CN204581484U - A kind of 3D with three-dimensional through loose structure prints bone screw - Google Patents
A kind of 3D with three-dimensional through loose structure prints bone screw Download PDFInfo
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- CN204581484U CN204581484U CN201520239774.XU CN201520239774U CN204581484U CN 204581484 U CN204581484 U CN 204581484U CN 201520239774 U CN201520239774 U CN 201520239774U CN 204581484 U CN204581484 U CN 204581484U
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Abstract
The utility model discloses a kind of 3D with three-dimensional through loose structure and print bone screw, this screw comprises ailhead, rivet nut, the head of a nail.Rivet nut comprises the porous network of the micropore formation be interconnected.Porous bone screw of the present utility model is made up of the medical material of human implantable, and the microcellular structure be interconnected that porous bone screw has is that growing into of osteocyte provides more spaces, facilitates the combination of pedicle screw and body bone tissue, makes grappling firm.
Description
Technical field
This utility model belongs to technical field of medical instruments, relates to a kind of porous bone screw, is specifically related to a kind of 3D with three-dimensional through loose structure and prints bone screw.This bone screw can be applicable in clinical osseous tissue injury repairing.
Background technology
Along with being on the rise of aging, increasing with bone amount decline, bone microstructure degeneration, bone fragility, osteoporosis disease (osteoporosis, OP that fracture is basic feature easily occur appears after arriving person in middle and old age in increasing people.According to statistics, the whole world is existing about has 200,000,000 people to suffer from osteoporosis, and its sickness rate has leapt to world's commonly encountered diseases the 7th, is one of the most common disease of middle-aged and elderly people.China has been the country that sufferers of osteoporosis face is maximum in the world, international osteoporosis foundation and China's Healthy promote that " osteoporosis prevents and treats Chinese white paper " that foundation is issued for 2008 jointly points out, China has 9,000 ten thousand sufferers of osteoporosis face at present, accounts for 7.1% of total population.Sufferers of osteoporosis face is easily fractured, be common in spinal column, hip joint and extremity etc., and because screw is to the hold deficiency of bone, the postoperative second operation often occurring screw loosening, move back nail and cause thus of sufferers of osteoporosis face, bring huge body and mind puzzlement to doctor and patient, its high medical expense brings heavy financial burden also to patient and society.
The method of current raising screw-bone interface stability mainly contains: (1) cement augmentation technology, as adopted polymethyl methacrylate (PMMA) bone cement material, screw nail road is strengthened, but the method easily causes surrounding bone, neural tissue injury because bone cement solidifies heat release, and PMMA Biocompatibility is poor, hinder osseous tissue to grow into material, interface loosely; And bone cement seepage easily causes the serious complication of nerve, breathing and cardiovascular system; Meanwhile, this type of technology is high to doctor's operation requirements, once occur bone cement to solidify and implantation position is undesirable, again overhauls and will face huge challenge.Develop the method for hollow side opening pedicle screw associating bone cement perfusion on this basis, but in this technology the effective using dosage of bone cement and seepage dosage very close, PMMA dosage can significantly improve the stability of screw when being greater than 1.5mL, and dosage about has 33% patient that seepage occurs when 2.02 ± 0.56mL, therefore this technology needs careful operation, and this technology still can not avoid aforementioned various bone cement nail road reinforcement technique institutes problems faced.(2) improvement of screw itself, mainly contain the length and diameter that change screw, change the out of shape of screw thread, tip of screw be designed to expandable structure and give screw biological coating etc., but above-mentioned various method still cannot solve the problems such as unbalance stress (excessive or too small), contact interface knitting, and high to operation technical requirement, easily cause secondary fracture, important organ blood vessel as other in vertebral body, spinal nerves root is intraspinal tube spinal cord injury even.In sum, the improvement opportunity of current various screws still can not meet the needs of sufferers of osteoporosis face clinically.
Summary of the invention
In order to address the deficiencies of the prior art, this utility model provides a kind of 3D with three-dimensional through loose structure and prints bone screw.The loose structure of screw allows that area of new bone is grown into screw inside, realizes grappling biology of screw-bone interface, greatly improves screw to the hold of bone, screw loosening after can effectively preventing fixation, moves back the generation of nail, has good clinical value.
