CN202161303U - Experimental research device for human placental permeability - Google Patents
Experimental research device for human placental permeability Download PDFInfo
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- CN202161303U CN202161303U CN2011202109180U CN201120210918U CN202161303U CN 202161303 U CN202161303 U CN 202161303U CN 2011202109180 U CN2011202109180 U CN 2011202109180U CN 201120210918 U CN201120210918 U CN 201120210918U CN 202161303 U CN202161303 U CN 202161303U
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Abstract
The utility model provides an experimental research device for human placental permeability, which comprises an insulation cabinet. The experimental research device is characterized in that a placenta container, a maternal pool and a fetus pool are arranged inside the insulation cabinet. The maternal pool and the fetus pool are respectively connected with the placenta container through a liquid feeding pipe, a pump arranged on the liquid feeding pipe and a return pipe. Due to the adoption of the experimental research device, a permeability test can be conveniently performed on an in-vitro placenta while the in-vitro physiological activity of the human placenta is maintained. Since the circulation process of nutrients conducted through a matrix and a placenta and then supplied to a fetus, which is performed by a placenta in the body of a pregnant woman, is really and accurately simulated, the permeability of environmental pollutants, drugs and other foreign substances in a human placenta can be observed. Meanwhile, the facts that whether substances in contact with a pregnant woman in daily life may influence a fetus in the pregnant woman or not and the influence degree of the influential substances can be intuitively known. Therefore, a pregnant woman is guided and provided with matters to be attended to so as to enable a fetus to healthly and quickly grow. Due to the adoption of the experimental research device, the health status of a fetus is improved and the danger of an in-vivo test performed on a human body is effectively avoided.
Description
Technical field
This utility model relates to a kind of test research device, and particularly a kind of human placenta's permeability test research device belongs to medical experimentation equipment technical field.
Background technology
In today of science and technology fast development, medical skill and means also obtain significant progress.In breeding the process of new life, more and more researchers and medical worker begin to pay close attention to fetus in the intravital growth promoter situation of mother, explore the influence of the various factors of the external world and parent self to embryo growth and development.Because in daily life; The anemia of pregnant woman can be lived, the restriction of occupation and environmental condition, inevitably touches various deleterious materials, such as the additive in the food, packaging for foodstuff bring the pollutant of food, due to illness air pollutants or mother of industrial occupancy take corresponding medicine or the like; These contacts; Can cause which type of influence to the growth promoter of fetus in the parent, and how or the like effect, is the subject that medical circle is constantly explored always actually.Owing to be the exchange of accomplishing nutrient substance through Placenta Hominis between parent and the fetus, therefore study intraplacental material exchange process, can understand the influence that extraneous factor causes embryo growth and development indirectly.
Prior art is mainly tested through Placenta Hominis permeability in animal embryo tertogenicity test and the body and is accomplished research.Wherein, The animal embryo tertogenicity test is to select to carry out with the approaching pregnancy period animal of the mankind on physiology, the zootaxy; Promptly adopt injection or mouthful feed mode to the pregnancy period animal give substances; With through animal embryo teratogenesis result, estimate the influence that fetus caused to material, and according to this zoopery result infer to the influence of material to fetus in the parent.This method can exist because of the difference between kind and depart from and mistake.And the experimental study of Placenta Hominis permeability can only be used for some just suffer from certain disease before pregnancy anemia of pregnant woman in the body; And study the influence of medicine and disease to embryo growth and development through apply Drug therapy to the anemia of pregnant woman; This not only can cause research range too narrow, but also can violate the Medical Ethics morals.Therefore be necessary prior art is improved.
Summary of the invention
For solving the above-mentioned deficiency that prior art exists, this utility model provides a kind of placental transmission property test research device.
This utility model is accomplished through following technical proposal: a kind of placental transmission property test research device; Comprise couveuse; It is characterized in that being provided with in the couveuse Placenta Hominis container; Parent pond and fetus pond; And the parent pond links to each other with the Placenta Hominis container through pump on feed pipe, the feed pipe and return duct respectively with the fetus pond, makes placentation circulation that fill in parent pond, the fetus pond and parent perfusate similar with the fetal composition and Placenta Hominis intracavity, and the nutrient substance of accomplishing with Placenta Hominis in the simulation anemia of pregnant woman body resupplies the cyclic process of fetus through parent, Placenta Hominis.
Said parent pond links to each other with the outer mixture of oxygen bottle of couveuse through air supply pipe, is in communication with the outside through exhaustor, to the parent pond mixture of oxygen to be provided again; Improve the oxygen content of perfusate; Stablize pH value, discharge unnecessary gas simultaneously, the truth of simulation uterus arterial blood.
Said fetus pond links to each other with the outer mixed with nitrogen gas cylinder of couveuse through air supply pipe, is in communication with the outside through exhaustor again, to the fetus pond mixing nitrogen to be provided, stablizes its pH value, discharges unnecessary gas simultaneously, the truth of simulation fetal umbilical.
