CN201453664U - Medicinal capsule - Google Patents
Medicinal capsule Download PDFInfo
- Publication number
- CN201453664U CN201453664U CN2009201092471U CN200920109247U CN201453664U CN 201453664 U CN201453664 U CN 201453664U CN 2009201092471 U CN2009201092471 U CN 2009201092471U CN 200920109247 U CN200920109247 U CN 200920109247U CN 201453664 U CN201453664 U CN 201453664U
- Authority
- CN
- China
- Prior art keywords
- utricule
- capsule
- medicated cap
- depression
- interior
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Abstract
The utility model provides a medicinal capsule which comprises a capsule cap (1), an inner capsule body (2), a middle capsule body (3) and an outer capsule body (4), wherein the opening end of the capsule cap (1) is opposite to the opening ends of the inner capsule body (2), the middle capsule body (3) and the outer capsule body (4); the capsule body wall of the opening end of the outer capsule body (4) is arranged in the opening end of the capsule cap (1); the middle body (3) is arranged in the outer capsule body (4); the inner capsule body (2) is arranged in the middle capsule body (3); and the inner capsule body (2), the middle capsule body (3) and the outer capsule body (4) are connected through friction force between capsule body walls of the opening ends.
Description
Technical field
This utility model relates to a kind of capsule for medicine, especially relates to the capsule with a capsule medicated cap and three utricules.This utility model belongs to pharmaceutical field.
Background technology
Capsule preparations is meant that medicine is loaded on a kind of preparation of making in the capsulae vacuus.Capsule preparations can be covered the bitterness and the stink of medicine discomfort, makes that it is clean and tidy, attractive in appearance, swallows easily.Content can not add binding agent, need not exert pressure when capsule preparations prepared, in gastrointestinal tract disintegrate fast, so improved bioavailability of medicament effectively.Simultaneously, capsule preparations can improve medicine stability, and as photosensitive medicine, the damp and hot unsettled medicine of chance, in the light tight capsule of can packing into, protection medicine is not subjected to the effect of oxygen, light in dampness and the air, thereby improves its stability.
The utility model content
Capsule preparations is widely used in pharmacy at present as a kind of preparation commonly used.Capsule in the present capsule preparations is made of a capsule medicated cap and a utricule, filling medicine in the utricule, and the capsule medicated cap invests outside the utricule, and shutoff utricule opening forms a chamber that is isolated from the outside.But filling must be single medicine and the adjuvant that matches with it in this capsule, perhaps filling physics or chemically can mix the effective ingredient and the adjuvant of existence.Yet in the clinical practice, taking several drugs simultaneously is a kind of common phenomenon, for example for the complication patient, and the perhaps disease that can not effectively control of single medicine such as diabetes etc.In order to reduce patient's medicining times and the quantity of taking medicine, improve patient's compliance, the exploitation of compound preparation has become an effective way of drug research and development.Yet, not all medicine can be made compound preparation, for some the effective ingredient or the excipient substance of physics or chemical reaction are arranged, then can not simply be filled in the existing capsule, for example have hygroscopicity, physical chemistry reflection or acid-base reaction between the ingredient.
At the technical problem that exists in the above-mentioned prior art, this utility model provide a kind of simple, be easy to practical complex capsule, this complex capsule is made of capsule medicated cap 1, interior utricule 2, middle utricule 3 and outer utricule 4, the opening subtend of capsule medicated cap 1 opening and interior utricule 2, middle utricule 3 and outer utricule 4, the bladder walls of outer utricule 4 openings is positioned at capsule medicated cap 1 opening, middle utricule 3 is positioned at outer utricule 4, interior utricule 2 is arranged in utricule 3, and interior utricule 2, middle utricule 3 and outer utricule 4 connect by the frictional force between the bladder walls of opening separately.Interior utricule 2 and capsule medicated cap 1 are connected to form enclosed cavity 8, and utricule 2 and middle utricule 3 are connected to form enclosed cavity 9, and middle utricule 3 is connected with outer utricule 4, form enclosed cavity 10.
