CN201596477U - Bubble oscillating micro-mixing system - Google Patents
Bubble oscillating micro-mixing system Download PDFInfo
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- CN201596477U CN201596477U CN2010201135713U CN201020113571U CN201596477U CN 201596477 U CN201596477 U CN 201596477U CN 2010201135713 U CN2010201135713 U CN 2010201135713U CN 201020113571 U CN201020113571 U CN 201020113571U CN 201596477 U CN201596477 U CN 201596477U
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Abstract
The utility model discloses a bubble oscillating micro-mixing system in the technical field of micro-mixers. In the bubble oscillating micro-mixing system, gas, liquid a and liquid b form convergent flow at an increasing nozzle of a main mixing micro-passage inlet, the convergent flow is controlled by gas-liquid interface tension and adhesive shearing force simultaneously to form a bubble sequence, under excitation of periodical alternative direct current impulse voltage, periodical alternative temperature rise is generated on thin-film resistance micro-heaters on two sides above the main mixing micro-passage, periodical reverse temperature gradient is formed in a corresponding width direction of the main mixing micro-passage, the temperature gradient causes interface tension gradient, liquid moves to a low temperature side, bubbles move towards a high temperature side, and the bubbles oscillate in high frequency in a passage width direction according to the periodical reverse temperature gradient, thereby strengthening fluid mixing. The bubble oscillating micro-mixing system can fast high-efficiently realize sufficient mixing of two different fluids under microscale, and has wide application prospect.
Description
Technical field
The utility model belongs to little hybrid technology field, particularly a kind of bubble swinging micro-mixing system.
Background technology
Since the nearly century, high-tech areas such as microelectric technique, information technology, biotechnology, nanometer technology have obtained tremendous development, and one of collaborative development trend of these new and high technologies is the microminiaturization and the integration of function of equipment and system.Under the continuous promotion of micro-processing technology, designing and make various functional form micro elements, micro equipment and micro-system has become possibility.Micro-total analysis system is that parts such as microactrator, microsensor, micro-mixer, microreactor, tiny segregator are integrated on one several square centimeters the chip, to realize systemic-functions such as sample delivery, premixed, biochemical reaction, separation and detection, have advantages such as the sample consumption is few, processing speed fast, the reaction contaminant discharging is few, be subjected to extensive concern in fields such as life science and analytical chemistry.Wherein, micro-mixer is used for realizing the abundant mixing of differential responses thing under the minute yardstick condition as the vitals of micro-total analysis system.
Abundant premixed between the differential responses thing is the prerequisite of various physics, chemistry and biological respinse.Under macro-scale, usually the churned mechanically mode of employing promotes the mixing between the differential responses thing, thereby or make to flow by the Reynolds number that improves moving fluid and be in turbulent area and increase mixed effect, i.e. mixing under the macro-scale mainly realizes by the convection current that increases between the different fluid.Under miniature scale, the mobile Laminar Flow that is generally low reynolds number in the passage, the mixing between the different fluid can only realize by molecular diffusion, often needs long incorporation time and long mixing length.Under micro-scale, the general character of the little mixed method of various promotions is to produce the disturbance perpendicular to fluid boundary to be mixed.At present, existing micro-mixer can be divided into two classes, promptly active micro-mixer and passive type micro-mixer.Active micro-mixer need have the high advantage of mixing efficiency at the inner integrated moving component of micro-mixer, but its processing technology complexity exists moving component to cause reliability to reduce; The passive type micro-mixer adopts the passage with complex geometry to form chaotic flow to mix with strengthening fluid, and mixing efficiency is lower than active blender usually, and the complex passages structure can cause the increase of flow resistance simultaneously.Therefore, the mixing of the fluid under the minute yardstick is not well solved as yet.
Summary of the invention
The utility model exists moving component to cause reliability to reduce at active micro-mixer processing technology complexity in the prior art; Passive type micro-mixer complex passages structure can cause the increase of flow resistance and the low problem of mixing efficiency and a kind of bubble swinging micro-mixing system is provided.
