltage high-speed switch 1 ,+5V the supply terminals of high direct voltage high-speed switch 1 is connected with described control signal input terminal TRI by voltage-stabiliser tube D1.
Operation principle of the present utility model is summarized as follows:
First voltage input terminal IN1 inputs 0 ~+10KV direct voltage, and the second voltage input terminal IN2 inputs 0 ~ 30KV direct voltage; The voltage follow high direct voltage high-speed switch 1 that pulse voltage outlet terminal OUT1 exports closed and changing, the input voltage of the voltage that metacoxal plate voltage outlet terminal OUT2 exports and the second voltage input terminal IN2 is consistent.
First voltage input terminal IN1, the second voltage input terminal IN2 input direct-current 10KV and direct current 30KV voltage respectively, when the control signal input terminal TRI of high direct voltage high-speed switch 1 is low level, switch between the high potential contact lug end HV+ of high direct voltage high-speed switch 1 and electronegative potential contact lug end HV-is in off-state, the output voltage of pulse voltage outlet terminal OUT1 is equal with the output voltage of metacoxal plate voltage outlet terminal OUT2, is 30KV (i.e. V
oUT1=V
oUT2=V
iN2=30KV); Current potential V1=10KV now between resistance R3 and electric capacity C3, current potential V2=30KV between electric capacity C4 and resistance R8, electric capacity C3 and electric capacity C4 are charged, voltage difference V=V2-V1=20KV; Electric capacity C9 is charged, the voltage V at electric capacity C9 two ends
c9=30KV.
When the control signal input terminal TRI of high direct voltage high-speed switch 1 sports high level, switch between the high potential contact lug end HV+ of high direct voltage high-speed switch 1 and electronegative potential contact lug end HV-is closed formation short circuit, now current potential V1=0 between resistance R3 and electric capacity C3; Electric capacity C3, electric capacity C4 and resistance R5 form discharge circuit, and between electric capacity C4 and resistance R8, voltage is V2=20KV; Electric capacity C9 and resistance R5 and resistance R6 forms discharge circuit, the current potential V at electric capacity C9 two ends
c9=30KV; Switch-closed time between the high potential contact lug end HV+ of high direct voltage high-speed switch 1 and electronegative potential contact lug end HV-only has 10us, electric capacity C3, electric capacity C4 and electric capacity C9 select breakdown voltage value to be 30KV and the larger electric capacity of capacity, because discharge time is shorter, effectively ensure that the magnitude of voltage of pulse voltage outlet terminal OUT1 and metacoxal plate voltage outlet terminal OUT2, the magnitude of voltage of two outputs is respectively 20KV and 30KV.
When switch between the high potential contact lug end HV+ of high direct voltage high-speed switch 1 and electronegative potential contact lug end HV-closes, first voltage input terminal IN1, resistance R1, resistance R3 and ground form loop, generation current, at about 7mA, can not cause damage to circuit; It is about 70mA that second voltage input terminal IN2, resistance R4, resistance R5 form loop generation current with ground, also can not cause damage to circuit.
The pulse falling edge exported to realize pulse voltage outlet terminal OUT1 is 200ns, pulse voltage outlet terminal OUT1 is connected with the prebasal plate 2 of time-of-flight mass spectrometer by high-pressure coaxial cable 4, the bare wire capacitance of high-pressure coaxial cable 4 is 100PF, withstand voltage is 30KV, effectively ensure that the time delay of prebasal plate 2 voltage jump, meet ion and obtain the actual demand leaving standstill hundreds of nanosecond after laser energy overflows; Substantially increase sensitivity and the resolution of whole Matrix Assisted Laser Desorption ionization time of flight mass spectrometry.
The utility model is summarized as follows for course of work during time-of-flight mass spectrometer:
When the control signal input terminal TRI of high direct voltage high-speed switch 1 receives the high level instruction of host computer 5 transmission, the switch between the high potential contact lug end HV+ of high direct voltage high-speed switch 1 and electronegative potential contact lug end HV-is closed formation short circuit.
