CN204964396U - Quick detection device of portable biochemistry based on quantum dot fluorescent label - Google Patents
Quick detection device of portable biochemistry based on quantum dot fluorescent label Download PDFInfo
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- CN204964396U CN204964396U CN201520677797.9U CN201520677797U CN204964396U CN 204964396 U CN204964396 U CN 204964396U CN 201520677797 U CN201520677797 U CN 201520677797U CN 204964396 U CN204964396 U CN 204964396U
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Abstract
The utility model discloses a quick detection device of portable biochemistry based on quantum dot fluorescent label. Including fluorescence detection module, optic fibre control module, autoinjection module, rotation detection bench formwork piece and motor control module, fluorescence detection module, optic fibre control module, autoinjection module, rotatory detection bench formwork piece and motor control module constitute a detection device, and as whole detection device's hardware part, motor control module links to each other with optic fibre control module, autoinjection module and rotatory detection bench formwork piece respectively, and the fluorescence detection module is connected with optic fibre control module. The utility model discloses process to the biochemical sample of fluorescent label method quantitative determination has realized automaticly and the high flux, and measurement accuracy is high, detects fastly, and required sample is few, the less portable of volume.
Description
Technical field
The utility model relates to biological sample detecting instrument field, especially relate to a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling, Quantum Dot Labeling analytical approach is controlled to form a set of automatic detection device system in conjunction with mechano-electronic.
Background technology
Fluorescence is a kind of phenomenon of photoluminescence.When light source irradiation Cucumber, namely during so-called fluorescein, fluorescein can send the light that is excited of different wave length; After removing light source, what fluorescein sent be excited, and light also can disappear.With fluorescein by certain means mark determinand, the linear relationship between the fluorescence intensity of then launching with fluorescein and testing concentration, for foundation, is exactly the Cleaning Principle of so-called fluorescence spectrum analysing method.
Although fluorescence spectrum analysing method compared to additive method have highly sensitive, specificity good and detect the advantages such as quick, but the character of fluorescein itself can cause larger impact to testing result, fluorescence lifetime is shorter or close with bias light wavelength, all can have a negative impact to last testing result.
Quantum dot, as a kind of emerging fluorescence labeling material, compared to traditional material, has many advantages.Such as it has very wide excitation spectrum and narrower emission spectrum, same excitation source therefore can be used simultaneously to excite multiple quantum dot, launch the fluorescence of different wave length separately, then detect simultaneously.Quantum dot has larger Stokes shift simultaneously, can obviously avoid the spectrum peak between exciting light with utilizing emitted light overlapping.In addition, quantum dot has long fluorescence lifetime, and has reasonable biocompatibility.
Such as in the quick detection of polynary food-borne bacterium, utilize quantum dot as label, adopt the method for fluoroimmunoassay to obtain reasonable laboratory result.The quantum dot that such as Yang and Li (2006) utilizes two kinds of emission wavelength to be respectively 525nm and 705nm marks Escherichia coli respectively and antibodies toward salmonella detects, Wang etc. (2011) are 530nm with wavelength of transmitted light, 580nm, three kinds of quantum dots of 620nm are as fluorescent marker, salmonella typhimurium, colon bacillus 0157: H7 and Listeria monocytogenes are detected simultaneously, have reasonable Detection results.
Utility model content
The purpose of this utility model, is for the deficiencies in the prior art, and providing a kind of is label with quantum dot, based on fluorescence analysis method, realizes the apparatus system one or more biochemical biased samples being carried out to detection fast of robotization.
For achieving the above object, the technical solution adopted in the utility model mainly comprises:
The utility model comprises fluoroscopic examination module, optical fiber control module, auto injection module, rotates monitor station module and motor control module, fluoroscopic examination module, optical fiber control module, auto injection module, rotation monitor station module and motor control module composition monitor station device, motor control module respectively with optical fiber control module, auto injection module with rotate monitor station module and be connected, fluoroscopic examination module is connected with optical fiber control module.
