CN204089598U - A kind of high-voltage power apparatus of capillary electrophoresis chip - Google Patents
A kind of high-voltage power apparatus of capillary electrophoresis chip Download PDFInfo
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Abstract
The utility model provides a kind of high-voltage power apparatus of capillary electrophoresis chip, and it comprises relay array device, and high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor that order is arranged; Described high-pressure installation connects described relay array device; Described microprocessor arranges input unit and output port.Adopt such scheme, the utility model improves existing high-voltage power apparatus, provides the high-voltage power apparatus being applicable to capillary electrophoresis chip, can reduce volume further, improves the stability that voltage exports, has very high using value.
Description
Technical field
The utility model relates to, in particular, and a kind of high-voltage power apparatus of capillary electrophoresis chip.
Background technology
Capillary Electrophoresis (Capillary Electrophoresis, CE) chip is an important component part of microfluidic system (Microfluidic System), has that cost is low, sample consumption is few, analysis speed is fast, sensitivity advantages of higher.It is split tunnel with minisize capillary pipe, take DC high-voltage power supply as power, applies voltage at split tunnel two ends, and realize being separated according to the characteristic difference of sample, such as, characteristic comprises electric charge, quality, polarity, affinity size etc.Due to the needs that capillary electrophoresis chip testing and analysis system is microminiaturized, integrated, the high-voltage direct current (DC) power system of, function-stable little in the urgent need to volume.
Partial monopoly discloses capillary electrophoresis chip and adopts DC high-voltage power supply to carry out the method for powering, such as, the high-voltage power apparatus CN100498272C of capillary electrophoresis chip discloses a kind of microfluid control chip capillary electrophoresis analysing device and the using method thereof that automatically can carry out liquid replacing, and this device forms by with the microcurrent controlled capillary tube electrophoresis chip of integrated probe, coupon array automatic liquid changing system, high voltage source and detection system four part.In analytic process, integration probe and electrode are by certain hour in solution in coupon breach immersion coupon, under high voltage drive, the solution in coupon enters in chip microchannel through integrated probe, completes electrophoresis sample introduction, separation and detection operation.
And for example, the high-voltage power apparatus CN100427944C of capillary electrophoresis chip discloses one piece of three-dimensional wick pipe array electrophoresis microchip containing multiple capillary electrophoresis separation unit, one with minipump as the Ngatively pressurized sampling of negative pressure source and the device be separated, a high-voltage DC power supply and a laser fluorescence detection system.Only just can complete the multiple parallel analysis of array chip capillary electrophoresis analysis system with a micro flow control chip negative pressure sampling with the device be separated and a high-voltage DC power supply to measure.
But these patents are all use ready-made high-voltage power apparatus substantially, lack and carry out designing, adjusting according to CE chip feature.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of high-voltage power apparatus of new capillary electrophoresis chip.
The technical solution of the utility model is as follows: a kind of high-voltage power apparatus of capillary electrophoresis chip, comprise supply unit protecting sheathing, be arranged on the relay array device in protecting sheathing, and by accumulation power supply module that wire connects, high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor, supply unit, charging module, DC boosting supply module, alarm module, system protection module, first silicon carbide MOSFET pipe of series connection and the second silicon carbide MOSFET pipe, the source electrode of the first silicon carbide MOSFET pipe is connected with the drain electrode of the second silicon carbide MOSFET pipe, the source ground of the second silicon carbide MOSFET pipe, supply unit, its high-pressure side is connected with the drain electrode of the first silicon carbide MOSFET pipe, low-pressure end ground connection, one storage capacitor, its one end is connected with the high-pressure side of supply unit, other end ground connection, transformer, one end of its primary coil is connected between the source electrode of the first silicon carbide MOSFET pipe and the drain electrode of the second silicon carbide MOSFET pipe, other end ground connection, and the two ends of its secondary coil form output, first photoelectrical coupler, its light-receiving device is connected through the gate pole of the first gate driver with the first silicon carbide MOSFET pipe, with the second photoelectrical coupler, its light-receiving device is connected through the gate pole of the second gate driver with the second silicon carbide MOSFET pipe, described high-pressure installation connects described relay array device, described microprocessor arranges input unit and output port.