Host computer 5 sends a signal to laser 6, and laser 6 produces the sample 7 above the metacoxal plate 3 of laser impact time-of-flight mass spectrometer, makes sample 7 ionization.Electric field region 8 is entered after ion excitation, host computer 5 sends a signal to high-voltage control circuit, by the voltage on high-voltage control circuit change of flight time mass spectrum instrument prebasal plate 2, thus make ion obtain initial kinetic energy formation ion current, enter in vacuum cavity 9, because ion mass-to-charge ratio is different, therefore the time arriving detector 10 is also different, detector 10 generation current signal, be transferred to data collecting card 11 and carry out data processing, be uploaded to host computer 5 finally by converting interface 12 and carry out data analysis and display.
Claims (3)
1. one kind is suitable for the high-voltage pulse generator of time-of-flight mass spectrometer, it is characterized in that: comprise high direct voltage high-speed switch, the first voltage input terminal IN1, the second voltage input terminal IN2, pulse voltage outlet terminal OUT1, metacoxal plate voltage outlet terminal OUT2; Described first voltage input terminal IN1 is connected with the parallel branch hot end be made up of voltage-stabiliser tube D3 and resistance R3 through resistance R2, the described parallel branch cold end be made up of voltage-stabiliser tube D3 and resistance R3 is divided into two-way to export, one tunnel is connected with the high potential contact lug end HV+ of described high direct voltage high-speed switch, separately leading up to series capacitance C3, C4 is connected with resistance R5 hot end, described resistance R5 cold end ground connection; Described second voltage input terminal IN2 is connected with resistance R5 hot end by resistance R4; One end of described pulse voltage outlet terminal OUT1 is connected with resistance R5 hot end by resistance R8, and the other end of pulse voltage outlet terminal OUT1 is connected with high-pressure coaxial cable; Described metacoxal plate voltage outlet terminal OUT2 is connected with resistance R5 hot end by resistance R7, R6; The tie point of resistance R7 and resistance R6 is by electric capacity C9 ground connection; The electronegative potential contact lug end HV-ground connection of described high direct voltage high-speed switch, the parallel branch ground connection of control signal input terminal TRI by being made up of voltage-stabiliser tube D2 and resistance R1 of high direct voltage high-speed switch, the supply terminals of high direct voltage high-speed switch is connected with described control signal input terminal TRI by voltage-stabiliser tube D1.
2. be suitable for the high-voltage pulse generator of time-of-flight mass spectrometer according to claim 1, it is characterized in that: the bare wire capacitance of described high-pressure coaxial cable is 100PF, withstand voltage is 30KV; Described resistance R6 is variable resistor.
3. according to claim 1 or 2, be suitable for the high-voltage pulse generator of time-of-flight mass spectrometer, it is characterized in that: the parallel branch ground connection that the cold end of described resistance R2 forms via electric capacity C1, C2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520939722.3U CN205122533U (en) | 2015-11-24 | 2015-11-24 | Be suitable for high voltage pulse generator of mass spectrograph |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520939722.3U CN205122533U (en) | 2015-11-24 | 2015-11-24 | Be suitable for high voltage pulse generator of mass spectrograph |
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| CN205122533U true CN205122533U (en) | 2016-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520939722.3U Withdrawn - After Issue CN205122533U (en) | 2015-11-24 | 2015-11-24 | Be suitable for high voltage pulse generator of mass spectrograph |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105355533A (en) * | 2015-11-24 | 2016-02-24 | 安图实验仪器(郑州)有限公司 | High-voltage pulse generator suitable for mass spectrometer |
| CN115549652A (en) * | 2022-11-29 | 2022-12-30 | 浙江迪谱诊断技术有限公司 | Self-recovery high-voltage pulse driver |
| WO2023218601A1 (en) * | 2022-05-12 | 2023-11-16 | 株式会社島津製作所 | Method for processing coaxial cable |
-
2015
- 2015-11-24 CN CN201520939722.3U patent/CN205122533U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105355533A (en) * | 2015-11-24 | 2016-02-24 | 安图实验仪器(郑州)有限公司 | High-voltage pulse generator suitable for mass spectrometer |
| WO2023218601A1 (en) * | 2022-05-12 | 2023-11-16 | 株式会社島津製作所 | Method for processing coaxial cable |
| CN115549652A (en) * | 2022-11-29 | 2022-12-30 | 浙江迪谱诊断技术有限公司 | Self-recovery high-voltage pulse driver |
| WO2024114096A1 (en) * | 2022-11-29 | 2024-06-06 | 浙江迪谱诊断技术有限公司 | Self-recovery high-voltage pulse driver |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160330 Effective date of abandoning: 20170531 |