CN204951010U - Cell collector - Google Patents
Cell collector Download PDFInfo
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- CN204951010U CN204951010U CN201520589537.6U CN201520589537U CN204951010U CN 204951010 U CN204951010 U CN 204951010U CN 201520589537 U CN201520589537 U CN 201520589537U CN 204951010 U CN204951010 U CN 204951010U
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- calparine cap
- cellular collector
- collection portion
- collector according
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Abstract
The utility model provides a cell collector, its including handheld portion with link firmly in circular or polygonal acicular collection portion is personally submitted to handheld portion one end transversal, collection portion includes the base member, and covers and locate the antibody layer that is used for the acquisition target cell of base member periphery side. Cell collector can overcome the not enough of the current cell mode of gathering based on the blood sampling.
Description
Technical field
This utility model relates to medical diagnostic techniqu field, particularly a kind of cellular collector.
Background technology
In medical diagnosis on disease or treatment, in order to accurately judge the cause of disease and carry out pathology cultivation etc., often need to gather the cell in blood of human body, to carry out corresponding check processing.Be directed to cell collection mode mostly at present to be to carry out blood sampling in human body, then by gathering cell in blood sample and for check processing.Above-mentioned cell collection mode is few due to blood sample amount, is generally 5-15 milliliter, and thus its sensitivity and selectivity are all lower, and easily loses activity because of the cell in blood sample, also causes gathered cell reliability lower.
Utility model content
In view of this, this utility model is intended to propose a kind of cellular collector, can overcome the deficiency of the existing cell collection mode based on blood sampling.
For achieving the above object, the technical solution of the utility model is achieved in that
A kind of cellular collector, it comprises Handheld Division and is fixed on the circular in cross-section of one end, described Handheld Division or the collection portion of polygonal needle-like, and described collection portion comprises matrix, and covers the antibody layer for target acquisition cell in described matrix outer circumferential side.
Further, the cylindrical needle-like in described collection portion.
Further, be covered with metal coating at the outer circumferential side of described matrix, described antibody layer is positioned on metal coating.
Further, be covered with biocompatible polymer layer at the outer circumferential side of described matrix, described antibody layer is positioned on biocompatible polymer layer.
Further, be covered with metal coating and biocompatible polymer layer successively at the outer circumferential side of described matrix, described antibody layer is positioned on biocompatible polymer layer.
Further, described matrix is rustless steel, and described metal coating is Gold plated Layer, and described biocompatible polymer layer is hydrogel layer.
Further, described Handheld Division is provided with at least one gear mark.
Further, also comprise the calparine cap being movably set in and described Handheld Division being close to side, collection portion, described calparine cap comprises calparine cap body, be installed in the plug of described calparine cap body one end, and be formed at that described calparine cap is intrinsic to connect with plug and the container cavity of other end opening in calparine cap body; Described Handheld Division is inserted on plug, and makes described collection portion be placed in described container cavity.
Further, described calparine cap is connected with the protective cap that the opening of described container cavity is closed.
Further, described protective cap is formed with the one end open in protective cap, and the protection chamber be connected when described protective cap is connected on calparine cap, with described container cavity.
Relative to prior art, this utility model has following advantage:
(1) cellular collector described in the utility model, by the design of collection portion and Handheld Division, and be provided with for gathering cell antibody layer in collection portion, thus when cell collection need be carried out in blood, can clamp Handheld Division via remaining needle, and collection portion is placed in the blood vessel of human body, carry out cell collection in the blood vessel to make collection portion.Because blood continues to flow through collection portion in the blood vessel, compared to existing blood sampling form, its cell quantity that can touch greatly increases, and cytoactive also can not lose, and thus greatly can improve the reliability of cell collection.
(2) matrix is rustless steel, and metal coating is Gold plated Layer, and biocompatible polymer layer is that hydrogel layer can make antibody layer be arranged at place of collection portion, and keeps the stability of antibody layer character.
(3) arrange when gear mark contributes to cell collection and control the inlet of collection portion in blood vessel.
(4) calparine cap is set, and container cavity is set on calparine cap can be convenient to protect collection portion in storage.
(5) protective cap being provided with protection chamber can coordinate the stable protection realized collection portion with calparine cap.