Described rotation monitor station module comprises disposable syringe shaft collar, cylindrical connection, disposable test tube fixing dish, rotation monitor station register pin, the second optoelectronic switch, the second optoelectronic switch holder, rotary actuation block, thrust ball bearing, thrust ball bearing ball retainer set collar and rotates monitor station drive motor; Rotate monitor station drive motor and be fixedly mounted on bottom surface in the middle part of monitor station base, the through hole that the output shaft rotating monitor station drive motor is upward through monitor station base is coaxially fixedly connected with the rotary actuation block being square body, rotary actuation block is sleeved in the square hole of disposable test tube fixing dish bottom center, be connected with thrust ball bearing between disposable test tube fixing dish and monitor station base top surface, thrust ball bearing outside is radial spacing fixing by thrust ball bearing ball retainer set collar; Many disposable test tubes are circumferentially vertically equipped with uniformly at intervals in disposable test tube fixing dish top, disposable test tube fixing dish top center is coaxially fixedly connected with disposable syringe shaft collar through cylindrical connection, disposable syringe shaft collar is circumferentially vertically equipped with disposable syringe corresponding to test tube disposable with each uniformly at intervals, and disposable syringe syringe needle is inserted in disposable test tube downwards; Second optoelectronic switch is positioned at disposable test tube fixing dish one side, second optoelectronic switch is installed on monitor station base by the second optoelectronic switch holder, rotation monitor station register pin is radially fixedly mounted on the side face bottom disposable test tube fixing dish, rotate monitor station register pin to coordinate with the second optoelectronic switch, optical fiber control module and auto injection module are arranged on the monitor station base of side around disposable test tube fixing dish.
Described auto injection module comprises line slideway, lifting slider, disposable syringe compression pushing plate, lifting slider orientation triggering plate, the 3rd optoelectronic switch, the 3rd optoelectronic switch shaft collar, the 4th optoelectronic switch, the 4th optoelectronic switch shaft collar, auto injection module drive motor and screw mandrel; Auto injection module drive motor is fixedly mounted on monitor station base end face, the through hole that the output shaft of auto injection module drive motor is upward through monitor station base is coaxially fixedly connected with screw mandrel, screw mandrel side is vertically parallel is provided with line slideway, screw mandrel overlaps have in lifting slider embedding line slideway and move up and down, lifting slider side is fixedly connected with lifting slider orientation triggering plate and disposable syringe compresses pushing plate; 3rd optoelectronic switch, the 4th optoelectronic switch are fixedly mounted in monitor station frame respectively by the 3rd optoelectronic switch shaft collar, the 4th optoelectronic switch shaft collar, and being positioned at the same side of lifting slider orientation triggering plate, lifting slider orientation triggering plate coordinates with the 3rd optoelectronic switch and the 4th optoelectronic switch; Disposable syringe compression pushing plate top is provided with extension rod towards rotation monitor station module, and be the station at disposable syringe place immediately below extension rod, extension rod is for extruding disposable syringe.
Described optical fiber control module comprises the first optoelectronic switch, first optoelectronic switch holder, fiber laser arrays head mount pad, optical fiber, fiber laser arrays head mount pad bolt and fiber laser arrays head drive motor, fiber laser arrays head drive motor is fixedly mounted on monitor station base end face, the through hole that the output shaft of fiber laser arrays head drive motor is upward through monitor station base is coaxially fixedly connected with fiber laser arrays head mount pad, fiber laser arrays head mount pad top is horizontally installed with optical fiber by fiber laser arrays head mount pad, fiber laser arrays head mount pad lower horizontal is provided with the fiber laser arrays head mount pad bolt parallel with optical fiber, first optoelectronic switch is arranged on fiber laser arrays head mount pad side by the first optoelectronic switch holder, fiber laser arrays head mount pad bolt coordinates with the first optoelectronic switch.
When described fiber laser arrays head mount pad bolt by fiber laser arrays head drive motor driven rotary to the detection mouth at the first optoelectronic switch place time, optical fiber align rotates the disposable test tube in monitor station module.
