CN202821734U - Magnetism alimentary canal support combined with hydrogel drug sustained release technology - Google Patents
Magnetism alimentary canal support combined with hydrogel drug sustained release technology Download PDFInfo
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- CN202821734U CN202821734U CN 201220454233 CN201220454233U CN202821734U CN 202821734 U CN202821734 U CN 202821734U CN 201220454233 CN201220454233 CN 201220454233 CN 201220454233 U CN201220454233 U CN 201220454233U CN 202821734 U CN202821734 U CN 202821734U
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- alimentary canal
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Abstract
The utility model discloses a magnetism alimentary canal support combined with hydrogel drug sustained release technology. The magnetism alimentary canal support has curing and supporting functions on an obstructed or narrow alimentary canal of a human body due to a tumor or relevant reasons. According to the outer shape of the magnetism alimentary canal support, the middle portion is cylindrical; two ends of the support are hemispherical in a transitional mode; and the edges of the support are circle. The overall support is in a double-layer net-shaped structure so as to be stronger and more durable in expansion capability than a single-layer support after placed in the human body and play a roe in supporting the alimentary canal. Hydrogel substances containing medicine or a trace of radioactive substances are filled between two layers of the net-shaped structure of the support so that the purpose of local drug sustained release is achieved, and a better curing effect is achieved. The support has magnetism so as to attract magnetism nano-liposomes containing drug to gather in specific parts, and therefore the best targeted therapy purpose is achieved.
Description
Technical field
This utility model relates to a kind of to because tumor or related causes cause blocking or narrow human body alimentary canal plays the device for the treatment of and supporting role, especially can utilize the intravenous technology that contains the magnetic nano liposome of medicine of hydrogel medicament slow release technology and magnetic bracket attraction to reach digestive tract expandable stent to the disease treatment purpose.
Background technology
Known alimentary stent mainly is the single-layer metal support at present, be mainly used in that digestive tract that tumor growth or other reasons cause blocks or narrow, especially the colorectal cancer patients that does not possess surgical condition can't normal defecation or esophageal cancer patients use can't take food the time.But, namely can't not suppress tumor and grow to the center because the centration of digestive tract tumor and ring-type growth characteristic and existing support itself do not have therapeutical effect, and its structure is comparatively thin, vertical direction in the intestinal tube traveling there is no the reinforcement supporting construction, support force a little less than, its supporting role and treatment block or narrow effect often effect is undesirable or be difficult to keep, can not obviously solve patient's misery, wasted again medical resource.
Summary of the invention
Can't block from the digestive tract that basic solution tumor causes or narrow problem of namely not treating function in order to overcome existing alimentary stent, this utility model provides a kind of alimentary stent, this alimentary stent can not only be to blocking or narrow digestive tract plays the effect of better lasting support, and can also carry out local individuation (selecting according to patient or the state of an illness) chemotherapy to diseased region, radiotherapy or other drug treatment, the more important thing is and to carry out targeted therapy to diseased region simultaneously, thereby suppress, slow down tumor growth, even dwindle tumor, to solving fundamentally that digestive tract blocks or narrow.
The technical scheme that its technical problem that solves this utility model adopts is: the self expandable alloy bracket is made double-deck network structure, its band is magnetic, utilize vacuum drawing technique, hydrogel and magnetic metal support are combined together, namely be full of the hydrogel materials that contains medicine between double-deck network structure, the medicine in the hydrogel can be the chemotherapeutics of individuation, radiotherapy material or the other drug of trace.Again this utility model is implanted the digestive tract position that pathological changes occurs, the double-layer alloy support plays than the stronger supporting role of existing support to the pathological changes digestive tract when, from the hydrogel of being close to pathological changes, discharge Individual Chemotherapy medicine, radiotherapy material or other drug, to reach the therapeutic purposes of local chemicotherapy; In addition, inject for simultaneously patient's vein and contain 5-FU(chemotherapeutics) or the magnetic nano liposome of other drug, because metal rack has magnetic action, it can make contain 5-FU or other drug magnetic nano liposome under the effect in tumor locus magnetic field the zero distance effective location to tumor tissues, magnetic nano liposome optionally is gathered in tumor tissues, tumor target area drug level significantly increases, and reaches the purpose of targeted therapy.Like this, when this utility model is played a supporting role to the pathological changes digestive tract, the function of radiotherapy and targeted therapy in addition localizes, can solve effectively not only that digestive tract that tumor growth or other reasons cause blocks or narrow, simultaneously also can suppress and slow down tumor growth, even dwindle tumor, reach therapeutic purposes.
