CN202821430U - Device used for forecasting pregnancy outcomes based on three dimensional-Ultrasound (3D-US) - Google Patents
Device used for forecasting pregnancy outcomes based on three dimensional-Ultrasound (3D-US) Download PDFInfo
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- CN202821430U CN202821430U CN 201220515581 CN201220515581U CN202821430U CN 202821430 U CN202821430 U CN 202821430U CN 201220515581 CN201220515581 CN 201220515581 CN 201220515581 U CN201220515581 U CN 201220515581U CN 202821430 U CN202821430 U CN 202821430U
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Abstract
The utility model discloses a device used for forecasting pregnancy outcomes based on three dimensional-Ultrasound (3D-US). The device comprises a 3D-US probe, a connecting wire, a comparator, a storage device and an output device, wherein the 3D-US probe is connected with the comparator through the connecting wire, the 3D-US probe is used for measuring ovarian reserve data and endometrial receptivity data, the storage device is connected with the comparator and is used for storing the ovarian reserve data and the endometrial receptivity data under the standard condition, the comparator compares the data measured by the3D-US probe and standard data in the storage device, and the output device is connected with the comparator and used for outputting the compared results. The device used for forecasting pregnancy outcomes based on 3D-US utilizes the 3D-US probe to measure data, compares the data with the standard data in the storage device, outputs the compared results, and is better in sensitivity, specificity, accuracy, repeatability and has a higher positive predictive function compared with two-dimensional ultrasonic measurement.
Description
Technical field
This utility model belongs to technical field of medical instruments, particularly relates to a kind of device based on 3D-US prediction pregnancy outcome.
Background technology
The reason of infertility is more, gets rid of the primary infertility of the factors such as salpingemphraxis, pituitary tumor, whole body illness and male sterility, may be relevant with the decline of reproductive function deposit.The potentia concipiendi of normal female reproductive system is subject to the impact of many factors, comprises age, Endocrine Levels, ovarian reserve function, endometrium receptivity etc.Ovarian reserve function (Ovarian reserve, OR) and endometrium receptivity (Endometrialreceptivity, ER) are two most important, indispensable factors.
Recent two decades comes, Assisted Reproductive Technology ART (Assisted reproductive technologies, ART) such as insémination intrautérine (Intrauterine insemination, IUl) and vitro fertilization-embryo implanting (in vitrofertilization and embryo transfer, IVF-ET) development is swift and violent, obtained very much progress, but Clinical Pregnancy Rate in is still undesirable.Because treatment cycle is subject to the impact of all too many levels, pregnancy outcome also is subject to impact and the restriction of multiple master, objective condition, such as proficiency level of condition of in vitro culture, embryo quality, operator etc., but patient's OR and ER are still the most basic, most important prerequisite.
The in good time maturation of ovum is prerequisite normal, that have plantation power embryo.OR refers to the ability of ovarian cortex district ovarian follicular growth, growth, the fertilizable oocyte of formation, generally includes and retains follicle number and ovum quality two aspects in the ovary.Better OR just can obtain synchronous maturation, high-quality ovum.Csemiczky etc. point out that the normal patient of OR obviously raises than pregnancy rate, the live birth rate that OR reduces the patient, and treatment cycle slightly shortens, and cycle cancellation rate significantly descends.On the contrary, follicular dysplasia, very few or poor quality be will cause, and then rate of fertilization, embryo quality and pregnancy rate affected.Particularly used since the ART technology treatment infertility, when the normal patient of some reproductive endocrine axles is carried out induced ovulation, often can cause follicular atresia and ovum quality to descend, ovary is to controlled super induced ovulation (Controlled Ovarian Hyperstimulation, COH) low reaction is inseparable with OR, is a superovulated difficult problem in the ART process.But excessive reaction may cause serious complication-ovarian hyperstimulation syndrome (OHSS), affects embryo's plantation, also have to termination of pregnancy even jeopardize patient's life of severe one.
