CN204122099U - A kind of Preparation equipment of medicine intermediate - Google Patents
A kind of Preparation equipment of medicine intermediate Download PDFInfo
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- CN204122099U CN204122099U CN201420264662.5U CN201420264662U CN204122099U CN 204122099 U CN204122099 U CN 204122099U CN 201420264662 U CN201420264662 U CN 201420264662U CN 204122099 U CN204122099 U CN 204122099U
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- chamber
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- extraction
- recrystallization
- stir
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Abstract
The utility model, provides a kind of Preparation equipment of medicine intermediate, relates to medicine intermediate technical field.It comprises reactor, and reactor comprises three, the upper, middle and lower independently reaction chamber be communicated with by valve, and top reaction chamber is stir chamber, and middle part reaction chamber is extraction chamber, and bottom reaction chamber is attached most importance to crystallization cavity; Stir chamber is provided with the first charging aperture, and the sidewall of stir chamber and the sidewall of reactor are configured to temperature control cavity; Be provided with the first three-way valve between extraction chamber and stir chamber, a port of the first three-way valve is connected with the first discharge pipe; Extraction top, chamber is provided with the second charging aperture, and be provided with the second three-way valve between extraction chamber and recrystallization chamber, a port of the second three-way valve is connected with the second discharge pipe; Recrystallization chamber is provided with the 3rd charging aperture and the 3rd discharging opening.The utility model can provide independent hybrid reaction, extraction, recrystallization or filter operation, also can complete and need these operations of coordinating arbitrarily of operation separately.
Description
Technical field
The utility model relates to medicine intermediate technical field, specifically, relates to a kind of Preparation equipment of medicine intermediate.
Background technology
So-called medicine intermediate, is actually some for some industrial chemicals in medicine synthesis process or chemical products.This chemical products, do not need the production licence of medicine, can produce in common chemical plant, as long as reach the rank of some, namely can be used for the synthesis of medicine.China about needs the raw material supporting with chemical industry and intermediate kind more than 2000 every year, and demand reaches more than 2,500,000 tons.Through the development of more than 30 years, the industrial chemicals needed for China's medicine production and intermediate substantially can be supporting, only have small part to need import.And due to china natural resources abundanter, the prices of raw and semifnished materials are lower, have many intermediates to achieve a large amount of outlet.
In the production process of medicine intermediate, need multiple hybrid reaction repeatedly, extraction, recrystallization and filter operation, on current market, when carrying out above operation, different equipment is normally utilized to carry out having coordinated above step, this just adds production cost undoubtedly, and too much equipment also can take more space.Such as, at (1S, 3aR, in the production of 6aS)-octahydro cyclopenta [c] pyrroles-1-carboxylic acid tert-butyl ester oxalates, just need to carry out repeatedly various mixing, extraction, recrystallization and filter operation to plurality of raw materials, need to adopt the existing weaponry and equipment of multiple types to cooperatively interact and can complete these operations, this will increase the cost of suitability for industrialized production.
Summary of the invention
Content of the present utility model is to provide a kind of Preparation equipment of medicine intermediate, and it can overcome certain or some defect of prior art.
According to the Preparation equipment of a kind of medicine intermediate of the present utility model, it comprises reactor, and reactor comprises three, the upper, middle and lower independently reaction chamber be communicated with by valve, and top reaction chamber is stir chamber, middle part reaction chamber is extraction chamber, and bottom reaction chamber is attached most importance to crystallization cavity; Stir chamber is provided with the first charging aperture, and the sidewall of stir chamber and the sidewall of reactor are configured to temperature control cavity; Be provided with the first three-way valve between extraction chamber and stir chamber, a port of the first three-way valve is connected with the first discharge pipe; Extraction top, chamber is provided with the second charging aperture, and be provided with the second three-way valve between extraction chamber and recrystallization chamber, a port of the second three-way valve is connected with the second discharge pipe; Recrystallization chamber is provided with the 3rd charging aperture and the 3rd discharging opening.
Reactor of the present utility model comprises three, the upper, middle and lower independently reaction chamber be communicated with by valve, these three reaction chambers from upper and write be followed successively by stir chamber, extraction chamber and recrystallization chamber, this structural design, make the utility model can possess hybrid reaction, extraction and recrystallization function simultaneously, when adopting the utility model to carry out medicine intermediate production, again do not need loaded down with trivial details various equipment, greatly save production cost.Stir chamber can also be provided with multiple first charging aperture, this design makes the utility model can to satisfy the demand the production of the different multiple medicine intermediate of raw material type.The connecting pipe of extraction chamber and stir chamber can also be provided with the first three-way valve, a port of the first three-way valve can also be connected with the first discharge pipe, this makes the utility model in actual production process, reacted material in stir chamber can be selected to enter extraction chamber by control first three-way valve to carry out extracting operation or directly enter the reaction of next step, considerably increase applicability of the present utility model.The sidewall of stir chamber and the sidewall of reactor can also be configured to temperature control cavity, and in the manufacture process of medicine intermediate, some hybrid reaction needs to carry out under certain temperature conditions, can be good at by temperature control cavity the reaction temperature adjusting stir chamber.