Described fluoroscopic examination module comprises fluorescence excitation light source, fluorescence detector, the Fiber connection of fluorescence excitation light source and fluorescence detector and optical fiber control module.
The optical fiber of described optical fiber control module is y-type optical fiber, and the two ends of fiber break connect fluorescence excitation light source and fluorescence detector respectively, and one end of set is aimed at bottom the disposable test tube that rotates and monitor station module holds liquid to be measured.
Described motor control module comprises electric machine controller and three motor drivers, electric machine controller is connected with three motor drivers, and three motor drivers are connected with the utility model optical fiber control module, auto injection module and three motors rotated in monitor station module respectively.
The beneficial effect that the utility model has is:
1, the utility model achieves the robotization of Quantum Dot Labeling method testing process.Simple and convenient, decrease error and cross-infection that manual operation may bring.
2, the syringe that uses of the utility model and test tube are disposable, to avoid in biochemistry detection because cleaning thoroughly comparatively difficulty and easily leave residual problem, improve the accuracy of detection.
3, the utility model rotates monitor station module and can realize multiple sample and jointly detect, and improves detection efficiency.
4, the utility model quantum dot that emission spectrum is narrower so that excitation spectrum is very wide is as fluorescence analysis label, makes only just can excite multiple quantum dot with a kind of light source, simplifies the optical texture of system; On the other hand, because the narrower emission spectrum of quantum dot, the utility model also can detect compound sample, has widened the scope of application of the present utility model.
5, the utility model structure is simple, and small volume, has good portable performance.
6, the Quantum Dot Labeling method method of the utility model employing is comparatively simple, and detects consuming time shorter, and precision is higher.
Accompanying drawing explanation
Fig. 1 is summary frame construction drawing of the present utility model.
Fig. 2 is the schematic diagram of physical construction module of the present utility model.
Fig. 3 is the structural drawing that the utility model rotates monitor station module.
Fig. 4 is the structural drawing of the utility model auto injection module.
Fig. 5 is the structural drawing of the utility model optical fiber control module.
Fig. 6 is the structural drawing of the utility model fluoroscopic examination module.
Fig. 7 is the anatomical connectivity schematic diagram of the utility model motor control module.
In figure: monitor station base 1, first optoelectronic switch holder 2, first optoelectronic switch 3, fiber laser arrays head mount pad 4, optical fiber 5, disposable test tube fixing dish 6, cylindrical connection 7, disposable syringe shaft collar 8, line slideway 9, lifting slider 10, disposable syringe compression pushing plate 11, lifting slider orientation triggering plate 12, 3rd optoelectronic switch 13, 3rd optoelectronic switch fixed block 14, 4th optoelectronic switch fixed block 15, 4th optoelectronic switch 16, disposable syringe 17, disposable test tube 18, rotate monitor station register pin 19, second optoelectronic switch 20, second optoelectronic switch holder 21, rotary actuation block 22, thrust ball bearing 23, thrust ball bearing ball retainer set collar 24, rotate monitor station drive motor 25, fiber laser arrays head mount pad bolt 26, fiber laser arrays head mount pad drive motor 27, auto injection module drive motor 28, screw mandrel 29.
Embodiment
Below in conjunction with Figure of description, the utility model is described further, but the utility model is not limited to following examples.
As shown in Figure 1, the utility model comprises fluoroscopic examination module, optical fiber control module, auto injection module, rotates monitor station module and motor control module, fluoroscopic examination module, optical fiber control module, auto injection module, rotation monitor station module and motor control module composition monitor station device, as shown in Figure 2, as the hardware components of whole pick-up unit, motor control module respectively with optical fiber control module, auto injection module with rotate monitor station module and be connected, fluoroscopic examination module is connected with optical fiber control module.