Preparation magnetic Self-expanded stent after the molding of double-deck network structure self expandable alloy bracket, adopts magnetization to process.Magnetization field, rear surface can reach 30mT, and this support is the permanent magnetism support after the magnetization, and 200 ℃ of high temperature of ability have shape memory function, in vivo anti-erosion, antioxidation.
Hydrogel has its unique advantage as the novel biological agent base material.The high-moisture of hydrogel can improve the degree of hydration of enteric cavity endothelium on the one hand, thereby increases the exchange rate of the permeability raising medicine of inner skin surface exchange; Can also increase substantially on the other hand the drug loading of water soluble drug, overcome the shortcoming of traditional pressure sensitive glue drug loading easy crystallize out when high.In addition, hydrogel can also be made the supersaturation water gel carrier of medicine, thus significantly improve medicine see through blood vessel local action usefulness.In addition, most hydrogels especially by the hydrogel of polysaccharide and derivant thereof preparation, all demonstrate the good biocompatibility with endothelium, are difficult for producing anaphylactic reaction, and biodegradable, can be used as slow-released carrier has good application prospect.
Magnetic liposome belong to the 4th generation targeting drug delivery system, have advantages of simultaneously liposome and magnetic target administration, be a kind of novel drug targeting carrier in the magnetic targeting drug delivery system.Magnetic liposome is applied to the treatment of malignant tumor as the carrier of chemotherapeutics, except the advantage with general liposome, can also the targeting of carrier further be improved by the action of a magnetic field.Under the effect in tumor locus magnetic field, magnetic nano liposome optionally is gathered in tumor tissues.Tumor tissues has tissue permeability and the retention effect of increase, the liposome that is gathered in the tumor vessel exosmoses to the tumor gap, 5-FU slowly discharges from liposome, higher drug level is kept the long period in tumor tissues, thereby in different cell cycle performance Graft Versus Tumor.
The beneficial effects of the utility model are, utilize vacuum drawing technique, the hydrogel and the magnetic Self-expanded stent that carry medicine are combined together, jointly bring into play usefulness at the cancerous protuberance position, utilize new bio technology individualized treatment carcinomatous ileus, realize removing and block, relief of symptoms, especially realize localization radiotherapy and targeted therapy, improve prognosis, improve patient's treatment at a specified future date and quality of life.Carry out the patient of chemotherapy for some digestion tumors, can make chemotherapeutic concentrate on the pathological changes digestive tract by using this utility model, alleviate chemotherapeutics to other organs, especially the injury of the important organs such as the heart, brain, kidney.Also can change emergency operation into limited operation, thereby obtain better postoperative outcome, have good using value.And expect to make the patient of the relatively poor inoperable colorectal cancer complicated with intestinal obstruction of more general status to be benefited, and avoid making throughout one's life the misery of mouth, obtain good society and economic benefit.
Description of drawings
Below in conjunction with drawings and Examples this utility model is further specified.
Fig. 1 is appearance assumption diagram of the present utility model.
Fig. 2 is vertical anatomical structure figure of the present utility model.
Fig. 3 is the internal anatomy of walking crosswise of the present utility model.