A kind of bubble swinging micro-mixing system is characterized in that: this bubble swinging micro-mixing system comprises two-way DC-pulse pressing system, solution feed pump system, fluid delivery pipeline system, micro-mixer main body and connection lead;
Described micro-mixer main body is formed by cover plate of upper layer and lower floor's substrate bonding;
Be processed with the main microchannel of mixing in the substrate of described lower floor, the gas access, the microchannel, gas access, liquid a inlet, the liquid a microchannel that enters the mouth, liquid b inlet, the liquid b microchannel that enters the mouth, mixing material flows out passage, mixing material flows out outlet, the bubble flow pass, bubble flows out outlet, divergent nozzle and lattice filter, the microchannel, gas access, liquid a inlet microchannel and liquid b inlet microchannel converge at the main porch, microchannel of mixing, be used for gas, liquid a and liquid b are passed to the main microchannel of mixing, in main porch of mixing the microchannel divergent nozzle is set, gas, liquid a and liquid b form convergence flow at the divergent nozzle place, this convergence flow forms the bubble sequence under the common domination of gas-liquid interface tension force and sticky shearing power, main mixing exit, microchannel is processed with the gentle burble of mixing material outflow passage respectively and goes out passage, the porch of flowing out passage at mixing material is processed with lattice filter, mixing material is the filtering bubble behind lattice filter, flow out outlet by mixing material and flow out after mixing material flows out passage, the waste liquid that contains bubble flows out outlet by bubble behind the bubble flow pass discharges;
Described cover plate of upper layer deposits film resistor micro-heater layer towards lower floor's substrate one side, film resistor micro-heater layer is divided into two parts, be respectively film resistor micro-heater a and film resistor micro-heater b, and between film resistor micro-heater layer and cover plate of upper layer, deposit insulation film, insulation film is used for the electric insulation between film resistor micro-heater layer and the cover plate of upper layer, plated metal goes between the major part covering of film resistor micro-heater a and b again on film resistor micro-heater a and film resistor micro-heater b, the part that is covered by metal lead wire is not effective heating region of film resistor micro-heater a and b, effective heating region of film resistor micro-heater a and film resistor micro-heater b all is provided with along main mixing microchannel length direction, be positioned at main mixing microchannel, and be distributed in main both sides, top of mixing the microchannel;
Described solution feed pump system is by providing gas and two kinds of liquid to be mixed in the fluid delivery tube road direction micro-mixer main body;
Described two-way DC-pulse pressing system links to each other with metal lead wire on the micro-mixer main body cover plate of upper layer by connecting lead, for the film resistor micro-heater a on the micro-mixer main body and film resistor micro-heater b provide periodically direct current ALT pulse driving voltage, thereby make and produce the reverse thermograde of periodicity of mixing on the width of microchannel in the mixing material along main, liquid moves to low temperature side, bubble moves to high temperature side, the main reverse thermograde of periodicity of mixing in the microchannel causes the bubble sequence to do periodic wobble on this microchannel width, and liquid is fully mixed.
The width of described cover plate of upper layer is greater than the width of described lower floor substrate, so that metal lead wire is connected with two-way DC-pulse pressing system.
The shape of described film resistor micro-heater a and the effective heating region of film resistor micro-heater b is the strip that mixes the microchannel length direction along main.
The width of described film resistor micro-heater a and the effective heating region of film resistor micro-heater b is all less than main 1/3rd of the microchannel width that mixes.
Described cover plate of upper layer, lower floor's substrate material are silicon, heat resistant glass, dimethyl silicone polymer (PDMS) or polymethyl methacrylate (PMMA).
Described insulation film material is a titanium dioxide.
Described film resistor micro-heater a and film resistor micro-heater b material are platinum or aluminium.
Described metal lead wire material is a gold.
The cross sectional shape that microchannel, described gas access, liquid a inlet microchannel, liquid b inlet microchannel, divergent nozzle, main mixing microchannel, the gentle burble of mixing material outflow passage go out passage is rectangle or square.
