CN203745411U - Blood coagulation comparison device and blood coagulation comparison components - Google Patents
Blood coagulation comparison device and blood coagulation comparison components Download PDFInfo
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- CN203745411U CN203745411U CN201420151254.9U CN201420151254U CN203745411U CN 203745411 U CN203745411 U CN 203745411U CN 201420151254 U CN201420151254 U CN 201420151254U CN 203745411 U CN203745411 U CN 203745411U
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Abstract
The utility model discloses a blood coagulation comparison device and blood coagulation comparison components. The blood coagulation comparison device comprises a first tube, a first blood coagulation detector, a second tube, a second blood coagulation detector, a leading mouth of the blood coagulation comparison device and a comparison circuit, wherein the first tube is used for transmitting a first blood; the first blood coagulation detector is connected with the first tube and used for detecting the first electrical parameter of the first blood; the second tube is used for transmitting a second blood; the second blood coagulation detector is connected with the second tube and used for detecting the second electrical parameter of the second blood; the leading mouth of the blood coagulation comparison device is selectively communicated with the first tube or the second tube; the comparison circuit is electrically connected with the first blood coagulation detector and the second blood coagulation detector; the comparison circuit is used for determining the first blood coagulation parameter on the basis of the first electrical parameter, determining the second blood coagulation parameter on the basis of the second electrical parameter and comparing the first blood coagulation parameter and with the second blood coagulation parameter. The blood coagulation comparison device and the blood coagulation comparison components can compare the condition of blood coagulation of two different blood samples.
Description
Technical field
The utility model relates to medical instruments field, particularly relates to a kind of blood clotting comparison means and blood clotting comparing component.
Background technology
Blood gas analysis technology is being brought into play vital effect always in acute respiratory failure diagnosis and treatment, operation, rescue and monitoring process.Along with scientific and technical fast development, the properties of blood gas analyzer is also greatly improved.At present, computer technology is further penetrated into blood gas analysis field.The progress of computer technology makes modern blood gas analyzer have super data processing, maintenance, storage and expert diagnosis function.
For preventing that blood sample from stopping up the ultra-thin pipe of pack, need in original blood sample, add appropriate anti-coagulants to keep biologically active pdgf.And, conventionally also need blood sample to carry out and filter and rock processing, to prevent that blood is imported to blood platelet and white blood cell before ultra-thin pipe condenses into piece.
Controlling in test, often have the demand of comparison coagulation status, to determine anti-coagulants effect.Such as, there is the demand that the blood clotting start time of interpolation anti-coagulants and the blood clotting start time of not adding anti-coagulants are compared.Equally, also there is the demand that the blood clotting speed of interpolation anti-coagulants and the blood clotting speed of not adding anti-coagulants are compared.
Utility model content
The utility model proposes a kind of blood clotting comparison means and blood clotting comparing component, can compare coagulation status.
According to first aspect of the present utility model, a kind of blood clotting comparison means is provided, comprising: one first pipe, for transmitting the first blood; One first blood clotting detecting device, it is connected with described the first pipe, for detection of the first electrical quantity of described the first blood; One second pipe, for transmitting the second blood; One second blood clotting detecting device, it is connected with described the second pipe, for detection of the second electrical quantity of described the second blood; A blood clotting comparison means draw mouth, be optionally communicated with described the first pipe or the second pipe; One comparator circuit, is electrically connected with described the first blood clotting detecting device and the second blood clotting detecting device, for determining the first blood clotting parameter based on described the first electrical quantity, determines the second blood clotting parameter based on described the second electrical quantity, and compares both.
In one embodiment, described blood clotting comparison means also comprises a waste liquid bag, for collecting through the first blood of described the first blood clotting detecting device and the second blood of this second blood clotting detecting device of process.
In one embodiment, described blood clotting comparison means also comprises one first suction pump, and it is connected with described the first pipe, for described the first blood being sucked to described the first blood clotting detecting device.
In one embodiment, described blood clotting comparison means also comprises one second suction pump, and it is connected with described the second pipe, for described the second blood being sucked to described the second blood clotting detecting device.
In one embodiment, described comparator circuit comprises: one first timer, and it is connected with the first blood clotting detecting device, the first blood clotting start time of record the first blood; One second timer, it is connected with the second blood clotting detecting device, the second blood clotting start time of record the second blood; One comparer, for more described the first blood clotting start time and the second blood clotting start time.
In one embodiment, described comparator circuit comprises: one first timer, comprise counting circuit, and this timer is connected with the first blood clotting detecting device, for determine the first blood clotting speed of the first blood based on described the first electrical quantity; One second timer, comprises counting circuit, and this timer is connected with the second blood clotting detecting device, for determine the second blood clotting speed of the second blood based on described the second electrical quantity; One comparer, for more described the first blood clotting speed and the second blood clotting speed.