The bone screw of what this utility model provided the have microcellular structure be interconnected comprises ailhead, rivet nut, the head of a nail; Described rivet nut comprises the porous network of the microcellular structure formation be interconnected; The aperture of described porous network is 200 μm-900 μm or 1100 μm-2500 μm, and porosity is 78%-92%.The advantage in above-mentioned aperture is adopted to be: to provide that porous is communicated with, high porosity and enough Bone Ingrowth amounts, to meet clinical needs.
Preferably, the aperture of described porous network is 600 μm.
Preferably, the porosity of described porous network is 80%.
Further, described rivet nut also can comprise central entity, and described porous network is positioned at the outside of described central entity.In a specific embodiments of the present utility model, described porous network is independent of described central entity surface and around described central entity.In another specific embodiments of the present utility model, described porous network is the porous area formed on the surface in described central entity.
Further, described rivet nut also can comprise the helicitic texture on the porous network surface being positioned at the microcellular structure formation be interconnected.
Further, the hole shape of described porous network includes but not limited to polyhedron, spheroid, irregularly shaped.
Preferably, described polyhedron is regular dodecahedron, and the advantage of the pore structure of employing regular dodecahedron shape is: the multistage pore space structure that regular dodecahedron can provide porous to be communicated with, is beneficial to the adhesion of early stage cell, propagation, and has good mechanical stability.
Further, the raw materials of described porous bone screw can be non-degradable material, also can be degradation material.The raw materials of described porous bone screw includes but not limited to: the medical metal material in human implantable, bioceramic, medical macromolecular materials.
Preferably, described medical metal material is titanium alloy.
Further, the diameter range of described rivet nut is: 2-8mm.
Further, the cross sectional shape of described rivet nut is multiple: circle, ellipse, triangle, square, polygon, rivet nut length range is: 1-10cm.
Further, the described head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.
Porous bone screw surface of the present utility model can cover biological coating, promotes integration and the growth of bone further.These biological coatings include but not limited to: hydroxyapatite coating layer, calcium titanate coating, titanium coating, titanium and hydroxyapatite meet active coating, the Afluon (Asta)/fluor-apatite composite coating of coating, wollastonite coating, hydroxyapatite and diphosphonate composite material.
Decorative material can be adhered in the microcellular structure surface that porous bone screw of the present utility model is interconnected, and induction osteocyte is grown into.Described decorative material includes but not limited to: natural polymer derived material, as collagen, fibrin, chitosan; Cell growth factor, as bone morphogenetic protein (BMP), basic fibroblast growth factor (bFGF), PDGF, VEGF; Poly-D-lysine; Polypeptides matter.
Above-mentioned biological coating and decorative material also can Application of composite, the integration of dual promotion bone and growth.
Porous bone screw of the present utility model can adopt 3D printing technique to be prepared from, and making step is: (1) carries out the three dimensional design modeling of the porous bone screw with loose structure in computer; (2) metal quick molding method is utilized directly to generate finished product by metal dust.Described metal dust is preferably titanium alloy (Ti6Al4V).
The metal quick molding method that this utility model adopts is lf method, utilizes the method to prepare the concrete steps of porous bone screw of the present utility model as follows:
1) by proe Three-dimensional Design Software, set up the threedimensional model of porous matrix structure construction unit in a computer, construction unit key element, porosity, aperture size are set;
2) according to step 1) in three-dimensional construction unit, by magics Three-dimensional Design Software with construction unit filling, expansion screw core, screw core is generated as porous matrix structure;
3) according to step 2) in threedimensional model, adopt Concept laser Mlab metal material 3D printer, print screw;
4) by step 3) after the printing screw that obtains heat-treats, cool to room temperature;
5) by step 4) the printing screw that obtains adopts Linear cut, cuts from work platforms;
6) by step 5) the printing screw that obtains adopts blasting treatment, and removing print surface glues molten unnecessary raw material;
7) by step 6) the printing screw that obtains adopts ultrasonic waves for cleaning, removing surface impurity;
8) above-mentioned screw is put into Epoxyethane sterilizing box and carry out sterilizing, independent subpackage process.