Clinically, can indirectly understand OR by a series of inspections relevant with the granular cell physiological function or the special expression of some Some Circulating Factors, index commonly used is mainly basic levels of reproductive hormones (FSH, LH, E2), basis inhibin B (INH-B) level, a series of dynamic tests, such as Chloramiphene irritant test (CCCT), the HMG irritant test, the GnRHa irritant test, the mensuration of the various hormones such as foreign aid's property FSH irritant test or the detection of relevant cell factor are estimated, but lack sensitivity and specificity, can not entirely accurate predict the relation of reproductive function deposit and pregnancy outcome.In addition, there is the scholar to propose some perspective marker genes, but also is restricted because somewhat expensive is carried out it.Moreover pathological biopsy is a kind of traumatic inspection method, and the patient usually is difficult to accept.Therefore, for the prediction of reproductive function deposit, still need further to seek easy, noinvasive, special index and method, these all are one of vast clinical position person problems of endeavouring to study.
The existing device of pregnancy outcome of predicting adopts two dimension and color Doppler ultrasonography, although extensively confirmed the prediction of OR and ER is had positive, important meaning, but mostly be the index of biochemical investigation, the data precision of measuring is not high, can not go out some morphologys and hemodynamic situation by objective expression.
The utility model content
The technical problem that (one) will solve
The technical problems to be solved in the utility model is: the existing device of pregnancy outcome of predicting adopts the data precision of two dimension and color Doppler ultrasonography measurement not high, can not go out some morphologys and hemodynamic situation by objective expression.
(2) technical scheme
In order to solve the problems of the technologies described above, this utility model provides a kind of device based on 3D-US prediction pregnancy outcome.
Wherein, described device comprises 3D-US probe, connecting line, comparator, memorizer and follower, and described 3D-US probe is connected with comparator by connecting line, and described 3D-US probe is used for measuring ovarian reserve data and endometrium receptivity data; Described memorizer is connected with comparator, is used for ovarian reserve data and endometrium receptivity data under the storage standards situation; Described comparator compares the data of 3D-US probe measurement and the normal data in the memorizer; Described follower is connected with comparator, is used for the result that output comparator compares.
Preferably, described memorizer is random access memory or read only memory.
Preferably, described device also comprises the low frequency power source, and described low frequency power source is connected with the 3D-US probe, is used for providing to the 3D-US probe low frequency power source of energy.
Preferably, described 3D-US probe comprises three row's ultrasonic probe and concave mirrors, and the both sides of described concave mirror respectively are provided with row's low frequency linear array ultrasonic probe, is provided with the high-frequency linear array ultrasonic probe between two row's low frequency linear array ultrasonic probes.
(3) beneficial effect
Technique scheme has following advantage: this utility model utilizes the 3D-US probe to measure hole Follicle number, hole follicle volume, Ovarian Volume, measure uterus and Endometrial volume, and detect the hemodynamic index of uterine artery, endometrium spiral artery, compare by the normal data in data measured and the memorizer, by comparative result prediction pregnancy outcome.Because 3D-US has preferably susceptiveness, specificity, accuracy, repeatability and higher positive prediction effect than the diameter measurement of two-dimensional ultrasound, compare by 3D-US data measured and normal data, thereby can objectively judge and pregnant result have Clinical feasibility.Adopt the leading indicator that 3D-US detects affects the reproductive function deposit, use Influencing factors method and ROC curve that variable is carried out overall merit, filter out significant parameter, objective, the noninvasive 3D-US diagnostic cast of the science of setting up, more proactive and accuracy is high than common ultrasonic monitoring.
Description of drawings
Fig. 1 is the structural representation of a kind of embodiment of the present utility model;
Fig. 2 is the structural representation of probe of the present utility model;
Fig. 3 is the workflow diagram of this utility model device.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present utility model is described in further detail.Following examples are used for explanation this utility model, but are not used for limiting scope of the present utility model.
