CN203909049U - Detection system for biological chips - Google Patents
Detection system for biological chips Download PDFInfo
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- CN203909049U CN203909049U CN201420177093.0U CN201420177093U CN203909049U CN 203909049 U CN203909049 U CN 203909049U CN 201420177093 U CN201420177093 U CN 201420177093U CN 203909049 U CN203909049 U CN 203909049U
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Abstract
The utility model discloses a detection system for biological chips. The detection system comprises a movement execution system, a fluid control system, a temperature control system, a clean air knife device, a biological chip scanning system and a computer control system which are mounted in a system case, wherein the computer control system is used for controlling the movement execution system, the fluid control system, the temperature control system, the clean air knife device and the biological chip scanning system through electric connection. The detection system compactly integrates execution mechanisms and control devices into the small-sized case, realizes complete isolation and full-automatic execution in the detection process, completes all the detection steps of sample adding, rinsing, cleaning, warming, cooling down, scanning imaging and the like at one time, greatly reduces manual operation in the whole process, effectively improves detection accuracy, and is high in integration level, moderate in size, easy to transport or transfer, and suitable for various places of hospitals, research organizations and the like.
Description
Technical field
The utility model relates to a kind of medical treatment detection device, specifically a kind of biological chips detection system.
Background technology
The testing of biochip at present need to be through the operation of multiple step, comprise application of sample, washing, reaction, heat up, cooling, clean, scanning imagery etc., wherein relate to plurality of devices and instrument, make detection efficiency very low, and in pilot process again very easily because manual operation and environmental change affect testing result, old friends constantly make great efforts as a set of perfect detection system of biochip test work design always, thereby complete all process steps of testing process more conveniently, reduce substantially workload and man-hour and human operational error, and promote the control accuracy of testing result, increase work efficiency, saving reagent consumes.
In order to realize the normal operation of biological chips detection system, wherein need to use numerous operating equipments and detection, preparation facilities, and connect electronic-controlled installation and the computer control system etc. of controlling these operating equipments and detection, preparation facilities, therefore to improve the full-automation that machinery and automatically controlled two parts cooperating could correctly be reached testing process efficiently.In prior art, have some for carrying out the detection system of biochip, its mode using open-sky technique platform is as the platform of implementing biochip test, volume die takes up room more, also be difficult for mobile, in the course of work, sample can not directly complete all process steps on single equipment, needs staff secondary transfer sample to several processing apparatus, can not reach automatically working, and do not keep enough isolation with the external world all the time, easily testing result is impacted.
Utility model content
In order to overcome the deficiencies in the prior art, the utility model provides a kind of isolation high, realizes the biological chips detection system of batch detection in detection without people's manual manipulation sample and efficiently and accurately.
The utility model solves the technical scheme that its technical matters adopts:
A kind of biological chips detection system, it comprises the Motor execution system, fluid control systems, temperature control system, clean air blade device, biochip scanning system and the computer control system that are arranged in system chassis;
Described Motor execution system is by respectively along X-axis, the X-axis straight line executing mechanism that Y-axis and Z-direction arrange mutual vertically, Y-axis straight line executing mechanism and Z axis straight line executing mechanism composition, the fastening system chassis that is arranged on of described X-axis straight line executing mechanism is in Y direction one side, on X-axis straight line executing mechanism, be provided with first Mobile base that can move along X-direction, described Y-axis straight line executing mechanism is arranged on X-axis straight line executing mechanism top, one end of Y-axis straight line executing mechanism is fastenedly connected on described the first Mobile base, the other end of Y-axis straight line executing mechanism is provided with traversing carriage, system chassis is provided with the guide rail parallel with X-axis straight line executing mechanism at Y direction opposite side, the bottom of described traversing carriage is slidably mounted on described guide rail, X-axis straight line executing mechanism drives Y-axis straight line executing mechanism to move with portal frame form, on Y-axis straight line executing mechanism, be provided with second Mobile base that can move along Y direction, described Z axis straight line executing mechanism is arranged on described the second Mobile base from Y-axis straight line executing mechanism one side vertically, on Z axis straight line executing mechanism, be provided with the 3rd Mobile base that can move along Z-direction,