Fig. 4 is that this utility model is implanted pathological changes digestive tract section schematic diagram
1. are with magnetic alloy bracket outer among the figure, 2. be with magnetic alloy bracket internal layer, 3. fill position, the 4. digestive tract of pathological changes with the hydrogel of medicine, 5. the band medicated magnet nanometer liposome of being assembled in the part by the support magnetic attraction, 6. hydrogel is at the medicine of part release.
The specific embodiment
In Fig. 1, Fig. 2, Fig. 3, this utility model is comprised of outer network (1) and the two-layer network of internal layer network (2), whole support has permanent magnetism, the support mid portion is cylindrical, the transition of support two ends is hemispherical, and the edge is mellow and full, to the gastral injury of patient and sense of discomfort, and has the ability of elasticity and self expansion when design can be avoided implanting like this.Double-deck network structure and the two-layer supporting role of all having strengthened support between netted in the coupling part of bracket edge.Space-filling between outer network (1) and the internal layer network (2) with the hydrogel materials (3) of medicine or micro-radioactive substance.
In the embodiment shown in fig. 4, after this utility model was implanted pathological changes digestive tract section (4), outer network (1) and internal layer network (2) had played supporting role to pathological changes digestive tract section (4), made digestive tract expand and keep clear.Simultaneously, the hydrogel materials (3) between outer network (1) and the internal layer network (2) discharges medicine or lonizing radiation (6) act on pathological changes digestive tract section (4) part, plays the effect of localization radiotherapy.In addition, because support has magnetic, attract a large amount of band medicated magnet nanometer liposomes (5) mobile to pathological changes digestive tract section (4) by blood vessel, and in these a large amount of gatherings, play the effect of targeted therapy.
Claims (3)
1. alimentary stent, the support mid portion is cylindrical, the transition of support two ends is hemispherical, and the edge is mellow and full, it is characterized in that: whole support is double-deck network structure, whole support has permanent magnetism, is full of the hydrogel that contains medicine between two-layer network structure, can expand voluntarily after putting into human body.
2. described alimentary stent according to claim 1 after the alloy bracket molding, makes it have magnetic, and the magnetic nano liposome that contains medicine that utilizes the local magnetic field effect to be drawn in the body is assembled at specific part, reaches the purpose of targeted therapy.
3. described alimentary stent according to claim 1 is full of the hydrogel materials that contains medicine or contains the hydrogel materials of micro-radiotherapy material between the two-layer netted supporting structure, reach medicine in the purpose of local sustained release treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220454233 CN202821734U (en) | 2012-09-07 | 2012-09-07 | Magnetism alimentary canal support combined with hydrogel drug sustained release technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220454233 CN202821734U (en) | 2012-09-07 | 2012-09-07 | Magnetism alimentary canal support combined with hydrogel drug sustained release technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202821734U true CN202821734U (en) | 2013-03-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220454233 Expired - Fee Related CN202821734U (en) | 2012-09-07 | 2012-09-07 | Magnetism alimentary canal support combined with hydrogel drug sustained release technology |
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| CN (1) | CN202821734U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691644A (en) * | 2017-01-12 | 2017-05-24 | 吉林大学 | Colorectum support with thermotherapy function |
| CN108543165A (en) * | 2018-02-27 | 2018-09-18 | 宁波胜杰康生物科技有限公司 | A kind of muscular function auxiliary device based on carrier |
-
2012
- 2012-09-07 CN CN 201220454233 patent/CN202821734U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691644A (en) * | 2017-01-12 | 2017-05-24 | 吉林大学 | Colorectum support with thermotherapy function |
| CN108543165A (en) * | 2018-02-27 | 2018-09-18 | 宁波胜杰康生物科技有限公司 | A kind of muscular function auxiliary device based on carrier |
| CN108543165B (en) * | 2018-02-27 | 2021-06-18 | 宁波胜杰康生物科技有限公司 | Carrier-based muscle function auxiliary device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130327 Termination date: 20130907 |