Accompanying drawing explanation
The accompanying drawing forming a part of the present utility model is used to provide further understanding of the present utility model, and schematic description and description of the present utility model, for explaining this utility model, is not formed improper restriction of the present utility model.In the accompanying drawings:
Fig. 1 is the structure diagram of the cellular collector described in this utility model embodiment;
Fig. 2 is the partial enlarged drawing of part A in Fig. 1;
Fig. 3 is the structure diagram of the calparine cap described in this utility model embodiment;
Fig. 4 is the sectional view in B-B face in Fig. 3;
The matching chart that Fig. 5 is the cellular collector described in this utility model embodiment and calparine cap;
Fig. 6 is the structure diagram of the protective cap described in this utility model embodiment;
Fig. 7 is the sectional view in C-C face in Fig. 6;
Fig. 8 is the matching chart of cellular collector, calparine cap and the protective cap described in this utility model embodiment;
Description of reference numerals:
1-collection portion, 2-Handheld Division, 3-gear identifies, 5-calparine cap; 6-protective cap, 11-matrix, 12-metal coating, 13-biocompatible polymer layer; 14-antibody layer, 51-calparine cap body, 52-plug, 53-cylinder; 54-container cavity, 55-shrinkage pool, the 56-conical surface, 57-female thread; 58-annular concave platform, 61-protective cap body, 62-protects chamber; 63-annular groove, 64-external screw thread, 65-adds female thread.
Detailed description of the invention
It should be noted that, when not conflicting, the embodiment in this utility model and the feature in embodiment can combine mutually.
Below with reference to the accompanying drawings and describe this utility model in detail in conjunction with the embodiments.
The present embodiment relates to a kind of cellular collector, shown in Fig. 1 composition graphs 2, and it collection portion 1 in needle-like comprising Handheld Division 2 and be fixed on one end, Handheld Division 2.Collection portion 2 comprises matrix 11, and covers in the metal coating 12 of matrix 11 outer circumferential side, biocompatible polymer layer 12 and the antibody layer 14 for target acquisition cell.Certainly, except making antibody layer 14 be placed on matrix 11 via metal coating 12 and biocompatible polymer layer 12, antibody layer 14 also can be made only to be placed on matrix 11 via metal coating 12 or biocompatible polymer layer 12.
In the present embodiment, matrix 11 is for adopting rustless steel, and for as the cross section in Fig. 1 being the cylindrical acicular texture of circle, and except being cylindrical acicular texture, it is triangle, square, rhombus, regular pentagon, regular hexagon or the polygonized structure such as pentagon, arbitrarily hexagon arbitrarily that matrix 11 also can be cross section.In the present embodiment, Handheld Division 2 is also the stainless steel structure of cylindricality, and can conformal in the shape of cross section of matrix 11, Handheld Division 2 can be made thus to be integral type structure with the matrix 11 in collection portion 1, thus to be convenient to the manufacture of this cellular collector.Certainly except adopting rustless steel, matrix 11 and Handheld Division 2 also can adopt other material, as glass fibre or the plastic stool based on organic polymer.The metal coating 12 covered in the present embodiment in matrix 11 outer circumferential side is Gold plated Layer, and except being Gold plated Layer, metal coating 12 also can adopt nickel, copper, palladium or the metal such as silver, platinum.Biocompatible polymer layer 12 can be employing hydrogel layer, and certainly except being hydrogel, biocompatible polymer layer 12 also can adopt other to have the material of water-wet behavior.
In the present embodiment, outermost antibody layer 14 for being fixed on biocompatible polymer layer 12 has bioactive antigen-antibody, this antigen-antibody can when collection portion 2 enters in human vas, the specific cells in blood is caught by immunoreation, namely required target cell, as tumor cell etc.According to the difference of required target cell, antigen-antibody can be variety classes.In the present embodiment as shown in fig. 1, for being convenient to control the inlet of collection portion 1 in blood vessel when cell collection, Handheld Division 2 is provided with two gear marks 3, certainly except being set to two, gear mark 3 also can be designed to other quantity, as required as 1 or three, four etc.And for the ease of the update of cellular collector, also not shown hand termination can be provided with relative to the other end of collection portion 1 in Handheld Division 2 in the present embodiment, this hand termination can be the hemispherical dome structure being formed at end, Handheld Division 2, or also can be platy structure.
Using and storing for ease of cellular collector in the present embodiment, the position that Handheld Division 2 is close to collection portion 1 also can sheathed one calparine cap 5 as shown in Figure 3.The concrete structure of calparine cap 5 can be as shown in Figures 3 and 4, it comprises calparine cap body 51, plug 52 is provided with in one end of calparine cap body 51, also comprise and be formed at connecting with plug 52 in calparine cap body 51, and the container cavity 54 of other end opening in calparine cap body 51, the collection portion 1 of cellular collector is and is placed in this container cavity 54, and calparine cap body 51 is also provided with the connecting portion for connecting calparine cap body 51 in the open at one end of container cavity 54.
In the present embodiment, calparine cap body 51 can by plastic warp injection mo(u)lding, and plug 52 is for being installed on the end of calparine cap body 51, and a side end face of plug 52 leaks outside in the end of calparine cap body 51.In the present embodiment, plug 52 can adopt rubber or silica gel material, and on calparine cap body 51, the shrinkage pool 55 of indent is also provided with relative to the other end of plug 52, and in shrinkage pool 55, be also provided with the cylinder 53 be fixed on calparine cap body 51, container cavity 44 is namely by calparine cap body 51 to prolong and in cylinder 53, and open-ended at cylinder 53 of container cavity 54.