In one embodiment, described blood clotting comparison means also comprises a display, for showing the comparative result of described comparator circuit.
According to second aspect of the present utility model, a kind of blood clotting comparing component is provided, comprising: a container, comprise one first tube and one second tube, described the first tube is used for storing the first blood, and described the second tube is used for storing the second blood; One blood clotting comparison means mentioned above, is wherein optionally communicated with described the first pipe with described the first tube or is communicated with described the second pipe and described the second tube by the mouth that draws of described blood clotting comparison means.
In one embodiment, described blood clotting comparing component also comprises an anti-coagulation device, and it comprises: an inlet tube, and it is connected with described the first tube; One stirs filtrator, for storing and stir the first blood filtering from described inlet tube inflow; With an outlet, for being communicated with the mouth that draws of described stirring filtrator and an anti-coagulation device.
As can be seen here, the utility model is measured respectively the electrical quantity of the first blood and the second blood by the first blood clotting detecting device and the second blood clotting detecting device, and determine blood clotting parameter separately based on electrical quantity, thereby can compare the coagulation status of two kinds of different blood samples, meet the relatively demand of coagulation status.
And the utility model is accurately determined the blood clotting start time by timer, and the comparison directly perceived of different blood sample blood clotting times can be provided.Further, the utility model is accurately determined blood clotting speed by counter, and the comparison directly perceived of different blood sample blood clotting speed can be provided.The utility model can provide the comprehensive comparison of coagulation status, for follow-up further blood clotting data analysis provides concrete quantitative basis.
Brief description of the drawings
Fig. 1 is according to the utility model blood clotting comparison means structural drawing.
Fig. 2 is according to the demonstrative structure block diagram of the utility model blood clotting comparison means.
Fig. 3 is according to the demonstrative circuit structural drawing of the utility model blood clotting detecting device.
Fig. 4 is the resistance of slide resistor and the graph of a relation of time parameter in Fig. 3.
Fig. 5 is according to the structural drawing of the utility model blood clotting comparing component.
In above-mentioned accompanying drawing, the Reference numeral adopting is as follows:
1 container 200 second tubes
2 anti-coagulation device 210 second tubular bodies
3 blood clotting comparison means 220 second sealed ends
20 second tube outlet 230 second links
The mouth 232 second that draws of 21 anti-coagulation devices connects boss
The mouth 233 second that draws of 22 blood clotting comparison means rotates boss
23 first pipes 300 connect housing
24 second pipe 400 first cock bodys
25 first blood clotting detecting device 410 first plug bizets
26 second blood clotting detecting device 411 first grooves
27 first suction pump 420 first plug necks
28 first timer 500 second cock bodys
29 second suction pump 510 second plug bizets
30 second timer 511 second grooves
The delivery outlet 520 second plug necks of 31 first pipes
The delivery outlet 521 of 32 second pipes the 3rd groove
33 waste liquid bag 601 inlet tubes
The 34 comparer 602 fluid inlet mouths of pipe
50 comparator circuits 603 are controlled mouth
100 first tube 604 drum ladles
110 first tubular body 605 filter elements
120 first sealed ends 606 stir filtrator
The 130 first link 607 fluid egress point mouths of pipe
132 first connect boss 608 outlets
133 first rotation boss 623 driver parts
Embodiment
In order to make the technical solution of the utility model and advantage clearer, below in conjunction with drawings and the embodiments, the utility model is further elaborated.Should be appreciated that embodiment described herein is only in order to illustrative explanation the utility model, and be not used in restriction protection domain of the present utility model.
Succinct and directly perceived on describing, below sets forth scheme of the present utility model by describing some representational embodiments.In embodiment only for helping to understand scheme of the present utility model.Can be not limited to these details when but clearly, the technical solution of the utility model realizes.
Fig. 1 is according to the structural drawing of the utility model blood clotting comparison means 3.As shown in Figure 1, blood clotting comparison means 3 comprises:
The the first blood clotting detecting device 25 being connected with the first pipe 23, for detection of the first electrical quantity of the first blood of first pipe 23 of flowing through;
The the second blood clotting detecting device 26 being connected with the second pipe 24, for detection of the second electrical quantity of the second blood of second pipe 24 of flowing through.
Blood clotting is the result of a series of clotting factor linksystem enzyme reaction.Clotting factor in blood exists with non-activity zymogen forms, after a certain clotting factor is activated, can make many clotting factor successively be activated according to a certain order, has each other complicated catalytic action.The resistance that blood clotting shows as blood on biophysical properties increases.Therefore, fibrin has the feature of electric conductivity without electric conductivity to utilize fibrinogen, and a part that can be using blood sample to be measured as circuit, judges fibrinous formation according to the variation of circuital current in coagulation process.
