CN204086247U - A kind of animal sucks exposing device - Google Patents
A kind of animal sucks exposing device Download PDFInfo
- Publication number
- CN204086247U CN204086247U CN201420508169.3U CN201420508169U CN204086247U CN 204086247 U CN204086247 U CN 204086247U CN 201420508169 U CN201420508169 U CN 201420508169U CN 204086247 U CN204086247 U CN 204086247U
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- exposure chamber
- animal experiment
- transverse tube
- minitype
- insulation interlayer
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Abstract
The utility model relates to a kind of minitype animal experiment and sucks exposing device, can be used for pharmacology, toxicologic teaching and scientific research.This device has circulating water heat insulation interlayer in exposure chamber periphery, passes into warm water and exposure chamber temperature stabilization can be made in required level; Meanwhile, the transverse tube of fixing minitype animal experiment also insulation interlayer surrounded, and also can ensure that the body temperature of minitype animal experiment is stable.This device can carry out the toxicity on inhalation evaluation of compound when maintaining minitype animal experiment body temperature, compared with existing goods gasifying device, the less impact being subject to environment temperature factor of animal physiological index, has obvious advantage.
Description
Technical field
The utility model relates to a kind of animal experiment device capable, and especially a kind of animal with circulating water heat insulation interlayer sucks exposing device.Be mainly used in pharmacology, toxicologic teaching and scientific research, can be used for evaluating the toxicity on inhalation of various compound to minitype animal experiment.
Background technology
Had ripe commercialization to suck exposing device to the toxicity on inhalation evaluation of minitype animal experiment at present available, but these devices are many can not be maintained to the body temperature of minitype animal experiment.According to the literature, because minitype animal experiment body surface area is relatively large, therefore the variation of environment temperature can cause minitype animal experiment that obvious physiological responses occurs; And when ambient temperature changes too greatly, minitype animal experiment can be made very soon to lose the constancy of body temperature.Low temperature can cause the reproductive capacity of minitype animal experiment to decline, and premunition declines, and continuous high temperature also can cause very large injury.Therefore, when minitype animal experiment is restrained when sucking in exposing device, the spontaneous regulating power of body temperature weakens more, obviously will affect physical signs, interference experiment result once run into the larger change of environment temperature.
Summary of the invention
The technical problems to be solved in the utility model is: (1) maintains animal used as test body temperature; (2) gas to be measured or gasoloid evenly spread; (3) animal is made to suck experimental result accurately and reliably.
For solving the problems of the technologies described above, the technical scheme that the utility model adopts is as follows:
Animal of the present utility model sucks exposing device, comprises exposure chamber 6, transverse tube 3, circulating water heat insulation interlayer 2.The circulating water heat insulation interlayer 2 of this device is around whole exposure chamber 6, and the two is concentric double-layer barrel structure, and material is organic glass.Circulating water heat insulation interlayer 2, around whole exposure chamber 6, forms concentric double-layer barrel structure; Circulating water heat insulation interlayer 2 surrounds the six roots of sensation transverse tube 3 of fixing minitype animal experiment 5; Circulating water heat insulation interlayer 2 bottom surface has water inlet 8, and end face has water delivering orifice 1, the body temperature of the temperature in exposure chamber 6 and minitype animal experiment 5 can be kept to stablize after water inlet 8 passes into warm water.Exposure chamber 6 upper cover designs for helixseal; Exposure chamber 6 end face and bottom surface circle centre position are connected with draft tube 9 and escape pipe 7 respectively, and side radially arranges six roots of sensation transverse tube 3,60 °, interval; Described transverse tube 3 is hollow round table shape near one end of exposure chamber 6, the other end of transverse tube 3 is hollow cylinder, and with can the piston 4 of push-and-pull, minitype animal experiment 5 can be fixed to front touching piston 4 put into minitype animal experiment 5 in transverse tube 3 after, minitype animal experiment 5 snout is stretched out by transverse tube 3 round platform end, be exposed to exposure chamber 6, minitype animal experiment 5 tail end is fixed by piston 4.Six minitype animal experiments 5 are individually fixed in the six roots of sensation transverse tube 3 of lateral symmetry distribution, can improve conventional efficient, ensure that experimental result is effectively parallel.Gas to be measured or gasoloid import in exposure chamber 6 by draft tube 9, and 1 ~ 3cm place, draft tube 9 mouthfuls of tops is provided with 3 ~ 6 perspex bars and is connected with circular cover 10, evenly spreads along circular cover 10 times direction surroundings for gas to be measured or gasoloid., avoid exposing the effect that indoor gas produces violent convection current, the mouth and nose realizing minitype animal experiment 5 expose and suck simultaneously.