Top, extraction chamber of the present utility model can also be provided with multiple second charging aperture, can drop into extractant or solution to be extracted, this utility model is possessed independent extraction function by these charging apertures in extraction chamber.The second three-way valve is provided with between extraction chamber and recrystallization chamber, a port of the second three-way valve is connected with the second discharge pipe, this makes the utility model in actual production process, recrystallization chamber can be entered carry out recrystallization operation by the material after extraction in control second three-way valve slective extraction chamber or directly enter the reaction of next step, considerably increase applicability of the present utility model.Chamber can also be provided with the 3rd charging aperture and the 3rd discharging opening to recrystallization, can adjust by the 3rd charging aperture the PH that enters recrystallization luminal solution or add and treat recrystallization solution in recrystallization chamber, making the utility model can also possess the function of recrystallization separately.
In a preferred embodiment of the present utility model, the structure in extraction chamber can adopt and be similar to the patent No. for structure disclosed in 201110184659.3.
In a preferred embodiment of the present utility model, the structure in recrystallization chamber can adopt and be similar to the patent No. for structure disclosed in 201320714332.7.
As preferably, in stir chamber, be provided with paddle.
Also paddle is provided with in stir chamber of the present utility model, the blade of paddle can also be provided with multiple projection, obtain material by the stirring action of paddle in reaction chamber, react more quick, complete, the multiple projections on blade can also increase the stirring area of blade, increase stirring efficiency.
As preferably, the first charging aperture comprises gas-phase feed mouth and liquid phase feeding mouth.
The utility model can be filled with nitrogen by gas-phase feed mouth to stir chamber, and the existence of nitrogen makes the reaction of material in stir chamber in a stable environment, and the raw material avoided in some medicine intermediate production process exposes oxidized in atmosphere.
As preferably, the bottom in recrystallization chamber is provided with filter chamber, and filter chamber is provided with on-off valve with the connecting pipe in recrystallization chamber, and filter chamber is provided with the 4th discharging opening.
The bottom in recrystallization chamber of the present utility model can also be provided with filter chamber, after needing to filter material in the production process of some medicine intermediate, carry out recrystallization operation again after being dissolved by residue in filter cake, this structure just can be good at meeting this demand.And the existence of filter chamber also made the utility model possess filter function.
As preferably, in temperature control cavity, be provided with heater and temperature-detecting device.
The utility model temperature control cavity can also be provided with trash ice input port and dewatering outlet, and this structure makes the utility model most stir chamber can carry out ice bath operation.The existence of temperature-detecting device makes the temperature conditions known in stir chamber that user can be real-time, thus determines whether to meet reaction requirement.Heater can be the resistance wire round stir chamber peripheral distribution, and this makes the utility model can carry out heating operation to stir chamber fast.
As preferably, the quantity of liquid phase feeding mouth is M, wherein, and 2≤M≤5.
Accompanying drawing explanation
Fig. 1 is the structural representation of the Preparation equipment of a kind of medicine intermediate in embodiment 1;
Fig. 2 is the sectional view of Fig. 1.
Detailed description of the invention
For understanding content of the present utility model further, in conjunction with the accompanying drawings and embodiments the utility model is described in detail.
Embodiment 1
As shown in Figure 1 and Figure 2, for the Preparation equipment of a kind of medicine intermediate of the present embodiment, it comprises reactor 100, reactor 100 comprises three, the upper, middle and lower independently reaction chamber be communicated with by valve, top reaction chamber is stir chamber 110, middle part reaction chamber is extraction chamber 120, and bottom reaction chamber is attached most importance to crystallization cavity 130; Stir chamber 110 is provided with the first charging aperture, and the sidewall of stir chamber 110 and the sidewall of reactor 100 are configured to temperature control cavity 140; The port being provided with the first three-way valve 114, first three-way valve 114 between extraction chamber 120 and stir chamber 110 is connected with the first discharge pipe 115; Extraction top, chamber 120 is provided with the second charging aperture 121, and the port being provided with the second three-way valve 122, second three-way valve 122 between extraction chamber 120 and recrystallization chamber 130 is connected with the second discharge pipe 123; Recrystallization chamber 130 is provided with the 3rd charging aperture 131 and the 3rd discharging opening 132.
In this enforcement, be provided with paddle 113 in stir chamber 110, the blade surface of paddle 113 is equipped with multiple protruding 200.First charging aperture comprises gas-phase feed mouth 111 and liquid phase feeding mouth 112.The quantity of liquid phase feeding mouth 112 can be any one in 2 ~ 5, and in the present embodiment, the quantity of liquid phase feeding mouth 112 is only illustrate 1 in 2, figure.The bottom in recrystallization chamber 130 is provided with filter chamber 150, and filter chamber 150 is provided with on-off valve 151 with the connecting pipe in recrystallization chamber 130, and filter chamber 150 is provided with the 4th discharging opening 152.Heater and temperature-detecting device is provided with in temperature control cavity 140.First three-way valve 114, second three-way valve 122 and on-off valve 151 are magnetic valve.