As shown in Figures 2 and 3, rotate monitor station module and comprise disposable syringe shaft collar 8, cylindrical connection 7, disposable test tube fixing dish 6, rotate monitor station register pin 19, second optoelectronic switch 20, second optoelectronic switch holder 21, rotary actuation block 22, thrust ball bearing 23, thrust ball bearing ball retainer set collar 24 and rotation monitor station drive motor 25, rotate monitor station drive motor 25 and be fixedly mounted on bottom surface in the middle part of monitor station base 1, the through hole that the output shaft rotating monitor station drive motor 25 is upward through monitor station base 1 is coaxially fixedly connected with the rotary actuation block 22 being square body, rotary actuation block 22 is sleeved in the square hole of disposable test tube fixing dish 6 bottom center, rotate monitor station main part when rotation monitor station drive motor 25 is rotated also can rotate thereupon.Be connected with thrust ball bearing 23 between disposable test tube fixing dish 6 and monitor station base 1 end face, thrust ball bearing 23 outside is radial spacing fixing by thrust ball bearing ball retainer set collar 24, many disposable test tubes 18 are circumferentially vertically equipped with at disposable test tube fixing dish 6 top uniformly at intervals, disposable test tube fixing dish 6 top center is coaxially fixedly connected with disposable syringe shaft collar 8 through cylindrical connection 7, between disposable test tube fixing dish 6 and cylindrical connection 7, all be bolted to connection between cylindrical connection 7 and disposable syringe shaft collar 8, disposable syringe shaft collar 8 is circumferentially vertically equipped with disposable syringe 17 corresponding to test tube 18 disposable with each uniformly at intervals, disposable syringe 17 syringe needle is inserted in disposable test tube 18 downwards, second optoelectronic switch 20 is positioned at disposable test tube fixing dish 6 one side, second optoelectronic switch 20 is installed on monitor station base 1 by the second optoelectronic switch holder 21, rotation monitor station register pin 19 is radially fixedly mounted on the side face bottom disposable test tube fixing dish 6, rotates monitor station register pin 19 and coordinates with the second optoelectronic switch 20, optical fiber control module and auto injection module are arranged on the monitor station base 1 of disposable test tube fixing dish 6 surrounding side.
When detecting, the uniform test tube mounting hole that disposable test tube 18 inserts disposable test tube fixing dish 6 positions, the uniform syringe mounting hole that disposable syringe 17 inserts disposable syringe shaft collar 8 positions, described test tube mounting hole is equal with syringe mounting hole quantity and coaxial, guarantee that disposable syringe 17 inserts disposable syringe shaft collar 8 its pin mouth rear and inserts disposable test tube 18, ensure that the reagent in disposable syringe is all expelled to disposable test tube 18.Disposable test tube fixing dish 6 and disposable syringe shaft collar 8 have the mounting hole specification of different number, select different size according to actual testing requirement.When rotating monitor station and rotating control end rotation, rotate monitor station integral part and rotate together.Rotate monitor station register pin 19 and start the front initialization location rotating monitor station for detecting.When rotate monitor station register pin 19 trigger in rotary course the second optoelectronic switch 20 respond time, then signal feedback to motor control module controls rotation monitor station drive motor 25 is stopped, namely test initialization completes and rotates monitor station and arrive initial position, and now optical fiber head axis is crossing with test tube axis thus it is nearest.In testing process, rotate monitor station drive motor 25 and rotarily drive each time and rotate monitor station and rotate 360/N ° (wherein N is the number in current uniform hole), namely make when keeping optical fiber 5 motionless optical fiber 5 just right treat that test sample is changed successively.The rotation monitor station main part rotated in monitor station module can be separated with rotation control end.Rotate 42 two-phase stepping motors that monitor station drive motor 25 can adopt Lei Sai scientific & technical corporation, but be not limited thereto.