Described fluid control systems comprises several pony pumps for imbitition, with supporting for controlling the microflow-controlling valve of flow, and for delivery of liquid and connect the liquid-feeding tube of described pony pump and microflow-controlling valve, described pony pump and microflow-controlling valve are arranged on respectively on mounting box and installing plate, described mounting box and installing plate be fastenedly connected respectively on described the second Mobile base and the 3rd Mobile base on, on mounting box, be provided with the liquid bottles of several loading liquids, pony pump is connected respectively described liquid bottles and microflow-controlling valve by liquid-feeding tube, described installing plate bottom is provided with application of sample needle plate, connect concentrated being fixed on described application of sample needle plate of the liquid-feeding tube mouth of pipe of microflow-controlling valve,
Described temperature control system is made up of upper heating plate and lower heating plate that can be bonded to each other, one end of described upper heating plate and lower heating plate is hinged by turning gear, upper heating plate can rotate and folding with described turning gear, lower heating plate is fastenedly connected on system chassis, turning gear is arranged on the side of system chassis in X-direction, in turning gear, be provided with the motor that drives its rotation, the original position of described Y-axis straight line executing mechanism is set in the opposite side of system chassis in X-direction, upper heating plate and lower heating plate are provided with the electric pad for heating accordingly, the corresponding described electric heating of lower heating plate pay somebody's debt and expect repayment later be provided with many for laying the draw-in groove of biochip, and for detection of the temperature sensor of temperature, lower heating plate below is also provided with heating radiator,
Clean air blade device comprises the air knife that is arranged on described the 3rd Mobile base bottom, and is arranged on the air pump of described Y-axis straight line executing mechanism original position below, described air pump by tracheae be connected described air knife for controlling the electromagnetic switch valve that air-flow opens and closes;
Biochip scanning system comprises the video camera and the polishing apparatus that are arranged on described the 3rd Mobile base;
Computer control system is made up of display, computing machine, electric and electronic controller and actuation means, and computer control system is by electrical connection controlled motion executive system, fluid control systems, temperature control system, clean air blade device and biochip scanning system.
As the improvement of technique scheme, described system chassis is by carrying out cabinet and automatically controlled cabinet forms, described Motor execution system, fluid control systems, temperature control system, clean air blade device and biochip scanning system are installed in described execution cabinet, described computer control system is arranged in described automatically controlled cabinet, carry out cabinet and be provided with matchingly and can carry out the removable quick Wiring port group being connected by cable with automatically controlled cabinet, execution cabinet is also provided with door-opening mechanism that can folding.
As the further improvement of technique scheme, described door-opening mechanism is hinged on described execution cabinet rotationally, between door-opening mechanism and execution cabinet, is connected with air spring, carries out in cabinet and is provided with the fluorescent tube for throwing light on.
Further, described X-axis straight line executing mechanism, in Y-axis straight line executing mechanism and Z axis straight line executing mechanism, be provided with motor, and by motor-driven screw rod, described the first Mobile base, the second Mobile base and the 3rd Mobile base respectively with X-axis straight line executing mechanism, Y-axis straight line executing mechanism is connected with the screw rod of Z axis straight line executing mechanism, Y-axis straight line executing mechanism is also provided with first drag chain and second drag chain mobile for the protection of cable or tracheae etc., the two ends of described the first drag chain connect respectively Y-axis straight line executing mechanism and system chassis, described the second drag chain is arranged along Y-axis straight line executing mechanism, the two ends of the second drag chain connect respectively Y-axis straight line executing mechanism and described the second Mobile base.
Further, on described mounting box, be also provided with a waste liquid bottle for Recycling of waste liquid, drawing liquid pump and liquid pumping valve, with cleaning solution bottle and a clean liquid pump that is used to liquid-feeding tube to provide cleaning solution to clean, and several couplings are connected to the dual stop valve between described microflow-controlling valve and described pony pump, described waste liquid bottle connects drawing liquid pump by sewer pipe, described sewer pipe end after drawing liquid pump is fixed on described application of sample needle plate, described cleaning solution bottle connects described clean liquid pump by cleaning solution pipe, described dual stop valve is again connected in parallel, finally be linked into described liquid-feeding tube, described system chassis is provided with washer bottle, described washer bottle is positioned at described Y-axis straight line executing mechanism origin position below.
Further, the fastening bottom surface that is fitted in lower heating plate of electric pad of described lower heating plate, described temperature sensor is arranged on lower heating plate bottom surface central authorities, on lower heating plate, be also provided with the travel switch for controlling heating plate heating, and surround described draw-in groove and install the ring groove of elastic sealing strip additional, in draw-in groove, be provided with the dip plane of being convenient to take out biochip, described heating radiator is provided with several just fans to the blowing of lower heating plate bottom surface, and the corresponding described fan in described system chassis bottom arranges many air vents.
