CN203220373U - Behavioristics device used for evaluating negative symptoms of schizophrenia - Google Patents
Behavioristics device used for evaluating negative symptoms of schizophrenia Download PDFInfo
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- CN203220373U CN203220373U CN 201320189017 CN201320189017U CN203220373U CN 203220373 U CN203220373 U CN 203220373U CN 201320189017 CN201320189017 CN 201320189017 CN 201320189017 U CN201320189017 U CN 201320189017U CN 203220373 U CN203220373 U CN 203220373U
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Abstract
The utility model discloses a behavioristics device used for evaluating negative symptoms of the schizophrenia. A tubular channel is arranged on the bottom of the behavioristics device, a columnar barrier matched with the tube diameter is arranged inside the channel, and a wall in the center of a device box body divides the box body into two portions. The tubular channel penetrates through the wall. A water outlet is formed in one side of the box body and directly faces an outlet of the tubular channel, and a mark supplying the environment clue for a subject animal is arranged above the water outlet. The character that rodents like penetrating through the tubular channel is utilized, and the paradigm is designed on the basis of the tube penetration experiment. According to the behavioristics device, other elements possibly participating in the behavioural process of the animal are filtered, and the behavioristics device focuses on the motivation element, simulates the clinical psychology mechanism well, and is applicable to the pre-clinical research. Meanwhile, the behavioristics device lowers the training difficulty effectively, improves the experiment success rate, quantizes the motivation level, can reflect the medicine effect accurately for the pre-clinical research, and has high practicality. In addition, the behavioristics device is simple in structure, high in operability, and capable of reducing intersystem errors caused by equipment and operation difference effectively.
Description
Technical field
This utility model belongs to technical field of medical instruments, relates in particular to a kind of behavioristics's device of estimating negative symptoms of schizophrenia.
Background technology
Schizoid core clinical manifestation mainly comprises the positive symptom, feminine gender and cognitive symptom, and wherein negative symptoms is that the patient is disabled, can't be returned one of major reason of social life.
Antipsychotic drug is the schizoid main means for the treatment of at present.Preceding clinical research is the main method that new drug development stage curative effect of medication is estimated.Yet, present behavioristics's normal form and the instrument that does not still have the effective evaluation negative symptoms of schizophrenia.Therefore this has hindered the new drug development at negative symptoms to a certain extent, and it is significant for preceding clinical pharmacology research to set up effective negative symptoms behavioristics normal form.
The utility model content
The purpose of this utility model is to provide a kind of behavioristics's device of estimating negative symptoms of schizophrenia, is intended to solve and does not still have behavioristics's normal form of effective evaluation negative symptoms of schizophrenia and the problem of instrument at present.
This utility model is to realize like this, a kind of behavioristics's device of estimating negative symptoms of schizophrenia, described behavioristics bottom of device is being arranged a tubular conduit, and the column barrier that is complementary with caliber is arranged in the passage, and device box central authorities have a body of wall that casing is divided into two parts; Tubular conduit is passed body of wall, and casing one side is provided with outlet over against the logical outlet of tubulose, and the outlet top has one to provide the labelling of related environmental cues for tested animal.
Further, described behavioristics device top is provided with photographic head, connects the tested path of animal movement of computer record.
This utility model utilizes the characteristic of rodent hobby drilling pipe shape passage, design pattern on the drilling pipe experiment basis.This utility model has been developed behavioristics's normal form of simulation negative symptoms of schizophrenia Division 12. Clinical Psychology mechanism, and utilizes drilling pipe to push away thing experimental evaluation laboratory animal motivation level.Because " social behavior " normal form comprises more behavioristics's element, as abnormal smells from the patient hobby, novel clue, memory preservation etc., so the Division 12. Clinical Psychology feature that this normal form can't the real embodiment negative symptoms of schizophrenia.This utility model has filtered other may participate in the element of model animal action process, focuses on the motivation composition, therefore can simulate the Division 12. Clinical Psychology mechanism that negative symptoms takes place better, more is applicable to preceding clinical research.Rodent has the characteristic of hobby drilling pipe, and this utility model is developed behavioristics's normal form on this basis, can effectively reduce the training difficulty, improves experiment success rate.Motivation by the tested animal of level measurement of placing obstacles can quantize motivation level, can embody the curative effect of medicine more accurately for preceding clinical research, has stronger practicality.
Simple and clear, the strong operability of this utility model normal form structure can effectively reduce error between the system that causes because of equipment and difference in operation, is special-purpose behavioristics's normal form of estimating negative symptoms of schizophrenia.
Description of drawings
Fig. 1 is the structural representation for the mice behavioristics normal form device of estimating negative symptoms of schizophrenia that this utility model provides.
Among the figure: 1, tubular conduit, 2, barrier, 3, body of wall, 4, outlet, 5, labelling, 6, photographic head, 7, computer.
The specific embodiment
In order to make the purpose of this utility model, technical scheme and advantage clearer, below in conjunction with drawings and Examples, this utility model is further elaborated.Should be appreciated that specific embodiment described herein only in order to explaining this utility model, and be not used in restriction this utility model.
