CN202537715U - Cervical artificial intervertebral disc capable of preventing heterotopic ossification - Google Patents
Cervical artificial intervertebral disc capable of preventing heterotopic ossification Download PDFInfo
- Publication number
- CN202537715U CN202537715U CN2011204940357U CN201120494035U CN202537715U CN 202537715 U CN202537715 U CN 202537715U CN 2011204940357 U CN2011204940357 U CN 2011204940357U CN 201120494035 U CN201120494035 U CN 201120494035U CN 202537715 U CN202537715 U CN 202537715U
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- China
- Prior art keywords
- soleplate
- artificial intervertebral
- intervertebral disc
- cervical vertebra
- intervertebral disk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The utility model provides a cervical artificial intervertebral disc capable of preventing heterotopic ossification. The cervical artificial intervertebral disc capable of preventing heterotopic ossification comprises an upper end plate, a lower end plate and a nucleus pulposus, wherein the nucleus pulposus is arranged between the upper end plate and the lower end plate; microporous coatings are distributed in the lateral regions and the peripheral regions of the lower surface of the upper end plate, and the lateral regions and the peripheral regions of the upper surface of the lower end plate; and medicines are filled in the micropores of the microporous coatings, and include celecoxib. According to the cervical artificial intervertebral disc capable of preventing heterotopic ossification, the cervical artificial intervertebral disc with micropores is taken as a stent to package the celecoxib in the micropores in the artificial intervertebral disc via a self-packaging technique, so that the artificial intervertebral disc has the function of slow release of celecoxib, and ensures that a durable celecoxib microenvironment with high concentration is formed in the operating local region. The cervical artificial intervertebral disc capable of preventing heterotopic ossification is a novel measure for preventing complication of heterotopic ossification after the replacement of cervical artificial intervertebral disc.
Description
Technical field
This utility model relates to the cervical vertebra implant, especially has the cervical vertebra plant that is loaded with medicine through microcellular structure, particularly, relates to the cervical vertebra artificial intervertebral disk that can prevent ectopic ossification.
Background technology
The cervical vertebra artificial intervertebral disk has been widely used in anterior cervical operation, but the incidence rate of postoperative ectopic ossification is high, the cervical vertebra artificial intervertebral disk takes place when serious merge, and influences cervical vertebrate active degree.At present, generally acknowledge that the Drug therapy that can prevent ectopic ossification is that whole body is used indomethacin.Yet whole body is used easy concurrent gastrointestinal hemorrhage of indomethacin and cardiovascular event.Selective COX-2-2 acceptor inhibitor celecoxib not only can suppress bone formation, its local incidence rate that also greatly reduces gastrointestinal hemorrhage and cardiovascular event of using.
The utility model content
To defective of the prior art, the purpose of this utility model provides a kind of cervical vertebra artificial intervertebral disk that prevents ectopic ossification.
An aspect according to this utility model provides the cervical vertebra that can prevent ectopic ossification artificial intervertebral disk, it is characterized in that, comprises soleplate, following soleplate and vertebral pulp, and wherein, said vertebral pulp is installed in said going up between soleplate and the following soleplate.
Preferably, said surface of going up soleplate and following soleplate is provided with micro porous coating.
Preferably, said micro porous coating be distributed in as in the lower area any or appoint on a plurality of zones: the said lateral side regions that goes up soleplate; The said lower surface outer peripheral areas that goes up soleplate; The said lateral side regions of soleplate down; The said upper surface outer peripheral areas of soleplate down.
Preferably, said micro porous coating is micropore titanium coating, micropore tricalcium phosphate/hydroxyapatite coating layer, micropore ceramics oxide-film coating or microporous polymer coating.
Preferably, be filled with medicine in the micropore of said micro porous coating.
Preferably, said go up soleplate and down soleplate following any or appoint and be equipped with micropore on a plurality of zones: the said lateral side regions that goes up soleplate; The said lower surface outer peripheral areas that goes up soleplate; The said lateral side regions of soleplate down; The said upper surface outer peripheral areas of soleplate down.
Preferably, be filled with medicine in the micropore of said upward soleplate and following soleplate.
Preferably, said medicine comprises celecoxib.
The cervical vertebra artificial intervertebral disk of this utility model through will having micropore is as support; Use self-assembling technique; Celecoxib is assembled in the micropore on the artificial intervertebral disk; Make artificial intervertebral disk have the function of slow release celecoxib, can make the local celecoxib microenvironment that forms lasting high concentration of operation, be the new tool of concurrent ectopic ossification behind the prevention cervical vertebra artificial disc replacement.