Further, described turning gear is hollow structure, and is provided with for passing through axle center hole and the cable-through hole of wire.
Further, between described air pump and described air knife, be also linked in sequence and be useful on the filtrator of filtered air particulate, with the air bag for storing compressed air, and for the pressure regulator valve of regulation output air pressure, described pressure regulator valve is also connected with the rain glass of real-time demonstration atmospheric pressure value.
Further, described air knife is set to wedge shape, and air knife tip and both sides end face are provided with several gas orifices that are arranged side by side and circulation port.
Further, described polishing apparatus is arranged on described video camera below, and the corresponding video camera of polishing apparatus is provided with lens and light source.
The beneficial effects of the utility model are: this product integrated level is high, the each topworks of compact integrated and control device are in small-sized machine box, the isolation completely realizing in testing process is carried out with full-automatic, once complete application of sample, clean, heat, all detecting steps such as scanning, greatly reduce the manual while of people of whole flow process, effectively improve and detect degree of accuracy, and its volume has been of moderate size, can easily transport or shift, be applicable in the multiple place such as hospital or research institution.
Brief description of the drawings
Below in conjunction with drawings and Examples, the utility model is further illustrated.
Fig. 1 is mounting structure schematic diagram of the present utility model;
Fig. 2 is the installment state structural representation of the utility model Motor execution system;
Fig. 3 is the installment state structural representation of another angle of the utility model Motor execution system;
Fig. 4 is the inner structure schematic diagram of the utility model X-axis straight line executing mechanism;
Fig. 5 is the inner structure schematic diagram of the utility model Y-axis straight line executing mechanism;
Fig. 6 is the installment state structural representation of the utility model fluid control systems;
Fig. 7 is the mounting box mounting structure schematic diagram of the utility model fluid control systems;
Fig. 8 is the installment state structural representation of the utility model temperature control system;
Fig. 9 is the cross-sectional view of heating plate under the utility model;
Figure 10 is the partial structurtes schematic diagram of the utility model turning gear;
Figure 11 is the installment state structural representation of the clean air blade device of the utility model and biochip scanning system;
Figure 12 is the installment state structural representation of the parts such as air pump in the clean air blade device of the utility model;
Figure 13 is the structural representation of the utility model air knife.
Embodiment
With reference to Fig. 1-Figure 13, a kind of biological chips detection system of the present utility model, it comprises the Motor execution system being arranged in system chassis 9, fluid control systems, temperature control system, clean air blade device, biochip scanning system and computer control system, described each system compact is integrated in system chassis 9 and concentrates and carry out every detection operation, make it have better protection can carry out overall movement or transport simultaneously, also control better the volume of detection system, thereby strengthen its applicability, system chassis 9 can arrange hatch door, or the structure such as window is to place biochip to system chassis 9,
Described Motor execution system is by respectively along X-axis, the X-axis straight line executing mechanism 11 that Y-axis and Z-direction arrange mutual vertically, Y-axis straight line executing mechanism 12 and Z axis straight line executing mechanism 13 form, the fastening system chassis 9 that is arranged on of described X-axis straight line executing mechanism 11 is in Y direction one side, on X-axis straight line executing mechanism 11, be provided with first Mobile base 111 that can move along X-direction, described Y-axis straight line executing mechanism 12 is arranged on X-axis straight line executing mechanism 11 tops, one end of Y-axis straight line executing mechanism 12 is fastenedly connected on described the first Mobile base 111, the other end of Y-axis straight line executing mechanism 12 is provided with traversing carriage 122, system chassis 9 is provided with the guide rail parallel with X-axis straight line executing mechanism 11 14 at Y direction opposite side, the bottom of described traversing carriage 122 is slidably mounted on described guide rail 14, X-axis straight line executing mechanism 11 drives Y-axis straight line executing mechanism 12 to move with portal frame form, on Y-axis straight line executing mechanism 12, be provided with second Mobile base 121 that can move along Y direction, described Z axis straight line executing mechanism 13 is arranged on described the second Mobile base 121 from Y-axis straight line executing mechanism 12 1 sides vertically, on Z axis straight line executing mechanism 13, be provided with the 3rd Mobile base 131 that can move along Z-direction, described the 3rd Mobile base 131 can arrive the interior space of system chassis 9 everywhere along with the movement of three topworkies, thereby realize the function that move in its space, be convenient to install fluid control systems and carry out application of sample operation in batches,