As shown in Figure 1, structural representation for a kind of embodiment of the present utility model, this device comprises 3D-US probe, connecting line, comparator, memorizer and follower, described 3D-US probe is connected with comparator by connecting line, and described 3D-US probe is used for measuring ovarian reserve data and endometrium receptivity data; Described memorizer is connected with comparator, is used for ovarian reserve data and endometrium receptivity data under the storage standards situation; Described comparator compares the data of 3D-US probe measurement and the normal data in the memorizer; Described follower is connected with comparator, is used for the result that output comparator compares.
This utility model utilizes the 3D-US probe to measure hole Follicle number, hole follicle volume, Ovarian Volume, measure uterus and Endometrial volume, and detect the hemodynamic index of uterine artery, endometrium spiral artery, compare by the normal data in data measured and the memorizer, prediction pregnancy outcome has preferably susceptiveness, specificity, accuracy, repeatability and higher positive prediction effect than the two-dimensional ultrasound measurement.
Preferably, described memorizer is random access memory or read only memory.Comparator of the present utility model can be any size device relatively that carries out.
Preferably, described device also comprises the low frequency power source, and described low frequency power source is connected with the 3D-US probe, is used for providing to the 3D-US probe low frequency power source of energy.
Preferably, described endometrium receptivity data comprise the hemodynamics data of uterus and Endometrial volume, uterine artery and endometrium spiral artery.
Preferably, described ovarian reserve data comprise hole Follicle number, hole follicle volume and Ovarian Volume.
Preferably, described device also comprises ovary marking system and inner membrance marking system, and described ovary marking system is used for the relatively ovarian reserve data normal data corresponding with memorizer of 3D-US probe measurement, to obtain the ovary appraisal result; Described inner membrance marking system is used for the relatively endometrium receptivity normal data corresponding with memorizer of 3D-US probe measurement, to obtain the endometrium appraisal result; Described comparator carries out analysis-by-synthesis to obtain pregnancy outcome to ovary appraisal result and endometrium appraisal result.Can set weighted value to ovary appraisal result and endometrium appraisal result, obtain the score basis of pregnancy outcome according to comprehensive grading.Also can according to appraisal result separately, judge separately pregnancy outcome.
Preferably, described memorizer Plays data to set up process as follows: utilize first the Logistic Return Law that the data of 3D-US probe measurement are screened, to choose comparative parameter, use the ROC curve to determine the threshold value of its parameter the comparative parameter of choosing, thereby obtain normal data.Wherein, the algorithm of the Logistic Return Law and ROC curve is prior art.The foundation of this memorizer is equivalent to create a 3D-US diagnostic cast, and data and the normal data of 3D-US probe measurement compared, and judges whether to belong to normal range.Certainly, normal data also can carry out chosen in advance, is stored in the memorizer.Can also make amendment to normal data as required.
As shown in Figure 2, structural representation for the probe of a kind of embodiment of this utility model, this 3D-US probe comprises three row's ultrasonic probe and concave mirrors 4, the both sides of described concave mirror 4 respectively are provided with left bank low frequency linear array ultrasonic probe 1 and right row's low frequency linear array ultrasonic probe 3, are provided with high-frequency linear array ultrasonic probe 2 between two row's low frequency linear array ultrasonic probes.This concave mirror focus is in the F point, and described low frequency ultrasound probe is connected with comparator by connecting line respectively with the high frequency ultrasound probe.This ultrasonic probe more meets the characteristics of organizational structure with form projection, the irradiation target region of three-dimensional column or taper.
As shown in Figure 3, be the workflow diagram of device of the present utility model, step is as follows:
1, the infertile patient of choosing medical row vitro fertilization-embryo implanting (IVF-ET) is totally 200 examples, is associated with endometrial polyp, uterus pathological changes, Poor ovarian response or because of OHSS with have the OHSS tendency to abandon IVF-ET person all not list this research in.Selected patient all goes operation on pelvis, gets rid of the ovary and uterus pathological changes, except the infertile and male sterility factor that causes of salpingemphraxis, pituitary tumor, whole body illness.Be divided into 3 groups by patient age, I organizes (25～30 years old), and II organizes (31～35 years old), and III organizes (36～40 years old), and the 8th～12 day, the 13rd～16 day, the 18th～23 day capable 3D-US with menstrual cycle checks respectively.