Among the embodiment that this utility model provides, the bladder walls of utricule 2 openings caves inward and forms depression 5 in the capsule for medicine, and the bladder walls of capsule medicated cap 1 has and depression 5 corresponding depressions 6, and the head of depression 6 is inserted in the depression 5.When depression 6 head is inserted in the depression 5, capsule medicated cap 1 snaps together with interior utricule 2, helps to prevent the disengaging of capsule medicated cap 1 and interior utricule 2.Capsule medicated cap 1 can also have depression 7 near opening, and the height of depression 7 is less than depression 6.The 7 depressor body walls that cave in, its effect are the frictional force that increases Large-pocket cap 1 and utricule.
As a kind of distortion, above-mentioned depression can be arranged to corresponding projection, when capsule medicated cap 1 and interior utricule 2 corresponding projections interlock, helps combining of capsule medicated cap 1 and interior utricule 2.Generally, this projection can have countless right, and it is right to preferably have corresponding projection 1-8, is more preferably 2 pairs.
In this utility model, capsule medicated cap 1, interior utricule 2, middle utricule 3 and outer utricule 4 can be made according to the preparation method of hard capsule by the stomach dissolution type material. and the stomach dissolution type material is selected from one or more in gelatin, animal glue or other protein component.
In this utility model, capsule medicated cap 1, interior utricule 2 and middle utricule 3 can be made according to the preparation method of hard capsule by the enteric solubility material.The enteric solubility material is selected from Lac; the cellulose acetate phthalate ester; crylic acid resin (as Eudragit L and S type etc.); the polyvinyl acetate phthalic acid ester; phthalic acid hypromellose ester; succinic acid acetic acid hydroxypropyl methylcellulose; and plasticizer is (as diethyl phthalate; Polyethylene Glycol; propylene glycol; glycerol triacetate; dimethyl phthalate; dibutyl sebacate; triethyl citrate; tributyl citrate; CitroflexA-2; the acetylated monoglycerides of Oleum Ricini and percentage; glycerol; dimethyl phthalate; diethyl phthalate; phthalic acid dibutyl ester; triethyl citrate; tributyl citrate; the acetyl group tributyl citrate; acetyl group tributyl citrate etc.) with porogen (as the PEG class; PVP; sucrose; salt) waits one or more.When capsule medicated cap 1, interior utricule 2 and middle utricule 3 were made by the enteric solubility material, outer utricule 4 can be made by the stomach dissolution type material, also can be made by the enteric solubility material, wherein stomach dissolution type material or enteric solubility material participation in the election above-mentioned substance.
Compare with traditional capsule preparations, the advantage of the complex capsule that this utility model provides is: 1. change the structure of conventional capsules, have three independently cavitys, can distinguish the filling effective ingredient; The bladder walls of 2. outer utricule 4, middle utricule 3 openings is sandwiched between the bladder walls of the bladder walls of capsule medicated cap 1 opening and interior utricule 2 openings, make the capsule structure compactness, be difficult for breaking away from, reduce the slotting phenomenon of splitting of capsule in the preparation process, improved the synthetic ratio of capsule preparations; 3. projection or depression increase the tight structure of capsule medicated cap 1 and utricule 2, make it to be difficult for peeling off; 4. the material of capsule medicated cap and utricule helps the position of control drug release, thus artificial adjustment drug release and blood drug level.
Four, description of drawings
Fig. 1, capsule for medicine structural representation.
1. capsule medicated cap; 2. interior utricule; 3. middle utricule; 4. outer utricule; 5. cave in; 6. cave in; 7. cave in; 8. the enclosed cavity that interior utricule 2 and capsule medicated cap 1 are connected to form; 9. the enclosed cavity that is connected to form of utricule 2 and middle utricule 3; 10. the enclosed cavity that middle utricule 3 and outer utricule 4 are connected to form.
Five, the specific embodiment
Capsule medicated cap 1 and interior utricule 2, middle utricule 3: application gelatin, titanium dioxide, coloring agent are material, and heat is melted back reverse mould drying in particular mold and formed.