Operation principle of the present utility model is: from gas, liquid a and liquid b gas flow channel, liquid a flow channel and the liquid b flow channel in the fluid delivery pipeline system enters the micro-mixer main body of solution feed pump system, form convergence flow at the main divergent nozzle place of mixing the microchannel inlet, this convergence flow forms the bubble sequence under the common domination of gas-liquid interface tension force and sticky shearing power, can control the size and the generated frequency of this bubble sequence by the flow of control gas, liquid a and liquid b.Equate under the condition that at liquid a and liquid b flow the bubble sequence of generation is positioned at main center of mixing the microchannel (be liquid a to be mixed and liquid b at the interface) and follows liquid a and liquid b flows.Two-way DC-pulse pressing system applies periodically alternately dc pulse voltage (promptly when applying voltage on the film resistor micro-heater in a certain side, the voltage that applies on the opposite side micro-heater is zero) by metal lead wire on the film resistor micro-heater that is positioned at both sides above the main mixing microchannel.Periodically replace under the excitation of dc pulse voltage at this, produce alternately temperature rise of periodicity on the film resistor micro-heater of both sides above the described main mixing microchannel, thereby on the respective width direction of described master's mixing microchannel, form oppositely thermograde of periodicity.On the described main gas-liquid interface that mixes in the microchannel, thereby thermograde causes interfacial tension gradient to cause the Marangoni convection current of gas-liquid interface, and promptly liquid moves to low temperature side, and bubble moves to high temperature side.Therefore, the main reverse thermograde of periodicity of mixing in the microchannel will cause the bubble sequence to do periodic wobble on this microchannel width, and its hunting frequency depends on the periodically alternately frequency of dc pulse voltage that applies.When the driving voltage frequency that is applied was KHz, bubble also can reach KHz in main hunting frequency of mixing on the microchannel width (being vertical liquid a and liquid b interface direction), thereby strengthens the mixing between liquid a and the liquid b greatly.In described mixing material flowed out passage, bubble was stopped that by described lattice filter only the mixed liquor physical efficiency is passed through, and the waste liquid that contains bubble is discharged from the bubble flow pass.
The utility model is compared with existing little hybrid technology, have the following advantages: in existing active micro-mixer, often by come the mixing between the strengthening fluid at moveable elements such as the inner integrated minute-pressure electric crystal of micro-mixer or little agitating devices, has higher mixing efficiency, but owing to adopted moving component, not only cause its processing technology complexity, and its reliability and service life are reduced greatly; In existing passive type micro-mixer, when flowing through the labyrinth passage, fluid to be mixed produces the mixing of chaotic flow strengthening fluid thereby often adopt passage to make with complex geometry.The passive type micro-mixer has and need not integrated moving component, advantage that reliability is high, but the more active micro-mixer of its mixing efficiency is low, and, need bigger pumping pressure and system sealing is proposed requirements at the higher level owing to adopt the complex geometry passage to increase pressure drop of flow.The utility model adopts convergence flow to flow through divergent nozzle and produces the bubble sequence, under the excitation of this bubble sequence high-frequency pulse voltage in main mixing microchannel, produces the swing in high frequency of channel width direction, thus the mixing between the strengthening fluid greatly.Micro-mixer provided by the utility model is not having under the condition of integrated moving component, only by the excitation of external high frequency alternate voltages, has realized the high frequency components of fluid boundary to be mixed.Therefore, micro-mixer provided by the utility model had both had the high advantage of active micro-mixer mixing efficiency, have the passive type micro-mixer again and need not integrated moving component, advantage that reliability is high, the methods, devices and systems of a kind of novelty, efficient, reinforcement Microfluidic Mixing that reliability is high are provided, have had broad application prospects.
Description of drawings
Fig. 1 is that bubble swinging micro-mixing system of the present utility model is implemented schematic diagram;
Fig. 2 is the structural representation of bubble swinging micro-mixer main body described in the utility model;
Fig. 3 is the lattice filter partial enlarged drawing;
Fig. 4 is the divergent nozzle partial enlarged drawing;
Fig. 5 is insulation film, film resistor micro-heater and metal lead wire electrode relative position schematic diagram;
Fig. 6 is effective heating region schematic diagram of film resistor micro-heater a and b;
Description of reference numerals: 1, two-way DC-pulse pressing system, 2, the solution feed pump system, 3, the fluid delivery pipeline system, 4, micro-mixer, 5, connect lead, 6, the gas access, 7, liquid a inlet, 8, liquid b inlet, 9, mixing material flows out outlet, 10, bubble flows out outlet, 41, cover plate of upper layer, 411, insulation film, 412, film resistor micro-heater a, 413, film resistor micro-heater b, 414, metal lead wire, 42, lower floor's substrate, 421, the microchannel, gas access, 422, the liquid a microchannel that enters the mouth, 423, the liquid b microchannel that enters the mouth, 424, divergent nozzle, 425, main microchannel, 426 of mixing, mixing material flows out passage, 427, the bubble efferent tract is logical, 428, lattice filter, 4120, effective heating region of film resistor micro-heater a, 4130, effective heating region of film resistor micro-heater b.
