CN201615880U - Intelligent recognition and analysis device of immunity-chromatography test paper strip - Google Patents

Intelligent recognition and analysis device of immunity-chromatography test paper strip Download PDF

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Publication number
CN201615880U
CN201615880U CN200920264982XU CN200920264982U CN201615880U CN 201615880 U CN201615880 U CN 201615880U CN 200920264982X U CN200920264982X U CN 200920264982XU CN 200920264982 U CN200920264982 U CN 200920264982U CN 201615880 U CN201615880 U CN 201615880U
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circuit
test paper
analysis device
paper strip
processing unit
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Expired - Lifetime
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CN200920264982XU
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王继华
李文美
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Guangzhou Wondfo Biotech Co Ltd
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王继华
李文美
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Priority to CN200920264982XU priority Critical patent/CN201615880U/en
Priority to PCT/CN2010/076075 priority patent/WO2011076014A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/7475User input or interface means, e.g. keyboard, pointing device, joystick
    • A61B5/7495User input or interface means, e.g. keyboard, pointing device, joystick using a reader or scanner device, e.g. barcode scanner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08Sensors provided with means for identification, e.g. barcodes or memory chips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/02Mechanical
    • G01N2201/025Mechanical control of operations
    • G01N2201/0256Sensor for insertion of sample, cuvette, test strip

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The utility model discloses an intelligent recognition and analysis device of an immunity-chromatography test paper strip. The device comprises a casing and a measurement control circuit installed inside the casing; an LCD display screen and a test paper strip testing slot are arranged on the surface of the casing; the measurement control circuit includes a power circuit, a photoelectric sensor, a signal amplifying circuit, an LED circuit and a central processor; the power circuit, the LCD display screen and the LED circuit are respectively connected with the central processor; and the photoelectric sensor, the signal amplifying circuit and the central processor are sequentially connected. The intelligent recognition and analysis device is characterized in that the measurement control circuit includes a barcode recognition circuit connected with the central processor. The intelligent recognition and analysis device is high in intelligent degree and simple in operation; and an operator can know the results of test items through the display screen only by inserting the immunity-chromatography test paper strip provided with a barcode into the specified position of the device and then contacting a sample adding end of the immunity-chromatography test paper strip with a sample.