Further, the technological process of described step 3 is as follows: the titanium alloy powder adopting 10 ~ 60 μm of normal distributions, and product is printed thickness and is set to 0.015 ~ 0.05mm, edge compensation is set to 0.02 ~ 0.08mm; Support that printing thickness is set to 0.015 ~ 0.05mm; Additional outlines arranges inside or outside 1-5, and distance is set to 0.02 ~ 0.1mm; Adopt island pattern, XY direction size is set to 0.5 ~ 10mm, and angle is 0 ~ 180 degree, and XY side-play amount is 0 ~ 5mm.
Further, the detailed process flow of described step 4 is as follows: by step 3) the printing screw that obtains heat-treats, under argon shield condition; 840 degree are warmed up in 4 hours; keep 2 hours, in stove, be then cooled to 500 degree of taking-ups, naturally cool to room temperature.
This utility model additionally provides the application of above-mentioned porous bone screw in the material of preparation reparation osseous tissue damage.Be generally used for Fracture internal fixaiion, internal fixation of spine, prosthese hold-down screw.
Advantage of the present utility model and beneficial effect as follows:
(1) titanium alloy has good biocompatibility, is a kind of good embedded material; Can reasonably be designed the mechanical property of porous titanium alloy screw by the parameter such as porosity, pore size, pore-size distribution, space pattern that controls porous titanium alloy screw and mate, make it, in the bone of human body different parts, there is suitable mechanical property.
(2) hole of porous bone screw of the present utility model is the microcellular structure be interconnected, and aperture is 200 μm-900 μm or 1100 μm-2500 μm, and porosity is 78%-92%.This pore structure and feature meet the requirement of Bone Ingrowth completely, are conducive to the transmission that body fluid is implanting.Osteoblast can be made to adhere to, break up and growth, allow osseous tissue to grow in the hole of porous bone screw simultaneously, bone-implant interfacial area is increased greatly, in addition the machinery between bone and loose structure is embedding to be acted on, make to form biological fixation between implant and osseous tissue, improve implant-bone interface bond strength.
(3) porous bone screw of the present utility model can coordinate the use of the adsorbable bone cement such as calcium phosphate, calcium sulfate, hydroxyapatite, is filled in by this type of material in porous bone screw hole, thus promotes integration and the growth of bone further.
(4), compared with conventional with this area 3D printing technique parameter, the technological parameter preparing porous bone screw of the present utility model employing substantially increases the precision of finished product.
Accompanying drawing explanation
Fig. 1 display has the structure chart of the porous bone screw of porous network and the helicitic texture be made up of the microcellular structure be interconnected; A: overall diagram, B: sectional view;
Fig. 2 display has the structure chart of the porous bone screw of the porous network be made up of the microcellular structure be interconnected; A: overall diagram, B: sectional view;
Fig. 3 display has the structure chart of the porous bone screw of porous network and the central entity be made up of the microcellular structure be interconnected; A: overall diagram, B: sectional view;
Fig. 4 display has the structure chart of the porous bone screw of porous network, central entity and the helicitic texture be made up of the microcellular structure be interconnected; A: overall diagram, B: sectional view.
Detailed description of the invention
Be described further below in conjunction with the concrete enforcement of accompanying drawing to porous bone screw of the present utility model.
The 3D that embodiment 1 one kinds has three-dimensional through loose structure prints bone screw
The 3D with three-dimensional through loose structure prints a bone screw, and this porous bone screw is made up of ailhead, rivet nut, the head of a nail; The porous network that rivet nut is made up of the microcellular structure be interconnected forms; Pore size is 200 μm, porosity is 78%.Shaft diameter scope is: 2mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, rivet nut length range is: 1cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.
The 3D that embodiment 2 one kinds has three-dimensional through loose structure prints bone screw
The 3D with three-dimensional through loose structure prints a bone screw, and this porous bone screw is made up of ailhead, rivet nut, the head of a nail; The porous network that rivet nut is made up of the microcellular structure be interconnected forms with the screw thread being positioned at porous network surface; Pore size is 600 μm, and porosity is 80%, and the diameter of rivet nut is 5mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, rivet nut length 5cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The hole shape of porous network is polyhedron, spheroid or irregularly shaped.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.