Description of drawings
Through reading the detailed description of non-limiting example being done with reference to following accompanying drawing, it is more obvious that the other features, objects and advantages of this utility model will become:
Fig. 1 illustrates the structural representation of this utility model;
Fig. 2 illustrates each regional structural representation of this utility model;
Fig. 3 illustrates the structural representation of the lateral side regions of the following soleplate in this utility model;
Fig. 4 illustrates the structural representation of the upper surface outer peripheral areas of the following soleplate in this utility model;
Fig. 5 illustrates the structural representation of the lateral side regions of the last soleplate in this utility model.
The specific embodiment
To shown in Figure 5, in an embodiment of this utility model, the said cervical vertebra artificial intervertebral disk that prevents ectopic ossification comprises soleplate 1, following soleplate 3 and vertebral pulp 2 like Fig. 1, and wherein, said vertebral pulp 2 is installed in said going up between soleplate 1 and the following soleplate 3.
In a preference of present embodiment, said surface of going up soleplate 1 and following soleplate 3 is provided with micro porous coating.Wherein, said micro porous coating is distributed in the said lateral side regions 10 that goes up soleplate 1; The said lower surface outer peripheral areas that goes up soleplate 1; The said lateral side regions 30 of soleplate 3 down; The said upper surface outer peripheral areas 32 of soleplate 3 down.Wherein, the upper surface of the lower surface of said upward soleplate 1 and said soleplate 3 down is relative; The said central area of the upper surface of soleplate down is used to install said vertebral pulp, and its marginal area is the said upper surface outer peripheral areas 32 of soleplate 3 down, shown in the shadow region among Fig. 4; The lateral side regions 30 of said soleplate 3 down is shown in the shadow region among Fig. 3; The said lateral side regions 10 that goes up soleplate 1 is shown in the shadow region among Fig. 5.
Further preferably, said micro porous coating is micropore titanium coating, micropore tricalcium phosphate/hydroxyapatite coating layer, micropore ceramics oxide-film coating or microporous polymer coating.Wherein, said micro porous coating can through ultrasonic atomization spraying or aerial spraying or directly coated technique be prepared in and saidly go up soleplate and down on the soleplate.Those skilled in the art combine prior art can adopt the preparation of more method to have the support of micro porous coating, and for example: application number be that " 99123708.0 ", the Chinese patent that is called " manufacturing approach of osteo-implanted body of porous titanium with biological coating " disclose the multiple manufacturing approach that is provided with the bone implant of micropore titanium coating in its background technology and embodiment; Be stated from preparation and deposition process that " Shanghai stomatology " document of the 5th phase in 2004 discloses " Application of I BAD method prepares the micro analysis of pure titanium porous surface TCP/HA coating material " micropore tricalcium phosphate/hydroxyapatite coating layer material; Application number is the manufacturing approach that Chinese patent that " 200910041977.7 ", name are called " a kind of method of modifying that is used for surface of magnesium alloy stent " discloses a kind of micropore ceramics oxide-film coating.
Further, preferably be filled with medicine in the micropore of said micro porous coating, wherein, said medicine comprises celecoxib.Wherein, Celecoxib can cf. publication be realized; For example; Be stated from that " " the nonsteroidal anti inflammatory medicine is to the progress of union of fracture influence " of 2009 the 2nd phases of clinical orthopaedics journal for example is stated from " Hangzhou Normal College's journal (medicine) " the 6th phase in 2008 " research and the progress of application of selective COX-2-inhibitor 2 celecoxib " again.Celecoxib is filled like the method in the micropore and can be realized referring to " research of Prevention of Cardiovascular restenosis nano-particle drug-carried coat support " that is stated from " Southeast China University's journal (natural science edition) " the 6th phase in 2004.
At another preference of present embodiment, said go up soleplate 1 and down soleplate 3 as being equipped with micropore on the lower area: the said lateral side regions 10 that goes up soleplate 1; The said lower surface outer peripheral areas that goes up soleplate 1; The said lateral side regions 30 of soleplate 3 down; The said upper surface outer peripheral areas 32 of soleplate 3 down.Preferably, be filled with medicine in the micropore of said upward soleplate 1 and following soleplate 3, said medicine comprises celecoxib.Wherein, Those skilled in the art can process micropore with reference to existing techniques in realizing on last soleplate and following soleplate, for example application number is that " 200910103260 ", the Chinese patent that is called " nano coating combined with micropore surface method for modifying endovascular stent " disclose the little roughening method of chemical etching; Again for example, " laser cutting parameter of microporous structure blood vessel stent " that be stated from " Central China University of Science and Technology's journal (natural science edition) " the S1 phase in 2007 discloses a kind of method of utilizing laser cutting parameter processing micropore support.
More than the specific embodiment of this utility model is described.It will be appreciated that this utility model is not limited to above-mentioned specific implementations, those skilled in the art can make various distortion or modification within the scope of the claims, and this does not influence the flesh and blood of this utility model.