Description

The intelligent discriminance analysis device of immuno-chromatographic test paper strip
Technical field
The utility model belongs to family health care and the disease family self check field in the medical detection range, particularly a kind of intelligent discriminance analysis device of immuno-chromatographic test paper strip.
Background technology
Immunochromatography technique (immunochromatography) is a kind of Fast Detection Technique of setting up on the basis of immunity percolation beginning of the nineties late 1980s, its technical characterictic is: the antibody (or antigen) that can play antigen-antibody reaction with the antigen (or antibody) in the sample to be checked is coated on the ad-hoc location of the immunity-chromatography test scraps of paper in advance with band shape, antigen in the sample to be checked (perhaps antibody) is identified by pigment in the process of utilizing developping solution to launch in advance, when being launched ad-hoc location (being the position that band shape is coated with antibody (or antigen)) by the antigen (perhaps antibody) in the sample to be checked on the pigment sign, be captured by antigen-antibody reaction by the antigen (perhaps antibody) in the sample to be checked on the pigment sign, therefore, formation is passed through pigment and the chromogenic line of color development on ad-hoc location.
Because immunochromatography technique must not carry out separating of binding label and free label, thereby simple to operate, quick, be fit to very much the usefulness of on-the-spot detection.Therefore, very fast based on the immuno-chromatographic test paper strip development of immunochromatography technique development, can both be undertaken by immunochromatography technique by immunoreactive detection.
But, present immuno-chromatographic test paper strip testing result mainly is to rely on naked eyes to come result of determination, therefore the immunity-chromatography test strip testing result generally can only be used to qualitatively judge the result, simultaneously in that to run into measurand content very low, it is very shallow to develop the color, and often at this time the naked eyes result of determination is difficult to, and is easy to cause erroneous judgement, and original testing result all can't keep file after detecting each time, and the personal considerations is difficult for following the tracks of.Therefore, detection immuno-chromatographic test paper strip result's device arises.There is following defective in currently reported reading immunity-chromatography technology test strips result's electronic pen: (1) can not discern the kind of immuno-chromatographic test paper strip automatically, for example the patent No. is US7,315,378B2 and US7.239, the United States Patent (USP) of 394B2, these two parts of patents all provide by optical principle preparation respectively, can analyze the device of reading immunity-chromatography test strip, but all there is not to discern automatically the function of immuno-chromatographic test paper strip kind, and the main difference of different types of immuno-chromatographic test paper strip is the antigen or the antibody difference of combination on it, appearance character is more or less the same, therefore in the occasion of using different types of immuno-chromatographic test paper strip in a large number, such as inspection department, test strips is disarrayed the testing result mistake that will cause obtaining, and the consequence influence is serious; (2) the intelligent degree of identification immuno-chromatographic test paper strip kind is not high, for example application number is 200710058401.2, the national inventing patent application that name is called " females physiologic status electronic detector " provides a kind of electronic detector of testing females physiologic status, whether conceived it can detect the test strips of test women onset of ovulation and test women test strips, its identifying to test strips is to differentiate the kind of test strips by machinery identification or pinhole imaging system method, this method is made gap or punching because of needs on test strips, intelligent degree is not high, in addition, this device does not have the function of data storage.
Summary of the invention
The purpose of this utility model is to overcome the not high shortcoming of intelligent degree of device identification immunochromatography technique test strips of the prior art, and a kind of intelligent discriminance analysis device of immuno-chromatographic test paper strip is provided.
The purpose of this utility model is achieved through the following technical solutions: a kind of intelligent discriminance analysis device of immuno-chromatographic test paper strip is made up of housing and the circuit of measurement and control that is installed on enclosure interior; The surface of housing is provided with LCD display and test strips testing jack; Circuit of measurement and control comprises power circuit, photoelectric sensor, signal amplification circuit, led circuit and central processing unit; Power circuit, LCD display and led circuit are connected with central processing unit respectively, and photoelectric sensor, signal amplification circuit and central processing unit are connected successively; Wherein, circuit of measurement and control also comprises the bar-code identification circuit that is connected with central processing unit.
Described bar-code identification circuit preferably comprises switch, light source, lens, photoelectric commutator, amplification and rectification circuit and bar code interface circuit; Light source, switch and bar code interface circuit are connected successively, and the bar code interface circuit is controlled by central processing unit; Lens and photoelectric commutator are positioned at the same side of light source; Photoelectric commutator is connected with amplification and rectification circuit, and amplification and rectification circuit is connected with central processing unit by the bar code interface circuit;
The intelligent discriminance analysis device of described immuno-chromatographic test paper strip also comprises the data storage circuitry that is connected with central processing unit, so that the storage of analysis result;
