CN204129005U - Electrolyte analyzer and biological chemistry in-vitro diagnosis equipment - Google Patents
Electrolyte analyzer and biological chemistry in-vitro diagnosis equipment Download PDFInfo
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- CN204129005U CN204129005U CN201420603969.3U CN201420603969U CN204129005U CN 204129005 U CN204129005 U CN 204129005U CN 201420603969 U CN201420603969 U CN 201420603969U CN 204129005 U CN204129005 U CN 204129005U
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Abstract
The utility model discloses a kind of electrolyte analyzer and biological chemistry in-vitro diagnosis equipment.Described electrolyte analyzer includes sample introduction cup, by the titer container that titer draw-off pump is connected with the entrance point conducting of described sample introduction cup, the electrode box be connected with the endpiece conducting of described sample introduction cup, the sampling pump be connected with described electrode box conducting and waste fluid container, ion-selective electrode measurement components is provided with in described electrode box, the endpiece of described sample introduction cup is directly connected to the entrance point of described electrode box by conduit, described sampling pump is by the endpiece of tubes connection to described electrode box, and detector of liquid is provided with on the pipeline between the endpiece and sampling pump of described electrode box.The utility model structure is simplified, volume is little, cost-saving, failure rate is low, is more suitable for being integrated in the outer diagnostic device of large-scale biochemical precursor; And be more conducive to the calibration operation and the accuracy rate of raising draw-off pump calibration, the stability improving system and the precision that simplify draw-off pump.
Description
Technical field
The utility model relates to biological chemistry in-vitro diagnosis apparatus field, particularly relates to a kind of electrolyte analyzer and biological chemistry in-vitro diagnosis equipment.
Background technology
Electrolyte analyzer is a kind of based on ion-selective electrode method and piezometric method, detects the extracorporeal diagnostic instrument of potassium ion, sodion, chlorion, ionized calcium (PH) from sample.Tested sample can be whole blood, serum, blood plasma, urine, dislysate and hydrating fluid etc.And ion-selective electrode to be a class utilize that membrane potential measures the activity of effects of ion or the electrochemical sensor of concentration, when it with containing when contacting until the solution of measured ion, the phase interface of its sensitive membrane and solution produces the membrane potential directly relevant with this ion activity.Utilize above-mentioned ion-selective electrode to the optionally voltage responsive of the ion in tested sample, the concentration of corresponding ion in sample can be calculated by measuring voltage.
Along with the continuous progress of automatic technology, extracorporeal diagnostic instrument is more and more rapidly towards at a high speed and the future development of miniaturization.And rely on the advantages such as easy to operate, quick based on the electrolyte analyzer of ion-selective electrode method, be widely used in clinical examination field.Meanwhile, high-speed intelligent and miniaturization are also the developing direction of electrolyte analyzer.While the function and performance of assurance device, by optimal design, simplify structure, not only cost-saving, and the failure rate of effective lowering apparatus, be an important goal of electrolyte analysis research.
In the electrolyte analysis module of prior art, except including sample introduction cup, except the critical piece such as measuring unit that draw-off pump, liquid container, control module, data acquisition circuit, the ion-selective electrode be placed in electrode box are formed, also need at least to include the detector liquid that two or more are located at electrode box two ends, draw-off pump is coordinated by detector liquid, use corresponding algorithm to calibrate draw-off pump, carry out electrolytical analysis on this basis.
There is following shortcoming in this electrolyte analysis module of two or more detector liquid that needs: volume ratio is comparatively large, complicated structure, is not easy to be integrated in the outer diagnostic device of large-scale biochemical precursor; Fluid path relative complex, after long-time use, the failure rate of easy increase equipment.
Utility model content
The technical matters that the utility model solves is, provides a kind of electrolyte analyzer, and this apparatus structure is simplified, volume is little, cost-saving, failure rate is low, is more suitable for being integrated in the outer diagnostic device of large-scale biochemical precursor; And be more conducive to the calibration operation and the accuracy rate of raising draw-off pump calibration, the stability improving system and the precision that simplify draw-off pump.