The connecting portion be arranged in the present embodiment on calparine cap body 51 is be formed at the female thread 57 on shrinkage pool 55 inwall, and after adopting female thread 57 that calparine cap 5 can be made to be connected with other component, its overall structure is comparatively compact, so that place and use.By the free end of cylinder 53 in the present embodiment, also namely the open at one end of container cavity 54 is inside, and the outer peripheral face of cylinder 53 is the gradually little taper in cross section, now as shown in Figure 4, the outer peripheral face of cylinder 53 forms the conical surface 56, designs this conical surface 56 and can be convenient to calparine cap 5 and be connected with other component via female thread 57.And in order to avoid stabbing finger when being plugged at plug 52 place of cellular collector on calparine cap 5, the one end being close to plug 52 in the present embodiment on the outer peripheral face of calparine cap body 51 is also formed with the annular concave platform 58 of indent, and this annular concave platform 58 also can clamp a not shown anti-rolling tube.
By the setting of annular concave platform 58 and upper anti-rolling tube thereof, cellular collector can be made to be restrained in anti-rolling tube, thus to avoid cellular collector to stab finger because offseting because of carelessness.In the present embodiment as shown in Figure 3, for ease of the attended operation of calparine cap 5 with other parts, the open at one end that the outer peripheral face of calparine cap body 51 is close to container cavity 54 is also formed with anti-skidding lines.Cellular collector is arranged at structure on calparine cap 5 as shown in Figure 5, is being placed in by cellular collector after on calparine cap 5, can be convenient to the various operations to cellular collector, as carried out cell collection or storage etc.Now, be placed in for the ease of cellular collector, after on calparine cap 5, protectiveness storage carried out to it, on calparine cap 5, in the present embodiment, also can connect the protective cap arranging and the opening of container cavity 54 is closed.
In the present embodiment, a kind of structure of protective cap can be as shown in figures 6 and 7; it comprises protective cap body 61; the protection chamber 62 of the one end open in protective cap body 61 is provided with in protective cap body 61; be close to the open at one end in protection chamber 62; the outer peripheral face of protective cap body 61 is also formed the external screw thread 64 for connecting protective cap body 61, and namely protective cap 6 is connected on calparine cap 5 with the coordinating of female thread 57 on calparine cap 5 by external screw thread 64.
In the present embodiment, protective cap body 61 is the different two-part structure of external diameter, and namely external screw thread 64 is arranged on the less part of protective cap body 61 top external diameter.Protective cap body 61 can adopt plastic warp injection mo(u)lding; and for ease of the connection between protective cap 6 and calparine cap 5; also protection chamber 62 is made to be inwardly the gradually little taper in cross section from its opening in the present embodiment; thus when connecting, the cylinder 53 being built-in with collection portion 1 on calparine cap 5 can insert in protection chamber 62 more easily.In addition; in order to make protective cap 6 lightweight; on protective cap body 61, annular recess 63 is also formed with relative to the other end of protection chamber 62 opening in the present embodiment; and on the inwall in outside, additional female thread 65 is also formed with in annular recess 63; the connection that additional female thread 65 can be convenient to protective cap 6 and other component is set, to be conducive to the arrangement of protective cap 6.
On protective cap body 61, not shown pad mounting groove in the form of a ring also can be formed with in the end of protection chamber 62 open at one end in the present embodiment; and that also establishes in this pad mounting groove has rubber cushion, by rubber cushion can promote protective cap 6 be connected with calparine cap 5 after sealing.Simultaneously; in the present embodiment as shown in Figure 6; on the outer peripheral face of the other end of protective cap body 61, also anti-skidding lines is formed with relative to external screw thread 64; this anti-skidding lines can be vertical raised structures as shown in Figure 6; and except vertical raised structures, this anti-skidding lines also can adopt multiple block structure or circular protrusion structure etc.Protective cap 6 is connected to and is provided with structure on the calparine cap 5 of cellular collector as shown in Figure 8, now in the protection chamber 62 of protective cap 6, injects protection liquid, thus can realize the digital preservation to collection portion 1 on cellular collector.
Protective cap 6 is except can be above-mentioned structure, and it also can adopt other version certainly, is threadedly connected to the simple cylindrical component with hollow cavity on calparine cap 5 as it can be one.And calparine cap 5 is except can adopting aforesaid version, it also can adopt other existing structure, and can be connected and sealed with protective cap 6.When specifically using; cellular collector is inserted on calparine cap 5; after collection portion 1 is placed in container cavity 54; protection liquid can be injected in the protection chamber 62 of protective cap 6; then protective cap 6 is connected on calparine cap 5, makes the collection portion 1 of the cellular collector being placed in container cavity 54 be placed in container cavity 54 with in the enclosed space protecting chamber 62 to be encircled into.And if when needing cellular collector to carry out cell collection, protective cap 6 can be removed, then the calparine cap 5 with cellular collector is connected on the remaining needle set, then by operation Handheld Division 2, one end, collection portion 1 is inserted in human vas.