Preferred version, described high-voltage power apparatus, also arranges a buffer before described high-pressure installation.
Preferred version, also arranges the display unit be connected with described microprocessor.
Preferred version, also arranges the digital to analog converter be connected with described microprocessor.
Preferred version, described high-voltage power apparatus, described microprocessor adopts ARM microprocessor.
Preferred version, described high-voltage power apparatus, described analog to digital converter is integrated to be arranged in described microprocessor.
Preferred version, described high-voltage power apparatus, described accumulation power supply module comprises storage capacitor unit, quick solid switch element, heat-exchange system composition.
Preferred version, described high-voltage power apparatus, described supply unit is divided into three tunnels, is connected respectively with charging power supply module, DC boosting supply module, supply unit detection module by unidirectional serial port.
Preferred version, described high-voltage power apparatus, described relay array device arranges GRL2412 high pressure dry-reed relay.
Preferred version, described high-voltage power apparatus, described relay array device arranges Darlington transistor.
Adopt such scheme, the utility model improves existing high-voltage power apparatus, provides the high-voltage power apparatus being applicable to capillary electrophoresis chip, can reduce volume further, improves the stability that voltage exports, has very high using value.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of an embodiment of the present utility model;
Fig. 2 is the schematic diagram of another embodiment of the present utility model;
Fig. 3, Fig. 4 are respectively the relay array electrical block diagram of an embodiment of the present utility model.
Embodiment
For the ease of understanding the utility model, below in conjunction with the drawings and specific embodiments, the utility model is described in detail.Give preferred embodiment of the present utility model in this specification and accompanying drawing thereof, but the utility model can realize in many different forms, is not limited to the embodiment described by this specification.On the contrary, provide the object of these embodiments be make the understanding of disclosure of the present utility model more comprehensively thorough.
It should be noted that, when a certain element is fixed on another element, comprise and this element is directly fixed on this another element, or this element is fixed on this another element by least one other element placed in the middle.When an element connects another element, comprise and this element is directly connected to this another element, or this element is connected to this another element by least one other element placed in the middle.
The utility model is based on portability, the consideration such as reliability and fail safe, design adopts the high-voltage power apparatus for capillary electrophoresis chip of integrated high voltage device, as shown in Figure 1, a kind of high-voltage power apparatus of capillary electrophoresis chip, comprise supply unit protecting sheathing, be arranged on the relay array device in protecting sheathing, and by accumulation power supply module that wire connects, high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor, supply unit, charging module, DC boosting supply module, alarm module, system protection module, first silicon carbide MOSFET pipe of series connection and the second silicon carbide MOSFET pipe, the source electrode of the first silicon carbide MOSFET pipe is connected with the drain electrode of the second silicon carbide MOSFET pipe, the source ground of the second silicon carbide MOSFET pipe, supply unit, its high-pressure side is connected with the drain electrode of the first silicon carbide MOSFET pipe, low-pressure end ground connection, one storage capacitor, its one end is connected with the high-pressure side of supply unit, other end ground connection, transformer, one end of its primary coil is connected between the source electrode of the first silicon carbide MOSFET pipe and the drain electrode of the second silicon carbide MOSFET pipe, other end ground connection, and the two ends of its secondary coil form output, first photoelectrical coupler, its light-receiving device is connected through the gate pole of the first gate driver with the first silicon carbide MOSFET pipe, with the second photoelectrical coupler, its light-receiving device is connected through the gate pole of the second gate driver with the second silicon carbide MOSFET pipe, described high-pressure installation connects described relay array device, described microprocessor arranges input unit and output port.
Preferred version, described high-voltage power apparatus, also arranges a buffer before described high-pressure installation.
Preferred version, also arranges the display unit be connected with described microprocessor.