When user uses the Preparation equipment of a kind of medicine intermediate of the present embodiment to carry out hybrid reaction operation, only need material to drop in stir chamber 110 by liquid phase feeding mouth 112, by paddle 113, stirring is carried out to it and get final product complete operation.Material after hybrid reaction flows out in the first discharge pipe 115 by arranging the first three-way valve 114.Paddle 113 is connected by shaft coupling with external motive device, is servomotor, illustrates not shown in the present embodiment.Can also select whether temperature control or nitrogen filled protection measure are carried out to stir chamber according to the reaction condition of carried out hybrid reaction by temperature control cavity 140 and gas phase charging aperture 111.The heater arranged in temperature control cavity 140 in the present embodiment is the heating wire (not shown) around stir chamber 110 peripheral distribution, and temperature-detecting device is thermometer (not shown).
When user uses the Preparation equipment of a kind of medicine intermediate of the present embodiment to carry out hybrid reaction and extracting operation, only need material reacted in stir chamber 110 to flow in extraction chamber 120 can carry out extracting operation by arranging the first three-way valve 114.
User use the Preparation equipment of a kind of medicine intermediate of the present embodiment carry out hybrid reaction, extraction and recrystallization operation time, only need by the second three-way valve 122 by extraction chamber 120 in material flow into recrystallization chamber 130 in can complete.
User use the Preparation equipment of a kind of medicine intermediate of the present embodiment carry out hybrid reaction, extraction, recrystallization and filter operation time, only need by on-off valve 151, the material in recrystallization chamber 130 to be flowed in filter chamber 150 and can complete filter operation.Material after filtration flows out from the 4th discharging opening 152.
By adopting the Preparation equipment of a kind of medicine intermediate of the present embodiment, user can carry out independent hybrid reaction, extraction, recrystallization or filter operation, also can complete and need these any operations coordinated of operation separately.The utility model is applicable to the synthesis of multiple medicine intermediate, and operation strategies is wide, and production cost is low.
Schematically above be described the utility model and embodiment thereof, this description does not have restricted, and also just one of the embodiment of the present utility model shown in accompanying drawing, actual structure is not limited thereto.So, if those of ordinary skill in the art enlightens by it, when not departing from the utility model and creating aim, design the frame mode similar to this technical scheme and embodiment without creationary, protection domain of the present utility model all should be belonged to.
Claims (4)
1. the Preparation equipment of a medicine intermediate, it is characterized in that: comprise reactor (100), reactor (100) comprises three, the upper, middle and lower independently reaction chamber be communicated with by valve, top reaction chamber is stir chamber (110), middle part reaction chamber is extraction chamber (120), and bottom reaction chamber is attached most importance to crystallization cavity (130); Stir chamber (110) is provided with the first charging aperture, and the sidewall of stir chamber (110) and the sidewall of reactor (100) are configured to temperature control cavity (140); Be provided with the first three-way valve (114) between extraction chamber (120) and stir chamber (110), a port of the first three-way valve (114) is connected with the first discharge pipe (115); Extraction chamber (120) top is provided with the second charging aperture (121), be provided with the second three-way valve (122) between extraction chamber (120) and recrystallization chamber (130), a port of the second three-way valve (122) is connected with the second discharge pipe (123); Recrystallization chamber (130) is provided with the 3rd charging aperture (131) and the 3rd discharging opening (132); Paddle (113) is provided with in stir chamber (110), the bottom of recrystallization chamber (130) is provided with filter chamber (150), filter chamber (150) is provided with on-off valve (151) with the connecting pipe of recrystallization chamber (130), and filter chamber (150) is provided with the 4th discharging opening (152); First three-way valve (114), the second three-way valve (122) and on-off valve (151) are magnetic valve.
2. the Preparation equipment of a kind of medicine intermediate according to claim 1, is characterized in that: the first charging aperture comprises gas-phase feed mouth (111) and liquid phase feeding mouth (112).
3. the Preparation equipment of a kind of medicine intermediate according to claim 1, is characterized in that: temperature control cavity is provided with heater and temperature-detecting device in (140).
4. the Preparation equipment of a kind of medicine intermediate according to claim 2, is characterized in that: the quantity of liquid phase feeding mouth (112) is M, wherein, and 2≤M≤5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420264662.5U CN204122099U (en) | 2014-05-22 | 2014-05-22 | A kind of Preparation equipment of medicine intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420264662.5U CN204122099U (en) | 2014-05-22 | 2014-05-22 | A kind of Preparation equipment of medicine intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204122099U true CN204122099U (en) | 2015-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420264662.5U Expired - Fee Related CN204122099U (en) | 2014-05-22 | 2014-05-22 | A kind of Preparation equipment of medicine intermediate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204122099U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112619575A (en) * | 2020-10-13 | 2021-04-09 | 峨眉山宏昇药业股份有限公司 | Medicine intermediate preparation facilities |
-
2014
- 2014-05-22 CN CN201420264662.5U patent/CN204122099U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112619575A (en) * | 2020-10-13 | 2021-04-09 | 峨眉山宏昇药业股份有限公司 | Medicine intermediate preparation facilities |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150128 Termination date: 20160522 |