CN202161436U - 植骨填充金属颗粒体 - Google Patents

植骨填充金属颗粒体 Download PDF

Info

Publication number
CN202161436U
CN202161436U CN2011202239150U CN201120223915U CN202161436U CN 202161436 U CN202161436 U CN 202161436U CN 2011202239150 U CN2011202239150 U CN 2011202239150U CN 201120223915 U CN201120223915 U CN 201120223915U CN 202161436 U CN202161436 U CN 202161436U
Authority
CN
China
Prior art keywords
bone
bone grafting
metallic particles
overlay
filling metallic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN2011202239150U
Other languages
English (en)
Inventor
蔡宏
张卫平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing AK Medical Co Ltd
Original Assignee
Beijing AK Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing AK Medical Co Ltd filed Critical Beijing AK Medical Co Ltd
Priority to CN2011202239150U priority Critical patent/CN202161436U/zh
Priority to CN2011202239131U priority patent/CN202154766U/zh
Application granted granted Critical
Publication of CN202161436U publication Critical patent/CN202161436U/zh
Priority to EP12804332.0A priority patent/EP2727559B1/en
Priority to PCT/CN2012/077255 priority patent/WO2013000373A1/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7094—Solid vertebral fillers; devices for inserting such fillers
    • A61B17/7095—Solid vertebral fillers; devices for inserting such fillers the filler comprising unlinked macroscopic particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/74—Devices for the head or neck or trochanter of the femur
    • A61B17/742—Devices for the head or neck or trochanter of the femur having one or more longitudinal elements oriented along or parallel to the axis of the neck
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30138—Convex polygonal shapes
    • A61F2002/30143—Convex polygonal shapes hexagonal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30159—Concave polygonal shapes
    • A61F2002/30181—Y-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30261—Three-dimensional shapes parallelepipedal
    • A61F2002/30263—Three-dimensional shapes parallelepipedal cubical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30289—Three-dimensional shapes helically-coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30303—Three-dimensional shapes polypod-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本实用新型涉及一种用于骨缺损填充的植骨填充金属颗粒体，该植骨填充金属颗粒体上设有容纳植入碎骨颗粒或骨泥的植骨孔，各个植骨孔之间相互贯通相连，颗粒体的外表面及植骨孔内表面分布有相互连通的微孔隙，手术时可根据需要将一定数量的植骨填充金属颗粒体与自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌用于骨缺损填充，以占位形式部分替代自体骨或异体骨填充物，患者康复过程中骨细胞与微细血管向植骨填充金属颗粒体内部长入，可以形成融合嵌入式的生物活性骨修复体。