Preferred version, also arranges the digital to analog converter be connected with described microprocessor.
Preferred version, described high-voltage power apparatus, described microprocessor adopts ARM microprocessor.
Preferred version, described high-voltage power apparatus, described analog to digital converter is integrated to be arranged in described microprocessor.
Preferred version, described high-voltage power apparatus, described accumulation power supply module comprises storage capacitor unit, quick solid switch element, heat-exchange system composition.
Preferred version, described high-voltage power apparatus, described supply unit is divided into three tunnels, is connected respectively with charging power supply module, DC boosting supply module, supply unit detection module by unidirectional serial port.
Preferred version, described high-voltage power apparatus, described relay array device arranges GRL2412 high pressure dry-reed relay.
Preferred version, described high-voltage power apparatus, described relay array device arranges a Darlington transistor embodiment of the present utility model, a kind of high-voltage power apparatus of capillary electrophoresis chip, it comprises relay array device, and high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor that order is arranged, and namely high-pressure installation connects filtering and amplifying circuit, filtering and amplifying circuit connection mode number converter, analog to digital converter connects microprocessor; Described high-pressure installation connects described relay array device; Described microprocessor arranges input unit and output port.Wherein, described high-pressure installation, i.e. high-voltage power apparatus, by 24V DC power supply, output voltage range is 0 ~ 5000V, and output current is 0 ~ 0.25mA.Preferably, arrange voltage monitoring end and high-voltage output end proportionate relationship is 1:1000, the output voltage range of adjustable side is 0 ~ 5V, and is linear corresponding relation; The High voltage output of 0 ~ 5V voltage control, the 0 ~ 5000V namely exported by low pressure adjustable side, and for voltage control and High voltage output be linear corresponding relation.Preferably, described high-pressure installation arranges indicating device, is used to indicate described linear corresponding relation and current output voltage.Preferably, described indicating device arranges a LCD display and control circuit thereof.Preferably, on the integrated surface being arranged at described high-pressure installation of described LCD display.Preferably, described high-pressure installation arranges shell body, wherein arranges vacant district, described vacant district arranges two parallel sliding trays, and described LCD display is slidably mounted in the sliding tray in described vacant district, and is fixed by a clamping part buckle, like this, installation and removal are easy to.
Wherein, described relay array device connects outside capillary electrophoresis chip, and preferably, described high-voltage power apparatus also comprises described capillary electrophoresis chip.Preferably, in described system, described relay array device arranges GRL2412 high pressure dry-reed relay.Preferably, described relay array device arranges Darlington transistor.When carrying out capillary electrophoresis chip and analyzing, needing between the liquid storage tank at sample intake passage two ends to apply certain voltage, simultaneously in order to prevent sample solution to the diffusion of split tunnel two ends, also will apply certain voltage between the liquid storage tank at split tunnel two ends.After sample introduction process completes, split tunnel two ends need to apply higher voltage to make sample separation, and the two ends of sample intake passage also need to keep certain voltage to limit the sample size of sample simultaneously.Therefore, voltage switching is the key ensureing sample feeding amount fast and accurately, and the utility model, in order to improve speed and the automaticity of voltage switching, adopts relay array to realize the switching of electrode.Because the output voltage of high-voltage power apparatus is up to 5000V, maximum output current is 0.25mA, and for safety, selected parameter will retain certain surplus.Therefore, preferably, described relay array adopts GRL2412 type high pressure dry-reed relay.Its rated voltage is 24V, and adhesive upper and lower bound voltage is respectively 18V, 4V, and the maximum current of high-voltage output end is 10A, and breakdown voltage is 15kV.Such as, microprocessor adopts the MCU of STM32 series; But, due to the GPIO mouth of STM32 Series MCU
v oH =3.3V, so the normal adhesive that can not drive GRL2412, therefore, the utility model related embodiment adopts Darlington transistor as driving, and such as Darlington transistor adopts ULN2803 as driving chip to strengthen the GPIO driving force of MCU.