As shown in Figure 2 and Figure 4, auto injection module comprises line slideway 9, lifting slider 10, disposable syringe compression pushing plate 11, lifting slider orientation triggering plate the 12, the 3rd optoelectronic switch 13, the 3rd optoelectronic switch shaft collar 14, the 4th optoelectronic switch 16, the 4th optoelectronic switch shaft collar 15, auto injection module drive motor 28 and screw mandrel 29; Auto injection module drive motor 28 is fixedly mounted on monitor station base 1 bottom surface, the through hole that the output shaft of auto injection module drive motor 28 is upward through monitor station base 1 is coaxially fixedly connected with screw mandrel 29, screw mandrel 29 side is vertically parallel is provided with line slideway 9, on screw mandrel 29, cover has lifting slider 10 to embed in line slideway 9 to move up and down, and lifting slider 10 side is fixedly connected with lifting slider orientation triggering plate 12 and compresses pushing plate 11 with disposable syringe; 3rd optoelectronic switch 13, the 4th optoelectronic switch 16 are fixedly mounted in monitor station frame respectively by the 3rd optoelectronic switch shaft collar 14, the 4th optoelectronic switch shaft collar 15, and being positioned at the same side of lifting slider orientation triggering plate 12, lifting slider orientation triggering plate 12 coordinates with the 3rd optoelectronic switch 13 and the 4th optoelectronic switch 16; Disposable syringe compression pushing plate 11 top is provided with extension rod towards rotation monitor station module, and be the station at disposable syringe 17 place immediately below extension rod, extension rod is for extruding disposable syringe 17.
When under the driving of auto injection module drive motor 28 at motor control module during action, drive rail plate to rotate by shaft coupling, and then drive disposable syringe compression pushing plate 11 to move at vertical direction together with lifting slider orientation triggering plate 12.When disposable syringe compression pushing plate 11 touches disposable syringe 17 top inserted in disposable syringe mounting disc 8 in decline process, the piston of disposable syringe 17 can be promoted, in the disposable test tube 18 immediately below being expelled to by the liquid to be measured in disposable syringe 17 under the drive of motor.And lifting slider orientation triggering plate 12 is in lifting process, the position of vertical direction remains between the 3rd optoelectronic switch 13 and the 4th optoelectronic switch 16.When lifting slider orientation triggering plate 12 move downward triggering the 4th optoelectronic switch 16 respond time, motor control module receives feedback signal and then controls auto injection module drive motor 28 and stop operating, namely lifting slider 10 stops moving downward, and disposable syringe compression pushing plate 11 stops pressing action; When lifting slider orientation triggering plate 12 moves upward triggering the 3rd optoelectronic switch 13, same motor control module receives feedback signal control auto injection module drive motor 28 and stops operating, and lifting slider 10 stops moving upward.Concrete auto injection module drive motor 28 can adopt 42 two-phase stepping motors of Lei Sai scientific & technical corporation, but is not limited thereto.
As shown in Figure 2 and Figure 5, optical fiber control module comprises the first optoelectronic switch 3, first optoelectronic switch holder 2, fiber laser arrays head mount pad 4, optical fiber 5, fiber laser arrays head mount pad bolt 26 and fiber laser arrays head drive motor 27, fiber laser arrays head drive motor 27 is fixedly mounted on monitor station base 1 bottom surface, the through hole that the output shaft of fiber laser arrays head drive motor 27 is upward through monitor station base 1 is coaxially fixedly connected with fiber laser arrays head mount pad 4, fiber laser arrays head mount pad 4 top is horizontally installed with optical fiber 5 by fiber laser arrays head mount pad 4, fiber laser arrays head mount pad 4 lower horizontal is provided with the fiber laser arrays head mount pad bolt 26 parallel with optical fiber 5, first optoelectronic switch 3 is arranged on fiber laser arrays head mount pad 4 side by the first optoelectronic switch holder 2, fiber laser arrays head mount pad bolt 26 coordinates with the first optoelectronic switch 3.
When fiber laser arrays head drive motor 27 rotates, drive fiber laser arrays head mount pad 4, and then drive optical fiber 5 to rotate, to aim at the disposable test tube 18 filling liquid to be measured.In addition, when fiber laser arrays head drive motor 27 rotates, fiber laser arrays head mount pad bolt 26 also rotates thereupon together.When fiber laser arrays head mount pad bolt 26 triggers the response of the first optoelectronic switch 3 in rotation, electric machine controller can receive Real-time Feedback, control fiber laser arrays head drive motor 27 to stop operating, realize accordingly the location of fiber laser arrays head mount pad 4 in rotary course and initialization.Fiber laser arrays head drive motor 27 in concrete enforcement can adopt 42 two-phase stepping motors of Lei Sai scientific & technical corporation, but is not limited thereto.