Fig. 1 shows the structure for the mice behavioristics normal form device of estimating negative symptoms of schizophrenia that this utility model provides.For convenience of explanation, only show the part relevant with this utility model.
This utility model bottom of device is being arranged a tubular conduit 1, and the column barrier 2 that is complementary with caliber is arranged in the passage 1, and device box central authorities have a body of wall 3 that casing is divided into two parts; Tubular conduit 1 is passed body of wall 3, and casing one side is provided with outlet 4 over against the outlet of tubulose logical 1, and there is a labelling 5 outlet 4 tops, for tested animal provides related environmental cues; The device top is provided with photographic head 6, connects the tested path of animal movement of computer 7 records.
This utility model normal form step:
1, animal is prohibited water treatment 12 hours, prohibits the water non-fasting.
2, experimental situation: background noise 60db, illumination 551ux, single only tested animal is equipped with single experimental provision or finishes one at every turn, and with 70% ethanol spray test device, wiping feces is to eliminate a last abnormal smells from the patient that stays.
3, adapt to: training begins the previous day, and tested animal is put into experimental situation adapt to, the free shuttling tubular conduit, making its understanding put into a passage offside has outlet.
4, training 1: animal is put into the right side casing, the offside outlet hangs a water droplet (about 10ul, 12h prohibits the hydrodynamic(al) thing needs the about 3ml of moisturizing total amount, therefore 10 training drink water 100ul, account for 3% of moisturizing total amount, can be defaulted as statistically animal training time and inferior between motivation that drinking-water is craved for consistent), after treating that animal passes passage and drinks water, it is put into the right side casing again, and circuit training 10 times makes animal on top of poling, the technical ability of drinking water.
5, training 2: put into the barrier of weight the lightest (weight grade 1) in tubular conduit, animal is put into the right side casing, train its association to release barrier and drink water, so circuit training is 10 times, the technical ability that makes animal on top of push away barrier, drink water.
6, test: the modeling animal is put into training environment, record time delay; When animal attempts promoting weight grade 1 barrier first, opening entry is carried out the time, until drinking water; After finishing in pipe same position put into weight grade 2 barriers (profile and big or small consistent with grade 1 barrier), animal is put into the right side casing, the retest flow process.This normal form from from the easier to the more advanced, arranges the barrier (profile and size are all consistent) of 5 weight grades altogether in the test link.When animal enter the right side casing after 120 seconds not inlet pipe push away thing, then artificially stop experiment, think to draw rein animal motivation deficiency.
Above process can be carried out path of animal movement and be followed the tracks of by the photographic head of device top.
The above only is preferred embodiment of the present utility model; not in order to limit this utility model; all any modifications of within spirit of the present utility model and principle, doing, be equal to and replace and improvement etc., all should be included within the protection domain of the present utility model.
Claims (2)
1. behavioristics's device of estimating negative symptoms of schizophrenia, it is characterized in that, described behavioristics bottom of device is being arranged a tubular conduit, and the column barrier that is complementary with caliber is arranged in the passage, and device box central authorities have a body of wall that casing is divided into two parts; Tubular conduit is passed body of wall, and casing one side is provided with outlet over against the outlet of tubular conduit, and outlet top has one to provide the labelling of related environmental cues for tested animal.
2. estimate behavioristics's device of negative symptoms of schizophrenia according to claim 1, it is characterized in that, described behavioristics device top is provided with photographic head, connects the tested path of animal movement of computer record.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320189017 CN203220373U (en) | 2013-04-16 | 2013-04-16 | Behavioristics device used for evaluating negative symptoms of schizophrenia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320189017 CN203220373U (en) | 2013-04-16 | 2013-04-16 | Behavioristics device used for evaluating negative symptoms of schizophrenia |
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| Publication Number | Publication Date |
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| CN203220373U true CN203220373U (en) | 2013-10-02 |
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| CN 201320189017 Expired - Fee Related CN203220373U (en) | 2013-04-16 | 2013-04-16 | Behavioristics device used for evaluating negative symptoms of schizophrenia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112237156A (en) * | 2020-10-23 | 2021-01-19 | 宁波大学 | Device and experimental method for testing autonomous social behaviors of small animals |
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2013
- 2013-04-16 CN CN 201320189017 patent/CN203220373U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112237156A (en) * | 2020-10-23 | 2021-01-19 | 宁波大学 | Device and experimental method for testing autonomous social behaviors of small animals |
| CN112237156B (en) * | 2020-10-23 | 2022-07-22 | 宁波大学 | Autonomous social behavior testing device and experimental method for small animals |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: KUIMING ANIMAL INSTITUTE OF CHINESE ACADEMY OF SCI Free format text: FORMER OWNER: ZHANG CHEN Effective date: 20131205 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200030 XUHUI, SHANGHAI TO: 650223 KUNMING, YUNNAN PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20131205 Address after: 650223 East Road, Kunming City, Yunnan province No. 32 Patentee after: Kuiming Animal Institute of Chinese Academy of Sciences Address before: 200030 Shanghai Wanping Road No. 600 Patentee before: Zhang Chen |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131002 Termination date: 20140416 |