Wherein, described relay array device arranges relay array circuit, and preferably, each relay protection diode in parallel, when disconnecting to avoid relay coil, inductance coil produces very large inverse electromotive force infringement contact and punctures the collector junction of Darlington transistor.Such as, described relay array circuit structure as shown in Figure 3, which employs ULN2803 transistor, its pin 1 to pin 6 connects relay 1 to relay 6 successively, pin 7, pin 8, pin 11 are vacant with pin 12, pin 9 ground connection, pin 10 connects 24V DC power supply, and pin 13 to pin 18 connects each relay (RELAY1 and K1 connects together) respectively.As shown in Figure 3, in described relay array circuit, only use 6 high-voltage relays, so only need 6 GPIO mouths namely to control the break-make of high-voltage relay by ULN2803.Each ULN2803 has 8 tunnels to export, and therefore only needs a slice ULN2803 chip.Wherein diode
d 1 ~
d 6 for protection diode IN5819, when disconnecting to avoid relay coil, inductance coil produces very large inverse electromotive force infringement contact and punctures the collector junction of Darlington transistor, electrochemical capacitor in parallel
c 1 ,
c 2 for the power filter of 24V.As shown in Figure 3, high-voltage power apparatus has three high-voltage power apparatus HV1, HV2 and HV3, and in order to reduce the use of relay, the electrode using 6 high-voltage relays to complete whole sample introduction and separation process switches.As shown in Figure 4, HV_1, HV_2 and HV_3 represent three high-pressure installations respectively.Relay_1 ..., Relay_6 represents 6 relays respectively.1. 4 electrodes be inserted in 4 liquid storage tanks of capillary electrophoresis chip, 2., 3. and are 4. represented respectively.When starting sample introduction, Relay_1 and Relay_3 conducting, simultaneously in order to contain that sample solution is to the diffusion of separate channels two ends, Relay_4 and Relay_5 be conducting also, other relay cut-off.After sample introduction process completes, Relay_3 and Relay_5 ends, Relay_4 and Relay_6 conducting, and for making sample introduction raceway groove two ends still apply certain voltage, Relay_2 conducting, sample solution starts to be separated; Wherein, AGND is analog signal ground wire.
Preferably, described high-voltage power apparatus also arranges the display unit be connected with described microprocessor.Such as, described microprocessor arranges video output terminals, and described display unit connects described video output terminals; Preferably, described display unit is a LCD display; Preferably, described LCD display obtains power supply from described high-pressure installation; Preferably, the catercorner length of described LCD display is less than 7 cun.Preferably, described microprocessor arranges video output terminals, outputs to mobile terminal and shows.Preferably, described video output terminals is USB output, and it is connected to mobile phone; Preferably, described mobile phone is also comprised.In capillary electrophoresis chip detection system, take DC high-voltage power supply as power, sample introduction and split tunnel two ends apply certain voltage respectively and produce electroosmotic flow.Due to component each in sample solution the difference of electrically charged and quality, its translational speed is also different, therefore their to arrive time of detector also different, thus realize the separation of each component in sample.
Such as, the sample introduction of the Channel Capillary Electrophoresis chip of " ten " font, separation process are described as follows.In the sample introduction stage, left liquid storage tank 1, upper liquid storage tank 3, lower liquid storage tank 4 apply different voltage respectively, right liquid storage tank 2 ground connection.The left electromotive force at left liquid storage tank 1, upper liquid storage tank 3, lower liquid storage tank 4 place
u 1 , upper electromotive force
u 3 , lower electromotive force
u 4 be greater than the electromotive force at " cross " passage place
u j , and
u j higher than the right electromotive force at right liquid storage tank 2 place
u 2 .Due in passage everywhere electromotive force vary in size, the direction of electroosmotic flow be left, upper and lower current-sharing to the right.Sample solution is extruded at " cross " channel intersections and attenuates, and finally flows into liquid storage tank 2.Enter separation phase, due to the switching of electrode, make
u 3 be greater than
u j ,
u 1 ,
u 2 be less than
u j , and
u j be greater than
u 4 , now in passage, the direction of electroosmotic flow is that upper reaches is to left, down, right.The sample being positioned at " cross " passage intersection place is pushed into split tunnel, the solution remaining in sample intake passage is pressed to left liquid storage tank 1 and right liquid storage tank 2 simultaneously, avoids buffer solution again to flow into split tunnel and causes background noise.Therefore, in electrophoresis sample introduction and separation process the magnitude of voltage of each liquid storage tank and switch speed thereof be whole capillary electrophoresis chip analysis, detect in key factor, adopt this DC high-voltage power supply, can guarantee that the magnitude of voltage of each liquid storage tank and switch speed thereof meet the requirement in electrophoresis sample introduction and separation process.