The through hole that the said feed pipe that links to each other with the parent pond passes on the Placenta Hominis container links to each other with the filling liquid pin that inserts the placental lobules parent face that exsomatizes; And the return duct that links to each other with the parent pond links to each other with through hole on the Placenta Hominis container; Perfusate in the Placenta Hominis container is refluxed; And keep maternal surface of placenta to be soaked in certain altitude 0.5-1cm under the perfusate, specifically highly look Placenta Hominis thickness and decide, in the arterial that the perfusate in the parent pond is filled into stripped placental lobules parent face; Duct of Arantius by the placental lobules parent face that exsomatizes is back in the parent pond again, to accomplish the simulation of intrauterine spiral artery.
The hole slot that the said feed pipe that links to each other with the fetus pond passes on the Placenta Hominis container links to each other with conduit in the placental lobules fetus facial artery pipe that insert to exsomatize; And the hole slot that the return duct that links to each other with the fetus pond passes on the Placenta Hominis container links to each other with conduit in the placental lobules fetus facial vein pipe that insert to exsomatize; In the arterial that the perfusate in the fetus pond is filled into the placental lobules fetus face that exsomatizes; Duct of Arantius by the placental lobules fetus face that exsomatizes is back in the fetus pond again, to accomplish the simulation of fetus artery and vein circulation.
Said Placenta Hominis container comprises base, is placed on the base its and establishes cavity, and bottom is established through hole; Establish support column in the cavity; Establish the cavity of through hole on the wall, be placed in its top band through hole at cavity top, the loam cake of sidewall band groove; Placenta Hominis is positioned in the cavity of cavity so that will exsomatize, and is used for placental transmission property experimentation.
The utlity model has advantage and effect: adopt such scheme; Can under the situation that keeps the physiologically active after Placenta Hominis exsomatizes, carry out permeability test, the ex vivo perfusion that promptly Placenta Hominis is carried out to the Placenta Hominis that exsomatizes easily through this device; The nutrient substance that Placenta Hominis is accomplished in the true and accurate simulation anemia of pregnant woman body resupplies the cyclic process of fetus through parent, Placenta Hominis; Thereby observe the permeabilitys of foreign substance in Placenta Hominis such as environmental contaminants, medicine, make research worker can understand the daily material that touches of anemia of pregnant woman intuitively and whether can intravital fetus be exerted an influence, and effect; How this notes just making foetus health growth promoter apace thereby instruct the anemia of pregnant woman; Improved the health level of fetus greatly, compared with studying in animal embryo tertogenicity test at present commonly used and the human body body, promptly avoided danger in the human body in vivo test; More meet the Medical Ethics morals; Avoid the species variation between the mankind and the experimental animal again, had stronger scientific meaning and researching value, simultaneously easy to utilize.
Description of drawings
Fig. 1 is the structural representation of this utility model;
Fig. 2 is Placenta Hominis structure of container figure among Fig. 1.
The specific embodiment
Below in conjunction with accompanying drawing this utility model is done and to be further described.
Like Fig. 1, Fig. 2; The placental transmission property test research device that this utility model provides comprises the couveuse 3 of establishing through hole and exhaust fan 19 on it, is located at the Placenta Hominis container 4 in the couveuse 3; Parent pond 17 and fetus pond 15; Couveuse 3 can be 37 ℃ of environment that the Placenta Hominis that exsomatizes provides similar parent, and wherein parent pond 17 is passed through feed pipe 6,14 respectively with fetus pond 15, and pump 1 on the feed pipe 6,14 and return duct 5,11 link to each other with Placenta Hominis container 4; Wherein, The through hole that the feed pipe 6 that links to each other with parent pond 17 passes on the Placenta Hominis container 4 links to each other with the perfusion pin 8 of the placental lobules parent face that insert to exsomatize, and the return duct 5 that links to each other with parent pond 17 links to each other with through hole 41 on the Placenta Hominis container 4, so that the perfusate in the Placenta Hominis container 4 is back in the parent pond 17; The maternal surface of placenta that keeps simultaneously exsomatizing immerses certain altitude under the perfusate; In the arterial that the perfusate in the parent pond 17 is filled into the placental lobules parent face that exsomatizes, the duct of Arantius by the placental lobules parent face that exsomatizes is back in the parent pond 17 again, to accomplish the simulation of intrauterine spiral artery; The hole slot that the said feed pipe 14 that links to each other with fetus pond 15 passes on the Placenta Hominis container 4 links to each other with conduit 10 in the placental lobules fetus facial artery pipe that insert to exsomatize; And the hole slot that the return duct 11 that links to each other with fetus pond 15 passes on the Placenta Hominis container 4 links to each other with return duct 9 in the placental lobules fetus facial vein pipe that insert to exsomatize; In the arterial that the perfusate in the fetus pond 15 is filled into the placental lobules fetus face that exsomatizes; Duct of Arantius by the placental lobules fetus face that exsomatizes is back in the fetus pond 15 