Outer utricule 4: using gelatin is that main material prepares conventional capsule, and the preparation enteric coating liquid carries out coating, and concrete coating solution prescription is as follows:
Each 2 parts of acrylic resin II number and acroleic acid resin III numbers, Oleum Ricini 2g, diethyl phthalate 2g, Tween 80 2g, 95% ethanol adds to 100ml.
Production technology: conventional capsule is being dipped in enteric coating liquid one time again after becoming mould on the mould, carry out drying, the demoulding, otch, fit, outer utricule 4.
Obtain above-mentioned capsule medicated cap 1 and interior utricule 2, behind the middle utricule 3, mechanical fill medicine in interior utricule 2, closed capsule medicated cap 1 and interior utricule 2, medicine is closed in the cavity 8, the head of projection 6 is inserted in the projection 5. behind the middle utricule 3 fill medicines, in the bladder walls of utricule 3 openings be inserted between the bladder walls of the bladder walls of capsule medicated cap 1 opening and interior utricule 2 openings, medicine is closed in the cavity 9. behind the outer utricule 4 fill medicines, the bladder walls of outer utricule 4 openings is inserted between the bladder walls of the bladder walls of capsule medicated cap 1 opening and middle utricule 3 openings, medicine is closed in the cavity 10, can forms the gastrointestinal complex type capsules.
Claims (3)
1. capsule for medicine, it is characterized in that constituting by capsule medicated cap (1), interior utricule (2), middle utricule (3) and outer utricule (4), the opening subtend of capsule medicated cap (1) opening and interior utricule (2), middle utricule (3) and outer utricule (4), the bladder walls of outer utricule (4) opening is positioned at capsule medicated cap (1) opening, middle utricule (3) is positioned at outer utricule (4), interior utricule (2) is arranged in utricule (3), and interior utricule (2), middle utricule (3) and outer utricule (4) connect by the frictional force between the bladder walls of opening.
2. capsule as claimed in claim 1, the bladder walls that it is characterized in that interior utricule (2) opening cave inward and form depression (5), and the bladder walls of capsule medicated cap (1) has and depression (5) corresponding depression (6), and the head of depression (6) is inserted in the depression (5).
3. capsule as claimed in claim 2 is characterized in that capsule medicated cap (1) has depression (7) near opening, and the height of depression (7) is less than depression (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201092471U CN201453664U (en) | 2009-06-19 | 2009-06-19 | Medicinal capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201092471U CN201453664U (en) | 2009-06-19 | 2009-06-19 | Medicinal capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201453664U true CN201453664U (en) | 2010-05-12 |
Family
ID=42381004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201092471U Expired - Lifetime CN201453664U (en) | 2009-06-19 | 2009-06-19 | Medicinal capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201453664U (en) |
-
2009
- 2009-06-19 CN CN2009201092471U patent/CN201453664U/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Collagen capsule for medicine and its making method Effective date of registration: 20130523 Granted publication date: 20100512 Pledgee: China Everbright Bank Shenzhen Bagualing branch Pledgor: Beijing Aosa Medicine Research Centre Co., Ltd. Registration number: 2013990000309 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160705 Granted publication date: 20100512 Pledgee: China Everbright Bank, Limited by Share Ltd, Shenzhen, Bagualing branch Pledgor: Beijing Aosa Medicine Research Centre Co., Ltd. Registration number: 2013990000309 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20160705 Registration number: 2013990000309 Pledgee after: China Everbright Bank, Limited by Share Ltd, Shenzhen, Bagualing branch Pledgee before: China Everbright Bank Shenzhen Bagualing branch |
|
| CP02 | Change in the address of a patent holder |
Address after: 100176 Beijing economic and Technological Development Zone, West Beijing Road, No. 18, block C, room 216 Patentee after: Beijing Aosa Medicine Research Centre Co., Ltd. Address before: 100176, No. 18 West South Road, Beijing economic and Technological Development Zone, C512 Patentee before: Beijing Aosa Medicine Research Centre Co., Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20100512 |
|
| CX01 | Expiry of patent term |