CN204073484U - Metronidazole crystallization reaction still - Google Patents
Metronidazole crystallization reaction still Download PDFInfo
- Publication number
- CN204073484U CN204073484U CN201420554393.6U CN201420554393U CN204073484U CN 204073484 U CN204073484 U CN 204073484U CN 201420554393 U CN201420554393 U CN 201420554393U CN 204073484 U CN204073484 U CN 204073484U
- Authority
- CN
- China
- Prior art keywords
- kettle
- metronidazole
- kettle cover
- reaction still
- crystallization reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model relates to the reactor of preparative chemistry product, be specially a kind of metronidazole crystallization reaction still, comprise kettle 1 and kettle cover 2, described kettle cover 2 is provided with charging aperture 3, the middle part of kettle cover 2 is provided with the puddler 4 extend into bottom kettle 1, and the end of described puddler 4 is provided with paddle 5.Described kettle 1 forms mezzanine space 6, and described mezzanine space 6 is built with brine ice, and the top of described kettle 1 has import 7 and outlet 8; Described kettle 1 is provided with steam pipe coil 9 from top to bottom along its inwall, and the two ends of described steam pipe coil 9 pass by kettle cover 2.The utility model is reasonable in design, reactor is heated up by brine ice cooling and steam and realizes dual-use function simultaneously, solve the problem of existing reactor function singleness, effectively improve the crystalline rate of metronidazole.
Description
Technical field
The utility model relates to the reactor of preparative chemistry product, is specially a kind of novel metronidazole reactor.
Background technology
Metronidazole is white or yellowish crystallization or crystalline powder; Tablet is white or off-white color sheet, has micro-smelly, bitter and slightly salty.
The existing reactor for the preparation of metronidazole is generally popular response still, due in preparation process, metronidazole needs to carry out crystallization under 76 ± 2 DEG C of conditions, crystallization temperature can not fluctuate too large, otherwise affect crystallization effect and the output of metronidazole, but existing popular response still cannot keep the temperature stabilization of crystallizing system in the scope required.
Summary of the invention
The utility model can not maintain the problem of crystallizing system temperature constant in order to solve existing metronidazole reactor, provide a kind of novel metronidazole reactor.
The utility model adopts following technical scheme to realize:
A kind of metronidazole crystallization reaction still, comprise kettle and kettle cover, described kettle cover is provided with charging aperture, the bottom surface of described kettle is fox shape, and central authorities are provided with discharging opening, and the middle part of kettle cover is provided with the puddler extending into autoclave body bottom, the end of described puddler is provided with paddle, described kettle forms mezzanine space, and described mezzanine space is built with brine ice, and the top of described kettle has import and outlet; Described kettle is provided with steam pipe coil from top to bottom along its inwall, and the two ends of described steam pipe coil pass by kettle cover.
During work, crystallizing system injects reactor, first, in the mezzanine space of kettle, pass into brine ice, the crystallizing system in kettle is lowered the temperature, to within the scope of 76 ± 2 DEG C, when in crystallization process, after the temperature reduction of crystallizing system, stop passing into brine ice, in steam pipe coil, pass into steam, require temperature for crystallizing system is warming up to; After temperature rises to and requires temperature, stop passing into steam.Known, the temperature of reactor intercrystalline system is in the fluctuation cyclic process of decline-rising-decline all the time, by the cooling of brine ice and the thermogenic action of steam, make within the scope of its equilibrium temperature being in 76 ± 2 DEG C all the time, ensure that the crystallization process of metronidazole can carry out smoothly.
Compared with prior art tool has the following advantages:
1, metronidazole reactant liquor carries out in the process of decrease temperature crystalline, requires after below temperature if be cooled to, and by Steam Heating rapid temperature increases to requiring temperature, also can be cooled to rapidly simultaneously and requiring temperature, the effect possessing intensification simultaneously and lower the temperature.
2, reduce field operation operation, production efficiency is provided.
The utility model is reasonable in design, reactor is heated up by brine ice cooling and steam and realizes dual-use function simultaneously, solve the problem of existing reactor function singleness, effectively improve the crystalline rate of metronidazole.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
In figure, 1-kettle, 2-kettle cover, 3-charging aperture, 4-puddler, 5-paddle, 6-mezzanine space, 7-import, 8-exports, 9-steam pipe coil.
Detailed description of the invention
Below in conjunction with accompanying drawing, specific embodiment of the utility model is described in detail.
A kind of metronidazole crystallization reaction still, as shown in Figure 1, comprise kettle 1 and kettle cover 2, described kettle cover 2 is provided with charging aperture 3, the bottom surface of described kettle 1 is fox shape, and central authorities are provided with discharging opening 10, the middle part of kettle cover 2 is provided with the puddler 4 extend into bottom kettle 1, and the end of described puddler 4 is provided with paddle 5.During specific works, puddler 4 is driven by stirring motor and rotates, and for the stirring operation in metronidazole crystallization process, shortens the temperature fall time of reactant liquor, is conducive to crystallization.
Described kettle 1 forms mezzanine space 6, and described mezzanine space 6 is built with brine ice, and the top of described kettle 1 has import 7 and outlet 8; Described kettle 1 is provided with steam pipe coil 9 from top to bottom along its inwall, and the two ends of described steam pipe coil 9 pass by kettle cover 2.