The specific embodiment
The utility model is described in further detail below in conjunction with accompanying drawing:
A kind of bubble swinging micro-mixing system, as shown in Figure 1, this bubble swinging micro-mixing system comprises two-way DC-pulse pressing system 1, solution feed pump system 2, fluid delivery pipeline system 3, micro-mixer main body 4 and connection lead 5;
Described micro-mixer main body 4 is formed by cover plate of upper layer 41 and lower floor's substrate 42 bondings; As shown in Figure 2;
Be processed with the main microchannel 425 of mixing in the described lower floor substrate 42, gas access 6, microchannel, gas access 421, liquid a inlet 7, the liquid a microchannel 422 that enters the mouth, liquid b inlet 8, the liquid b microchannel 423 that enters the mouth, mixing material flows out passage 426, mixing material flows out outlet 9, bubble flow pass 427, bubble flows out outlet 10, divergent nozzle 424 and lattice filter 428, microchannel, gas access 421, liquid a inlet microchannel 422 and liquid b inlet microchannel 423 converge at main 425 porch, microchannel of mixing, be used for gas, liquid a and liquid b are passed to the main microchannel 425 of mixing, in main porch of mixing microchannel 425 divergent nozzle 424 is set, the partial enlarged drawing of divergent nozzle 424 as shown in Figure 3, gas, liquid a and liquid b form convergence flow (flow focusing) at divergent nozzle 424 places, this convergence flow forms the bubble sequence under the common domination of gas-liquid interface tension force and sticky shearing power, the bubble sequence follows liquid a and liquid b flows into the main microchannel 425 of mixing, the frequency of the bubble sequence that forms and size can be regulated by the flow-control of solution feed pump system 1, main mixing 425 exits, microchannel are processed with mixing material outflow passage 426 gentle burbles respectively and go out passage 427, the porch of flowing out passage 426 at mixing material is processed with lattice filter 428, the partial enlarged drawing of lattice filter 428 as shown in Figure 4, the square column array of this lattice filter for adopting micro fabrication to make, independently mix in the fluid-mixing of microchannel 425 contained bubble at this lattice filter place by filtering, only the mixed liquor physical efficiency is passed through, mixing material is the filtering bubble behind lattice filter 428, flow out outlet 9 by mixing material and flow out after mixing material flows out passage 426, the waste liquid that contains bubble flows out outlet 10 by bubble behind bubble flow pass 427 discharges;
Described cover plate of upper layer 41 deposits film resistor micro-heater layer towards lower floor's substrate 42 1 sides, film resistor micro-heater layer is divided into two parts, be respectively film resistor micro-heater a412 and film resistor micro-heater b413, and between film resistor micro-heater layer and cover plate of upper layer 41, deposit insulation film 411, insulation film 411 is used for the electric insulation between film resistor micro-heater layer and the cover plate of upper layer 41, plated metal lead-in wire 414 covers the major parts of film resistor micro-heater a412 and b413 again on film resistor micro-heater a412 and film resistor micro-heater b413, the part that is covered by metal lead wire 414 is not effective heating region of film resistor micro-heater a412 and b413, as shown in Figure 6, the part of effective heating region 4120 of film resistor micro-heater a412 for not covered by metal lead wire 414, the part of effective heating region 4130 of film resistor micro-heater b413 for not covered by metal lead wire 414, effective heating region 4120 of film resistor micro-heater a412 and film resistor micro-heater b413,4130 all along main mixing microchannel 425 length direction settings, be positioned at main mixing microchannel 425, and be distributed in main both sides, top of mixing microchannel 425; As shown in Figure 5, the titanium dioxide insulation film 411 of cover plate of upper layer 41 towards lower floor's substrate 42 sides has been shown among Fig. 5, the relative position figure of film resistor micro-heater a412, film resistor micro-heater b413 and gold electrode lead-in wire 414, when making, at first the bottom deposits insulation film, and then deposit film resistance micro-heater layer covers insulation film, the superiors are the metal electrode lead-in wire, the major part of film resistor micro-heater is covered, only keep the effective heating region of stripe region conduct over against main hybrid channel;
Described solution feed pump system 2 provides gas and two kinds of liquid to be mixed by fluid delivery pipeline 3 in micro-mixer main body 4;
Described two-way DC-pulse pressing system 1 links to each other with metal lead wire 414 on micro-mixer main body 4 cover plate of upper layer 41 by connecting lead 5, for the film resistor micro-heater a412 on the micro-mixer main body 4 and film resistor micro-heater b413 provide periodically direct current ALT pulse driving voltage, thereby make and produce the reverse thermograde of periodicity of mixing on 425 widths of microchannel in the mixing material along main, liquid moves to low temperature side, bubble moves to high temperature side, the main reverse thermograde of periodicity of mixing in the microchannel 425 causes the bubble sequence to do periodic wobble on this microchannel width, and liquid is fully mixed.Frequency, amplitude and the phase place of this two-way DC pulse driving voltage can be set by two-way DC-pulse pressing system 1 as required.