The 3D that embodiment 3 one kinds has three-dimensional through loose structure prints bone screw
The 3D with three-dimensional through loose structure prints a bone screw, and this porous bone screw is made up of ailhead, rivet nut, the head of a nail; The porous network that rivet nut is made up of central entity and the microcellular structure be interconnected being positioned at central entity outside forms; Porous network is independent of central entity surface and around central entity.The pore size of the microcellular structure be interconnected is 900 μm, and porosity is 92%, and the diameter of rivet nut is 8mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, and rivet nut length model is 10cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The hole shape of porous network is polyhedron, spheroid or irregularly shaped.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.
The 3D that embodiment 4 one kinds has three-dimensional through loose structure prints bone screw
The 3D with three-dimensional through loose structure prints a bone screw, and this porous bone screw is made up of ailhead, rivet nut, the head of a nail; The porous network that rivet nut is made up of central entity, the microcellular structure be interconnected that is positioned at central entity outside and the screw thread be positioned on porous network surface form; Porous network is independent of central entity surface and around central entity.The pore size of the microcellular structure be interconnected is 1100 μm, and porosity is 78%; The diameter of rivet nut is 3mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, and rivet nut length is 3cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The hole shape of porous network is polyhedron, spheroid or irregularly shaped.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.
The 3D that embodiment 5 one kinds has three-dimensional through loose structure prints bone screw
The 3D with three-dimensional through loose structure prints a bone screw, and this porous bone screw is made up of ailhead, rivet nut, the head of a nail, the decorative material be positioned on rivet nut surface; The porous network that described rivet nut is made up of central entity, the microcellular structure be interconnected that is positioned at central entity periphery and the screw thread be positioned on porous network surface form; Porous network is independent of central entity surface and around central entity; Decorative material is attached on screw thread and/or is attached on the Kong Zhu of loose structure.The pore size of the microcellular structure be interconnected is 1500 μm, and porosity is 80%, and the diameter of rivet nut is 7mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, and rivet nut length is 9cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The hole shape of porous network is polyhedron, spheroid or irregularly shaped.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.Decorative material includes but not limited to: natural polymer derived material, as collagen, fibrin, chitosan; Cell growth factor, as bone morphogenetic protein (BMP), basic fibroblast growth factor (bFGF), PDGF, VEGF; Poly-D-lysine; Polypeptides matter.
The 3D that embodiment 6 one kinds has three-dimensional through loose structure prints bone screw
Have a porous bone screw for three-dimensional through hole structure, this porous bone screw is made up of ailhead, rivet nut, the head of a nail, the decorative material be positioned on rivet nut surface; Described rivet nut is made up of central entity, the porous network being positioned at the three-dimensional through hole Structure composing of central entity periphery and the screw thread be positioned on porous network surface; Porous network is independent of central entity surface and around central entity; Decorative material is attached on screw thread and/or is attached on the Kong Zhu of loose structure.The pore size of three-dimensional through hole structure is 2000 μm, and porosity is 85%, and the diameter of rivet nut is 7mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, and rivet nut length is 9cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The hole shape of porous network is polyhedron, spheroid or irregularly shaped.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.Decorative material includes but not limited to: natural polymer derived material, as collagen, fibrin, chitosan; Cell growth factor, as bone morphogenetic protein (BMP), basic fibroblast growth factor (bFGF), PDGF, VEGF; Poly-D-lysine; Polypeptides matter.
