CN204839432U - Mirror system in digestion of high accuracy multimode - Google Patents

Abstract

The utility model discloses a mirror system in digestion of high accuracy multimode, including being used for getting into the scope module that image information was gathered to people's body cavity way, the scope module includes mirror tube and installs the scope probe at the mirror tube front end, be provided with illumination optic fibre in the scope probe, a plurality of passageways have still been offered to the scope probe in the axial, and the biography that is used for installing the qi lunkefu scope respectively is like the biography of optical fiber bundle and laser copolymerization jiao scope like the optical fiber bundle to and mirror system in the white light electronics, the scope is popped one's head in and still offer a water course that is used for the water spray cleaning camera lens in the axial, the utility model discloses an once play the mirror can realize multiple functions, the effective pathological change signal of mirror existence down many times and problem of image registration solved to can save operation time and alleviate the disease misery, and greatly reduced the surgical cost of this type of operation of present home.

Description

The multi-modal digestive endoscopy system of a kind of high accuracy

[technical field]

This utility model belongs to technical field of medical instruments, is specifically related to the multi-modal digestive endoscopy system of a kind of high accuracy.

[background technology]

Gastric cancer is one of malignant tumor of serious threat human life health, in global range, its sickness rate occupies malignant tumor the 4th, case fatality rate occupies second, Asia is the hotspot of gastric cancer, especially with China, Japan and Korea S attach most importance to, China's incidence gastric cancer rate occupies malignant tumor second, case fatality rate occupies first, and death toll accounts for 44% of global mortality of gastric carcinoma number, therefore, improve top priority and working difficult point that patients with gastric cancer survival rate is China gastric cancer worker, it is closely related that the high case fatality rate of gastric cancer and pathological changes when finding have been in late period, related data shows, the late gastric cancer survival rate of postoperative 5 years is less than 61%, and early gastric cancer can reach 84% ~ 99%, for small gastric carcinoma and small gastric cancer, within postoperative 10 years, survival rate can reach 100%, therefore the early diagnosis of gastric cancer is the key link and the effective means that reduce gastric cancer case fatality rate, but early gastric cancer does not have specific symptom to occur, existing gastroscope adds the change of the diagnostic method Main Basis tumor morphology of biopsy, is thus difficult to find early gastric cancer, research shows, tumor cell molecular function changes early than morphological change, and research and development identifiable design early gastric cancer molecular function changes, and improves the brand-new endoscope system of Morphologic Diagnosis degree of accuracy simultaneously, greatly will shift to an earlier date diagnosing gastric cancer and Deal with Time, be the developing direction of the design of following gastroscope system and research and development.

[utility model content]

The purpose of this utility model is to provide the multi-modal digestive endoscopy system of a kind of high accuracy, several functions can be realized by once playing mirror, the problem of the pathological changes signal that effective solution repeatedly plays mirror to exist and image registration, endoscope system of the present utility model can be saved operating time and alleviate sufferer misery, and greatly reduces the surgery cost of this type of operation domestic at present.

In order to achieve the above object, the technical solution adopted in the utility model is: the multi-modal digestive endoscopy system of a kind of high accuracy, comprise the scope module gathering image information for entering body cavities, described scope module comprises mirror pipe and is arranged on the endoscopic probe of mirror pipe front end, lighting fiber is provided with in described endoscopic probe, endoscopic probe also offers some passages in the axial direction, be respectively used to the image-carrying fiber bundle of Cerenkov scope and the image-carrying fiber bundle of laser co-focusing scope are installed, and white light video image dendoscope system, endoscopic probe also offers one in the axial direction for the water channel of spraying-rinsing camera lens.

Described white light video image dendoscope system comprises the image sensing coupling camera lens and the video sensor for signal transmission that are arranged on endoscopic probe end face.

Described image sensing coupling camera lens is made up of, for carrying out image taking minisize optical lens and miniature image sensor ccd video camera.

The image-carrying fiber bundle of described laser co-focusing scope is dismountable to be arranged in the passage of endoscopic probe, as service aisle after this passage taking-up laser co-focusing scope.