And for example, in " cross " Channel Capillary Electrophoresis chip sample introduction process, should ensure that sample is full of whole sample intake passage, also require that sample can not be diffused into split tunnel, all these will rely on the voltage proportioning adjusting each liquid storage tank to realize.In separation process, first require that each liquid storage tank magnitude of voltage changes fast, ensure only to make the sample of crossing enter split tunnel, and the sample of sample intake passage returns to rapidly in corresponding liquid storage tank, does not produce conditions of streaking.As can be seen here, accurate voltage output, suitable voltage proportioning and magnitude of voltage switching are fast the keys that capillary electrophoresis chip realizes Accurate Analysis.Preferably, arrange " cross " passage sample introduction under different voltage proportioning, determine separation process effect corresponding with it, such as, voltage proportioning when folder sample is suitable is: during sample introduction,
u 1 =
u 4 =600V,
u 2 =0V,
u 3 =400V; During separation,
u 1 =
u 2 =600V,
u 3 =800V,
u 4 =0V.
Preferably, before described high-pressure installation, a buffer is also set, for filtering buffering, avoids the described high-voltage power apparatus of the excessive damage of immediate current.Such as, buffer comprises an operational amplifier LM358, for carrying out amplification filtering to the voltage signal of monitoring side.Preferably, described buffer also arranges the filter circuit be made up of electric capacity, inductance and resistance, and the fuse be connected with described filter circuit.Described fuse one end connects described filter circuit, and the other end connects described high-pressure installation.Preferably; one protective cover is also set; two containing cavities are wherein set; the accommodating described buffer of one, another accommodating described high-pressure installation, described protective cover is arranged display lamp and control circuit thereof; for when described fuse disconnects; described display lamp is lighted, and indicates described blown fuse, reminding user.
Preferably, as shown in Figure 2, another embodiment of the present utility model is, a kind of high-voltage power apparatus of capillary electrophoresis chip, it comprises relay array device, and buffer, high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor that order is arranged; Described high-pressure installation connects described relay array device; Described microprocessor arranges input unit and output port, and described microprocessor connects described display unit, described digital to analog converter respectively.Wherein, microprocessor is the core of whole described high-voltage power apparatus, preferably, buffer, high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor and digital to analog converter are linked in sequence, form a closed-loop system, the utility model and each embodiment thereof are controlled high-pressure installation by closed-loop system.After the signal of filtering and amplifying circuit to high-pressure installation monitoring side processes, voltage signal is delivered to ADC(Analog-to-Digital Converter, analog to digital converter), microprocessor compares according to the voltage of the magnitude of voltage preset with input ADC, by DAC(Digital-to-Analog Converter after process, digital to analog converter) by the output voltage of buffer control high-pressure installation.Such as, described digital to analog converter connects described buffer, by the output voltage of buffer control high-pressure installation.DAC for controlling the output voltage of high-pressure installation, the analog electrical output pressure-controlled high-pressure installation adjustable side of the 0-5V produced by DAC, thus produce the High voltage output of 0-5000V.