Perhaps described central processing unit is preferably the central processing unit with storage data function, to realize inventory analysis result's function;
Described photoelectric sensor is preferably photodiode;
Described power circuit is preferably disconnectable battery, helps using the back classification to be handled, and helps environmental protection;
Described battery is preferably lithium battery;
Described circuit of measurement and control also comprises the sound circuit that is connected with central processing unit, helps pointing out the user to browse the result at reasonable time;
The surface of described housing preferably also is provided with the button that is connected with central processing unit; Described button can be selected the routine analyzer of test item, so that can't can't discern immuno-chromatographic test paper strip by identification circuit the time, can access suitable routine analyzer by button; Described button can also be stored the operation of data and access the storage data;
Described button is preferably three-dimensional button.
The utility model has following advantage and effect with respect to prior art:
1, the intelligent degree height of the utility model can be discerned the immuno-chromatographic test paper strip that be provided with bar code according to the bar-code identification circuit, and the utility model can detect and analyze the immuno-chromatographic test paper strip that is provided with bar code of existing different test items.
2, the utility model can be analyzed the immuno-chromatographic test paper strip that is provided with bar code of different test items, and the immuno-chromatographic test paper strip that promptly is provided with bar code can be changed, thereby causes use cost very low.The utility model is by central processing unit photosignal to be carried out analyzing and processing, and the result is objective, accurate, has avoided because the error that subjective observation produces.
3, the utility model is simple to operate, the immuno-chromatographic test paper strip that only needs to be provided with bar code is inserted in the test strips testing jack of check and analysis device, open switch, the immuno-chromatographic test paper strip that will be provided with bar code again contacts with sample and gets final product, and does not need the training of specialty.
4, the utility model uses disconnectable battery, helps environmental protection.
5, the utility model is provided with the central processing unit that data storage circuitry or use have data storage function, then helps tester's situation is followed the tracks of.
6, the utility model is applied to can be used for the detection of projects such as FOB, HCG, HBsAg, HBsAb, BeAb, HbcAb, HbeAg, LH, PSA and HIV in the medical detection range.
Description of drawings
Fig. 1 is the structural representation of the intelligent discriminance analysis device of embodiment 1 described immuno-chromatographic test paper strip.
Fig. 2 is the principle of work block scheme of the intelligent discriminance analysis device of embodiment 1 described immuno-chromatographic test paper strip.
Fig. 3 is the functional-block diagram of the utility model bar-code identification circuit.
Fig. 4 is the principle of work block scheme of the intelligent discriminance analysis device of embodiment 2 described immuno-chromatographic test paper strips.
Fig. 5 is the principle of work block scheme of the intelligent discriminance analysis device of embodiment 3 described immuno-chromatographic test paper strips.
Fig. 6 is the structural representation of the intelligent discriminance analysis device of embodiment 4 described immuno-chromatographic test paper strips.
Fig. 7 is the principle of work block scheme of the intelligent discriminance analysis device of embodiment 4 described immuno-chromatographic test paper strips.
Fig. 8 is the principle of work block scheme of the intelligent discriminance analysis device of embodiment 5 described immuno-chromatographic test paper strips.
Embodiment
Below in conjunction with embodiment and accompanying drawing the utility model is described in further detail, but embodiment of the present utility model is not limited thereto.
Embodiment 1
The intelligent discriminance analysis device of the immuno-chromatographic test paper strip of present embodiment as shown in Figure 1, the intelligent discriminance analysis device of described immuno-chromatographic test paper strip is made up of housing 3 and the circuit of measurement and control that is installed on enclosure interior; The surface of housing is provided with test strips testing jack 2, LCD display 4 and button 5 (three-dimensional button) and forms.
As shown in Figure 2, circuit of measurement and control comprises power circuit, bar-code identification circuit, photodiode, signal amplification circuit, led circuit, data storage circuitry and central processing unit; Wherein, power circuit, bar-code identification circuit, LCD display, data storage circuitry and led circuit are connected with central processing unit respectively, and photodiode, signal amplification circuit and central processing unit are connected successively.By the bar code on the bar-code identification circuit identification test strips, definite project that is detected, also can select concrete test item by button, device calls corresponding handling procedure automatically and handles, and analysis result is presented on the lcd screen intuitively the most at last.
Wherein, the bar-code identification circuit as shown in Figure 3, light source, switch and bar code interface circuit are connected successively, the bar code interface circuit is controlled by central processing unit; Lens and photoelectric commutator are positioned at the same side of light source; Photoelectric commutator is connected with amplification and rectification circuit, and amplification and rectification circuit is connected with central processing unit.The bar code interface circuit is with the switch of closed bar code identification circuit when the immuno-chromatographic test paper strip that is provided with bar code inserts the test strips testing jack 2 of device shown in Figure 1, the light of the light emitted in the bar-code identification circuit is radiated at scioptics on the bar code of the immuno-chromatographic test paper strip that is provided with bar code, the light of reflection is converted to electric signal by photoelectric commutator, transmit signals to CPU through amplification and rectification circuit, come according to the electric signal that comes from the bar-code identification circuit that receives by CPU, transfer and be provided with the corresponding routine analyzer of immuno-chromatographic test paper strip kind of bar code, thus beginning test-strips result's judgement.
The immuno-chromatographic test paper strip 1 that will be provided with bar code when detecting earlier inserts test strips testing jack 2, the bar-code identification circuit is provided with identification the bar code layers on the immuno-chromatographic test paper strip 1 of bar code, electric signal is transported to CPU, CPU takes out corresponding routine analyzer, then, the application of sample end that is provided with the immuno-chromatographic test paper strip 1 of bar code is contacted with sample, central processing unit control led circuit sends visible light, shine on the test strips that is coated with antibody (or antigen) that watch window 8 comprises, the light of reflection is absorbed by photodiode, convert electric signal to, amplified by signal amplification circuit, be transported in the central processing unit and analyze with the routine analyzer of having transferred, analysis result is presented at output on the LCD display 4.Analysis result is stored data storage circuitry by the operation of button 5.Also can take out by the analysis result that the operation of button 5 will have been stored.
The principle of reflection of this device utilization light is as follows: white light is made up of multiple coloured light, human eye sees that the color of object is because the catoptrical cause of object, the catoptrical ability of various objects is different, thereby human eye can be distinguished different colors, for example the object of white reflects all light, and the color of human eye identification is a white; The red main reflect red of object, other coloured light is absorbed by this object, and the color of human eye identification is red; The object of black can absorb all coloured light, and the color of the identification of reflected light not, so human eye basically is a black.Principle of the present utility model is similar to the principle that human eye distinguishes between colors, the utility model utilizes light emitting diode emission light, the light that photodiode acceptance reflects, shone the zone of colour developing band when light, if colour band does not develop the color, because the substrate of most fast diagnosis reagents all is a white, this Shu Guang just substantially is returned so, if colour band colour developing, so just only returned and be with corresponding color with colour developing, and other color relations are absorbed by this colour band, so just can judge having or not of colour band very easily, thereby the result that will test is the conspicuous tester of presenting to.The reflection ray that photodiode of the present utility model is accepted is fully from specific light emitting diode, and do not disturbed by adjacent light emitting diode or other light.Photodiode is the same with general-purpose diode, all is a kind of semiconductor element, all has a PN junction.But photodiode has a special performances, is exactly when photodiode work at reverse bias voltage state or no-bias state the time, can produce a reverse electric current, and the size of inverse current is relevant with the power of incident light.The power of incident light is big, and then inverse current is just big more; Otherwise the power of incident light is little, and then inverse current is just more little.The photodiode current that utilizes the variation of light to cause exactly changes this characteristic, and photodiode just can convert light signal to electric signal.In the side circuit utilization, utilize reverse bias voltage and pull-up resistor to convert the current signal that gets by photodiode converts luminous energy to voltage signal, and by analog to digital conversion circuit the voltage signal of simulating is converted to digital signal, carries out computing to make things convenient for central processing unit.But because the current signal that photodiode converts luminous energy obtains is very little, thereby cause its resolution to reduce, so need here signal to be amplified suitable multiple by signal amplification circuit, can obtain good resolution, can not make the signal state that reaches capacity again.Central processing unit is judged the result of test by calculating the resulting digital signal of conversion.
Embodiment 2
The check and analysis device of present embodiment is with embodiment 1, and difference only is that the circuit of measurement and control in the check and analysis device also comprises the sound circuit that is connected with central processing unit, as shown in Figure 4.
Embodiment 3
The check and analysis device of present embodiment is with embodiment 2, and the power circuit of distinguishing in the circuit of measurement and control that only is the check and analysis device is a detachable lithium, as shown in Figure 5.
Embodiment 4
The check and analysis device of present embodiment is with embodiment 1, and difference only is not contain button (as shown in Figure 6) on the check and analysis device middle shell, and principle of work as shown in Figure 7.
Embodiment 5
The check and analysis device of present embodiment is with embodiment 2, and difference only is to use the central processing unit with data storage function, does not contain data storage circuitry, and fundamental diagram as shown in Figure 8.
The foregoing description is the utility model preferred implementation; but embodiment of the present utility model is not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present utility model and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within the protection domain of the present utility model.

Claims (10)

1. the intelligent discriminance analysis device of an immuno-chromatographic test paper strip is made up of housing and the circuit of measurement and control that is installed on enclosure interior; The surface of housing is provided with LCD display and test strips testing jack; Circuit of measurement and control comprises power circuit, photoelectric sensor, signal amplification circuit, led circuit and central processing unit; Power circuit, LCD display and led circuit are connected with central processing unit respectively, and photoelectric sensor, signal amplification circuit and central processing unit are connected successively, it is characterized in that: circuit of measurement and control comprises the bar-code identification circuit that is connected with central processing unit.
2. according to the intelligent discriminance analysis device of the described immuno-chromatographic test paper strip of claim 1, it is characterized in that: described bar-code identification circuit comprises switch, light source, lens, photoelectric commutator, amplification and rectification circuit and bar code interface circuit; Light source, switch and bar code interface circuit are connected successively, and the bar code interface circuit is controlled by central processing unit; Lens and photoelectric commutator are positioned at the same side of light source; Photoelectric commutator is connected with amplification and rectification circuit, and amplification and rectification circuit is connected with central processing unit by the bar code interface circuit.
3. according to the intelligent discriminance analysis device of the described immuno-chromatographic test paper strip of claim 1, it is characterized in that: the surface of described housing is provided with the button that is connected with central processing unit.
4. according to the intelligent discriminance analysis device of the described immuno-chromatographic test paper strip of claim 3, it is characterized in that: described button is three-dimensional button.
5. according to the intelligent discriminance analysis device of the described immuno-chromatographic test paper strip of claim 1, it is characterized in that: described photoelectric sensor is a photodiode.
6. according to the intelligent discriminance analysis device of the described immuno-chromatographic test paper strip of claim 1, it is characterized in that: described central processing unit is the central processing unit with data storage function.
7. according to the intelligent discriminance analysis device of each described immuno-chromatographic test paper strip of claim 1~5, it is characterized in that: described circuit of measurement and control comprises the data storage circuitry that is connected with central processing unit.
8. according to the intelligent discriminance analysis device of claim 6 or 7 described immuno-chromatographic test paper strips, it is characterized in that: described power circuit is disconnectable battery.
9. the intelligent discriminance analysis device of described immuno-chromatographic test paper strip according to Claim 8, it is characterized in that: described battery is a lithium battery.
10. the intelligent discriminance analysis device of described immuno-chromatographic test paper strip according to Claim 8, it is characterized in that: described circuit of measurement and control comprises the sound circuit that is connected with central processing unit.
CN200920264982XU 2009-12-22 2009-12-22 Intelligent recognition and analysis device of immunity-chromatography test paper strip Expired - Lifetime CN201615880U (en)

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CN200920264982XU CN201615880U (en) 2009-12-22 2009-12-22 Intelligent recognition and analysis device of immunity-chromatography test paper strip
PCT/CN2010/076075 WO2011076014A1 (en) 2009-12-22 2010-08-17 Intelligent apparatus for identifying and analyzing immunochromatographic test strip

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WO2011076013A1 (en) * 2009-12-22 2011-06-30 广州万孚生物技术有限公司 Method and system for intelligently identifying and reading immunochromatographic test strip
WO2011076015A1 (en) * 2009-12-22 2011-06-30 广州万孚生物技术有限公司 Immunochromatographic test strip with barcode layer
CN107677604A (en) * 2017-10-31 2018-02-09 广东省测试分析研究所(中国广州分析测试中心) A kind of miniaturization detection means of Visual retrieval card
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CN108414747A (en) * 2017-02-10 2018-08-17 国家纳米科学中心 The preparation method of bar code chromatograph test strip, its detection device and application
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WO2011076013A1 (en) * 2009-12-22 2011-06-30 广州万孚生物技术有限公司 Method and system for intelligently identifying and reading immunochromatographic test strip
WO2011076015A1 (en) * 2009-12-22 2011-06-30 广州万孚生物技术有限公司 Immunochromatographic test strip with barcode layer
CN108414747A (en) * 2017-02-10 2018-08-17 国家纳米科学中心 The preparation method of bar code chromatograph test strip, its detection device and application
CN108414747B (en) * 2017-02-10 2023-03-31 国家纳米科学中心 Preparation method of bar-coded chromatographic test strip, detection device and application thereof
CN107677604A (en) * 2017-10-31 2018-02-09 广东省测试分析研究所(中国广州分析测试中心) A kind of miniaturization detection means of Visual retrieval card
CN108387749A (en) * 2018-03-07 2018-08-10 广州浩强生物科技有限公司 Detection method and detection pen a kind of or become pregnant
CN109239338A (en) * 2018-10-09 2019-01-18 邱华遗 Wide-range immuno-chromatography detection device and method
CN109239338B (en) * 2018-10-09 2023-09-08 邱华遗 Wide-range immunochromatography detection device and method
CN114200131A (en) * 2021-12-13 2022-03-18 成都云芯医联科技有限公司 Detection system for luminous characteristics of luminous pearl-like material and preparation method of matched detection test paper
CN114200131B (en) * 2021-12-13 2023-08-15 成都云芯医联科技有限公司 Detection system for luminous characteristics of luminous beads and preparation method of matched detection test paper

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