again, to accomplish the simulation of fetus artery and vein circulation.Parent pond 17 links to each other with mixture of oxygen bottle 2 through air supply pipe 18; Again through exhaustor 16; So that mixture of oxygen (95% oxygen+5% carbon dioxide) to be provided to parent pond 17, improve the oxygen content of perfusate, stablize pH value; Discharge unnecessary gas through exhaustor 16 and calorstat fan simultaneously, the truth of simulation uterus arterial blood; Fetus pond 15 links to each other with mixed with nitrogen gas cylinder 13 through air supply pipe 12; Again through exhaustor 16; Mix nitrogen (95% nitrogen+5% carbon dioxide) to provide to fetus pond 15; Stablize its pH value, discharge unnecessary gas through exhaustor 16 and calorstat fan simultaneously, the truth of simulation fetal umbilical.Said Placenta Hominis container 4 comprises base 40, is placed on the base 40 its and establishes cavity 43, and through hole 48 is established in cavity 43 bottoms; Establish support column 47 in the cavity 43, establish through hole 41 on cavity 43 sidewalls, the cavity 42 of groove 49 is established in cavity 43 bottoms; Be placed in its top band through hole 45 at cavity 42 tops; The loam cake 44 of sidewall band groove 46, so that the Placenta Hominis that will exsomatize is positioned in the cavity 43 of cavity 42, and by support column 47 supports; And the feed pipe 6,14 that will be communicated with via through holes 45 and groove 46 introducings respectively with parent pond 17 and fetus pond 15; Respectively with the Placenta Hominis that insert to exsomatize in pouring pipe 8,10 link to each other, and return duct 5,11 via through holes 41,48 that are communicated with parent pond 17 and fetus pond 15 are introduced, respectively with the stripped Placenta Hominis of insertion in return duct 7,9 link to each other; Make perfusate and the placentation circulation similar with the fetal composition that fill in parent pond 17, the fetus pond 15, resupply the cyclic process of fetus with the nutrient substance of Placenta Hominis completion in the simulation anemia of pregnant woman body through parent, Placenta Hominis with parent.
Claims (6)
1. a placental transmission property test research device comprises couveuse, it is characterized in that being provided with in the couveuse Placenta Hominis container, parent pond and fetus pond, and the parent pond links to each other with the Placenta Hominis container through pump on feed pipe, the feed pipe and return duct respectively with the fetus pond.
2. placental transmission property test research device according to claim 1 is characterized in that said parent pond links to each other with the outer mixture of oxygen bottle of couveuse through air supply pipe, is in communication with the outside through exhaustor again.
3. placental transmission property test research device according to claim 1 is characterized in that said fetus pond links to each other with the outer mixed with nitrogen gas cylinder of couveuse through air supply pipe, is in communication with the outside through exhaustor again.
4. placental transmission property test research device according to claim 1; It is characterized in that the through hole that the said feed pipe that links to each other with the parent pond passes on the Placenta Hominis container links to each other with the filling liquid pin of the placental lobules parent face that insert to exsomatize, and the return duct that links to each other with the parent pond links to each other with through hole on the Placenta Hominis container.
5. placental transmission property test research device according to claim 1; It is characterized in that the hole slot that the said feed pipe that links to each other with the fetus pond passes on the Placenta Hominis container links to each other with conduit in the placental lobules fetus facial artery pipe that insert to exsomatize, and the hole slot that the return duct that links to each other with the fetus pond passes on the Placenta Hominis container links to each other with conduit in the stripped placental lobules fetus facial vein pipe of insertion.
6. placental transmission property test research device according to claim 1; It is characterized in that said Placenta Hominis container comprises base, be placed on the base its and establish cavity that bottom is established through hole; Establish support column in the cavity; Establish the cavity of through hole on the wall, be placed in its top band through hole at cavity top, the loam cake of sidewall band groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202109180U CN202161303U (en) | 2011-06-21 | 2011-06-21 | Experimental research device for human placental permeability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202109180U CN202161303U (en) | 2011-06-21 | 2011-06-21 | Experimental research device for human placental permeability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202161303U true CN202161303U (en) | 2012-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011202109180U Expired - Fee Related CN202161303U (en) | 2011-06-21 | 2011-06-21 | Experimental research device for human placental permeability |
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| CN (1) | CN202161303U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105679165A (en) * | 2014-11-18 | 2016-06-15 | 复旦大学附属妇产科医院 | Human placenta extracorporeal circulation irrigating box |
-
2011
- 2011-06-21 CN CN2011202109180U patent/CN202161303U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105679165A (en) * | 2014-11-18 | 2016-06-15 | 复旦大学附属妇产科医院 | Human placenta extracorporeal circulation irrigating box |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120314 Termination date: 20190621 |
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| CF01 | Termination of patent right due to non-payment of annual fee |