The 3D that embodiment 7 one kinds has three-dimensional through loose structure prints bone screw
The 3D with three-dimensional through loose structure prints a bone screw, and this porous bone screw is made up of ailhead, rivet nut, the head of a nail, the decorative material be positioned on rivet nut surface; Described rivet nut is made up of central entity, the porous network being positioned at the three-dimensional through hole Structure composing of central entity periphery and the screw thread be positioned on porous network surface; Porous network is independent of central entity surface and around central entity; Decorative material is attached on screw thread and/or is attached on the Kong Zhu of loose structure.The pore size of three-dimensional through hole structure is 2500 μm, and porosity is 92%, and the diameter of rivet nut is 7mm.The cross sectional shape of rivet nut is multiple: circle, ellipse, triangle, square, polygon, and rivet nut length is 9cm.The head of a nail is entity structure, and cross sectional shape is multiple: can be circle, oval, square, triangle, polygon.The hole shape of porous network is polyhedron, spheroid or irregularly shaped.The raw materials of porous bone screw is medical metal material, bioceramic, medical macromolecular materials in human implantable.Medical metal material includes but not limited to titanium, titanium alloy.Decorative material includes but not limited to: natural polymer derived material, as collagen, fibrin, chitosan; Cell growth factor, as bone morphogenetic protein (BMP), basic fibroblast growth factor (bFGF), PDGF, VEGF; Poly-D-lysine; Polypeptides matter.
The preparation method of embodiment 8 porous bone screw
The present embodiment uses 3D printing technique, is that the porous bone screw described in embodiment 1-8 prepared by raw material with titanium alloy.Concrete operation step is as follows:
1) by proe Three-dimensional Design Software, set up the threedimensional model of porous matrix structure construction unit in a computer, build the construction unit key element that volume XYZ direction is 0.5 ~ 5mm, arranging pore size is 0.25 ~ 5mm, and porosity is 78-92%;
2) according to step 1) in three-dimensional construction unit, by magics Three-dimensional Design Software with construction unit filling, expansion screw core, screw core is generated as porous matrix structure;
3) according to step 2) in threedimensional model, adopt Concept laser Mlab metal material 3D printer, print screw.Technique conditional optimum configurations is as follows: the titanium alloy powder adopting 10 ~ 60 μm of normal distributions, and product is printed thickness and is set to 0.015 ~ 0.05mm, edge compensation is set to 0.02 ~ 0.08mm; Support that printing thickness is set to 0.015 ~ 0.05mm; Additional outlines arranges inside or outside 1-5, and distance is set to 0.02 ~ 0.1mm; Adopt island pattern, XY direction size is set to 0.5 ~ 10mm, and angle is 0 ~ 180 degree, and XY side-play amount is 0 ~ 5mm, and other conditional parameters are conveniently arranged;
4) by step 3) the printing screw that obtains heat-treats, under argon shield condition, is warmed up to 840 degree in 4 hours, keeps 2 hours, in stove, be then cooled to 500 degree of taking-ups, naturally cool to room temperature;
5) by step 4) the printing screw that obtains adopts Linear cut, cuts from work platforms;
6) by step 5) the printing screw that obtains adopts blasting treatment, and removing print surface glues molten unnecessary raw material;
7) by step 6) the printing screw that obtains adopts ultrasonic waves for cleaning, removing surface impurity;
8) above-mentioned screw is put into Epoxyethane sterilizing box and carry out sterilizing, independent subpackage process.
For the remarkable technique effect of the machined parameters generation that checking this utility model embodiment provides, inventors performed detailed contrast experiment.Concrete correction data is as shown in table 1.
Comparing of the technique effect that the machined parameters of table 1 the present embodiment obtains with conventional machining parameter
| The aperture of the three-dimensional through hole arranged | 200 | 600 | 900 | 1100 | 2500 |
| Effective aperture often under (μ advises m and adds) work parameter | 162 | 488 | 732 | 896 | 2049 |
| Effective aperture under excellent (μization M adds) work parameter | 198±8 | 596±17 | 894±24 | 1092±28 | 2413±31 |
(μM note): conventional machining parameter refers to machined parameters conventional in prior art, and the aperture value in table is the aperture average of the porous bone screw using the different conventional machining parameter of many groups to process; Optimizing machining technology parameter refers to the machined parameters that this utility model embodiment provides, corresponding aperture value is the aperture average of the porous bone screw using the different optimizing machining technology parameter of many groups to process, meanwhile, also show the error amount in the aperture under optimizing machining technology parameter in table.
From experimental result, at least from aperture this numerically, the aperture of the porous bone screw that the machined parameters using this utility model embodiment to provide processes is more close to the aperture of target three-dimensional, and precision provide at least 10%.