Because high-pressure installation is high frequency switch power, and the voltage exported from monitoring side is obtained by the sampling resistor of inside, the therefore inevitable ripple having high frequency that mixes in voltage, and then the voltage having influence on monitoring side exports.Utilize filtering and amplifying circuit not only can filtering high frequency ripple, the function of level range conversion can also be realized, meet ADC and normally work in full range, ensure the accuracy of ADC sampling.Preferably, based on the consideration of practicality and complexity two aspect, described filtering and amplifying circuit adopts second order Butterworth low pass wave circuit, such as, and the buffer that the previous stage of filter circuit is made up of amplifier LM358, monitoring side voltage signal
v dis the ADC of microprocessor internal is sent into after amplification filtering.The cut-off frequency of circuit is 1KHz, and passband voltage gain is 0dB.
Preferably, D/A converting circuit is adopted to be used for controlling the output voltage of high-pressure installation in digital to analog converter.Controlled the adjustable side of high-pressure installation by the analog output voltage of D/A converting circuit generation 0 ~ 5V, and then produce the linear High voltage output of 0 ~ 5000V.Preferably, the ADC of D/A converting circuit adopts the TLC5618A that Texas Instruments company produces.It is the D/A converter of two-way 12 cmos voltages outputs of a programmable band buffering benchmark input.Preferably, because the output voltage of TLC5618A and input reference voltage have direct relation,
v ref the minor fluctuations instability that TLC5618A just may be caused to export, and then make the output of high voltage source produce large fluctuation.Therefore the input reference voltage of integrated reference voltage source MC1403 as TLC5618A of high accuracy, low noise, Low Drift Temperature is adopted.Preferably, for reducing system noise to the impact of conversion accuracy, integrated reference voltage source MC1403's
v out pin is except connecting TLC5618A's
ref in outside pin, also by 0.1
μthe tantalum capacity earth of F.Preferably, MC1403
v in pin, except connecting VCC input, also passes through 1
μthe shunt capacitance ground connection of F, for the High-frequency Interference between filter out power and ground; And/or, TLC5618A's
vDDpin, except connecting VCC input, also passes through 1
μthe shunt capacitance ground connection of F, for the High-frequency Interference between filter out power and ground.
Preferably, in described high-voltage power apparatus, described microprocessor adopts ARM microprocessor.Preferably, in described high-voltage power apparatus, described analog to digital converter is integrated to be arranged in described microprocessor.Preferably, described high-voltage power apparatus also arranges the digital to analog converter be connected with described microprocessor.Preferably, described digital to analog converter is integrated is arranged in described microprocessor.Preferably, described high-voltage power apparatus also arranges DMA(Direct Memory Access, direct memory access) device, it adopts the data exchange mode without microprocessor directly from memory access data.In dma mode, microprocessor need only assign instruction to DMA device, and allow DMA device carry out the transmission of deal with data, Data Transfer Done gives microprocessor information feed back again, so just alleviate the resources occupation rate of microprocessor to a great extent, greatly can save system resource.Preferably, described DMA device is integrated is arranged in described microprocessor; Preferably, described microprocessor is STM32F103; And/or described analog to digital converter is TLC5618A.
Such as, adopt STM32F103 microprocessor as the core of whole system, STM32F series belongs to 32 intermediate size enhancement mode, based on the band 64K of ARM core or the microprocessor of 128K byte flash memory.It is a MCU in STMicw Electronics (ST) company STM32 series, and its inside has an Embedded ARM Cortex
tM-M3 kernel, with all ARM developing instruments and softwarecompatible.Its periphery configure main circuit will comprise power management, start configuration, clock generating, JTAG hardware debug and hardware reset circuit etc.Built-in ADC in STM32F103
The normal operating voltage of microprocessor is 3.3V, and usually external supply voltage is 5V, and therefore design adopts AMS1117 voltage conversion chip by 5V(VCC) be converted to 3.3V(VDD).In addition, STM32F103 has two clock generation circuits: the crystal oscillator of a 8MHz is as the clock source of MCU; The crystal oscillator of another 32KHz is as the clock source of RTC.Not only by code programming in the FLASH of chip, can also can be created conditions for the further debugging of program by JTAG debug circuit.