Description

植骨填充金属颗粒体
技术领域
本实用新型涉及骨科手术植入体，特别是一种用于骨缺损填充的植骨填充金属颗粒体。
背景技术
在各种骨科切除治疗、人工关节置换、正畸手术等会遇到不同程度的骨缺损的问题，以往常规的解决方法是使用自体骨或异体骨的骨块、骨颗粒、骨泥等将缺损部位进行填充塑形，再植入相应的假体或固定用器械以完成手术，但由于自体骨来源有限，异体骨价格昂贵且有生物学方面的风险，因此并不是每一位需要进行骨缺损填充的患者都能够得到满意的治疗。
实用新型内容
本实用新型的目的是提供一种植骨填充金属颗粒体，手术时可根据需要将一定数量的植骨填充金属颗粒体与自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌用于骨缺损填充，以占位形式部分替代自体骨或异体骨填充物，患者康复过程中骨细胞与微细血管向植骨填充金属颗粒体内部长入，可以形成融合嵌入式的生物活性骨修复体。
为实现上述目的，本实用新型采取以下设计方案：
植骨填充金属颗粒体，其特征在于，该颗粒体形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该颗粒体外形尺寸为2～15mm，使用时将适当数量的植骨填充金属颗粒体与自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌后填充于骨缺损部位。
所述植骨填充金属颗粒体其特征在于，在植骨填充金属颗粒体上设有容纳植入碎骨颗粒或骨泥的植骨孔，植骨孔由植骨填充金属颗粒体的外表面向内延伸，植骨孔孔径1～10mm，各个植骨孔之间相互贯通相连。
所述植骨填充金属颗粒体其特征在于，该颗粒体的金属实体部分外表面及植骨孔内表面分布有相互连通的微孔隙，该微孔隙的孔径为50μm～900μm。
所述植骨填充金属颗粒体其特征在于它采用医用金属制成，所述医用金属包括钛及钛合金、钴合金、不锈钢以及钽金属、镁合金。
所述植骨填充金属颗粒体表面全部或局部具有羟基磷灰石涂层，该羟基磷灰石涂层有诱导骨细胞生长的功能。
所述植骨填充金属颗粒体的加工方法是：锻造、铸造、机械切削钻孔、放电加工成型等；其他的加工方法还包括采用激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术，特别是激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术除可以制作植骨填充金属颗粒体的金属实体外同时还能够在该实体表面及植骨孔内表面生成相互连通的微孔隙；羟基磷灰石涂层则通过高温喷涂或电化学沉积得到。
本实用新型的优点是：
1.本实用新型植骨填充金属颗粒体，该颗粒体形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该颗粒体外部尺寸为2～15mm，在使用时形状、大小和数量有多种选择，配以自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌后能有效填充并充盈于各种形状的骨缺损部位。
2.本实用新型植骨填充金属颗粒体，在该颗粒体上设有容纳植入碎骨颗粒或骨泥的植骨孔，植骨孔由植骨填充金属颗粒体外轮廓向内延伸，植骨孔孔径1～10mm，各个植骨孔之间相互贯通相连；植骨填充金属颗粒体的植入方法是：手术中医生根据需要选择适当数量、大小和形状的植骨填充金属颗粒体与患者自体或异体碎骨颗粒及骨泥混合搅拌成混合植入物，必要时将碎骨颗粒及骨泥直接植入植骨填充金属颗粒体的植骨孔，然后将搅拌好的混合植入物装填于骨缺损处加压捣实以获得填充体的初始稳定，术后恢复期时缺损周围的骨质与植骨填充金属颗粒体植骨孔内的骨泥、碎骨颗粒融合生长成一体后即可达到长久有效地防止该植骨填充金属颗粒体发生松动的作用。由于使用植骨填充金属颗粒体部分替代自体骨和异体骨，可大大降低患者的经济负担并一定程度上克服了获取自体骨和异体骨的数量上的困难与不足；患者自体碎骨颗粒及骨泥可以在手术中通过必要的截骨、钻骨、破碎等操作过程得到。
3.本实用新型植骨填充金属颗粒体，其特征在于，该颗粒体的金属实体部分外表面及植骨孔内表面分布有相互连通的微孔隙，该微孔隙与骨质紧密接触有利于骨细胞及血管的长入以获得长期稳定，该微孔隙的孔径为50μm～900μm，此种尺度的微孔隙有利于骨细胞与微细血管向植骨填充金属颗粒体内部爬行长入，可以形成融合嵌入式的生物活性骨修复体。
4.本实用新型植骨填充金属颗粒体，其特征在于，颗粒体表面全部或局部具有羟基磷灰石涂层，该羟基磷灰石涂层具有诱导骨细胞生长的功能。
5、本实用新型植骨填充金属颗粒体，其特征在于，颗粒体采用可用于植入人体的医用金属制成，包括钛及钛合金、钴合金、不锈钢以及钽金属、镁合金，此类金属材料的生物相容性已经得到国内外多年骨科植入应用的实践证实；所述植骨填充金属颗粒体的加工方法是：锻造、铸造、机械切削钻孔、放电加工成型等；其他的加工方法还包括采用激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术，特别是激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术除可以制作植骨填充金属颗粒体的金属实体外同时还能够在该实体表面及植骨空内表面生成相互连通的微孔隙；羟基磷灰石涂层则通过高温喷涂或电化学沉积得到；上述各种加工方法均已为金属加工行业公知的成熟技术，故本说明书中不做更多阐述。
附图说明
图1为本实用新型实施例球体结构示意图
图2为本实用新型实施例圆柱体结构示意图
图3为本实用新型实施例螺旋体结构示意图
图4为本实用新型实施例网状体结构示意图
图5为本实用新型实施例多面体结构示意图
图6、图7为本实用新型实施例各种形状体的组合体结构示意图
图8为本实用新型实施例微孔隙放大示意图
图9为本实用新型实施例填充于骨缺损部位示意图
具体实施方式
以下结合附图对本实用新型的具体实施做进一步详细说明。
如图1、图2、图3、图4、图5、图6、图7、所示，本实用新型植骨填充金属颗粒体(1)，其形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该颗粒体外部尺寸为2～15mm，在植骨填充金属颗粒体(1)上设有容纳植入碎骨颗粒或骨泥的植骨孔(2)，植骨孔(2)由植骨填充金属颗粒体(1)的外表面向内延伸，植骨孔(2)孔径1～10mm，各个植骨孔(2)之间相互贯通相连，如图8所示植骨填充金属颗粒体(1)金属实体部分的外表面及植骨孔(2)的内表面分布有相互连通的微孔隙(3)，该微孔隙(3)的孔径为50μm～900μm。
本实用新型植骨填充金属颗粒体(1)采用可用于植入人体的医用金属制成，包括钛及钛合金、钴合金、不锈钢以及钽金属、镁合金，其加工制作的方法是：锻造、铸造、机械切削钻孔、放电加工成型等；其他的加工方法还包括采用激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术，微孔隙(3)可以由激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术加工得到，羟基磷灰石涂层则通过高温喷涂或电化学沉积得到；所述各种加工方法均已为金属加工行业公知的成熟技术。
如图9所示本实用新型植骨填充金属颗粒体使用时医生可以根据需要选择适当大小和形状的植骨填充金属颗粒体(1)安置在骨缺损处并通过打压将其固定在骨床上以获得该植骨填充金属颗粒体(1)的早期稳定；植骨填充金属颗粒体(1)在适当位置设有容纳植骨碎骨颗粒或骨泥的植骨孔(2)用于填充自体或异体的碎骨颗粒，此外在金属实体部分的外表面及植骨孔(2)的内表面分布有相互连通的微孔隙(3)，手术植入后待到外部骨组织渗透长入微孔隙(3)并与植骨孔(2)中填充的碎骨颗粒或骨泥融合生长成一体后即可达到长久有效地防止该植骨填充金属颗粒体(1)发生松动的目的。