The width of described cover plate of upper layer 41 is greater than the width of described lower floor substrate 42, so that metal lead wire 414 is connected with two-way DC-pulse pressing system 1.
The shape of effective heating region 4130 of the effective heating region 4120 of described film resistor micro-heater a412 and film resistor micro-heater b413 is the strip that mixes microchannel 425 length directions along main.
The width of effective heating region 4130 of the effective heating region 4120 of described film resistor micro-heater a412 and film resistor micro-heater b413 is all less than main 1/3rd of microchannel 425 width that mix.
Described cover plate of upper layer 41, lower floor's substrate 42 materials are silicon.
Described insulation film 411 materials are titanium dioxide.
Described film resistor micro-heater a412 and film resistor micro-heater b413 material are platinum.
Described metal lead wire 414 materials are gold.
The cross sectional shape that microchannel, described gas access 421, liquid a inlet microchannel 422, liquid b inlet microchannel 423, divergent nozzle 424, main mixing microchannel 425, mixing material outflow passage 426 gentle burbles go out passage 427 is a rectangle.
Claims (5)
1. bubble swinging micro-mixing system, it is characterized in that: this bubble swinging micro-mixing system comprises two-way DC-pulse pressing system (1), solution feed pump system (2), fluid delivery pipeline system (3), micro-mixer main body (4) and connection lead (5);
Described micro-mixer main body (4) is formed by cover plate of upper layer (41) and lower floor's substrate (42) bonding;
Be processed with the main microchannel (425) of mixing in the described lower floor substrate (42), gas access (6), microchannel, gas access (421), liquid a enter the mouth (7), the liquid a microchannel (422) that enters the mouth, liquid b enter the mouth (8), the liquid b microchannel (423) that enters the mouth, mixing material flows out passage (426), mixing material flows out outlet (9), bubble flow pass (427), bubble flows out outlet (10), divergent nozzle (424) and lattice filter (428), microchannel, gas access (421), liquid a inlet microchannel (422) and liquid b inlet microchannel (423) converge at the main porch, microchannel (425) of mixing, be used for gas, liquid a and liquid b are passed to the main microchannel (425) of mixing, in main porch of mixing microchannel (425) divergent nozzle (424) is set, gas, liquid a and liquid b locate to form convergence flow at divergent nozzle (424), this convergence flow forms the bubble sequence under the common domination of gas-liquid interface tension force and sticky shearing power, main mixing exit, microchannel (425) is processed with the gentle burble of mixing material outflow passage (426) respectively and goes out passage (427), the porch of flowing out passage (426) at mixing material is processed with lattice filter (428), mixing material is the filtering bubble behind lattice filter (428), flow out outlet (9) by mixing material and flow out after mixing material flows out passage (426), the waste liquid that contains bubble flows out outlet (10) by bubble behind bubble flow pass (427) discharges;
Described cover plate of upper layer (41) deposits film resistor micro-heater layer towards lower floor's substrate (42) one sides, film resistor micro-heater layer is divided into two parts, be respectively film resistor micro-heater a (412) and film resistor micro-heater b (413), and between film resistor micro-heater layer and cover plate of upper layer (41), deposit insulation film (411), insulation film (411) is used for the electric insulation between film resistor micro-heater layer and the cover plate of upper layer (41), on film resistor micro-heater a (412) and film resistor micro-heater b (413) again plated metal lead-in wire (414) with major part covering of film resistor micro-heater a (412) and b (413), the part that is covered by metal lead wire (414) is not effective heating region of film resistor micro-heater a (412) and b (413), effective heating region of film resistor micro-heater a (412) and film resistor micro-heater b (413) is all along main mixing microchannel (425) length direction setting, be positioned at main mixing microchannel (425), and be distributed in main both sides, top of mixing microchannel (425);
Described solution feed pump system (2) provides gas and two kinds of liquid to be mixed by fluid delivery pipeline (3) in micro-mixer main body (4);
Described two-way DC-pulse pressing system (1) links to each other with metal lead wire (414) on micro-mixer main body (4) cover plate of upper layer (41) by connecting lead (5), for the film resistor micro-heater a (412) on the micro-mixer main body (4) and film resistor micro-heater b (413) provide periodically direct current ALT pulse driving voltage, thereby make and produce the reverse thermograde of periodicity of mixing on the width of microchannel (425) in the mixing material along main, liquid moves to low temperature side, bubble moves to high temperature side, the main reverse thermograde of periodicity of mixing in the microchannel (425) causes the bubble sequence to do periodic wobble on this microchannel width, and liquid is fully mixed.