2, basic hormone determination
The basic hormone that selected patient measures is: estradiol (E2), progesterone (P), FSH (FSH), interstitialcellstimulating hormone (ICSH) (LH), pituitary gland prolactin (PRL), testosterone (T).Serum specimen adopts stock solution to measure in principle, and concentration exceeds 10 times of the dilutions of measurement range and measures.Adopt routinely the COH scheme to surpass induced ovulation to the object of study that meets inclusive criteria, depending on age, body weight, ovarian function and FSH, LH, E2 level, adjust dosage and scheme.
3,3D-US detects ovary, inner membrance situation
Routinely uterus, bilateral attachment area are carried out ultrasonic scan.Compose with different score values according to endometrial echo, form situation.The standard that endometrial echo, Type of injury are commonly used with reference to us.Endometrium echo is divided into I type, II type, III type, IV type.The endometrium form is divided into A type, Type B, C type.
Start 3D-US scanning pattern, obtain ovary, follicle, uterus, endometrium volume.Being divided into several class according to its volume also composes with different score values.The 3rd day hole follicle sum (2～10mm) in the 3D-US measurement menstrual cycle.Same period beginning in the 8th～10 day 3D-US monitoring follicular development gives the HCG intramuscular injection when follicle maturity is arranged.
Start color Doppler and make spectrum measurement, the hemodynamic index of record uterine artery, endometrium spiral artery, ovary, be pulsatility index (PI), drag index (RI), peak systolic velocity (PVS), each hemodynamic index be divided into some levels by degree also compose with different score values.
4, the foundation of ovary marking system and inner membrance marking system
The index that the ovary marking system comprises: hole follicle volume, hole follicle quantity, Ovarian volume and every Ovarian Blood Flow dynamics index, final scoring is the summation of bilateral ovaries and follicle single index score value.
The index that the endometrium marking system comprises: inner membrance volume, inner membrance echo, endometrial morphology, uterine volume, uterine artery and endometrium spiral artery hemodynamics, final scoring is the summation of each single index score value.
5, set up the 3D-US diagnostic cast that the reproductive function deposit is assessed
Use Influencing factors method and ROC curve that ovary marking system and inner membrance Score index system are carried out overall merit, filter out significant index variable, check the reliability of each variable, set up the threshold value of 3D-US diagnostic cast and definite diagnosis index of correlation, normal data is deposited among the data base; 3D-US diagnostic cast and ovary marking system, inner membrance marking system carry out correlation analysis, and evaluation index is sensitivity, specificity, accuracy rate, outstanding mounting index etc.; Analyze 3D-US diagnostic cast and the levels of reproductive hormones same period (estrogen 2, progestogen P, interstitialcellstimulating hormone (ICSH) LH, FSH FSH etc.), age (three groups) and embryo quality dependency; Consider the coordinate synchronization of endometrium receptivity and ovarian reserve ability, to observe ovary and endometrium to the promoting sexual gland hormone drug reaction, adjust dosage and time, in order to get ovum and transplanting in good time.
6, the prediction of Clinical Outcome
Ultrasonic monitoring sees that follicle disappears, and follicle subsides, and a little hydrops of arched roof is for there being ovulation behind the uterus.Capable urine pregnancy test in 14 days or blood HCG measure behind the embryo transfer, and the urine pregnancy test positive or blood HCG＞5U/L be biochemical gestation, go ultrasonic examinations after 2 weeks, gestation sac and core barrel occur and beat and be diagnosed as clinical pregnancy.