The first blood clotting detecting device 25 can detect the resistance of the first blood in the first pipe 23, and determines the first electrical quantity of the first blood based on this resistance.Exemplarily, the first electrical quantity comprises the resistance value of the first blood in the first pipe 23 and other physical change forms based on this resistance value, such as magnitude of voltage, current value etc.
Similarly, the second blood clotting detecting device 26 can detect the resistance of the second blood in the second pipe 24, and determines the second electrical quantity of the second blood based on this resistance.Exemplarily, the second electrical quantity comprises the resistance value of the second blood in the second pipe 24 and other physical change forms based on this resistance value, such as magnitude of voltage, current value etc.
Blood clotting comparison means 3 can also comprise and draws mouthfuls 22, is optionally connected with the first pipe 23 or the second pipe 24.
When drawing mouthfuls 22 while being connected with the first pipe 23, can input the first blood to the first pipe by drawing mouth 22; When drawing mouthfuls 22 while being connected with the second pipe 24, can input the second blood to the second pipe by drawing mouth 22.Wherein, the first blood is the whole blood quality control liquid through anti-freezing processing, and the second blood is the whole blood quality control liquid that does not pass through anti-freezing processing.
In one embodiment, device 3 also comprises a waste liquid bag 33, for collecting through the first blood of the first blood clotting detecting device 25 and through the second blood of the second blood clotting detecting device 26.The delivery outlet 32 of the delivery outlet 31 of the first pipe 23 and the second pipe 24 is connected respectively to waste liquid bag 33.
In one embodiment, device 3 also comprises the first suction pump 27 being connected with the first pipe 23, for when draw mouthfuls 22 while being connected with the first pipe 23 by the first blood from drawing mouth 22 suction first blood clotting detecting devices 25.
In one embodiment, device 3 also comprises the second suction pump 29 being connected with the second pipe 24, for when draw mouthfuls 22 while being connected with the second pipe 24 by the second blood from drawing mouth 22 suction second blood clotting detecting devices 26.
Preferably, the first blood is the whole blood quality control liquid through anti-freezing processing, and the second blood is the whole blood quality control liquid that does not pass through anti-freezing processing.Such as, anti-coagulants can comprise the stabilizing agent of liquaemin, heparin lithium, sodium citrate, EDTAP dipotassium ethylene diamine tetraacetate, ethylenediamine tetraacetic acid tripotassium, disodium ethylene diamine tetraacetate, potassium oxalate, sodium oxalate, hirudin and target detection thing, only otherwise can impact the subsequent detection index of inner blood.
Blood clotting comparison means 3 also comprises comparator circuit 50, for determine the first blood clotting parameter of the first blood based on the first electrical quantity, determines the second blood clotting parameter of the second blood based on the second electrical quantity, and compares the first blood clotting parameter and the second blood clotting parameter.
Here, comparator circuit 50 receives the first electrical quantity from the first blood clotting detecting device 25 respectively, and receives the second electrical quantity from the second blood clotting detecting device 26.
As can be seen here, the utility model is by the electrical quantity of blood clotting detector measures the first blood and the second blood, and determine blood clotting parameter separately based on electrical quantity, finally realize the comparison to blood clotting parameter, can compare the coagulation status of two kinds of different blood, thereby provide quantitative basis for follow-up further blood clotting data analysis.
Fig. 2 is according to the demonstrative structure block diagram of the utility model blood clotting comparison means.As shown in Figure 2, blood clotting comparison means 3 also can be used for the comparison blood clotting time, and this device also comprises for this reason: the first timer 28 being connected with the first blood clotting detecting device 25, for determined for the first blood clotting start time based on the first electrical quantity; The second timer 30 being connected with the second blood clotting detecting device 26, for determining for the second blood clotting start time based on the second electrical quantity.
First the first timer 28 records the initial time of first blood input the first pipe 23.The first blood clotting detecting device 25 detects the resistance of the first blood, in the time detecting that the resistance of the first blood significantly becomes large, assert that the first blood starts to condense, and the first timer 25 records this and starts the moment of condensing.
Similarly, first the second timer 30 records the initial time of second blood input the second pipe 24, and second blood clotting detecting device 26 detect the resistance of the second blood, in the time detecting that the resistance of the second blood significantly becomes large, assert that the second blood starts to condense, and the second timer 30 records this and starts the moment of condensing.
Device 3 can also comprise the comparer 34 being connected respectively with the first timer 28 and the second timer 30.Comparer 34 calculates the difference of condensing between moment and initial time of starting of the first blood, is the beginning setting time of the first blood; Comparer 34 also calculates the difference of condensing between moment and initial time of starting of the second blood, is the beginning setting time of the second blood, and the beginning setting time of comparer 34 to the first blood and the beginning setting time of the second blood compare.
Preferably, comparative result is sent to display screen (not illustrating in Fig. 2) by comparer 34, and shown.
In another embodiment, the first timer 28 comprises counting circuit, is connected, for determine the first blood clotting speed of the first blood based on the first electrical quantity with the first blood clotting detecting device 25.The second timer 30 also comprises counting circuit, is connected, for determine the second blood clotting speed of the second blood based on the second electrical quantity with the second blood clotting detecting device 26; Comparer 34, for comparing the first blood clotting speed and the second blood clotting speed.
Such as, first the first timer 28 records the initial time of first blood input the first pipe 23, and first blood clotting detecting device 25 detect the resistance of the first blood, in the time detecting that the resistance of the first blood significantly becomes large, assert that the first blood starts to condense, and the first timer 28 records this and starts the moment of condensing.The first timer 28 calculates and starts the difference of condensing between moment and initial time, is the beginning setting time of the first blood.Then, the first counter 28, since the setting time of the first blood, calculates the resistance change rate of the first blood being detected by the first blood clotting detecting device 25, is the first blood clotting speed.
Similarly, first the second counter 30 records the initial time of second blood input the second pipe 24, and second blood clotting detecting device 26 detect the resistance of the second blood, in the time detecting that the resistance of the second blood significantly becomes large, assert that the second blood starts to condense, and the second counter 30 records this and starts the moment of condensing.The second counter 30 calculates and starts the difference of condensing between moment and initial time, is the beginning setting time of the second blood.The second counter 30, since the setting time of the second blood, calculates the resistance change rate of the second blood being detected by the second blood clotting detecting device 26, is the second blood clotting speed.
Then, comparer 34 can compare the second blood clotting speed of the first blood clotting speed of the first blood and the second blood.
In the utility model, also the first blood clotting detecting device 25 and the second blood clotting detecting device 26 can be interconnected, with forming circuit bridge.
Fig. 3 is according to the demonstrative circuit structural drawing of the utility model blood clotting detecting device.
As shown in Figure 3, the first blood clotting detecting device 25 is connected to the first arm of circuit bridge 45; The second arm of resistance 38 forming circuit bridges 45; The 3rd arm of the second blood clotting detecting device 26 forming circuit bridges 45; The 4th arm of the resistance 39 being connected in series and adjustable resistor 40 forming circuit bridges 45.Exemplarily, resistance 39 is 20 kilo-ohms, and the maximal regulated value of adjustable resistor 40 is 10 kilo-ohms; Resistance 38 is 25 kilo-ohms.
Do not condense in the second blood clotting detecting device 26 through the whole blood quality control liquid of anti-freezing processing, condense in the first blood clotting detecting device 25 through the whole blood quality control liquid of anti-freezing processing.The condensation process of the whole blood quality control liquid of process anti-freezing processing seriously postpones.
Provide sinusoidal voltage by battery-driven oscillator 44 for electric bridge 45, peak value is 1.2 volts.Two air trimmers 41 and 42 (adjustable extent is that 3 pico farads are to 30 pico farads) are connected in parallel with the second arm and the 4th arm respectively, to realize exact matching.
Dualbeam oscillograph 43 connects across electric bridge 45, and a wave beam shows the voltage difference between electric bridge point a and some b; Another wave beam shows the voltage difference between electric bridge mid point c and some d.
The first blood clotting detecting device 25 and the second blood clotting detecting device 26 have identical structure.
Exemplarily, the first blood clotting detecting device 25 and the second blood clotting detecting device 26 comprise respectively heavy wall glass capillary, can in heavy wall glass capillary, flow through respectively blood sample to be measured.Exemplarily, heavy wall glass capillary external diameter is 5 millimeters, and internal diameter is 2 millimeters, and axial length is 40 millimeters, and oblique angle is worn in one end of heavy wall glass capillary.
The heavy wall glass capillary of the first blood clotting detecting device 25 has platinum electrode 36; The heavy wall glass capillary of the second blood clotting detecting device 26 has platinum electrode 37.On the heavy wall glass capillary glass inwall of the first blood clotting detecting device 25, there is platinum, on the heavy wall glass capillary inwall of the second blood clotting detecting device 26, also there is platinum.
And, on the heavy wall glass capillary of the first blood clotting detecting device 25, there is boring; Platinum electrode 36 contacts by the platinum on the heavy wall glass capillary glass inwall of boring and the first blood clotting detecting device 25.On the heavy wall glass capillary of the second blood clotting detecting device 26, also there is boring; Platinum electrode 37 contacts by the platinum on the heavy wall glass capillary glass inwall of boring and the second blood clotting detecting device 26.
In Blood Coagulation Process, by regulating adjustable resistor 40 to keep electric bridge 43 balances.In the time of electric bridge 43 balance, the voltage difference between electric bridge point 8 and point 6 has minimum value.Can understand the equilibrium condition of electric bridge 45 by the beamformer output of oscillograph 43.
Fig. 4 is the resistance of slide resistor 40 and the graph of a relation of time parameter in Fig. 3.As seen from Figure 4, started at the 18th minute, the blood in the first blood clotting detecting device 25 starts to solidify.
Based on above-mentioned analysis, describe a kind of exemplary blood clotting comparing component below in detail.The one of describing blood clotting comparison means of the present utility model is specifically used exemplaryly.
Fig. 5 is according to the structural drawing of the utility model blood clotting comparing component.As shown in Figure 5, container 1 comprises: the first tube 100, the second tube 200, connection housing 300, the first cock body 400 and the second cock body 500.
Wherein, the first tube 100 has the first tubular body 110, is positioned at the first sealed end 120 of the first tubular body 110 1 sides and is positioned at the first link 130 of the first tubular body 110 opposite sides.
The second tube 200 has the second tubular body 210, be positioned at the second sealed end 220 of the second tube 200 1 sides and be positioned at the second link 230 of the second tube 200 opposite sides.The first tube 100 and the second tube 200 coaxially arrange and the first link 130 and the second link 230 dock dorsad.
Connect week that housing 300 is positioned at the first link 130 and the second link 230 to the periphery, and the docking end face of the first link 130 and the second link 230 is sealed and spacing.The first link 130 and the second link 230 can rotate relatively being connected in housing 300.
The first cock body 400 comprises that the first plug bizet 410 and the first plug neck 420, the first plug necks 420 fill in the first sealed end 120 and the first sealed end 120 is sealed.
The second cock body 500 comprises that the second plug bizet 510 and the second plug neck 520, the second plug necks 520 fill in the second sealed end 220 and the second sealed end 220 is sealed.
In present embodiment, the first link 130 can be one-body molded with the first tubular body 110, or can be also the first sealing cock body being fixedly connected with the first tubular body 110.In like manner, the second link 230 can be one-body molded with the second tubular body 210, or can be also the second sealing cock body being fixedly connected with the second tubular body 210.
In present embodiment, be no matter to adopt one-body moldedly to obtain link or adopt independently sealing cock body and obtaining link by the mode being fixedly connected with, the convenient structure that housing encapsulates that connects can be set on this link.For example, the first link 130 (as the first cock body 400) can have the first connection boss 132, the second links 230 (as the second cock body 500) in a side of docking the second link 230 (as the second cock body 500) can have the second connection boss 232 in a side of docking the first link 130 (as the first cock body 400); Now, connection housing 300 can be positioned at described the first connection boss 132 and be connected on the outside surface of boss 232 with second, and the first link 130 and the second link 230 are applied to certain docking pressure, so that the docking end face of the first link 130 and the second link 230 keeps close contact, prevent possible leak of liquid; This docking pressure must ensure that the first link 130 can rotate relatively with the second link 230 simultaneously.
In present embodiment, for realizing the relative rotation of the first link 130 and the second link 230, one-body molded with the first link 130 or be connected very firm for the first tubular body 110, and second tubular body 210 one-body molded with the second link 230 or be connected very firmly in situation, can be by the relative rotation gripping and rotation the first tubular body 110 and the second tubular body 210 are realized the first link 130 and the second link 230 relatively; Be connected and be not firm especially with the first link 130 at the first tubular body 110, and second tubular body 210 be connected with the second link 230 and be not especially firmly in situation, or to be on the safe side, a convenient rotation boss gripping can be set on the first link 130 and the second link 230 respectively.For example, can away from a side of the second link 230 (as the second sealing cock body), the first rotation boss 133 be set at the first link 130 (as the first sealing cock body), and away from a side of the first link 130 (as the first sealing cock body), the second rotation boss 233 be set at the second link 230 (as the second sealing cock body).
In present embodiment, also can be further in the first link 130 (as the first sealing cock body) and/or the upper corresponding primary importance of the second link 230 (as the second sealing cock body) and the second place, a position limiting structure (not shown) be set, to point out two through holes on link whether be communicated with completely or be not communicated with completely.
In present embodiment, require higher application for some to leaking, the first sealing cock body and the second sealing cock body are optional with the good material of impermeability, such as rubber (as brombutyl, natural rubber, halogenated butyl rubber, synthetic rubber), thermoplastic elastomer etc.; Correspondingly, connect housing 300 and can contact with rubber etc. the material not reacting for aluminum material etc.
In present embodiment, the first cock body 400 and the second cock body 500 can have identical structure also can have different structures.In addition,, according to different application demands, the first cock body 400 and the second cock body 500 also can adopt the cock body of more existing biological medicines container.For example, in the time that the biological medicine in present embodiment can be used as blood collecting containers with container, if when its first tubular body 110 and/or the second tubular body 210 have the structure identical with existing heparin tube and size, its first cock body 400 and/or the second cock body 500 can use the plug of existing heparin tube.In the time that the biological medicine in present embodiment can be used as drug container with container, if when its first tubular body 110 and/or the second tubular body 210 have the structure identical with existing drug container and size, its first cock body 400 and/or the second cock body 500 can use plug, stopper or the sawdust plug etc. of existing drug container.
In Fig. 5 when being applied to blood collecting containers as example, show wherein a kind of version of the first cock body 400 and the second cock body 500.As shown in Figure 5, plug bizet 410 1 sides of the first cock body 400 have a truncated cone-shaped or hemispheric the first groove 411, and such structure is applicable to the needle bodies such as blood taking needle and penetrates cock body.Plug bizet 510 1 sides of the second cock body 500 have the second groove 511 of a truncated cone-shaped, and plug neck 520 1 sides have the 3rd groove 521 of a cylindrical or truncated cone-shaped.Such structure, because entity part is relatively thin, is therefore applicable to the needle bodies such as inserting tube and penetrates cock body, and certain this structure blood taking needle also can penetrate.In practical application, these two cock bodys 400,500 also can exchange.; plug bizet 510 1 sides that can be also the second cock body 500 have a truncated cone-shaped or hemispheric the first groove; and plug bizet 410 1 sides of the first cock body 400 have the second groove of a truncated cone-shaped, plug neck 420 1 sides have the 3rd groove of a cylindrical or truncated cone-shaped.Or the first cock body 400 and the second cock body 500 all have identical structure.As plug bizet one side of the first cock body 400 and the second cock body 500 all has a truncated cone-shaped or hemispheric the first groove.Or plug bizet one side of the second cock body 500 and the first cock body 400 has the second groove of a truncated cone-shaped, plug neck one side has the 3rd groove of a cylindrical or truncated cone-shaped.In order to ensure that needle body penetrates after cock body, cock body still can be realized sealing, and the first cock body 400 and the second cock body 500 can be rubber cock body processed (abbreviation plug).
In addition, when being applied to the application scenarios of body fluid such as need to gathering blood, urine, blood gas analysis liquid and cerebrospinal fluid, chest ascites, the first tube 100 in present embodiment can be after the plug neck of the first cock body 400 be filled in, and its inside cavity has first pressure differential (i.e. the first vacuum tightness) that can suck the first predeterminable quantity of liquid; The second tube 200 can be after the plug neck of the second cock body 500 be filled in, and its inside cavity has second pressure differential (i.e. the second vacuum tightness) that can suck the second predeterminable quantity of liquid.
Further, in order to realize above-mentioned collection, the first cock body 400 in present embodiment and/or the second cock body 500 can have the external structure matching with sampling syringe needle (as blood taking needle etc.), so that this sampling is contained in to this biological medicine with on container with pinhead sleeve, thereby realize with existing sampling use for compatibility, make full use of existing resource.
In present embodiment, be the situation of rubber cock body for the first cock body 400 and the second cock body 500, its material can be above-mentioned brombutyl, natural rubber, halogenated butyl rubber, synthetic rubber, thermoplastic elastomer etc. equally, preferably halogenated butyl rubber and brombutyl, it is not only easy to moulding, and at the first tube 100 with the second tube 200 is interior while there is preset vacuum tightness, it possesses enough elasticity can effectively ensure the first tube 100 and the interior preset vacuum tightness of the second tube 200, is also easy to extract after use.
In present embodiment, can further on the first tubular body 110 and the second tubular body 210, be provided for respectively representing the scale value (not shown) of content capacity, like this, without determine the capacity of content by other measuring equipment, and can directly obtain according to the scale value on tubular body.In addition, by after the contents mixed in the first tube 100 and the second tube 200, the capacity that obtains potpourri that can also further facilitate.
Further, on the inwall of the first tubular body 110, scribble anti-coagulants (not shown).For example, if content is blood, anti-coagulants can comprise the stabilizing agent of liquaemin, heparin lithium, sodium citrate, EDTAP dipotassium ethylene diamine tetraacetate, ethylenediamine tetraacetic acid tripotassium, disodium ethylene diamine tetraacetate, potassium oxalate, sodium oxalate, hirudin and target detection thing, only otherwise can impact the subsequent detection index of inner blood.On the inwall of the second tubular body 210, do not scribble anti-coagulants.
Exemplarily, in the first tubular body 110, preserve the whole blood quality control liquid through anti-freezing processing; In the second tubular body 210, preserve the whole blood quality control liquid that does not pass through anti-freezing processing.
In present embodiment, the first tubular body 110 and the second tubular body 210 can adopt one or more compound the making in hard and transparent glass, polyester plastic cement, macromolecular material.Make Deng material.For example, can be nylon, Polyvinylchloride, polystyrene, polyetheramine, polycarbonate etc.Because above-mentioned material not only make after for transparent tube body and also can effective guarantee body in negative pressure, material is easy to obtain, cost is relatively cheap.Its concrete processing mode can be: the modes such as blowing, injection moulding, vacuum forming.
Through the whole blood quality control liquid of anti-freezing processing from the first tubular body 110 anti-coagulation device 2 of flowing through, and not through the whole blood quality control liquid of anti-freezing processing from the second tubular body 210 via the second tube outlet 20 and draw mouthfuls 21 enter blood clotting comparison means 3 draw mouthfuls 22.
Anti-coagulation device 2 comprises:
Inlet tube 601, it is for importing the whole blood quality control liquid through anti-freezing processing;
Stir filtrator 606, the filter element with hollow tube-shape passage 605 that it comprises a drum ladle 604 and is arranged in described drum ladle 604; Described drum ladle 604 comprises the fluid inlet mouth of pipe 602 and the fluid egress point mouth of pipe 607.Inlet tube 601 is connected with the hollow tube-shape passage of filter element 605 through the fluid inlet mouth of pipe 602;
Driver part 623, itself and described stirring filtrator 606 mechanical connections, and can drive described stirring filtrator 606 to move; With
Outlet 608, its with stir the fluid egress point mouth of pipe 607 of filtrator 606 and be connected, for drawing mouthfuls 22 via drawing mouthfuls 21 by what export to blood clotting comparison means 3 through the whole blood quality control liquid of anti-freezing processing.
As shown in Figure 5, blood clotting comparison means 3 comprises:
The the first blood clotting detecting device 25 being connected with the first pipe 23, for detection of the first electrical quantity of the first blood of first pipe 23 of flowing through;
The the second blood clotting detecting device 26 being connected with the second pipe 24, for detection of the second electrical quantity of the second blood of second pipe 24 of flowing through.
The first blood clotting detecting device 25 can detect the resistance variations of the first blood, and determines the first electrical quantity of the first blood.Exemplarily, the first electrical quantity comprises the resistance value of the first blood in the first pipe 23.Similarly, the second blood clotting detecting device 26 can the resistance variations based on the second blood be determined the second electrical quantity of the second blood.Exemplarily, the second electrical quantity comprises the resistance value of the second blood in the second pipe 24.
Device 3 also comprises and draws mouthfuls 22, is optionally connected with the first pipe 23 or the second pipe 24.When drawing mouthfuls 22 while being connected with the first pipe 23, can input the first blood to the first pipe 23 by drawing mouth 22; When drawing mouthfuls 22 while being connected with the second pipe 24, can input the second blood to the second pipe 24 by drawing mouth 22.Wherein, the first blood is the whole blood quality control liquid through anti-freezing processing, and the second blood is the whole blood quality control liquid that does not pass through anti-freezing processing.
Device 3 also comprises a waste liquid bag 33, for collecting through the first blood of the first blood clotting detecting device 25 and through the second blood of the second blood clotting detecting device 26.The delivery outlet 32 of the delivery outlet 31 of the first pipe 23 and the second pipe 24 is connected respectively to waste liquid bag 33.
Device 3 also comprises the first suction pump 27 being connected with the first pipe 23, for when draw mouthfuls 22 while being connected with the first pipe 23 by the first blood from drawing mouth 22 suction first blood clotting detecting devices 25.Device 3 also comprises the second suction pump 29 being connected with the second pipe 24, for when draw mouthfuls 22 while being connected with the second pipe 24 by the second blood from drawing mouth 22 suction second blood clotting detecting devices 26.
Device 3 also comprises: the first timer 28 being connected with the first blood clotting detecting device 25, for determined for the first blood clotting start time based on the first electrical quantity; The second timer 30 being connected with the second blood clotting detecting device 26, for determining for the second blood clotting start time based on the second electrical quantity.
First the first timer 28 records the initial time of first blood input the first pipe 23, and first blood clotting detecting device 25 detect the resistance of the first blood, in the time detecting that the resistance of the first blood significantly becomes large, assert that the first blood starts to condense, and the first timer 25 records this and starts the moment of condensing.
Similarly, first the second timer 30 records the initial time of second blood input the second pipe 24, and second blood clotting detecting device 26 detect the resistance of the second blood, in the time detecting that the resistance of the second blood significantly becomes large, assert that the second blood starts to condense, and the second timer 30 records this and starts the moment of condensing.
Device 3 can also comprise the comparer 34 being connected respectively with the first timer 28 and the second timer 30.Comparer 34 calculates the difference of condensing between moment and initial time of starting of the first blood, is the beginning setting time of the first blood; Comparer 34 also calculates the difference of condensing between moment and initial time of starting of the second blood, is the beginning setting time of the second blood, and the beginning setting time of comparer 34 to the first blood and the beginning setting time of the second blood compare.
As can be seen here, the utility model is measured respectively the electrical quantity of the first blood and the second blood by the first blood clotting detecting device and the second blood clotting detecting device, and determine blood clotting parameter separately based on electrical quantity, thereby can compare the coagulation status of two kinds of different blood samples, meet the relatively demand of coagulation status.
And the utility model is accurately determined the blood clotting start time by timer, and the comparison directly perceived of different blood sample blood clotting times can be provided.Or the utility model is accurately determined blood clotting speed by counter, and the comparison directly perceived of different blood sample blood clotting speed can be provided.The utility model can provide the comprehensive comparison of coagulation status, for follow-up further blood clotting data analysis provides concrete quantitative basis.
The above, be only preferred embodiments of the present utility model, is not intended to limit protection domain of the present utility model.All within spirit of the present utility model and principle, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection domain of the present utility model.
Claims (9)
1. a blood clotting comparison means, is characterized in that, comprising:
One first pipe (23), for transmitting the first blood;
One first blood clotting detecting device (25), it is connected with described the first pipe (23), for detection of the first electrical quantity of described the first blood;
One second pipe (24), for transmitting the second blood;
One second blood clotting detecting device (26), it is connected with described the second pipe (24), for detection of the second electrical quantity of described the second blood;
The drawing of a blood clotting comparison means mouthful (22), be optionally communicated with described the first pipe or the second pipe;
One comparator circuit (50), be electrically connected with described the first blood clotting detecting device (25) and the second blood clotting detecting device (26), for determining the first blood clotting parameter based on described the first electrical quantity, determine the second blood clotting parameter based on described the second electrical quantity, and compare both.
2. blood clotting comparison means according to claim 1, it is characterized in that, also comprise a waste liquid bag (33), for collecting through the first blood of described the first blood clotting detecting device (25) and the second blood of this second blood clotting detecting device (26) of process.
3. blood clotting comparison means according to claim 1, it is characterized in that, also comprise one first suction pump (27), it is connected with described the first pipe (23), for described the first blood being sucked to described the first blood clotting detecting device (25).
4. blood clotting comparison means according to claim 1, it is characterized in that, also comprise one second suction pump (29), it is connected with described the second pipe (24), for described the second blood being sucked to described the second blood clotting detecting device (26).
5. blood clotting comparison means according to claim 1, is characterized in that, described comparator circuit (50) comprising:
One first timer (28), it is connected with the first blood clotting detecting device (25), the first blood clotting start time of record the first blood;
One second timer (30), it is connected with the second blood clotting detecting device (26), the second blood clotting start time of record the second blood;
One comparer (34), for more described the first blood clotting start time and the second blood clotting start time.
6. blood clotting comparison means according to claim 1, is characterized in that, described comparator circuit comprises:
One first timer (28), comprises counting circuit, and this timer is connected with the first blood clotting detecting device (25), for determine the first blood clotting speed of the first blood based on described the first electrical quantity;
One second timer (30), comprises counting circuit, and this timer is connected with the second blood clotting detecting device (26), for determine the second blood clotting speed of the second blood based on described the second electrical quantity;
One comparer (34), for more described the first blood clotting speed and the second blood clotting speed.
7. blood clotting comparison means according to claim 1, is characterized in that, also comprises a display, for showing the comparative result of described comparator circuit.
8. a blood clotting comparing component, is characterized in that, comprising:
One container (1), comprise one first tube (100) and one second tube (200), described the first tube (100) is for storing the first blood, and described the second tube (200) is for storing the second blood;
Just like the blood clotting comparison means described in any one in claim 1 to 7, be wherein optionally communicated with described the first pipe (23) with described the first tube (100) or be communicated with described the second pipe (24) and described the second tube (200) by described blood clotting comparison means draw mouthful (22).
9. blood clotting comparing component according to claim 8, is characterized in that, also comprises an anti-coagulation device (2), and it comprises: an inlet tube (601), and it is connected with described the first tube (100);
One stirs filtrator (606), for storing and stir the first blood filtering from described inlet tube (601) inflow; With an outlet (608), for being communicated with draw mouthful (21) for described stirring filtrator (606) and an anti-coagulation device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201420151254.9U CN203745411U (en) | 2014-03-31 | 2014-03-31 | Blood coagulation comparison device and blood coagulation comparison components |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420151254.9U CN203745411U (en) | 2014-03-31 | 2014-03-31 | Blood coagulation comparison device and blood coagulation comparison components |
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| CN203745411U true CN203745411U (en) | 2014-07-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104132969A (en) * | 2014-08-27 | 2014-11-05 | 刘玉菲 | Novel portable thrombus detection device |
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2014
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104132969A (en) * | 2014-08-27 | 2014-11-05 | 刘玉菲 | Novel portable thrombus detection device |
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Granted publication date: 20140730 |