Described fluid control systems comprises several pony pumps 21 for imbitition, with supporting for controlling the microflow-controlling valve 22 of flow, and for delivery of liquid and connect the liquid-feeding tube 23 of described pony pump 21 and microflow-controlling valve 22, described pony pump 21 and microflow-controlling valve 22 are arranged on respectively on mounting box 241 and installing plate 242, described mounting box 241 and installing plate 242 be fastenedly connected respectively on described the second Mobile base 121 and the 3rd Mobile base 131 on, on mounting box 241, be provided with the liquid bottles 211 of several loading liquids, pony pump 21 is connected respectively described liquid bottles 211 and microflow-controlling valve 22 by liquid-feeding tube 23, described installing plate 242 bottoms are provided with application of sample needle plate 25, connect concentrated being fixed on described application of sample needle plate 25 of liquid-feeding tube 23 mouths of pipe of microflow-controlling valve 22, therefore whole fluid control systems is followed in real time Z axis straight line executing mechanism 13 and is moved, wherein all liquid-feeding tubes 23 just can not stretch because of the movement of application of sample needle plate 25 or swing, simultaneously described mounting box 241 and installing plate 242 and the liquid bottles 211 of respective numbers is installed in response to different demands, pony pump 21 and microflow-controlling valve 22, and connect corresponding liquid-feeding tube 23, realize accurately quick application of sample operation,
Described temperature control system is made up of upper heating plate 31 and lower heating plate 32 that can be bonded to each other, one end of described upper heating plate 31 and lower heating plate 32 is hinged by turning gear 33, upper heating plate 31 can rotate and folding with described turning gear 33, lower heating plate 32 is fastenedly connected on system chassis 9, turning gear 33 is arranged on the side of system chassis 9 in X-direction, in turning gear 33, be provided with the motor that drives its rotation, the original position of described Y-axis straight line executing mechanism 12 is set in the opposite side of system chassis 9 in X-direction, upper heating plate 31 and lower heating plate 32 are provided with the electric pad 34 for heating accordingly, the corresponding described electric pad 34 of lower heating plate 32 is also provided with many for laying the draw-in groove 321 of biochip, and for detection of the temperature sensor 35 of temperature, lower heating plate 32 belows are also provided with heating radiator 36, lower heating plate 32 is the operator's console that whole biochip test process is laid biochip, from being loaded onto heating again to scanning, the detection operation of biochip all completes on lower heating plate 32, in heating process, heating plate 31 closes to lower heating plate 32 with wheelwork 33, thereby realize Fast Heating temperature control,
Clean air blade device comprises the air knife 41 that is arranged on described the 3rd Mobile base 131 bottoms, and be arranged on the air pump 42 of described Y-axis straight line executing mechanism 12 belows, original positions, described air pump 42 by tracheae with for control air-flow open and close electromagnetic switch valve be connected described air knife 41, air pump 42 is manufactured pressurized air, by air knife 41 with high velocity jet, can fast the residue application of sample liquid moment of biochip surface be blown away, avoid being polluted;
Biochip scanning system comprises the video camera 51 and the polishing apparatus 52 that are arranged on described the 3rd Mobile base 131, described video camera 51 scans the image information on biochip, analyse and compare thereby be sent in computer control system, 52 of described polishing apparatus play the supplementary effect of light source, to guarantee that video camera 51 successfully scans;
Computer control system is made up of display, computing machine, electric and electronic controller and actuation means, and computer control system is by electrical connection controlled motion executive system, fluid control systems, temperature control system, clean air blade device and biochip scanning system.
As the improvement of above-mentioned embodiment, described system chassis 9 forms by carrying out cabinet 91 and automatically controlled cabinet 92, described Motor execution system, fluid control systems, temperature control system, clean air blade device and biochip scanning system are installed in described execution cabinet 91, described computer control system is arranged in described automatically controlled cabinet 92, carrying out cabinet 91 is provided with matchingly and can carries out the removable quick Wiring port group being connected by cable with automatically controlled cabinet 92, carry out cabinet 91 be also provided with can folding door-opening mechanism 911, the separation design of system chassis 9 has further improved applicability and the flexibility ratio of detection system.