2. a kind of bubble swinging micro-mixing system according to claim 1, it is characterized in that: the width of described cover plate of upper layer (41) is greater than the width of described lower floor substrate (42), so that metal lead wire (414) is connected with two-way DC-pulse pressing system (1).
3. a kind of bubble swinging micro-mixing system according to claim 1 is characterized in that: described film resistor micro-heater a (412) and film resistor micro-heater b (413) the effectively shape of heating region are the strip that mixes microchannel (425) length direction along main.
4. a kind of bubble swinging micro-mixing system according to claim 1 is characterized in that: described film resistor micro-heater a (412) and film resistor micro-heater b (413) the effectively width of heating region all mix 1/3rd of microchannel (425) width less than the master.
5. a kind of bubble swinging micro-mixing system according to claim 1 is characterized in that: the cross sectional shape that microchannel, described gas access (421), liquid a inlet microchannel (422), liquid b inlet microchannel (423), divergent nozzle (424), main mixing microchannel (425), the gentle burble of mixing material outflow passage (426) go out passage (427) is rectangle or square.
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| CN2010201135713U CN201596477U (en) | 2010-02-09 | 2010-02-09 | Bubble oscillating micro-mixing system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757864B (en) * | 2010-02-09 | 2012-05-09 | 华北电力大学 | Bubble swinging micro-mixing system |
| CN102895905A (en) * | 2012-10-26 | 2013-01-30 | 重庆大学 | Nanoscale fluid mixing method and mixer thereof |
| CN105233890A (en) * | 2015-10-16 | 2016-01-13 | 武汉工程大学 | Droplet jet microfluid mixed chip and machining method |
| CN106119085A (en) * | 2016-08-23 | 2016-11-16 | 闫维新 | A kind of real-time fluorescence PCR mixing microchannel chip |
| GB2562762A (en) * | 2017-05-24 | 2018-11-28 | Univ Heriot Watt | Microfluidic mixing |
-
2010
- 2010-02-09 CN CN2010201135713U patent/CN201596477U/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757864B (en) * | 2010-02-09 | 2012-05-09 | 华北电力大学 | Bubble swinging micro-mixing system |
| CN102895905A (en) * | 2012-10-26 | 2013-01-30 | 重庆大学 | Nanoscale fluid mixing method and mixer thereof |
| CN102895905B (en) * | 2012-10-26 | 2015-02-18 | 重庆大学 | Nanoscale fluid mixing method and mixer thereof |
| CN105233890A (en) * | 2015-10-16 | 2016-01-13 | 武汉工程大学 | Droplet jet microfluid mixed chip and machining method |
| CN105233890B (en) * | 2015-10-16 | 2017-04-26 | 武汉工程大学 | Droplet jet microfluid mixed chip and machining method |
| CN106119085A (en) * | 2016-08-23 | 2016-11-16 | 闫维新 | A kind of real-time fluorescence PCR mixing microchannel chip |
| CN106119085B (en) * | 2016-08-23 | 2018-12-11 | 闫维新 | A kind of real-time fluorescence PCR mixing microchannel chip |
| GB2562762A (en) * | 2017-05-24 | 2018-11-28 | Univ Heriot Watt | Microfluidic mixing |
| GB2562762B (en) * | 2017-05-24 | 2022-07-13 | Univ Heriot Watt | Microfluidic mixing |
| US11760625B2 (en) | 2017-05-24 | 2023-09-19 | Heriot-Watt University | Microfluidic mixing |
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Granted publication date: 20101006 Effective date of abandoning: 20120509 |