As shown in Figure 6, fluoroscopic examination module comprises fluorescence excitation light source, fluorescence detector, fluorescence excitation light source is connected with the optical fiber 5 of optical fiber control module with fluorescence detector, and the optical fiber 5 of optical fiber control module is y-type optical fiber, and the two ends of optical fiber 5 bifurcated connect fluorescence excitation light source and fluorescence detector respectively; When fiber laser arrays head mount pad bolt 26 by fiber laser arrays head drive motor 27 driven rotary to the detection mouth at the first optoelectronic switch 3 place time, one end that optical fiber 5 is gathered is aimed at bottom the disposable test tube 18 that rotates and monitor station module holds liquid to be measured.The light that fluorescence excitation light source is launched is transmitted by optical fiber 5, excites the quantum dot in the liquid to be measured be contained in disposable test tube 18 to produce fluorescence.Fluorescence to fluorescence detector, obtains fluorescence spectrum by Optical Fiber Transmission.Described fluorescence detector can adopt PMT, spectrometer or CCD, but is not limited thereto.
As shown in Figure 7, motor control module comprises electric machine controller and three motor drivers, electric machine controller is connected with three motor drivers, three motor drivers are connected with the utility model optical fiber control module, auto injection module and three motors rotated in monitor station module respectively, and electric machine controller exports pwm pulse to motor driver and then the motion state controlling motor.
Electric machine controller can adopt the Atmega16A single-chip microcomputer of Atmel company, and described motor driver can adopt the digital stepper motors driver DM422C of Lei Sai scientific & technical corporation, but is all not limited thereto.
Disposable test tube fixing dish 6 is identical with the quantity of disposable syringe shaft collar 8, and detecting according to reality needs to adopt different quantity specifications.
Concrete implementation process of the present utility model is as follows:
1) liquid to be measured prepares: conveniently detection method, configures liquid to be measured.
1. determinand solution is configured;
2. biochemical modification is carried out to quantum dot used, make it can there be good specific binding effect with determinand;
3. get appropriate liquid to be measured according to testing requirement to mix with the quantum dot solution modified and to make it reaction bonded, until form stable quantum dot-trim-determinand shape as the final solution of " sandwich " type;
2) according to detection demand, disposable test tube fixing dish 6 and the disposable syringe shaft collar 8 of suitable installation hole count is selected; Open monitor station, take out and rotate monitor station, require to extract liquid to be measured with some disposable syringes 17 according to current detection, then disposable syringe shaft collar 8 is inserted respectively with the disposable test tube 18 of equal number and disposable test tube fixing dish 6 is fixed, then rotation monitor station is put back to original position, determine not have crooked after, occlusion detection platform again.Open the power supply of hardware components, make the parts such as fluorescence excitation light source enter duty;
3) system initialization: after initialization, the lifting slider orientation triggering plate 12 of auto injection module is positioned at and just in time triggers the 3rd optoelectronic switch 13 position, the fiber laser arrays head drive motor 27 of optical fiber control module rotates until fiber laser arrays head mount pad bolt 26 triggers the first optoelectronic switch 3 responds, and the rotation monitor station register pin 19 rotating monitor station module rotates and responds to triggering the second optoelectronic switch 20;
4) spectral detection: to current be in detect position treat that test sample carries out spectral detection, open excitation source and irradiate this solution, excitation quantum point produces fluorescence, receives the fluorescence spectrum produced, and obtains spectroscopic data and also carries out data processing and preservation;
5) wheel goes to next sample: after a liquid to be measured has detected, rotates monitor station module and rotates to an angle under the drive of rotation control end, optical fiber 5 is aimed at and treats test sample in next disposable test tube 18.Repeat step 4 ~ 5, until one takes turns all liquid to be measured and detected;
6) check data, rehabilitation, measure and terminate: motor control module controls auto injection module and rotate monitor station module to arrive halted state position.Then open monitor station, take out and rotate monitor station, discard used disposable syringe 17 and disposable test tube 18.Inspection does not have liquid contamination to rotate after monitor station, puts back to original position, determine not have crooked after, occlusion detection platform again.Powered-down.