The entrance point of described steam pipe coil 9 is provided with by-pass valve control; Control the amount entering steam, and then regulate the heating-up temperature to reactant liquor.Steam enters in coil pipe by inlet end, and after transferring heat, steam water interface is discharged by exporting the other end.
Upper inlet 7 place of described kettle 1 is provided with by-pass valve control; Control the amount entered of brine ice, and then control the cooling degree to reactant liquor.
By passing into and stopping of Valve controlling cryosel water and steam, realize heating up and cooling function, the temperature of reactor intercrystalline liquid is maintained in metastable OK range.
During concrete enforcement, described kettle 1 is connected by flange arrangement with kettle cover 2, ensures globality and the sealing of reactor.
Claims (4)
1. a metronidazole crystallization reaction still, comprise kettle (1) and kettle cover (2), described kettle cover (2) is provided with charging aperture (3), the bottom surface of described kettle (1) is fox shape, and central authorities are provided with discharging opening (10), the middle part of kettle cover (2) is provided with the puddler (4) extending into kettle (1) bottom, the end of described puddler (4) is provided with paddle (5), it is characterized in that: described kettle (1) forms mezzanine space (6), described mezzanine space (6) is built with brine ice, and the top of described kettle (1) has import (7) and outlet (8); Described kettle (1) is provided with steam pipe coil (9) from top to bottom along its inwall, and the two ends of described steam pipe coil (9) pass by kettle cover (2).
2. metronidazole crystallization reaction still according to claim 1, is characterized in that: described kettle (1) and kettle cover (2) are tightly connected by flange arrangement.
3. metronidazole crystallization reaction still according to claim 1 and 2, is characterized in that: the entrance point of described steam pipe coil (9) is provided with by-pass valve control; Upper inlet (7) place of described kettle (1) is provided with by-pass valve control.
4. metronidazole crystallization reaction still according to claim 1, is characterized in that: described discharging opening (10) goes out to be provided with valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420554393.6U CN204073484U (en) | 2014-09-25 | 2014-09-25 | Metronidazole crystallization reaction still |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420554393.6U CN204073484U (en) | 2014-09-25 | 2014-09-25 | Metronidazole crystallization reaction still |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204073484U true CN204073484U (en) | 2015-01-07 |
Family
ID=52166252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420554393.6U Active CN204073484U (en) | 2014-09-25 | 2014-09-25 | Metronidazole crystallization reaction still |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204073484U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111781108A (en) * | 2020-07-06 | 2020-10-16 | 西安交通大学 | System and method for testing crystallization-deposition of inorganic salt in subcritical/supercritical water |
-
2014
- 2014-09-25 CN CN201420554393.6U patent/CN204073484U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111781108A (en) * | 2020-07-06 | 2020-10-16 | 西安交通大学 | System and method for testing crystallization-deposition of inorganic salt in subcritical/supercritical water |
| CN111781108B (en) * | 2020-07-06 | 2021-07-27 | 西安交通大学 | System and method for testing crystallization-deposition of inorganic salt in subcritical/supercritical water |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN202136972U (en) | Reaction kettle waste heat utilization device | |
| CN103803584B (en) | Ammonium bifluoride preparation method | |
| CN204338161U (en) | A kind of temperature control reactor | |
| CN102060821A (en) | Chlorination method and device used in ethyl maltol production | |
| CN204073484U (en) | Metronidazole crystallization reaction still | |
| CN208865648U (en) | Crystallization reactor is used in a kind of production of novel chemical | |
| CN205361349U (en) | Alkali fusion cauldron with steam heating device | |
| CN201265013Y (en) | Xylose massecuite refrigeration water temperature-lowering device | |
| CN202376984U (en) | Reaction kettle | |
| CN204251354U (en) | A kind of energy-saving copper sulfate crystal tripping device | |
| CN201978736U (en) | Chlorination reaction device in production of ethyl maltol | |
| CN204815756U (en) | Concentrated crystallizer of potassium salt | |
| CN106215830A (en) | A kind of reaction unit of Biformyl oxidation synthesis glyoxylate | |
| CN103170155B (en) | Method for concentrating and crystallizing in reaction kettle | |
| CN205412995U (en) | Reation kettle is used in preparation of controllable temperature type inhibition antisludging agent | |
| CN103819732B (en) | Production device and method for epoxy plasticizer | |
| CN203778060U (en) | Novel adhesive reaction kettle | |
| CN201940221U (en) | Special reaction device for essence | |
| CN102895934A (en) | Improved cold and heat exchange reaction kettle | |
| CN106622030B (en) | A kind of vertical decompression cycles chemical reaction equipment | |
| CN206463952U (en) | A kind of hydrogenation reaction cauldron | |
| CN202173797U (en) | Methyl alcohol recovering and rectifying equipment for preparing acetylacetone calcium | |
| CN203498103U (en) | White carbon black thin pulp circulation type heat-exchange preparation system | |
| CN205216827U (en) | Concentrated reation kettle of cobaltous chloride | |
| CN204310987U (en) | A kind of system of refining oxalic acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |