CN203244631U - Plasma storage bag for plasma exchange, absorbing and filtering treatment - Google Patents
Plasma storage bag for plasma exchange, absorbing and filtering treatment Download PDFInfo
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- CN203244631U CN203244631U CN 201320248220 CN201320248220U CN203244631U CN 203244631 U CN203244631 U CN 203244631U CN 201320248220 CN201320248220 CN 201320248220 CN 201320248220 U CN201320248220 U CN 201320248220U CN 203244631 U CN203244631 U CN 203244631U
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Abstract
The utility model discloses a plasma storage bag for plasma exchange, absorbing and filtering treatment. The plasma storage bag for the plasma exchange, absorbing and filtering treatment comprises a plasma storage bag and an auxiliary connecting pipeline of the plasma storage bag. The plasma storage bag comprises an outer bag and an inner bag, and an inner cavity and an outer cavity are connected through a one-way valve composed of a double-layer membrane; a separated plasma inlet communicated with the outer cavity and a purified plasma inlet communicated with the inner cavity are formed in the top of the plasma storage bag; a backflow plasma outlet serving as an outflow opening of the inner cavity and a purified plasma outlet serving as an outflow opening of the outer layer are formed in the bottom of the plasma storage bag. The plasma storage bag for the plasma exchange, absorbing and filtering treatment solves the problem that extracorporeal circulation capacity is too large after complex treatment modes are combined, and therefore the treatment can be more conveniently, faster and more safely carried out; through the design of the inner cavity and the outer cavity and the construction of liquid flowing speed difference in the operation process, the purpose that plasma of a patient having hepatic failure flows, is absorbed, filtered and purified and circulates in vitro repeatedly is achieved, an efficient circulation access is formed, ineffective circulation is avoided, and the plasma storage bag can exert better treatment effect.
Description
Technical field
This utility model belongs to field of biomedicine technology, relates to a kind of medical apparatus and instruments, treats special-purpose blood plasma reservoir bag for a kind of for the plasmapheresis absorption filtration.
Background technology
The liver failure state of an illness is critical, progress rapidly, case fatality rate is high, is global problem for the treatment of liver failure always.The artificial liver replacement therapy can temporarily substitute liver function, removes the relevant toxin of liver failure, promotes liver cell regeneration, has become an important means of hepatitis gravis liver failure treatment.Artificial liver in treatment is divided into Biotype artificial liver and abiotic type artificial liver, the Biotype artificial liver lacks powerful cell source and efficient bioreactor because being subject to, do not enter clinical practice, in the world extensive use, effect are the inanimate artificial liver the most significantly at present always.The basic means of abiotic artificial liver is: plasmapheresis, blood (or blood plasma) absorption, hemodialysis, hemofiltration, albumin dialysis etc. are arranged.Remove for the toxin in different molecular weight interval in view of different treatment meanss, effect is also different, and the curative effect that single treatment means can obtain is limited, and present multiple base therapy means link and are combined into the development trend of abiotic artificial liver.
The representational method of external abiotic artificial liver has molecular adsorbent recirculation system (MARS) and composition separating plasma absorption filtration system (Prometheus).The MARS system is connected albumin dialysis in parallel with absorption, dialysis, and the albumin take 20% is dialysed as medium carries out circularly purifying.But the MARS treatment is excessively low because of dialyzer exchange of toxins efficient, and a large amount of human albumin finally are not fully utilized in the albumen decontamination cycle, and shortage is replenished the materials such as patient's albumin, thrombin, and clinical efficacy is subjected to certain influence.Carry out again hemodiafiltration with the similar Prometheus of MARS therapy system system with after the composition separating plasma absorption, compare with the MARS system, greatly reduce the albumin consumption, but plasma separator is connected with the Hemodiafiltration device and is carried out, and has greatly increased the unstability of system's operation, the clinical manipulation difficulty, and the extracorporeal circulation capacity is at least more than the 600ml, very big to patient with severe symptoms's hemodynamic effects, the patient often is difficult to tolerance, so do not obtain large scale application at home and abroad.
Domestic, abiotic artificial liver in treatment is take plasmapheresis as main, and effect is more outstanding than MARS.But finishing a plasmapheresis need to use about fresh plasma 3000ml, and the artificial liver in treatment of a course for the treatment of need to carry out 5-6 time plasmapheresis, consumption for blood plasma is very big, along with making constant progress of medical skill, clinical treatment is increasing for the demand of blood plasma, the blood plasma imbalance between supply and demand becomes increasingly conspicuous, and a large amount of sufferers are difficult to effectively be given treatment to.And advantage that how can the existing various Therapeutic Method of integrated application realizes that the cycling and reutilizations of a large amount of discarded blood plasma in the plasmapheresis process become people's problems of concern.
At present, idol is used simple liquid storage tank in order to storing blood plasma in the Biotype artificial liver therapy system, but because simple structure, the blood plasma after the processing mixes in same cavity with untreated blood plasma, so that the plasma purification inefficiency.Chinese patent application 200720058961.3 discloses a kind of dual-cavity liquid storage tank for biological artificial liver support system.But be that swabbing action by peristaltic pump realizes in the one-way flow of using this dual-cavity liquid storage tank, when collecting blood plasma and meet with the mechanical breakdown such as unexpected termination of pumping and operation mistake, the liquid in the two-chamber can mix.In the therapeutic alliance system of abiotic artificial liver, there is no the design of using the storage sizing device.
Summary of the invention
The purpose of this utility model is to provide a kind of plasmapheresis absorption filtration to treat special-purpose blood plasma reservoir bag, plasmapheresis and blood plasma are adsorbed, are used for the treatment of convenient effectively combining of three kinds of methods of hemofiltration, the excessive difficult problem of extracorporeal circulation blood volume in the combined process of solution multimodality treatment, make the hepatic failure patients blood plasma absorption filtration clean unit of repeatedly flowing through, form the efficient circulation path, reduce invalid circulation, play better therapeutic effect.
This utility model is achieved through the following technical solutions:
The plasmapheresis absorption filtration is treated special-purpose blood plasma reservoir bag, comprise blood plasma reservoir bag and attached connecting line thereof, described blood plasma reservoir bag: comprise an outer bag and an inner bag, two bags of bonding linking to each other of top, so that inner bag overhangs within the outer bag, inner bag consists of the inner chamber that stores liquid, consists of the exocoel that stores liquid between inner bag and outer bag, the unidirectional valve that consists of by a double-deck diaphragm between the interior outer chamber links to each other, and guarantees that liquid can only flow into exocoel from inner chamber; Blood plasma reservoir bag bag top is provided with the separated plasma import that communicates with exocoel, with blood plasma import after the purification that inner chamber communicates; Be provided with the backflow blood plasma outlet as the inner chamber flow export at the bottom of the blood plasma reservoir bag bag, as the purification blood plasma outlet of exocoel flow export.
Blood plasma import after described four opening separated plasma imports, the purification, the outlet of purification blood plasma, the outlet of backflow blood plasma further are connected with respectively supporting connecting line, overlap respectively on the supporting connecting line a movable clip is arranged, be the first movable clip, the second movable clip, the 3rd movable clip, the 4th movable clip, supporting connecting line is connected by knob joint each pipeline with the treatment of plasmapheresis absorption filtration.
Described inner bag top is provided with link, is used for hanging the blood plasma reservoir bag.
The beneficial effects of the utility model are behind the plasmapheresis absorption filtration therapy system application specific blood plasma reservoir bag of novelty, to have solved the complex treatment mode and united excessive this problem of rear extracorporeal circulation capacity, so that treat more Portable safety; The poor structure of flow rate of liquid has realized that the blood plasma of hepatic failure patients is in the external absorption filtration decontamination cycle of repeatedly flowing through during design and running by interior exocoel, form the efficient circulation path, the blood plasma that had purified simultaneously with isolate by the unidirectional valve realization without the blood plasma that purified, make the blood plasma that returns human body that returns human body through the above purified treatment of at least one circulation, avoid invalid circulation, thereby can give play to better therapeutic effect.
This plasmapheresis absorption filtration is treated special-purpose blood plasma reservoir bag and is simple and easy to processing, be used for collecting the discarded blood plasma of plasmapheresis, the blood purification method parallel connections such as displacement, filtration, absorption can be combined, realize that by the two-chamber circulation absorption repeatedly of discarded blood plasma, filtration purify, and are recycled displacement and feed back human body.The design of its pair bag structure and unidirectional valve is avoided without the situation in the blood plasma direct feedback body that effectively purifies, the elimination of maximum possible invalid circulation.
Description of drawings
Fig. 1 plasmapheresis absorption filtration is treated the structural representation of special-purpose blood plasma reservoir bag.
Fig. 2 is that this utility model plasmapheresis absorption filtration is treated special-purpose blood plasma reservoir bag application sketch map.
Fig. 3 is the structural representation of the unidirectional valve used in this utility model.
Wherein, separated plasma import 1, purify after blood plasma import 2, link 3, unidirectional valve 4, purify blood plasma outlet 5, backflow blood plasma outlet 6, outer bag 7, inner bag 8, the first movable clip 9, the second movable clip 10, the 3rd movable clip 11, the 4th movable clip 12, treatment patient 13, main blood pump 14, plasma separator 15, separating plasma pump 16, return stock pump 17, blood plasma reservoir bag 18, circulating pump 19, high flux filter 20, resin absorption device 21, active carbon adsorber 22.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is described further.
Referring to Fig. 1, the plasmapheresis absorption filtration is treated special-purpose blood plasma reservoir bag, comprise blood plasma reservoir bag and attached connecting line thereof, described blood plasma reservoir bag: comprise an outer bag 7 and an inner bag 8, two bags of volume-variables, preferred outer bag capacity 1000ml, inner bag capacity 500ml, two bags all can be adopted medical PVC to make.The top is bonding to link to each other, so that inner bag 8 overhangs within the outer bag 7, inner bag 8 consists of the inner chamber that stores liquid, 7 of inner bag 8 and outer bags consist of the exocoel that stores liquid, the unidirectional valve 4(that consists of by a double-deck diaphragm between the interior outer chamber is as shown in Figure 3) link to each other, guarantee that liquid can only flow into exocoel from inner chamber; Blood plasma reservoir bag bag top is provided with the separated plasma import 1 that communicates with exocoel, with blood plasma import 2 after the purification that inner chamber communicates; Be provided with the backflow blood plasma outlet 6 as the inner chamber flow export at the bottom of the blood plasma reservoir bag bag, as the purification blood plasma outlet 5 of exocoel flow export.
Described inner bag 8 tops are provided with link 3, are used for hanging the blood plasma reservoir bag.
Embodiment
As shown in Figure 2, use first Special artificial liver therapeutic instrument to carry out plasmapheresis, draw venous blood from patient's 13 femoral vein, draw blood flow speed 100-120ml/min, blood arrives plasma separator 15 through main blood pump 14, through blood plasma separate pump 16, keeps separating plasma speed 20ml/min, fresh plasma feeds back by returning stock pump 17, and it is identical with separating rate that speed keeps.Carry out first about 1 hour plasmapheresis, finish about plasma exchange dosage 1500ml, in the second half section of plasmapheresis, the discarded blood plasma of separation enters the exocoel of blood plasma reservoir bag from separated plasma import 1, and clip 9 is opened, clip 10,11,12 presss from both sides always and closes, when collecting the discarded blood plasma of about 600ml, the outer bag elastic expansion, and blood plasma flattens inner chamber, two valves of unidirectional valve that are positioned at exocoel are pressed off, and the blood plasma storage all is stored in the exocoel of blood plasma reservoir bag and can't enters exocoel.Then open clip 9,10,11,12, speed continuation separated plasma with 20ml/min enters exocoel, simultaneously operation purifying regeneration circulation at a high speed, blood plasma flows out from purifying blood plasma outlet 5, flow velocity 200ml/min through circulating pump 19, enters high flux blood filter 20 and carries out the persistence hemofiltration, carry out toxicant absorption through resin absorption device 21 and active carbon adsorber 22 successively again, the final inner chamber that returns the blood plasma reservoir bag by purifying rear blood plasma import 2.The blood plasma that inner chamber stores, a part is returned by backflow blood plasma outlet 6 flow velocitys with 20ml/min, replaces feedback, another part enters exocoel by action of gravity through unidirectional valve 4, continuation with enter decontamination cycle after exocoel blood plasma mixes and repeatedly purify.Because the action of gravity of the elasticity of liquid storing bag and blood plasma, when Double-cavity bag is hung up, can guarantee that blood plasma will flow to exocoel from the liquid storing bag inner chamber, until interior exocoel liquid level is consistent, backflow blood plasma exports 6 place's liquid except action of gravity is arranged, return in addition stock pump 17 and attract, negative pressure is lower, returns but not all flows into the exocoel mixing even can guarantee therefore that purification blood plasma that the exocoel liquid level crosses inner chamber when low also preferentially exports from backflow blood plasma.Like this, the blood plasma that flows out from backflow human plasma mouth does not mix with the blood plasma that firm separated and collected enters exocoel, and liquid circulation is stablized and carried out.Purification process can be so that every milliliter of discarded blood plasma feeds back human body through ability after 9-10 the circulation from refluxing opening at least by current difference.The high speed absorption filtration circulation continuous of whole system carried out 7 hours.When finishing treatment, close clip 9,10,12, open clip 11 slowly feeds back blood plasma after the purification of institute's inner chamber.
As mentioned above, blood purification system when operation, take the blood plasma reservoir bag as hinge, so that plasmapheresis is connected with the form of absorption filtration with parallel connection, can be so that it separately during independent operation, can not influence each other.Because the collection of the discarded blood plasma that provides in the plasmapheresis process is purification utilization again, both effectively solved not enough this difficult problem of clinical blood plasma supply, excessive this problem of extracorporeal circulation capacity when having overcome again Various Complex treatment pattern and carrying out simultaneously.
What more than announce only is specific embodiment of the utility model.All distortion that those of ordinary skill in the art can directly derive or associate from the disclosed content of this utility model all should be thought protection domain of the present utility model.
Claims (3)
1. a plasmapheresis absorption filtration is treated special-purpose blood plasma reservoir bag, it is characterized in that, it comprises blood plasma reservoir bag and attached connecting line thereof, described blood plasma reservoir bag: comprise an outer bag (7) and an inner bag (8), two bags of bonding linking to each other of top, so that inner bag (8) overhangs within the outer bag (7), inner bag (8) consists of the inner chamber that stores liquid, consist of the exocoel that stores liquid between inner bag (8) and outer bag (7), the unidirectional valve (4) that consists of by a double-deck diaphragm between the interior outer chamber links to each other, and guarantees that liquid can only flow into exocoel from inner chamber; Blood plasma reservoir bag bag top is provided with the separated plasma import (1) that communicates with exocoel, with blood plasma import (2) after the purification that inner chamber communicates; Be provided with the backflow blood plasma outlet (6) as the inner chamber flow export at the bottom of the blood plasma reservoir bag bag, as the purification blood plasma outlet (5) of exocoel flow export.
2. plasmapheresis absorption filtration according to claim 1 is treated special-purpose blood plasma reservoir bag, it is characterized in that: described four opening separated plasma imports (1), blood plasma import (2) after purifying, purify blood plasma outlet (5), backflow blood plasma outlet (6) further is connected with respectively supporting connecting line, overlap respectively on the supporting connecting line a movable clip is arranged, it is the first movable clip (9), the second movable clip (10), the 3rd movable clip (11), the 4th movable clip (12), supporting connecting line is connected by knob joint each pipeline with the treatment of plasmapheresis absorption filtration.
3. plasmapheresis absorption filtration according to claim 1 is treated special-purpose blood plasma reservoir bag, it is characterized in that, described inner bag (8) top is provided with link (3), is used for hanging the blood plasma reservoir bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320248220 CN203244631U (en) | 2013-05-09 | 2013-05-09 | Plasma storage bag for plasma exchange, absorbing and filtering treatment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320248220 CN203244631U (en) | 2013-05-09 | 2013-05-09 | Plasma storage bag for plasma exchange, absorbing and filtering treatment |
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| CN203244631U true CN203244631U (en) | 2013-10-23 |
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| CN 201320248220 Expired - Lifetime CN203244631U (en) | 2013-05-09 | 2013-05-09 | Plasma storage bag for plasma exchange, absorbing and filtering treatment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263706A (en) * | 2013-05-09 | 2013-08-28 | 浙江大学 | Plasma storage bag special for plasma exchange, absorption, and filtration treatment |
| CN103877631A (en) * | 2014-03-06 | 2014-06-25 | 浙江大学 | Bioartificial liver system |
-
2013
- 2013-05-09 CN CN 201320248220 patent/CN203244631U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263706A (en) * | 2013-05-09 | 2013-08-28 | 浙江大学 | Plasma storage bag special for plasma exchange, absorption, and filtration treatment |
| CN103877631A (en) * | 2014-03-06 | 2014-06-25 | 浙江大学 | Bioartificial liver system |
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| GR01 | Patent grant | ||
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Granted publication date: 20131023 |