The technical matters that the utility model is further solved is, provide a kind of biological chemistry in-vitro diagnosis equipment, this device structure is simplified, volume is little, cost-saving, failure rate is low; And be more conducive to the calibration operation and the accuracy rate of raising draw-off pump calibration, the stability improving system and the precision that simplify draw-off pump.
In order to solve the problems of the technologies described above, the utility model discloses following scheme:
A kind of electrolyte analyzer, include sample introduction cup, by the titer container that titer draw-off pump is connected with the entrance point conducting of described sample introduction cup, the electrode box be connected with the endpiece conducting of described sample introduction cup, the sampling pump be connected with described electrode box conducting and waste fluid container, ion-selective electrode measurement components is provided with in described electrode box, the endpiece of described sample introduction cup is directly connected to the entrance point of described electrode box by conduit, described sampling pump is by the endpiece of tubes connection to described electrode box, and detector of liquid is provided with on the pipeline between the endpiece and sampling pump of described electrode box.
Preferably, described detector of liquid is arranged on the pipeline of the exit position of described electrode box.
Preferably, described titer draw-off pump and sampling pump are located on same level line side by side.
Preferably, described electrode box is located at the top of described titer draw-off pump side by side and sampling pump.
Preferably, described titer container includes the first titer container and the second titer container, described titer draw-off pump include the first titer draw-off pump and the second titer draw-off pump accordingly.
Preferably, described first titer container, the second titer container, waste fluid container are arranged side by side in the same horizontal line, and are connected with described first titer draw-off pump, the second titer draw-off pump, sampling pump respectively by curvilinear conduit.
Preferably, the bottom of described sample introduction cup is inverted cone-shaped structure, and the endpiece of sample introduction cup is located at the bottom of described back taper, and the upper water mean place of described back taper and the upper water mean place of described electrode box concordant.
Preferably, also data acquisition circuit is provided with in described electrode box.
Preferably, described data acquisition circuit includes the signal amplification circuit, filtering circuit and the A/D convertor circuit that are electrically connected successively.
Correspondingly, the invention also discloses a kind of biological chemistry in-vitro diagnosis equipment, include electrolyte analysis module, described electrolyte analysis module is electrolyte analyzer as above.
The beneficial effects of the utility model are:
Embodiment of the present utility model is by the pipeline only between electrode box and sampling pump arranges liquid sensor, thus decrease the quantity of liquid sensor, simplify structure, reduced volume, saved cost and reduced failure rate, be more suitable for being integrated among the outer diagnostic device of large-scale biochemical precursor; And reach the calibration operation and the accuracy rate improving draw-off pump calibration, the raising stability of system and the effect of precision that are more conducive to simplify draw-off pump.
Accompanying drawing explanation
In order to be illustrated more clearly in the utility model embodiment or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of an electrolyte analyzer of the present utility model embodiment.
Fig. 2 is the fluid path structural representation of an electrolyte analyzer of the present utility model embodiment.
Embodiment
An embodiment of the electrolyte analyzer that the utility model provides is described in detail below with reference to Fig. 1 and Fig. 2, as shown in the figure, the present embodiment mainly includes sample introduction cup 1, by the titer container 3 that titer draw-off pump 2 is connected with the entrance point conducting of described sample introduction cup 1, the electrode box 4 be connected with the endpiece conducting of described sample introduction cup 1, the sampling pump 5 be connected with the conducting of described electrode box 4 and the waste fluid container 6 be connected with the conducting of described sampling pump 5, ion-selective electrode measurement components (not shown) is provided with in described electrode box 4, wherein, the endpiece of described sample introduction cup 1 is directly connected to the entrance point of described electrode box 4 by conduit, described sampling pump 5 is by the endpiece of tubes connection to described electrode box 4, and detector of liquid 7 is provided with on the pipeline between the endpiece and sampling pump 5 of described electrode box 4.
During specific implementation, described detector of liquid 7 can be arranged on the pipeline of the exit position of described electrode box 4.