As the further improvement of above-mentioned embodiment, preferably, described door-opening mechanism 911 is hinged on described execution cabinet 91 rotationally, between door-opening mechanism 911 and execution cabinet 91, be connected with air spring 912, carry out in cabinet 91 and be provided with the fluorescent tube for throwing light on, carry out cabinet 91 and automatically controlled cabinet 92 both sides and be also provided with handle groove to facilitate carrying.
Further, described X-axis straight line executing mechanism 11, in Y-axis straight line executing mechanism 12 and Z axis straight line executing mechanism 13, be provided with motor, and by motor-driven screw rod, described the first Mobile base 111, the second Mobile base 121 and the 3rd Mobile base 131 respectively with X-axis straight line executing mechanism 11, Y-axis straight line executing mechanism 12 is connected with the screw rod of Z axis straight line executing mechanism 13, Y-axis straight line executing mechanism 12 is also provided with first drag chain 123 and second drag chain 124 mobile for the protection of cable or tracheae etc., the two ends of described the first drag chain 123 connect respectively Y-axis straight line executing mechanism 12 and system chassis 9, described the second drag chain 124 is arranged along Y-axis straight line executing mechanism 12, the two ends of the second drag chain 124 connect respectively Y-axis straight line executing mechanism 12 and described the second Mobile base 121, cable or tracheae etc. can be received Y-axis straight line executing mechanism 12 along the first drag chain 123 from system chassis 9, receive described mounting box 241 other parts such as grade from the second drag chain 124 again, thereby protection cable.
Further, on described mounting box 241, be also provided with a waste liquid bottle 261 for Recycling of waste liquid, drawing liquid pump 26 and liquid pumping valve 27, with cleaning solution bottle 281 and a clean liquid pump 28 that is used to liquid-feeding tube 23 to provide cleaning solution to clean, and several couplings are connected to the dual stop valve 29 between described microflow-controlling valve 22 and described pony pump 21, described waste liquid bottle 261 connects drawing liquid pump 26 by sewer pipe 262, described sewer pipe 262 end after drawing liquid pump 26 is fixed on described application of sample needle plate 25, described cleaning solution bottle 281 connects described clean liquid pump 28 by cleaning solution pipe 282, described dual stop valve 29 is again connected in parallel, finally be linked into described liquid-feeding tube 23, described system chassis 9 is provided with washer bottle 283, described washer bottle 283 is positioned at described Y-axis straight line executing mechanism 12 origin position belows, act on by dual stop valve 29, make liquid-feeding tube 23 can select to clean by cleaning solution, cleaning solution is discharged in washer bottle 283 and temporarily deposits from liquid-feeding tube 23, then draw and be recycled in waste liquid bottle 261 by sewer pipe 262, when sewer pipe 262 also can be drawn application of sample simultaneously, remain in the liquid on biochip, and then use clean air blade device to clean, thereby reduce the disperse amount of liquid in system chassis 9, further reduce and pollute.
Further, the fastening bottom surface that is fitted in lower heating plate 32 of electric pad 34 of described lower heating plate 32, described temperature sensor 35 is arranged on lower heating plate 32 bottom surface central authorities, on lower heating plate 32, be also provided with the travel switch 37 for controlling heating plate heating, to guarantee that only covering lower heating plate 32 at upper heating plate 31 just can carry out heating operation, and lower heating plate 32 is also provided with the ring groove 322 that surrounds described draw-in groove 321 and install elastic sealing strip additional, to strengthen sealing property, in draw-in groove 321, be provided with the dip plane 323 of being convenient to take out biochip, be used for pressing biochip one end and perk is carried out fast dismantling and removed, described heating radiator 36 is provided with several just fans to lower heating plate 32 bottom surface blowings, the corresponding described fan in described system chassis 9 bottoms arranges many air vents, improve heat dissipation ventilation effect, because biochip is placed on lower heating plate 32, the electric pad 34(accompanying drawing of upper heating plate 31 does not draw) can be arranged in heating plate 31, to avoid electric pad 34 to expose the latent defect of being brought, for example, while opening because of upper heating plate 31 and other parts bump.
Further, described turning gear 33 is hollow structure, and is provided with for axle center hole 331 and cable-through hole 332 by wire, and relevant wire just can enter from axle center hole 331, then draw and connect corresponding parts from cable-through hole 332, avoided wire unordered placement in system chassis 9.