Claims (6)

1.一种植骨填充金属颗粒体，其特征在于，该植骨填充金属颗粒体(1)形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该植骨填充金属颗粒体(1)外形尺寸为2～15mm。
2.根据权利要求1所述的植骨填充金属颗粒体，其特征在于，在植骨填充金属颗粒体(1)上设有容纳植入碎骨颗粒或骨泥的植骨孔(2)，植骨孔(2)由植骨填充金属颗粒体(1)的外表面向内延伸，植骨孔(2)孔径1～10mm。
3.根据权利要求1和权利要求2所述的植骨填充金属颗粒体，其特征在于，各个植骨孔(2)之间相互贯通相连。
4.根据权利要求1和权利要求2所述的植骨填充金属颗粒体，其特征在于，该植骨填充金属颗粒体(1)的金属实体部分外表面及植骨孔(2)内表面分布有相互连通的微孔隙(3)，该微孔隙(3)的孔径为50μm～900μm。
5.根据权利要求1和权利要求2所述的植骨填充金属颗粒体，其特征在于，植骨填充金属颗粒体(1)外表面和植骨孔(2)的内表面具有羟基磷灰石涂层。
6.根据权利要求1所述的植骨填充金属颗粒体，其特征在于，该植骨填充金属颗粒体(1)采用医用金属制成，所述医用金属包括钛及钛合金、钴合金、不锈钢以及钽金属、镁合金。
CN2011202239150U 2011-06-29 2011-06-29 植骨填充金属颗粒体 Expired - Lifetime CN202161436U (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2011202239150U CN202161436U (zh) 2011-06-29 2011-06-29 植骨填充金属颗粒体
CN2011202239131U CN202154766U (zh) 2011-06-29 2011-06-29 棘状金属颗粒体
EP12804332.0A EP2727559B1 (en) 2011-06-29 2012-06-20 Spinous metal particle
PCT/CN2012/077255 WO2013000373A1 (zh) 2011-06-29 2012-06-20 棘状金属颗粒体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011202239150U CN202161436U (zh) 2011-06-29 2011-06-29 植骨填充金属颗粒体
CN2011202239131U CN202154766U (zh) 2011-06-29 2011-06-29 棘状金属颗粒体

Publications (1)

Publication Number Publication Date
CN202161436U true CN202161436U (zh) 2012-03-14

Family

ID=47423425

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011202239131U Expired - Lifetime CN202154766U (zh) 2011-06-29 2011-06-29 棘状金属颗粒体
CN2011202239150U Expired - Lifetime CN202161436U (zh) 2011-06-29 2011-06-29 植骨填充金属颗粒体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2011202239131U Expired - Lifetime CN202154766U (zh) 2011-06-29 2011-06-29 棘状金属颗粒体

Country Status (3)

Country Link
EP (1) EP2727559B1 (zh)
CN (2) CN202154766U (zh)
WO (1) WO2013000373A1 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102698317A (zh) * 2012-04-24 2012-10-03 王岩 一种治疗骨缺损的镁或镁合金降解修复单体及修复体
CN102846408A (zh) * 2011-06-29 2013-01-02 北京爱康宜诚医疗器材股份有限公司 植骨填充金属颗粒体
WO2013000373A1 (zh) * 2011-06-29 2013-01-03 北京爱康宜诚医疗器材股份有限公司 棘状金属颗粒体
CN107847327A (zh) * 2015-07-09 2018-03-27 沃尔德马连接两合公司 用于骨植入物的多孔结构