Claims (9)
1. the cervical vertebra artificial intervertebral disk that can prevent ectopic ossification is characterized in that, comprises soleplate, following soleplate and vertebral pulp, and wherein, said vertebral pulp is installed in said going up between soleplate and the following soleplate.
2. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 1 is characterized in that, said surface of going up soleplate and following soleplate is provided with micro porous coating.
3. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 2 is characterized in that, said micro porous coating be distributed in as in the lower area any or appoint on a plurality of zones:
-said the lateral side regions that goes up soleplate;
-said lower surface the outer peripheral areas that goes up soleplate;
-said the lateral side regions of soleplate down;
-said upper surface the outer peripheral areas of soleplate down.
4. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 3 is characterized in that, said micro porous coating is micropore titanium coating, micropore ceramics oxide-film coating or microporous polymer coating.
5. according to each described cervical vertebra artificial intervertebral disk that prevents ectopic ossification in the claim 2 to 4, it is characterized in that, be filled with medicine in the micropore of said micro porous coating.
6. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 5 is characterized in that said medicine comprises celecoxib.
7. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 1 is characterized in that, said go up soleplate and down soleplate following any or appoint and be equipped with micropore on a plurality of zones:
-said the lateral side regions that goes up soleplate;
-said lower surface the outer peripheral areas that goes up soleplate;
-said the lateral side regions of soleplate down;
-said upper surface the outer peripheral areas of soleplate down.
8. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 7 is characterized in that, is filled with medicine in the micropore of said upward soleplate and following soleplate.
9. the cervical vertebra artificial intervertebral disk that prevents ectopic ossification according to claim 8 is characterized in that said medicine comprises celecoxib.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204940357U CN202537715U (en) | 2011-12-02 | 2011-12-02 | Cervical artificial intervertebral disc capable of preventing heterotopic ossification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204940357U CN202537715U (en) | 2011-12-02 | 2011-12-02 | Cervical artificial intervertebral disc capable of preventing heterotopic ossification |
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| Publication Number | Publication Date |
|---|---|
| CN202537715U true CN202537715U (en) | 2012-11-21 |
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| CN2011204940357U Expired - Fee Related CN202537715U (en) | 2011-12-02 | 2011-12-02 | Cervical artificial intervertebral disc capable of preventing heterotopic ossification |
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| CN (1) | CN202537715U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106618811A (en) * | 2017-02-22 | 2017-05-10 | 无锡宝莱福医疗器械有限公司 | Functional bionic artificial cervical disc |
| CN106726022A (en) * | 2017-02-22 | 2017-05-31 | 无锡宝莱福医疗器械有限公司 | A kind of artificial intervertebral disk and its forming method without interface friction |
| CN106901876A (en) * | 2017-02-22 | 2017-06-30 | 无锡宝莱福医疗器械有限公司 | A kind of biomimetic type artificial intervertebral disk and its forming method |
| CN110464516A (en) * | 2019-09-04 | 2019-11-19 | 北京积水潭医院 | A kind of Invasive lumbar fusion device |
| CN111938880A (en) * | 2020-08-18 | 2020-11-17 | 四川大学华西医院 | Artificial cervical intervertebral disc device and cover film suitable for same |
-
2011
- 2011-12-02 CN CN2011204940357U patent/CN202537715U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106618811A (en) * | 2017-02-22 | 2017-05-10 | 无锡宝莱福医疗器械有限公司 | Functional bionic artificial cervical disc |
| CN106726022A (en) * | 2017-02-22 | 2017-05-31 | 无锡宝莱福医疗器械有限公司 | A kind of artificial intervertebral disk and its forming method without interface friction |
| CN106901876A (en) * | 2017-02-22 | 2017-06-30 | 无锡宝莱福医疗器械有限公司 | A kind of biomimetic type artificial intervertebral disk and its forming method |
| CN106618811B (en) * | 2017-02-22 | 2019-01-29 | 无锡宝莱福医疗器械有限公司 | A kind of function bionics type cervical artificial disc |
| CN106901876B (en) * | 2017-02-22 | 2019-03-01 | 无锡宝莱福医疗器械有限公司 | A kind of biomimetic type artificial intervertebral disk and its forming method |
| CN106726022B (en) * | 2017-02-22 | 2019-06-18 | 无锡宝莱福医疗器械有限公司 | A kind of artificial intervertebral disk and its forming method of no interface friction |
| CN110464516A (en) * | 2019-09-04 | 2019-11-19 | 北京积水潭医院 | A kind of Invasive lumbar fusion device |
| CN110464516B (en) * | 2019-09-04 | 2020-05-22 | 北京积水潭医院 | Intervertebral fusion cage |
| CN111938880A (en) * | 2020-08-18 | 2020-11-17 | 四川大学华西医院 | Artificial cervical intervertebral disc device and cover film suitable for same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121121 Termination date: 20151202 |
|
| EXPY | Termination of patent right or utility model |