Further, between described air pump 42 and described air knife 41, be also linked in sequence and be useful on the filtrator 45 of filtered air particulate, with the air bag 43 for storing compressed air, and for the pressure regulator valve 44 of regulation output air pressure, described pressure regulator valve 44 is also connected with the rain glass 46 of real-time demonstration atmospheric pressure value, thereby improves quality and the effect of described air knife 41 gas jet.
Further, described air knife 41 is set to wedge shape, air knife 41 tips and both sides end face are provided with several gas orifices that are arranged side by side 411 and circulation port 412, the main corresponding below of described gas orifice 411 is jet, circulation port 412 produces blast synergistic effect, thereby clears up more up hill and dale liquid or particulate on biochip.
Further, described polishing apparatus 52 is arranged on described video camera 51 belows, and the corresponding video camera 51 of polishing apparatus 52 is provided with lens and light source, and video camera 51 scioptics scan, and avoids when clean on the airborne camera lens of being stained with video camera 51.
The basic operating procedure of a kind of biological chips detection system of the present utility model is:
First, biochip is placed on the draw-in groove 321 of described lower heating plate 32, then start described computer control system, by specific control software, described in computer control system control, each system is carried out testing, described Motor execution system drives described fluid control systems and clean air blade device to carry out application of sample and the cleaning process of biochip, described application of sample needle plate 25 and air knife 41 are movable to each biochip with Z axis straight line executing mechanism 13 and carry out application of sample and cleaning process, subsequently, carry out temperature control by described temperature control system, be that described upper heating plate 31 closes to lower heating plate 32, and be heated to specified temp, the sample of biochip is answered, complete heating plate 31 in this process and just can open and be cooled to normal temperature, finally, when biochip sample obtains after enough chemical reactions, can scan by described biochip scanning system, described video camera 51 is sent to the sample image taking in computer control system, to utilize software analysis, comparison, thereby complete biochip test, and according to actual needs, above-mentioned every operation can be through specific or not specific order, the number of times of single or repetition is carried out.
The above, be preferred embodiments of the present utility model, but the utility model is not limited to above-described embodiment, as long as it reaches technique effect of the present utility model with any same or similar means, within all should falling into protection domain of the present utility model.
Claims (10)
1. a biological chips detection system, is characterized in that: comprise the Motor execution system, fluid control systems, temperature control system, clean air blade device, biochip scanning system and the computer control system that are arranged in system chassis (9);
Described Motor execution system is by respectively along X-axis, the X-axis straight line executing mechanism (11) that Y-axis and Z-direction arrange mutual vertically, Y-axis straight line executing mechanism (12) and Z axis straight line executing mechanism (13) composition, the fastening system chassis (9) that is arranged on of described X-axis straight line executing mechanism (11) is in Y direction one side, on X-axis straight line executing mechanism (11), be provided with first Mobile base (111) that can move along X-direction, described Y-axis straight line executing mechanism (12) is arranged on X-axis straight line executing mechanism (11) top, one end of Y-axis straight line executing mechanism (12) is fastenedly connected on described the first Mobile base (111), the other end of Y-axis straight line executing mechanism (12) is provided with traversing carriage (122), system chassis (9) is provided with the guide rail (14) parallel with X-axis straight line executing mechanism (11) at Y direction opposite side, the bottom of described traversing carriage (122) is slidably mounted on described guide rail (14), X-axis straight line executing mechanism (11) drives Y-axis straight line executing mechanism (12) to move with portal frame form, on Y-axis straight line executing mechanism (12), be provided with second Mobile base (121) that can move along Y direction, described Z axis straight line executing mechanism (13) is arranged on described the second Mobile base (121) from Y-axis straight line executing mechanism (12) one sides vertically, on Z axis straight line executing mechanism (13), be provided with the 3rd Mobile base (131) that can move along Z-direction,
Described fluid control systems comprises several pony pumps for imbitition (21), with supporting for controlling the microflow-controlling valve (22) of flow, and for delivery of liquid and connect described pony pump (21) and the liquid-feeding tube (23) of microflow-controlling valve (22), described pony pump (21) and microflow-controlling valve (22) are arranged on respectively on mounting box (241) and installing plate (242), described mounting box (241) and installing plate (242) are fastenedly connected respectively on and the 3rd Mobile base (131) upper at described the second Mobile base (121), on mounting box (241), be provided with the liquid bottles (211) of several loading liquids, pony pump (21) is connected respectively described liquid bottles (211) and microflow-controlling valve (22) by liquid-feeding tube (23), described installing plate (242) bottom is provided with application of sample needle plate (25), connect concentrated being fixed on described application of sample needle plate (25) of liquid-feeding tube (23) mouth of pipe of microflow-controlling valve (22),