The performance of embodiment 9 porous bone screw
According to document (SL.Zhua et al.Effect of porous NiTi alloy on bone formation:acomparative investigation with bulk NiTi alloy for 15weeks in vivo, materalsscience and engineering C, 2008,28 (8): 1271-1275; Liu binds, porous titanium alloy pore size on the impact of new bone formation, master thesis) in the step that describes set up femur injury model, the situation of growing into of new bone after observing the porous bone screw implanting different porosities.Constant aperture is 600 μm, prepares the porous bone screw of different porosities according to the method for preceding embodiment, porosity is respectively 35%, 50%, 77%, 78%, 79%, 80%, 82%, 85%, 90%, 92%, 93%, 94%.Result shows, after the porous bone screw of porosity within the scope of 78%-92% is implanted, compared with the porous bone screw of other porositys, Bone Ingrowth amount is many, the bond strength at bone and screw material interface is strong, angiogenic growth amount is many.And the porous bone screw that porosity is 80% causes injury repairing effect best.
According to document (SL.Zhua et al.Effect of porous NiTi alloy on bone formation:acomparative investigation with bulk NiTi alloy for 15weeks in vivo, materals scienceand engineering C, 2008,28 (8): 1271-1275; Liu binds, porous titanium alloy pore size on the impact of new bone formation, master thesis) in the step that describes set up femur injury model, the situation of growing into of new bone after observing the porous bone screw implanting different pore size.Permanent porosity is 80%, prepare the porous bone screw of different pore size according to the method for preceding embodiment, pore size is respectively 10 μm, 30 μm, 50 μm, 100 μm, 200 μm, 300 μm, 500 μm, 600 μm, 800 μm, 900 μm, 1000 μm, 1100 μm, 1200 μm, 1500 μm, 2000 μm, 2500 μm, 2700 μm, 3000 μm.Result shows, after the porous bone screw of aperture within the scope of 200 μm-900 μm and 1100 μm-2500 μm is implanted, compared with the porous bone screw in other apertures, Bone Ingrowth amount is many, the bond strength at bone and screw material interface is strong, angiogenic growth amount is many.And the porous bone screw that aperture is 600 μm causes injury repairing effect best.
The above embodiment only have expressed several embodiment of the present utility model, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to this utility model the scope of the claims.It should be pointed out that for the person of ordinary skill of the art, without departing from the concept of the premise utility, can also make some distortion and improvement, these all belong to protection domain of the present utility model.Therefore, the protection domain of this utility model patent should be as the criterion with claims.
Claims (9)
1. the 3D with three-dimensional through loose structure prints a bone screw, and it is characterized in that, described bone screw comprises ailhead, rivet nut, the head of a nail; Described rivet nut comprises the porous network of the micropore formation be interconnected; The aperture of described porous network is 200 μm-900 μm or 1100 μm-2500 μm, and porosity is 78%-92%.
2. bone screw according to claim 1, is characterized in that, described rivet nut comprises central entity, and described porous network is positioned at the outside of described central entity.
3. bone screw according to claim 2, is characterized in that, described porous network is independent of described central entity surface and around described central entity.
4. bone screw according to claim 2, is characterized in that, described porous network is the porous area generated on the surface in described central entity.
5. the bone screw according to any one of claim 1-4, is characterized in that, described rivet nut comprises the screw thread be positioned on described porous network surface.
6. the bone screw according to any one of claim 1-4, is characterized in that, the hole shape of described porous network is polyhedron, spheroid or irregularly shaped.
7. bone screw according to claim 6, is characterized in that, described polyhedron is regular dodecahedron.
8. bone screw according to claim 1, is characterized in that, the raw materials of described bone screw is selected from following group: medical metal material, bioceramic, medical macromolecular materials.
9. bone screw according to claim 8, is characterized in that, described medical metal material is titanium alloy.
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| US10993753B2 (en) | 2018-05-09 | 2021-05-04 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
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Effective date of registration: 20180801 Address after: 100730 Wangfujing, Dongcheng District, Dongcheng District, Beijing Patentee after: Beijing Xiehe Hospital, Chinese Academy of Medical Sciences Address before: 100730 Peking Union Medical College Hospital, 1 Shuai Fu Garden, Dongcheng District, Beijing. Patentee before: Wu Zhihong |