Described Cerenkov scope image-carrying fiber bundle, laser co-focusing scope image-carrying fiber bundle and white light video image dendoscope system are installed in the different passages of endoscopic probe.

Described endoscopic probe front end face is provided with camera lens cover plate.

Described mirror pipe rear end is connected with the external module for the treatment of signal, and described external module is connected to computer.

Described external module comprises: complete video image dendoscope pop one's head in the analog digital conversion of the video signal collected and output processing white light video image dendoscope module, complete the laser co-focusing scope module of laser scanning control and the burnt light signal collection of copolymerization and complete the Cerenkov fluorescence scope module of Cerenkov fluorescence signal acquisition.

Described white light video image dendoscope module comprises processing system for video and lighting source, lighting source adopts LED, lighting source provides illumination by lighting fiber for white light video image dendoscope, and the video signal that the image sensing coupling camera lens being arranged at endoscopic probe front end photographs passes to computer through wire transmission after processing system for video process;

Laser co-focusing scope module comprises photodetector, laser instrument, dichroic mirror, X is to scanning galvanometer, Y-direction scanning galvanometer, filter plate, the object lens that pin hole is adjustable with the coupled lens and position that are arranged on high coupling efficiency in interior pry head, laser instrument provides lighting source, obtain point source through light source pin hole and entered scanning optical path by dichroic mirror reflects, the computer X controlled in high-precision X and Y both direction realizes exciting light to scanning galvanometer and Y-direction scanning galvanometer and imports image transmission optical fibre quick point by point scanning on imaging focal plane, reflected light on imaging plane is after same light path is by dichroic mirror and filter plate, finally only having fluorescence signal to be detected pin hole converges on photodetector,

Described Cerenkov fluorescence scope module comprises photoelectric signal collection equipment, Cerenkov image-carrying fiber bundle, coupling camera lens and imaging camera bellows, Cerenkov scope module completes the collection of the Cerenkov fluoroscopic image that nucleic sends, the Cerenkov fluorescence signal that the tumor tissues of nucleic high-selenium corn sends is via Cerenkov image-carrying fiber bundle, through coupling camera lens, be projeced on high-sensitive CCD camera, the Cerenkov fluoroscopic image gathered is transferred to processing system for video through video data line and processes further.

Described laser co-focusing scope is sonde-type laser co-focusing scope.

Compared with prior art, this utility model at least has following beneficial effect, there is based on white light video image dendoscope the advantage checking that field range is large, on the basis of white light electronic endoscopy result, specific molecular functional imaging is realized by Cerenkov fluorescence scope, cellularity imaging and the confocal microscopic image of subcellsular level resolution is carried out by the burnt scope of copolymerization, carry out the in-vivo tissue realtime imaging of mucous layer further, this utility model merges high definition white light video image dendoscope, Cerenkov fluorescence scope (eCLI) and the burnt microendoscopic (pCLE) of copolymerization based on probe, three kinds of imaging systems are melted into a whole and form the multi-modal digestive endoscopy system of a kind of high accuracy, for early stage digestive tract tumor minimal disease, achieve morphosis, metabolic function and microstructure three kinds of information fusion imagings, for the earlier detection of digestive tract tumor, good pernicious judgement, wait diagnostic procedure to provide strong instrument by stages, and this utility model reasonable in design, several functions will can be realized by once playing mirror, effectively solve the problem of pathological changes signal and the image registration repeatedly playing mirror to exist, and once play mirror to significantly reduce sufferer misery, and greatly reduce the surgery cost of this type of operation domestic at present, save operating time.

Further, after being taken out by laser co-focusing scope, laser co-focusing scope place passage carries out the operations such as cover bundle, expansion, biopsy or taking foreign body as service aisle, and reasonable in design is simple to operate.

Further, in multi-modal digestive endoscopy system of the present utility model, different scope uses separately independently optical channel, and ensureing separately can normal table work and non-interference.