The beneficial effects of the utility model are, make exposure chamber 6 temperature stabilization in required level, ensure that the body temperature of minitype animal experiment 5 is stablized simultaneously, also gas to be measured in exposure chamber 6 or gasoloid even diffusion profile towards periphery naturally can be made, the gas to be measured that each animal is sucked or aerosol concentration parallel homogeneous, ensure suck expose experimental result accurately and reliably.
Accompanying drawing explanation
Fig. 1 is that animal sucks exposing device structural representation.
Fig. 2 is that animal sucks exposing device vertical view.
Fig. 3 is that animal sucks exposing device working state schematic representation.
Wherein: 1, water delivering orifice, 2, circulating water heat insulation interlayer, 3, transverse tube, 4, piston, 5, minitype animal experiment, 6, exposure chamber, 7, escape pipe, 8, water inlet, 9, draft tube, 10, circular cover, 11, aerosol generator, 12, absorption bottle, 13, sampling pump, 14, gas outlet, 15, flowmeter.
Embodiment
Describe concrete animal by Fig. 1, Fig. 2 and suck exposing device, comprise exposure chamber 6, transverse tube 3, circulating water heat insulation interlayer 2.The circulating water heat insulation interlayer 2 of this device is around whole exposure chamber 6, and the two is concentric double-layer barrel structure, and material is organic glass.Circulating water heat insulation interlayer 2, around whole exposure chamber 6, forms concentric double-layer barrel structure; Circulating water heat insulation interlayer 2 surrounds the six roots of sensation transverse tube 3 of fixing minitype animal experiment 5; Circulating water heat insulation interlayer 2 bottom surface has water inlet 8, and end face has water delivering orifice 1, the body temperature of the temperature in exposure chamber 6 and minitype animal experiment 5 can be kept to stablize after water inlet 8 passes into warm water.Exposure chamber 6 upper cover designs for helixseal; Exposure chamber 6 end face and bottom surface circle centre position are connected with draft tube 9 and escape pipe 7 respectively, and side radially arranges six roots of sensation transverse tube 3,60 °, interval; Described transverse tube 3 is hollow round table shape near one end of exposure chamber 6, the other end of transverse tube 3 is hollow cylinder, and with can the piston 4 of push-and-pull, minitype animal experiment 5 can be fixed to front touching piston 4 put into minitype animal experiment 5 in transverse tube 3 after, minitype animal experiment 5 snout is stretched out by transverse tube 3 round platform end, be exposed to exposure chamber 6, minitype animal experiment 5 tail end is fixed by piston 4.Six minitype animal experiments 5 are individually fixed in the six roots of sensation transverse tube 3 of lateral symmetry distribution, can improve conventional efficient, ensure that experimental result is effectively parallel.Gas to be measured or gasoloid import in exposure chamber 6 by draft tube 9,2cm place, draft tube 9 mouthfuls top has the circular cover 10 that 4 perspex bars support, gas to be measured in exposure chamber 6 or gasoloid even diffusion profile towards periphery naturally below circular cover 10 can be made, avoid exposing the effect that indoor gas produces violent convection current, the mouth and nose realizing minitype animal experiment 5 expose and suck simultaneously.
Embodiment 1
At room temperature 16 DEG C, extract the piston 4 of this device out, six mouse are put into transverse tube 3 respectively, piston 4 is inwardly gently pushed, is fixed well to mouse, till exposure chamber 6 is stretched at snout tip.Import the CO gas of variable concentrations subsequently from draft tube 9, start that mouth and nose are carried out to mouse and expose suction, start timing simultaneously, stop after 4 hours importing.Then extract piston 4 out, take out mouse, breeding observing symptom one week is record also.
At room temperature 16 DEG C, first constant temperature water bath, micro pump are connected to water inlet 8 and the water delivering orifice 1 of circulating water heat insulation interlayer 2, internally persistent loop passes into 35 DEG C of warm water.Extract the piston 4 of this device out, six mouse are put into transverse tube 3 respectively, piston 4 is inwardly gently pushed, is fixed well to mouse, till exposure chamber 6 is stretched at snout tip.Import the CO gas of variable concentrations subsequently from draft tube 9, start that mouth and nose are carried out to mouse and expose suction, start timing simultaneously, stop after 4 hours importing.Then extract piston 4 out, take out mouse, breeding observing symptom one week is record also.