Further, described titer draw-off pump 2, sampling pump 5 are located on same level line side by side.
Further, described electrode box 2 can be located at the top of described titer draw-off pump 2 side by side and sampling pump 5.
Further, described titer container 3 can specifically include for the first titer container 31 of accommodating A titer and described titer draw-off pump 2 includes the first titer draw-off pump Pa and the second titer draw-off pump Pb with may correspond to for the second titer container 32 of accommodating B standard liquid.
Further, described first titer container 31, second titer container 32, waste fluid container 6 are arranged side by side in the same horizontal line, and are connected with described first titer draw-off pump Pa, the second titer draw-off pump Pb, sampling pump Pc respectively by curvilinear conduit.
Above-mentioned each parts arrange according to its structural stratification, and mutually isostructural arrangement of parts is in the setting of same layer, compared with the dispersed arrangement structure of prior art, greatly can increase space of effectively arranging, reduce small product size.
Further, the bottom of described sample introduction cup 1 can be set to inverted cone-shaped structure, and the endpiece of sample introduction cup 1 is located at the bottom of described back taper, and the upper water mean place of described back taper is concordant with the upper water mean place of described electrode box 4; The entrance point of described electrode box 4 and endpiece are then located on two sides bottom it respectively.
In addition, the present embodiment also can include control module (not shown) and data acquisition circuit (not shown).Described control module is used for controlling the workflow of whole system; Described data acquisition circuit specifically can include the signal amplification circuit, filtering circuit and the A/D convertor circuit that are electrically connected successively.During specific implementation, described data acquisition circuit can be located in described electrode box 4.
During specific implementation, each draw-off pump in the present embodiment can adopt at least one pump configuration arbitrarily such as peristaltic pump, straightway pump or vacuum pump.
Calibrating principle and the calibration steps of each draw-off pump in the present embodiment are described below in detail.
In the present embodiment, the length connecting conduit between sample introduction cup 1 and electrode box 4 is that internal diameter that determine, conduit is determined, thus can determine the internal capacity of this conduit; In addition, the liquid capacity in electrode box 4 is also determined.Therefore, sample introduction cup 1 is confirmable to the pipe volume V of liquid sensor 7.
Based on above-mentioned, the present embodiment can utilize liquid sensor 7, coordinates the stepper motor in draw-off pump, adopts following step and algorithm, calibrate draw-off pump:
During system initialization, sampling pump 5 works, the pipeline between emptying sample introduction cup 1 to liquid sensor 7;
After initialization, the first titer draw-off pump Pa works, and rotates a known step number steps1, injects a certain amount of A titer to sample introduction cup 1;
Sampling pump 5 works, and liquid sensor 7 detects the position whether having liquid to arrive liquid sensor 7 simultaneously, when detecting that liquid arrives liquid sensor 7, records the turned step number steps2 of current sampling pump 5;
Sampling pump 5 is rotated further, and liquid sensor 7 detects the position whether air arrives liquid sensor 7 simultaneously, when detecting that air arrives liquid sensor 7, records the turned step number steps3 of current sampling pump 5;
Calculate according to above data, pump amount corresponding to sampling pump 5 single step is:
Pump amount corresponding to the first titer draw-off pump Pa single step is:
Use the calibration steps identical with above-mentioned first titer draw-off pump Pa can calibrate the second titer draw-off pump Pb, repeat no more.
Compared with prior art, the present embodiment has the following advantages:
Simplify structure, reduced volume, saved cost, thus be more suitable for being integrated among large-scale biochemistry and immune instrument;
Use the sample adding system of main equipment, simplified the structure of whole equipment on the one hand, reduced integral device cost, improve application of sample efficiency and precision on the other hand;
Calibration steps accurately easy to use can be calibrated by each draw-off pump, the stability and precision improving system is very helpful.
In addition, in the sample introduction scheme of prior art, be adopt structure of reversing valve mostly, carry out the application of sample of two kinds of titers.This loading schemes fluid path is complicated, and long-time use easily causes reversal valve aged deterioration, increases the failure rate of instrument.