Described temperature control system is made up of upper heating plate (31) and lower heating plate (32) that can be bonded to each other, one end of described upper heating plate (31) and lower heating plate (32) is hinged by turning gear (33), upper heating plate (31) can rotate and folding with described turning gear (33), lower heating plate (32) is fastenedly connected on system chassis (9), turning gear (33) is arranged on the side of system chassis (9) in X-direction, in turning gear (33), be provided with the motor that drives its rotation, the original position of described Y-axis straight line executing mechanism (12) is set in the opposite side of system chassis (9) in X-direction, upper heating plate (31) and lower heating plate (32) are provided with the electric pad (34) for heating accordingly, the corresponding described electric pad of lower heating plate (32) (34) is also provided with many for laying the draw-in groove (321) of biochip, and for detection of the temperature sensor (35) of temperature, lower heating plate (32) below is also provided with heating radiator (36),
Clean air blade device comprises the air knife (41) that is arranged on described the 3rd Mobile base (131) bottom, and be arranged on the air pump (42) of described Y-axis straight line executing mechanism (12) original position below, described air pump (42) by tracheae be connected described air knife (41) for controlling the electromagnetic switch valve that air-flow opens and closes;
Biochip scanning system comprises the video camera (51) and the polishing apparatus (52) that are arranged on described the 3rd Mobile base (131);
Computer control system is made up of display, computing machine, electric and electronic controller and actuation means, and computer control system is by electrical connection controlled motion executive system, fluid control systems, temperature control system, clean air blade device and biochip scanning system.
2. a kind of biological chips detection system according to claim 1, it is characterized in that: described system chassis (9) forms by carrying out cabinet (91) and automatically controlled cabinet (92), described Motor execution system, fluid control systems, temperature control system, clean air blade device and biochip scanning system are installed in described execution cabinet (91), described computer control system is arranged in described automatically controlled cabinet (92), carrying out cabinet (91) is provided with matchingly and can carries out the removable quick Wiring port group being connected by cable with automatically controlled cabinet (92), carry out cabinet (91) be also provided with can folding door-opening mechanism (911).
3. a kind of biological chips detection system according to claim 2, it is characterized in that: described door-opening mechanism (911) is hinged on described execution cabinet (91) rotationally, between door-opening mechanism (911) and execution cabinet (91), be connected with air spring (912), carry out in cabinet (91) and be provided with the fluorescent tube for throwing light on.
4. according to claim 1, a kind of biological chips detection system described in 2 or 3, it is characterized in that: described X-axis straight line executing mechanism (11), in Y-axis straight line executing mechanism (12) and Z axis straight line executing mechanism (13), be provided with motor, and by motor-driven screw rod, described the first Mobile base (111), the second Mobile base (121) and the 3rd Mobile base (131) respectively with X-axis straight line executing mechanism (11), Y-axis straight line executing mechanism (12) is connected with the screw rod of Z axis straight line executing mechanism (13), Y-axis straight line executing mechanism (12) is also provided with first drag chain (123) and second drag chain (124) mobile for the protection of cable or tracheae etc., the two ends of described the first drag chain (123) connect respectively Y-axis straight line executing mechanism (12) and system chassis (9), described the second drag chain (124) is arranged along Y-axis straight line executing mechanism (12), the two ends of the second drag chain (124) connect respectively Y-axis straight line executing mechanism (12) and described the second Mobile base (121).
5. according to claim 1, a kind of biological chips detection system described in 2 or 3, it is characterized in that: on described mounting box (241), be also provided with a waste liquid bottle for Recycling of waste liquid (261), drawing liquid pump (26) and liquid pumping valve (27), with cleaning solution bottle (281) and a clean liquid pump (28) that is used to liquid-feeding tube (23) to provide cleaning solution to clean, and several couplings are connected to the dual stop valve (29) between described microflow-controlling valve (22) and described pony pump (21), described waste liquid bottle (261) connects drawing liquid pump (26) by sewer pipe (262), described sewer pipe (262) end after drawing liquid pump (26) is fixed on described application of sample needle plate (25), described cleaning solution bottle (281) connects described clean liquid pump (28) by cleaning solution pipe (282), described dual stop valve (29) is again connected in parallel, finally be linked into described liquid-feeding tube (23), described system chassis (9) is provided with washer bottle (283), described washer bottle (283) is positioned at described Y-axis straight line executing mechanism (12) origin position below.