[accompanying drawing explanation]

Fig. 1 is structural representation of the present utility model.

Fig. 2 is this utility model endoscopic probe end face structure schematic diagram.

Fig. 3 is the structural representation of this utility model external module.

In accompanying drawing: 1-scope module, 11-mirror pipe, 12-white light video image dendoscope module, 121-processing system for video, 122-lighting source, 13-endoscopic probe, 14-Cerenkov fluorescence scope module, 141-photoelectric signal collection equipment, 142-Cerenkov image-carrying fiber bundle, 143-is coupled camera lens, 15-lighting fiber, 16-laser co-focusing scope module, 161-laser instrument, 162-light source pin hole, 163-dichroic mirror, 164-X is to scanning galvanometer, 165-Y is to scanning galvanometer, 166-filter plate, 167-detecting pinhole, 168-photodetector, 31-Cerenkov scope light path system, 33-laser co-focusing scope, 35-white light video image dendoscope system, 37-water channel.

[detailed description of the invention]

Below in conjunction with the drawings and specific embodiments, this utility model is described further.

See Fig. 1 and Fig. 2, the multi-modal digestive endoscopy system of a kind of high accuracy, comprise the scope module 1 gathering image information for entering body cavities, scope module 1 comprises mirror pipe 11 and is arranged on the endoscopic probe 13 of mirror pipe 11 front end, mirror pipe 11 rear end is connected with the external module for the treatment of signal, external module comprises: complete video image dendoscope and to pop one's head in the analog digital conversion of the video signal collected and the white light video image dendoscope module 12 of output processing, complete the laser co-focusing scope module 16 of laser scanning control and the burnt light signal collection of copolymerization and complete the Cerenkov fluorescence scope module 14 of Cerenkov fluorescence signal acquisition, lighting fiber 15 is provided with in endoscopic probe 13, the signal output part of external module connects computer,

Lighting fiber 15 is provided with in endoscopic probe 13, endoscopic probe 13 also offers some passages in the axial direction, be respectively used to the image-carrying fiber bundle 31 installing Cerenkov scope, the image-carrying fiber bundle 33 of laser co-focusing scope and white light video image dendoscope system 35, Cerenkov scope image-carrying fiber bundle 31, laser co-focusing scope image-carrying fiber bundle 33 and white light video image dendoscope system 35 are installed in different passage, ensureing separately can normal table work and non-interference, the image-carrying fiber bundle 33 of laser co-focusing scope is dismountable to be arranged in passage, as service aisle after this passage taking-up laser co-focusing scope, carry out cover to prick, expansion, the operation such as biopsy or taking foreign body,

White light video image dendoscope system 35 comprises the image sensing coupling camera lens and the video sensor for signal transmission that are arranged on endoscopic probe 13 end face, image sensing coupling camera lens is made up of minisize optical lens and miniature image sensor ccd video camera, image sensing coupling camera lens enters body interior and is used for observing and shooting image, it is figure collecting part, the visual field of white light video image dendoscope camera lens, viewing angle, directions etc. all can regulate, be coupled by image sensing video signal that camera lens photographs of processing system for video is supplied to computer through analog digital conversion and carries out subsequent treatment,

Endoscopic probe 13 also offers one in the axial direction for the water channel 37 of spraying-rinsing camera lens, and endoscopic probe 13 front end face is provided with camera lens cover plate.

See Fig. 3, white light video image dendoscope module comprises processing system for video 121 and lighting source 122, lighting source 122 adopts LED, lighting source 122 provides illumination by lighting fiber 15 for white light video image dendoscope, and the video signal that the image sensing coupling camera lens being arranged at endoscopic probe 11 front end photographs passes to computer through wire transmission after processing system for video process;

Laser co-focusing scope module comprises image-carrying fiber bundle, photodetector 168, laser instrument 161, dichroic mirror 163, scanning device, filter plate 166, pin hole and be arranged on the adjustable object lens of the coupled lens of high coupling efficiency in interior pry 13 and position, coupled lens and object lens achieve the coupling to fibre bundle of the collection of organizational structure picture and light, connected by piezoelectric ceramics between coupled lens and object lens, utilize piezoelectric ceramics piezoelectric property, the external input voltage changing piezoquartz causes piezoquartz physical size in the Z-axis direction to occur accurately to stretch, thus drive object lens to carry out stretching motion subtly along depth direction, regulate the position of object lens, thus realize the change of object lens position, image-carrying fiber bundle carries out the indispensable Primary Component of based endoscopic imaging, it mainly contains two effects: one is the transmitting medium as optical signal, two is illumination pin holes, image-carrying fiber bundle plays very large impact as the performance of an important component part on system of this system, select in this programme to consider emphatically following 4 points during image transmission optical fibre: first, the coupling of simple optical fiber core diameter and Laser Scanning Confocal Microscope output facula diameter, if spot diameter is greater than core diameter part light reduces system light output efficiency by being depleted, light also can be coupled in some optical fiber the crosstalk which results between optical fiber simultaneously in addition, seriously reduces resolution and the contrast of image, second, the coupling of fiber numerical aperture and numerical aperture of objective, the numerical aperture of optical fiber should be less than or equal to the numerical aperture of object lens, and the numerical aperture that the numerical aperture as optical fiber is greater than object lens will have part useful signal can not be received by object lens thus reduce the delivery efficiency of light, 3rd, from the angle of patient, the size of fibre bundle, considers that fibre bundle is more thin better, and can not be too thin from the diameter of imaging viewing field fibre bundle, also needs to consider this two factors when therefore selecting, 4th, reflection can be produced when illumination light enters fiber end face on its surface and received by detector, this will increase system noise, reduce picture contrast, adopt inclination fibre bundle and fiber end face coat these two kinds of methods of index matching liquid can reduce fiber end face reflection to reduce system noise,

Photodetector 168 adopts PMT detector, PMT detector is a kind of light-detecting device with high sensitivity and ultrafast time response, there are good frequency response and time resolution characteristics, good photoelectric characteristic, higher photo-quantum efficiency, less dark current, is widely used in the aspect such as photon counting and atomic weak light detection, adopt high sensitivity, low noise here, respond fast high-performance PMT detector as the collecting unit of optical signal;

Laser instrument 161 provides light source for the burnt scope of copolymerization, and adopt the continuous-wave laser of the variable wavelength output of high stable as exciting light sources, input wavelength scope covers 400 ~ 700nm;

Dichroic mirror 163, realizes being separated of the burnt optical signal of exciting light and copolymerization; Scanning device has comprised the burnt excitation source X of copolymerization to scanning galvanometer 164 and Y-direction scanning galvanometer 165; Filter plate 166 is when the confocal scanning of combined with fluorescent probe, and specific other wave band optical signals of filter plate filtering for fluorescent probe wave band obtain useful fluorescence signal;

Pin hole comprises the detecting pinhole 167 before the light source pin hole 162 before laser instrument and detector, light source pin hole 162 obtains point source, by realizing point by point scanning on imaging sample focal plane after light path, the light that detecting pinhole 167 sends for the focus place assembling focal plane of lens;

See Fig. 3, laser co-focusing scope module realizes the micro-cell structure imaging of local organization, laser instrument 161 provides lighting source, obtain point source through light source pin hole 162 and entered scanning optical path by dichroic mirror 163 reflection, the computer X controlled in high-precision X and Y both direction realizes exciting light to scanning galvanometer 164 and Y-direction scanning galvanometer 165 and imports image transmission optical fibre quick point by point scanning on imaging focal plane, reflected light on imaging plane is after same light path is by dichroic mirror 163 and filter plate 166, finally only having fluorescence signal to be detected pin hole 167 converges on PMT detector 168, the point by point scanning formula imaging of the imaging focal plane of imaging object finally can be realized by this confocal imaging optical path and two-dimensional scan detection, in conjunction with the interior pry 13 of focus adjustable, this laser co-focusing scope module 16 can complete the two-dimensional scan imaging of different depth aspect, and then realize three-dimensional confocal scanning imaging.

Described Cerenkov fluorescence scope module comprises photoelectric signal collection equipment 141, Cerenkov image-carrying fiber bundle 142, coupling camera lens 143 and imaging camera bellows, in order to gather faint nucleic Cerenkov fluorescence signal, dark refrigeration, back-illuminated type and highly sensitive EM-CCD camera are used as photoelectric signal collection equipment, it has high sensitivity, high read-out speed, the advantages such as low reading noise and dark current, especially have up to more than 90% quantum efficiency and electron multiplication function,-90 DEG C are cooled to by semiconductor refrigerating technology, the impact of electronic noise can be effectively reduced, (in eCLI imaging, faint Cerenkov fluorescence signal detects to be very suitable for Cerenkov fluorescence scope, Cerenkov image-carrying fiber bundle 142 selective light loses little optical fiber, is especially used in Cerenkov fluorescence spectral coverage and has the high optical fiber of efficiency of transmission, effectively can improve the detection efficiency of faint Cerenkov fluorescence signal, the camera lens that coupling camera lens 143 selects numerical aperture large, can effectively gather Cerenkov fluorescence signal, Cerenkov fluorescence is very faint, and require higher for imaging circumstances, highly airtight imaging camera bellows contributes to collecting faint plain Cerenkov fluorescence signal,

See Fig. 3, Cerenkov scope module completes the collection of the Cerenkov fluoroscopic image that nucleic sends, the Cerenkov fluorescence signal that the tumor tissues of nucleic high-selenium corn sends is via Cerenkov image-carrying fiber bundle 142, through coupling camera lens 143, be projeced on high-sensitive CCD camera 141, the Cerenkov fluoroscopic image gathered is transferred to processing system for video through video data line and processes further.

White light electronic endoscopy has positive recall rate and checks the advantage that field range is large, but white light video image dendoscope lesion detection heavy dependence checks the experience level of doctor, especially for the early gastric cancer that mucosal surface structure changing features is small, the person of lacking experience very easily fails to pinpoint a disease in diagnosis, Cerenkov scope (EndoscopicCerenkovLuminescenceImaging, eCLI is highly sensitive, image taking speed is fast, price is relatively low, scope is utilized to detect the tract systems such as digestive tract, solve the problem that optical signal penetration power is weak, and can imaging in art, flexibly and easily, in addition, probe is that PET checks nucleic probe used, avoid bio-toxicity problem, but the loss of signal of Cerenkov system in light path on broadcasting system is very large, this is on the one hand for the Cerenkov imaging that signal itself is more weak, therefore imaging effect can have a greatly reduced quality, on the other hand, for reaching good imaging effect, just need the radionuclide to animal body or patient injection heavy dose, but the nucleic of heavy dose brings non-essential irradiation can to patient and doctor, in addition, Cerenkov only provides functional imaging, cannot realize structure imaging, can not understand the fine structure at suspicious lesions position, the burnt scope of copolymerization is front end Laser Scanning Confocal Microscope being integrated in scope, form amplification at the magnifying endoscope of 500 ~ 1000 times, its image-forming principle is equal to Laser Scanning Confocal Microscope, high-resolution and the living cells imaging of subcellsular level can be provided, the in-vivo tissue realtime imaging of mucous layer can be carried out, the selectively targeted imaging of gastric cancer can be realized, but its areas imaging is too little, and the physiological and pathological information of cellular and molecular level can not be provided, this utility model is for early stage digestive tract tumor minimal disease, obtain the shape information of digestive tract imaging region simultaneously, isotopically labeled cellular metabolism function information and micro-cell structural information, there is provided more comprehensively from multi information dimension and many imagings yardstick, meticulousr inner peeping type imaging, effectively solve the problem of pathological changes signal and the image registration repeatedly playing mirror to exist, and once play mirror to significantly reduce sufferer misery, and greatly reduce the surgery cost of this type of operation domestic at present, save operating time.

Claims (10)

1. the multi-modal digestive endoscopy system of high accuracy, it is characterized in that, comprise the scope module (1) gathering image information for entering body cavities, described scope module (1) comprises mirror pipe (11) and is arranged on the endoscopic probe (13) of mirror pipe (11) front end, lighting fiber (15) is provided with in described endoscopic probe (13), endoscopic probe (13) also offers some passages in the axial direction, be respectively used to the image-carrying fiber bundle (31) of Cerenkov scope and the image-carrying fiber bundle (33) of laser co-focusing scope are installed, and white light video image dendoscope system (35).

2. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 1, it is characterized in that, described white light video image dendoscope system (35) comprises the image sensing coupling camera lens and the video sensor for signal transmission that are arranged on endoscopic probe (13) end face.

3. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 2, is characterized in that, described image sensing coupling camera lens is made up of, for carrying out image taking minisize optical lens and miniature image sensor ccd video camera.

4. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 1, it is characterized in that, the image-carrying fiber bundle (33) of described laser co-focusing scope is dismountable to be arranged in the passage of endoscopic probe (13), as service aisle after this passage taking-up laser co-focusing scope.

5. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 1, it is characterized in that, described Cerenkov scope image-carrying fiber bundle, laser co-focusing scope image-carrying fiber bundle and white light video image dendoscope system are installed in the different passages of endoscopic probe.

6. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 1, is characterized in that, described endoscopic probe (13) front end face is provided with camera lens cover plate.

7. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 1, is characterized in that, described mirror pipe (11) rear end is connected with the external module for the treatment of signal, and described external module is connected to computer (15).

8. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 7, it is characterized in that, described external module comprises: complete video image dendoscope pop one's head in the analog digital conversion of the video signal collected and output processing white light video image dendoscope module (12), complete the laser co-focusing scope module (16) of laser scanning control and the burnt light signal collection of copolymerization and complete Cerenkov fluorescence scope module (14) of Cerenkov fluorescence signal acquisition.

9. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 8, it is characterized in that, described white light video image dendoscope module comprises processing system for video (121) and lighting source (122), lighting source (122) adopts LED, lighting source (122) provides illumination by lighting fiber (15) for white light video image dendoscope, and the video signal that the image sensing coupling camera lens being arranged at endoscopic probe (11) front end photographs passes to computer through wire transmission after processing system for video process;

Laser co-focusing scope module comprises photodetector (168), laser instrument (161), dichroic mirror (163), X is to scanning galvanometer (164), Y-direction scanning galvanometer (165), filter plate (166), the object lens that pin hole is adjustable with the coupled lens and position that are arranged on high coupling efficiency in interior pry head (13), laser instrument (161) provides lighting source, obtain point source through light source pin hole (162) and entered scanning optical path by dichroic mirror (163) reflection, the computer X controlled in high-precision X and Y both direction realizes exciting light to scanning galvanometer (164) and Y-direction scanning galvanometer (165) and imports image transmission optical fibre quick point by point scanning on imaging focal plane, reflected light on imaging plane is after same light path is by dichroic mirror (163) and filter plate (166), finally only having fluorescence signal to be detected pin hole (167) converges on photodetector (168),

Described Cerenkov fluorescence scope module comprises photoelectric signal collection equipment (141), Cerenkov image-carrying fiber bundle (142), coupling camera lens (143) and imaging camera bellows, Cerenkov scope module completes the collection of the Cerenkov fluoroscopic image that nucleic sends, the Cerenkov fluorescence signal that the tumor tissues of nucleic high-selenium corn sends is via Cerenkov image-carrying fiber bundle (142), through coupling camera lens (143), be projeced on high-sensitive CCD camera (141), the Cerenkov fluoroscopic image gathered is transferred to processing system for video through video data line and processes further.

10. the multi-modal digestive endoscopy system of a kind of high accuracy according to claim 1, is characterized in that, described endoscopic probe (13) also offers one in the axial direction for the water channel (37) of spraying-rinsing camera lens.