IAR development platform software is adopted to carry out the experimental design of described high-voltage power apparatus, in conjunction with the firmware library of STM32, achieve a series of functions such as D/A conversion, A/D conversion, keyboard scan, system display, relay array switching, voltage stabilizing and serial communication, software systems are write by C language, PC carries out compile, connect, after the emulator debug of ARM is errorless, is downloaded in the Flash of microprocessor and runs.In test process, respectively repetitious test is carried out to three road High voltage outputs.Set point is value entered from the keyboard, and regulated value is the magnitude of voltage that D/A converter exports after filtering, and output valve is actual High voltage output value.It is 1000:1:1000 that the Theory comparison of three closes.All meet expection between the set point that three road voltages export and output voltage deviate, maximum deflection difference value is 6V.With this, the manufacture actual product of described high-voltage power apparatus.
Time drift characteristic refer to that voltage exports relation over time, it weighs an important parameter of power source performance.For avoiding High voltage output passing in time and causing departing from of sample introduction and separation voltage, thus cause the inaccurate of testing result, characteristic test is floated when 10 times having been carried out to each road high pressure within the scope of the sample introduction that electrophoresis experiment needs and separation voltage, then average, the time of each test is one hour; During the high-voltage power apparatus that the utility model designs, drift is less than 1V, precision≤0.1%/h, has good stability, can meet the requirement of experiment completely.
Preferably, described high-voltage power apparatus also arranges the interface circuit be connected with described microprocessor, such as usb circuit or RS-232 interface circuit etc.Such as, RS-232 interface is adopted, for setting up data and the information exchange of ARM and PC.Like this, two effects can be reached: one be by download program that PC is debugged by IAR Embedded Workbench in the Flash of ARM, be that the data of preserving in the RAM by MCU are sent to PC by serial ports on the other hand, be convenient to draw and analyze.Like this, based on ARM9 embedded platform exploitation client, design microprocessor periphery configure interface circuit, under Visual C++ development environment, by graphic plotting function, achieve the analysis to system parameters, then finished product is manufactured experimently, test the main performance index of system and application, experimental result shows, system can meet the needs of capillary electrophoresis chip analytical test completely.
Further, embodiment of the present utility model also comprises, each technical characteristic of the various embodiments described above, the high-voltage power apparatus of the capillary electrophoresis chip be mutually combined to form.For reducing the stability of volume and the output of raising voltage further, adopting closed-loop system to control high-pressure installation and exporting; Utilize the resources such as the abundant I/O port of ARM microprocessor and built-in ADC to process voltage stabilizing algorithm, more in time high-pressure installation is adjusted, make High voltage output more stable; Use relay array to realize the automatic switchover of electrode, and on LCD, show current residing working stage and magnitude of voltage, be convenient to carry out real-time oversight to testing process.
High-voltage power apparatus also arranges radio source acquisition device, comprises and gets energy unit, energy management circuit and energy-storage battery; Described getting can comprise and get energy portion and adjusting portion by unit; Described get energy portion comprise main getting can coil, protective circuit, regulator rectifier circuit, storage capacitor; The main output getting energy coil connects the input of protective circuit, and the output of protective circuit connects the input of regulator rectifier circuit; The output of regulator rectifier circuit is connected with the input of preceding energy management circuit, and storage capacitor in parallel between the two; Described adjusting portion comprises status adjustment coil, major loop Energy Monitoring Circuit, controllable compensating load; Described status adjustment coil can be wound on same magnetic core by coil with main getting in the opposite direction, the input of major loop Energy Monitoring Circuit connects the aforementioned output getting the storage capacitor in energy portion, the output of major loop Energy Monitoring Circuit connects the input of controllable compensating load, the input of the output connection status regulating winding of controllable compensating load; The output of described energy management circuit connects the input of energy-storage battery and the load of peripheral hardware respectively.