By above gonadal hormone detection and result of ultrasonography the reproductive function deposit is divided into: ovary response is normal and endometrium receptivity is normal, Poor ovarian response and endometrium receptivity are normal, ovary response is normal and endometrium receptivity is bad bad with Poor ovarian response and endometrium receptivity, and with the as a result relative analysis of final clinical pregnancy, find out the factor that may affect patient clinical pregnancy outcome.
7, the clinical evaluation of 3D-US diagnostic cast
For checking the predictive diagnosis usefulness of this 3D-US diagnostic cast, select at random suitable patient affected by inspection, the feature detection parameter is inputted this model, and compare with final result, with this system is tested; Extract characteristic index and consist of information bank and is revised, make it more to tally with the actual situation, the performance with further raising system reduces error to greatest extent.
The above only is preferred implementation of the present utility model; should be understood that; for those skilled in the art; under the prerequisite that does not break away from this utility model know-why; can also make some improvement and replacement, these improvement and replacement also should be considered as protection domain of the present utility model.
Claims (4)
1. device based on 3D-US prediction pregnancy outcome, it is characterized in that, described device comprises 3D-US probe, connecting line, comparator, memorizer and follower, described 3D-US probe is connected with comparator by connecting line, and described 3D-US probe is used for measuring ovarian reserve data and endometrium receptivity data; Described memorizer is connected with comparator, is used for ovarian reserve data and endometrium receptivity data under the storage standards situation; Described comparator compares the data of 3D-US probe measurement and the normal data in the memorizer; Described follower is connected with comparator, is used for the result that output comparator compares.
2. the device based on 3D-US prediction pregnancy outcome according to claim 1 is characterized in that described memorizer is random access memory or read only memory.
3. the device based on 3D-US prediction pregnancy outcome according to claim 1 is characterized in that described device also comprises the low frequency power source, and described low frequency power source is connected with the 3D-US probe, is used for providing to the 3D-US probe low frequency power source of energy.
4. the device based on 3D-US prediction pregnancy outcome according to claim 1, it is characterized in that, described 3D-US probe comprises three row's ultrasonic probe and concave mirrors, the both sides of described concave mirror respectively are provided with row's low frequency linear array ultrasonic probe, are provided with the high-frequency linear array ultrasonic probe between two row's low frequency linear array ultrasonic probes.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109805963A (en) * | 2019-03-22 | 2019-05-28 | 深圳开立生物医疗科技股份有限公司 | The determination method and system of one Endometrium parting |
| CN111933290A (en) * | 2020-08-14 | 2020-11-13 | 苏州赫亚斯顿智能科技有限公司 | Method and device for establishing artificial reproduction pregnancy prediction by machine learning model |
| WO2022006942A1 (en) * | 2020-07-10 | 2022-01-13 | 北京大学第三医院（北京大学第三临床医学院） | System and method for predicting fixed number of years after which new ovarian reserve change occurs in subject |
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2012
- 2012-10-10 CN CN 201220515581 patent/CN202821430U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109805963A (en) * | 2019-03-22 | 2019-05-28 | 深圳开立生物医疗科技股份有限公司 | The determination method and system of one Endometrium parting |
| CN109805963B (en) * | 2019-03-22 | 2022-07-05 | 深圳开立生物医疗科技股份有限公司 | Method and system for judging endometrium typing |
| WO2022006942A1 (en) * | 2020-07-10 | 2022-01-13 | 北京大学第三医院（北京大学第三临床医学院） | System and method for predicting fixed number of years after which new ovarian reserve change occurs in subject |
| CN111933290A (en) * | 2020-08-14 | 2020-11-13 | 苏州赫亚斯顿智能科技有限公司 | Method and device for establishing artificial reproduction pregnancy prediction by machine learning model |
| CN111933290B (en) * | 2020-08-14 | 2023-10-10 | 北京赫雅智能科技有限公司 | Method and device for predicting artificial reproduction conception by machine learning model |
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Granted publication date: 20130327 |