Table 1 carbon monoxide exposes result (4h) to the Acute inhalation of mouse
As can be seen from Table 1, after this device implements 35 DEG C of insulations, the animal dead number that Acute inhalation exposes, than few when not implementing to be incubated, shows that this suction exposing device can reduce the impact of ambient temperature on experimental result.
Embodiment 2
As shown in Figure 3, first constant temperature water bath, micro pump are connected to water inlet 8 and the water delivering orifice 1 of circulating water heat insulation interlayer 2, internally persistent loop passes into 35 DEG C of warm water.Extract the piston 4 of this device out, six mouse are put into transverse tube 3 respectively, piston 4 is inwardly gently pushed, is fixed well to mouse, till exposure chamber 6 is stretched at snout tip.In aerosol generator 11, put into azacyclotin solution subsequently, concentration needs depending on experiment.Open aerosol generator 11 and sampling pump 13 simultaneously, start that mouth and nose are carried out to mouse and expose suction, start timing simultaneously.In process-exposed, note the valve of adjust flux meter 14 at any time, make extraction flow slightly larger than the delivery rate of aerosol generator 11, keep the slight negative pressure state in exposure chamber 6.Expose after 4 hours, close aerosol generator 11 and sampling pump 13 simultaneously, terminate to expose.Then extract piston 4 out, take out mouse, breeding observing symptom one week is record also.Take out the absorbing liquid in absorption bottle 12, carry out quantitative test, aerocolloidal concentration in exposure chamber can be calculated.After this experiment repeated several times, the symptom of contrast aerosol concentration and mouse, can calculate the acute inhalation toxicity of azacyclotin gasoloid to mouse.
Table 2 azacyclotin gasoloid exposes result (4h) to the Acute inhalation of mouse
Finally calculating azacyclotin gasoloid for the LC50 of mouse is 30.8mg/m
3.
Other gas or gasoloid suck the exposure of minitype animal experiment, also can be studied by similar method.
Claims (1)
1. animal sucks an exposing device, it is characterized in that: described animal sucks exposing device and comprises exposure chamber (6), transverse tube (3), circulating water heat insulation interlayer (2); Circulating water heat insulation interlayer (2), around whole exposure chamber (6), forms concentric double-layer barrel structure; Circulating water heat insulation interlayer (2) surrounds the six roots of sensation transverse tube (3) of fixing minitype animal experiment (5); Circulating water heat insulation interlayer (2) bottom surface has water inlet (8), and end face has water delivering orifice (1); Exposure chamber (6) upper cover designs for helixseal; Exposure chamber (6) end face and bottom surface circle centre position are connected with draft tube (9) and escape pipe (7) respectively, and side radially arranges six roots of sensation transverse tube (3), 60 °, interval; Described transverse tube (3) is hollow round table shape near one end of exposure chamber (6), the other end of transverse tube (3) is hollow cylinder, and with can the piston (4) of push-and-pull, put in transverse tube (3) minitype animal experiment (5) backward before touch piston (4) minitype animal experiment (5) can be fixed, minitype animal experiment (5) snout is stretched out by transverse tube (3) round platform end, be exposed to exposure chamber (6), minitype animal experiment (5) tail end is fixed by piston (4); Gas to be measured or gasoloid import in exposure chamber (6) by draft tube (9), above draft tube (9) mouth, 1 ~ 3cm place is provided with 3 ~ 6 perspex bars and is connected with circular cover (10), evenly spreads along direction surrounding under circular cover (10) for gas to be measured or gasoloid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420508169.3U CN204086247U (en) | 2014-09-05 | 2014-09-05 | A kind of animal sucks exposing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420508169.3U CN204086247U (en) | 2014-09-05 | 2014-09-05 | A kind of animal sucks exposing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204086247U true CN204086247U (en) | 2015-01-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420508169.3U Expired - Fee Related CN204086247U (en) | 2014-09-05 | 2014-09-05 | A kind of animal sucks exposing device |
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| Country | Link |
|---|---|
| CN (1) | CN204086247U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105136619A (en) * | 2015-07-29 | 2015-12-09 | 上海市浦东新区气象局 | Artificial climate environment exposure system and use method thereof |
-
2014
- 2014-09-05 CN CN201420508169.3U patent/CN204086247U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105136619A (en) * | 2015-07-29 | 2015-12-09 | 上海市浦东新区气象局 | Artificial climate environment exposure system and use method thereof |
| CN105136619B (en) * | 2015-07-29 | 2018-01-26 | 长三角环境气象预报预警中心（上海市环境气象中心） | A kind of artificial climate environmental exposure system and application process |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150107 Termination date: 20180905 |