The foregoing is only preferred embodiment of the present utility model; not in order to limit this utility model; all within spirit of the present utility model and principle, any amendment done, equivalent replacement, improvement etc., all should be included within protection domain of the present utility model.
Claims (10)
1. a cellular collector, it is characterized in that: comprise Handheld Division and be fixed on the circular in cross-section of one end, described Handheld Division or the collection portion of polygonal needle-like, described collection portion comprises matrix, and covers the antibody layer for target acquisition cell in described matrix outer circumferential side.
2. cellular collector according to claim 1, is characterized in that: the cylindrical needle-like in described collection portion.
3. cellular collector according to claim 1 and 2, is characterized in that: be covered with metal coating at the outer circumferential side of described matrix, and described antibody layer is positioned on metal coating.
4. cellular collector according to claim 1 and 2, is characterized in that: be covered with biocompatible polymer layer at the outer circumferential side of described matrix, and described antibody layer is positioned on biocompatible polymer layer.
5. cellular collector according to claim 1 and 2, is characterized in that: be covered with metal coating and biocompatible polymer layer successively at the outer circumferential side of described matrix, described antibody layer is positioned on biocompatible polymer layer.
6. cellular collector according to claim 5, is characterized in that: described matrix is rustless steel, and described metal coating is Gold plated Layer, and described biocompatible polymer layer is hydrogel layer.
7. cellular collector according to claim 1, is characterized in that: on described Handheld Division, be provided with at least one gear mark.
8. cellular collector according to claim 1, it is characterized in that: also comprise the calparine cap being movably set in and described Handheld Division being close to side, collection portion, described calparine cap comprises calparine cap body, be installed in the plug of described calparine cap body one end, and be formed at that described calparine cap is intrinsic to connect with plug and the container cavity of other end opening in calparine cap body; Described Handheld Division is inserted on plug, and makes described collection portion be placed in described container cavity.
9. cellular collector according to claim 8, is characterized in that: on described calparine cap, be connected with the protective cap closed the opening of described container cavity.
10. cellular collector according to claim 9, is characterized in that: on described protective cap, be formed with the one end open in protective cap, and the protection chamber be connected when described protective cap is connected on calparine cap, with described container cavity.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520589537.6U CN204951010U (en) | 2015-08-07 | 2015-08-07 | Cell collector |
| KR2020160004021U KR200486491Y1 (en) | 2015-08-07 | 2016-07-12 | A cell-collection device and a cell-collection assembly |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520589537.6U CN204951010U (en) | 2015-08-07 | 2015-08-07 | Cell collector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204951010U true CN204951010U (en) | 2016-01-13 |
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ID=55046108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520589537.6U Active CN204951010U (en) | 2015-08-07 | 2015-08-07 | Cell collector |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204951010U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625534A (en) * | 2016-07-18 | 2018-01-26 | 上海千山医疗科技有限公司 | Indwelling needle assembly and the circulating tumor cell supporting with remaining needle are in body acquisition equipment |
| CN107625524A (en) * | 2016-07-18 | 2018-01-26 | 上海千山医疗科技有限公司 | PICC/CVC components and circulating tumor cell are in body acquisition equipment |
| CN110251164A (en) * | 2019-06-14 | 2019-09-20 | 上海交通大学医学院附属仁济医院 | A kind of dyeing interpretation method of cell capture device, cystoscope and sample cell |
-
2015
- 2015-08-07 CN CN201520589537.6U patent/CN204951010U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625534A (en) * | 2016-07-18 | 2018-01-26 | 上海千山医疗科技有限公司 | Indwelling needle assembly and the circulating tumor cell supporting with remaining needle are in body acquisition equipment |
| CN107625524A (en) * | 2016-07-18 | 2018-01-26 | 上海千山医疗科技有限公司 | PICC/CVC components and circulating tumor cell are in body acquisition equipment |
| CN110251164A (en) * | 2019-06-14 | 2019-09-20 | 上海交通大学医学院附属仁济医院 | A kind of dyeing interpretation method of cell capture device, cystoscope and sample cell |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190508 Address after: 050035 7th Floor, Building No. 136 Huanghe Avenue, Shijiazhuang High-tech Zone, Hebei Province Patentee after: Germany Road (Shijiazhuang) Biotechnology Co., Ltd. Address before: Room 409, Block A, China Foreign Language Building, 89 West Third Ring North Road, Haidian District, Beijing, 100089 Patentee before: BEIJING DELUTONG BIOTECHNOLOGY CO., LTD. |