It should be noted that, above-mentioned each technical characteristic continues combination mutually, is formed not in above-named various embodiment, is all considered as the scope that the utility model specification is recorded; Further, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection range that all should belong to the utility model claims.
Claims (10)
1. the high-voltage power apparatus of a capillary electrophoresis chip, it is characterized in that, comprise supply unit protecting sheathing, be arranged on the relay array device in protecting sheathing, and by accumulation power supply module that insulated conductor connects, high-pressure installation, filtering and amplifying circuit, analog to digital converter, microprocessor, supply unit, charging module, DC boosting supply module, alarm module, system protection module, first silicon carbide MOSFET pipe of series connection and the second silicon carbide MOSFET pipe, the source electrode of the first silicon carbide MOSFET pipe is connected with the drain electrode of the second silicon carbide MOSFET pipe, the source ground of the second silicon carbide MOSFET pipe, supply unit, its high-pressure side is connected with the drain electrode of the first silicon carbide MOSFET pipe, low-pressure end ground connection, one storage capacitor, its one end is connected with the high-pressure side of supply unit, other end ground connection, transformer, one end of its primary coil is connected between the source electrode of the first silicon carbide MOSFET pipe and the drain electrode of the second silicon carbide MOSFET pipe, other end ground connection, and the two ends of its secondary coil form output, first photoelectrical coupler, its light-receiving device is connected through the gate pole of the first gate driver with the first silicon carbide MOSFET pipe, with the second photoelectrical coupler, its light-receiving device is connected through the gate pole of the second gate driver with the second silicon carbide MOSFET pipe, described high-pressure installation connects described relay array device, described microprocessor arranges input unit and output port.
2. high-voltage power apparatus according to claim 1, is characterized in that, also arrange a buffer before described high-pressure installation.
3. high-voltage power apparatus according to claim 2, is characterized in that, also arranges the display unit be connected with described microprocessor.
4. high-voltage power apparatus according to claim 3, is characterized in that, also arranges the digital to analog converter be connected with described microprocessor.
5. high-voltage power apparatus according to claim 4, is characterized in that, described microprocessor adopts ARM microprocessor.
6. high-voltage power apparatus according to claim 5, it is characterized in that, described analog to digital converter is integrated to be arranged in described microprocessor.
7. high-voltage power apparatus according to claim 1, is characterized in that, described accumulation power supply module comprises storage capacitor unit, quick solid switch element, heat-exchange system composition.
8. high-voltage power apparatus according to claim 6, it is characterized in that, described supply unit is divided into three tunnels, is connected respectively with charging power supply module, DC boosting supply module, supply unit detection module by unidirectional serial port.
9. according to the arbitrary described high-voltage power apparatus of claim 1 to 8, it is characterized in that, described relay array device arranges GRL2412 high pressure dry-reed relay.
10. high-voltage power apparatus according to claim 9, it is characterized in that, described relay array device arranges Darlington transistor.
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|---|---|---|---|
| CN201420674955.0U Expired - Fee Related CN204089598U (en) | 2014-11-12 | 2014-11-12 | A kind of high-voltage power apparatus of capillary electrophoresis chip |
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| CN (1) | CN204089598U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102198936B1 (en) * | 2019-08-06 | 2021-01-05 | 경희대학교 산학협력단 | Micro-capillary electrophoresis system using step-up converter device |
| CN113565661A (en) * | 2021-07-23 | 2021-10-29 | 武汉天富海科技发展有限公司 | Electromagnetic valve drive control device of intelligent electric control booster pump |
-
2014
- 2014-11-12 CN CN201420674955.0U patent/CN204089598U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102198936B1 (en) * | 2019-08-06 | 2021-01-05 | 경희대학교 산학협력단 | Micro-capillary electrophoresis system using step-up converter device |
| CN113565661A (en) * | 2021-07-23 | 2021-10-29 | 武汉天富海科技发展有限公司 | Electromagnetic valve drive control device of intelligent electric control booster pump |
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