And two kinds of titers in the present embodiment pump into sample introduction cup from front end in pump liquid mode respectively by two titer draw-off pumps, then by sampling pump from rear end with drawing liquid mode suction measuring chamber.This structure, without the need to adopting reversal valve, also eliminates complicated fluid path structure, also reduces failure rate.
Be described below in detail an embodiment of the biological chemistry in-vitro diagnosis equipment that the utility model provides, the present embodiment mainly includes electrolyte analysis module.During specific implementation, the electrolyte analysis module of the present embodiment can adopt the electrolyte analyzer described in previous embodiment, repeats no more.
Above content is in conjunction with concrete preferred implementation further detailed description of the utility model, can not assert that concrete enforcement of the present utility model is confined to these explanations.For the utility model person of an ordinary skill in the technical field, without departing from the concept of the premise utility, some simple deduction or replace can also be made, all should be considered as belonging to protection domain of the present utility model.
Claims (10)
1. an electrolyte analyzer, include sample introduction cup, by the titer container that titer draw-off pump is connected with the entrance point conducting of described sample introduction cup, the electrode box be connected with the endpiece conducting of described sample introduction cup, the sampling pump be connected with described electrode box conducting and waste fluid container, ion-selective electrode measurement components is provided with in described electrode box, it is characterized in that, the endpiece of described sample introduction cup is directly connected to the entrance point of described electrode box by conduit, described sampling pump is by the endpiece of tubes connection to described electrode box, and detector of liquid is provided with on the pipeline between the endpiece and sampling pump of described electrode box.
2. electrolyte analyzer as claimed in claim 1, it is characterized in that, described detector of liquid is arranged on the pipeline of the exit position of described electrode box.
3. electrolyte analyzer as claimed in claim 1 or 2, it is characterized in that, described titer draw-off pump and sampling pump are located on same level line side by side.
4. electrolyte analyzer as claimed in claim 3, is characterized in that, described electrode box is located at above described titer draw-off pump side by side and sampling pump.
5. electrolyte analyzer as claimed in claim 4, it is characterized in that, described titer container includes the first titer container and the second titer container, described titer draw-off pump include the first titer draw-off pump and the second titer draw-off pump accordingly.
6. electrolyte analyzer as claimed in claim 5, it is characterized in that, described first titer container, the second titer container, waste fluid container are arranged side by side in the same horizontal line, and are connected with described first titer draw-off pump, the second titer draw-off pump, sampling pump respectively by curvilinear conduit.
7. electrolyte analyzer as claimed in claim 6, it is characterized in that, the bottom of described sample introduction cup is inverted cone-shaped structure, and the endpiece of sample introduction cup is located at the bottom of described back taper, and the upper water mean place of described back taper and the upper water mean place of described electrode box concordant.
8. electrolyte analyzer as claimed in claim 7, is characterized in that, be also provided with data acquisition circuit in described electrode box.
9. electrolyte analyzer as claimed in claim 8, it is characterized in that, described data acquisition circuit includes the signal amplification circuit, filtering circuit and the A/D convertor circuit that are electrically connected successively.
10. a biological chemistry in-vitro diagnosis equipment, includes electrolyte analysis module, it is characterized in that, described electrolyte analysis module is electrolyte analyzer as claimed in any one of claims 1-9 wherein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420603969.3U CN204129005U (en) | 2014-10-17 | 2014-10-17 | Electrolyte analyzer and biological chemistry in-vitro diagnosis equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420603969.3U CN204129005U (en) | 2014-10-17 | 2014-10-17 | Electrolyte analyzer and biological chemistry in-vitro diagnosis equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204129005U true CN204129005U (en) | 2015-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420603969.3U Active CN204129005U (en) | 2014-10-17 | 2014-10-17 | Electrolyte analyzer and biological chemistry in-vitro diagnosis equipment |
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| Country | Link |
|---|---|
| CN (1) | CN204129005U (en) |
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2014
- 2014-10-17 CN CN201420603969.3U patent/CN204129005U/en active Active
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