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846409A (zh) * 2011-06-29 2013-01-02 北京爱康宜诚医疗器材股份有限公司 棘状金属颗粒体
DE102015107600B4 (de) * 2015-05-13 2017-08-10 Heraeus Medical Gmbh Partikuläres alloplastisches Knochenersatzmaterial und Verfahren zur Herstellung eines frei geformten porösen Körpers
CN105342726B (zh) * 2015-08-21 2018-08-10 郭开今 3d打印微孔嵌合式骨粒
US11213403B2 (en) 2019-03-14 2022-01-04 Medos International Sarl Devices and methods for optimized spinal fixation
IT202000014881A1 (it) * 2020-06-22 2021-12-22 Mt Ortho S R L Granulo cilindrico in materiale metallico biocompatibile per vertebroplastica

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4106971C1 (zh) * 1991-03-05 1992-03-19 Eska Medical Luebeck Medizintechnik Gmbh & Co, 2400 Luebeck, De
SE515227C2 (sv) * 1999-04-28 2001-07-02 Bruce Medical Ab Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen
AU2001239874A1 (en) * 2000-03-03 2001-09-17 Smith & Nephew, Inc. Shaped particle and composition for bone deficiency and method of making the particle
AU2005237934B2 (en) * 2004-05-04 2011-01-20 Tibone Limited A composite
CN202154766U (zh) * 2011-06-29 2012-03-07 北京爱康宜诚医疗器材股份有限公司 棘状金属颗粒体

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846408A (zh) * 2011-06-29 2013-01-02 北京爱康宜诚医疗器材股份有限公司 植骨填充金属颗粒体
WO2013000373A1 (zh) * 2011-06-29 2013-01-03 北京爱康宜诚医疗器材股份有限公司 棘状金属颗粒体
CN102846408B (zh) * 2011-06-29 2015-09-16 北京大学第三医院 植骨填充金属颗粒体
CN102698317A (zh) * 2012-04-24 2012-10-03 王岩 一种治疗骨缺损的镁或镁合金降解修复单体及修复体
CN107847327A (zh) * 2015-07-09 2018-03-27 沃尔德马连接两合公司 用于骨植入物的多孔结构
CN107847327B (zh) * 2015-07-09 2021-06-29 沃尔德马连接两合公司 用于骨植入物的多孔结构

Also Published As

Publication number Publication date
CN202154766U (zh) 2012-03-07
EP2727559B1 (en) 2024-05-22
EP2727559A4 (en) 2015-01-28
EP2727559A1 (en) 2014-05-07
WO2013000373A1 (zh) 2013-01-03

Similar Documents

Publication Publication Date Title
CN202161436U (zh) 植骨填充金属颗粒体
CN102846408B (zh) 植骨填充金属颗粒体
Pei et al. 3D printed titanium scaffolds with homogeneous diamond-like structures mimicking that of the osteocyte microenvironment and its bone regeneration study
CN103357063B (zh) 一种可引导骨生长的金属复合材料及其应用
CN105796214A (zh) 一种定向缓释rhBMP-2的多孔金属颈椎间融合器
CN105877874A (zh) 仿生设计类骨多孔骨制品及其制备方法和用途
CN204636623U (zh) 3d金属骨小梁椎间融合器
CN102113924A (zh) 髋臼骨缺损填充体
CN101843533A (zh) 骨小梁微孔表面人工髋关节
CN201558197U (zh) 髋臼骨缺损填充体
CN201755260U (zh) 骨小梁微孔表面人工髋关节
CN101912635A (zh) 一种生物医用多孔钛材料及其制备方法
CN106798601B (zh) 一种支架
CN104368040A (zh) 一种复合脱钙骨基质的3d打印多孔金属支架及其制备方法
CN112076009A (zh) 一种基于曲面3d打印的多层仿生关节及其制备方法
CN101708134A (zh) 低弹性模量人工髋关节股骨柄
CN105797208A (zh) 一种颅骨修复用可降解金属植入体及其制备方法
CN204411030U (zh) 组配解剖型人工胫骨平台假体
CN201394097Y (zh) 低弹性模量人工髋关节股骨柄
CN209075034U (zh) 一种多孔金属人工犬髋关节假体
CN203315125U (zh) 一种髋关节假体
CN201394098Y (zh) 人工髋关节骨融合股骨柄
CN105105879A (zh) 一种改进的带多孔薄层的人工髋关节股骨柄及其制备方法
CN102048601B (zh) 活塞式钛金属丝网笼及其制作方法
CN205391219U (zh) 载有rhBMP-2缓释***的颈椎间融合器

Legal Events

Date Code Title Description
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20120314

CX01 Expiry of patent term