Disregard liquid to be measured setup time, the detection time of single sample, comprise the entire protocol such as spectra collection, data processing, the detection control of single station sample is within 1 minute.Whole one takes turns detection, for nine holes, can be controlled in implementation process T.T. within 10 minutes, has both achieved high flux and detected fast, also eliminates the loaded down with trivial details manual data process of later stage in the past.
Above-mentioned embodiment is used to explain and the utility model is described; instead of the utility model is limited; in the protection domain of spirit of the present utility model and claim, any amendment make the utility model and correcting, all fall into protection domain of the present utility model.
Claims (8)
1. the portable biochemical device for fast detecting based on Quantum Dot Labeling, it is characterized in that: comprise fluoroscopic examination module, optical fiber control module, auto injection module, rotate monitor station module and motor control module, fluoroscopic examination module, optical fiber control module, auto injection module, rotation monitor station module and motor control module composition monitor station device, motor control module is respectively with optical fiber control module, auto injection module with rotate monitor station module and be connected, and fluoroscopic examination module is connected with optical fiber control module.
2. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 1, it is characterized in that: described rotation monitor station module comprises disposable syringe shaft collar (8), cylindrical connection (7), disposable test tube fixing dish (6), rotate monitor station register pin (19), second optoelectronic switch (20), second optoelectronic switch holder (21), rotary actuation block (22), thrust ball bearing (23), thrust ball bearing ball retainer set collar (24) and rotation monitor station drive motor (25),
Rotate monitor station drive motor (25) and be fixedly mounted on bottom surface, monitor station base (1) middle part, the through hole that the output shaft rotating monitor station drive motor (25) is upward through monitor station base (1) is coaxially fixedly connected with the rotary actuation block (22) being square body, rotary actuation block (22) is sleeved in the square hole of disposable test tube fixing dish (6) bottom center, thrust ball bearing (23) is connected with between disposable test tube fixing dish (6) and monitor station base (1) end face, thrust ball bearing (23) outside is radial spacing fixing by thrust ball bearing ball retainer set collar (24), many disposable test tubes (18) are circumferentially vertically equipped with at disposable test tube fixing dish (6) top uniformly at intervals, disposable test tube fixing dish (6) top center is coaxially fixedly connected with disposable syringe shaft collar (8) through cylindrical connection (7), disposable syringe shaft collar (8) is circumferentially vertically equipped with uniformly at intervals disposable syringe (17) corresponding to test tube (18) disposable with each, disposable syringe (17) syringe needle is inserted in disposable test tube (18) downwards,
Second optoelectronic switch (20) is positioned at disposable test tube fixing dish (6) side, second optoelectronic switch (20) is installed on monitor station base (1) by the second optoelectronic switch holder (21), rotate the side face that monitor station register pin (19) is radially fixedly mounted on disposable test tube fixing dish (6) bottom, rotate monitor station register pin (19) to coordinate with the second optoelectronic switch (20), optical fiber control module and auto injection module are arranged on the monitor station base (1) of side around disposable test tube fixing dish (6).
3. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 1, is characterized in that: described auto injection module comprises line slideway (9), lifting slider (10), disposable syringe compression pushing plate (11), lifting slider orientation triggering plate (12), the 3rd optoelectronic switch (13), the 3rd optoelectronic switch shaft collar (14), the 4th optoelectronic switch (16), the 4th optoelectronic switch shaft collar (15), auto injection module drive motor (28) and screw mandrel (29), auto injection module drive motor (28) is fixedly mounted on monitor station base (1) bottom surface, the through hole that the output shaft of auto injection module drive motor (28) is upward through monitor station base (1) is coaxially fixedly connected with screw mandrel (29), screw mandrel (29) side is vertically parallel is provided with line slideway (9), the upper cover of screw mandrel (29) has lifting slider (10) to embed in line slideway (9) to move up and down, lifting slider (10) side is fixedly connected with lifting slider orientation triggering plate (12) and compresses pushing plate (11) with disposable syringe, 3rd optoelectronic switch (13), the 4th optoelectronic switch (16) are fixedly mounted in monitor station frame respectively by the 3rd optoelectronic switch shaft collar (14), the 4th optoelectronic switch shaft collar (15), and being positioned at lifting slider orientation triggering plate (12) same side, lifting slider orientation triggering plate (12) coordinates with the 3rd optoelectronic switch (13) and the 4th optoelectronic switch (16), disposable syringe compression pushing plate (11) top is provided with extension rod towards rotation monitor station module, and be the station at disposable syringe (17) place immediately below extension rod, extension rod is for extruding disposable syringe (17).
4. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 1, it is characterized in that: described optical fiber control module comprises the first optoelectronic switch (3), first optoelectronic switch holder (2), fiber laser arrays head mount pad (4), optical fiber (5), fiber laser arrays head mount pad bolt (26) and fiber laser arrays head drive motor (27), fiber laser arrays head drive motor (27) is fixedly mounted on monitor station base (1) bottom surface, the through hole that the output shaft of fiber laser arrays head drive motor (27) is upward through monitor station base (1) is coaxially fixedly connected with fiber laser arrays head mount pad (4), fiber laser arrays head mount pad (4) top is horizontally installed with optical fiber (5) by fiber laser arrays head mount pad (4), fiber laser arrays head mount pad (4) lower horizontal is provided with fiber laser arrays head mount pad bolt (26) parallel with optical fiber (5), first optoelectronic switch (3) is arranged on fiber laser arrays head mount pad (4) side by the first optoelectronic switch holder (2), fiber laser arrays head mount pad bolt (26) coordinates with the first optoelectronic switch (3).
5. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 4, it is characterized in that: when described fiber laser arrays head mount pad bolt (26) by fiber laser arrays head drive motor (27) driven rotary to the detection mouth at the first optoelectronic switch (3) place time, the disposable test tube (18) rotated in monitor station module aimed at by optical fiber (5).
6. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 1, it is characterized in that: described fluoroscopic examination module comprises fluorescence excitation light source, fluorescence detector, fluorescence excitation light source is connected with the optical fiber (5) of optical fiber control module with fluorescence detector.
7. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 6, it is characterized in that: the optical fiber (5) of described optical fiber control module is y-type optical fiber, the two ends of optical fiber (5) bifurcated connect fluorescence excitation light source and fluorescence detector respectively, and disposable test tube (18) bottom rotating and monitor station module holds liquid to be measured is aimed in one end of set.
8. a kind of portable biochemical device for fast detecting based on Quantum Dot Labeling according to claim 1, it is characterized in that: described motor control module comprises electric machine controller and three motor drivers, electric machine controller is connected with three motor drivers, and three motor drivers are connected with optical fiber control module, auto injection module and three motors rotated in monitor station module respectively.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520677797.9U CN204964396U (en) | 2015-09-01 | 2015-09-01 | Quick detection device of portable biochemistry based on quantum dot fluorescent label |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520677797.9U CN204964396U (en) | 2015-09-01 | 2015-09-01 | Quick detection device of portable biochemistry based on quantum dot fluorescent label |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106802290A (en) * | 2016-11-29 | 2017-06-06 | 武汉市宇驰检测技术有限公司 | A kind of fluorescence spectrophotometry that E. CoIi content is detected based on carbon quantum dot |
-
2015
- 2015-09-01 CN CN201520677797.9U patent/CN204964396U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106802290A (en) * | 2016-11-29 | 2017-06-06 | 武汉市宇驰检测技术有限公司 | A kind of fluorescence spectrophotometry that E. CoIi content is detected based on carbon quantum dot |
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