6. according to claim 1, a kind of biological chips detection system described in 2 or 3, it is characterized in that: the fastening bottom surface that is fitted in lower heating plate (32) of electric pad (34) of described lower heating plate (32), described temperature sensor (35) is arranged on lower heating plate (32) bottom surface central authorities, on lower heating plate (32), be also provided with the travel switch (37) for controlling heating plate heating, and surround described draw-in groove (321) and install the ring groove (322) of elastic sealing strip additional, in draw-in groove (321), be provided with the dip plane (323) of being convenient to take out biochip, described heating radiator (36) is provided with several just fans to the blowing of lower heating plate (32) bottom surface, the corresponding described fan in described system chassis (9) bottom arranges many air vents.
7. according to a kind of biological chips detection system described in claim 1,2 or 3, it is characterized in that: described turning gear (33) is hollow structure, and be provided with for the axle center hole by wire (331) and cable-through hole (332).
8. according to a kind of biological chips detection system described in claim 1,2 or 3, it is characterized in that: between described air pump (42) and described air knife (41), be also linked in sequence and be useful on the filtrator (45) of filtered air particulate, with the air bag (43) for storing compressed air, and for the pressure regulator valve (44) of regulation output air pressure, described pressure regulator valve (44) is also connected with the rain glass (46) of real-time demonstration atmospheric pressure value.
9. according to a kind of biological chips detection system described in claim 1,2 or 3, it is characterized in that: described air knife (41) is set to wedge shape, air knife (41) tip and both sides end face are provided with several gas orifices that are arranged side by side (411) and circulation port (412).
10. according to a kind of biological chips detection system described in claim 1,2 or 3, it is characterized in that: described polishing apparatus (52) is arranged on described video camera (51) below, and the corresponding video camera of polishing apparatus (52) (51) is provided with lens and light source.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420177093.0U CN203909049U (en) | 2014-04-11 | 2014-04-11 | Detection system for biological chips |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420177093.0U CN203909049U (en) | 2014-04-11 | 2014-04-11 | Detection system for biological chips |
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| CN203909049U true CN203909049U (en) | 2014-10-29 |
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| CN201420177093.0U Withdrawn - After Issue CN203909049U (en) | 2014-04-11 | 2014-04-11 | Detection system for biological chips |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103954782A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
| WO2016135541A1 (en) * | 2015-02-25 | 2016-09-01 | Wong Kwong Hou | Biological chip systems |
| CN107847936A (en) * | 2015-05-29 | 2018-03-27 | 亿明达股份有限公司 | Sample carrier and the measurement system for specify reaction |
| CN108057389A (en) * | 2017-11-27 | 2018-05-22 | 北京莱伯泰科仪器股份有限公司 | Automatical dosing instrument |
| CN108931660A (en) * | 2018-07-25 | 2018-12-04 | 江苏瑞明生物科技有限公司 | High-throughput full-automatic Susceptibility Test Analysis instrument |
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2014
- 2014-04-11 CN CN201420177093.0U patent/CN203909049U/en not_active Withdrawn - After Issue
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103954782A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
| CN103954782B (en) * | 2014-04-11 | 2015-05-20 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
| WO2016135541A1 (en) * | 2015-02-25 | 2016-09-01 | Wong Kwong Hou | Biological chip systems |
| CN107847936A (en) * | 2015-05-29 | 2018-03-27 | 亿明达股份有限公司 | Sample carrier and the measurement system for specify reaction |
| CN107847936B (en) * | 2015-05-29 | 2021-09-07 | 亿明达股份有限公司 | Sample carrier and assay system for carrying out a specified reaction |
| CN108057389A (en) * | 2017-11-27 | 2018-05-22 | 北京莱伯泰科仪器股份有限公司 | Automatical dosing instrument |
| CN108931660A (en) * | 2018-07-25 | 2018-12-04 | 江苏瑞明生物科技有限公司 | High-throughput full-automatic Susceptibility Test Analysis instrument |
| CN108931660B (en) * | 2018-07-25 | 2024-01-26 | 江苏瑞明生物科技有限公司 | High-flux full-automatic drug sensitivity test analyzer |
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