CN201197744Y - Locating and breaking instrument for brain nuclei of rat - Google Patents
Locating and breaking instrument for brain nuclei of rat Download PDFInfo
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- CN201197744Y CN201197744Y CNU2008200282436U CN200820028243U CN201197744Y CN 201197744 Y CN201197744 Y CN 201197744Y CN U2008200282436 U CNU2008200282436 U CN U2008200282436U CN 200820028243 U CN200820028243 U CN 200820028243U CN 201197744 Y CN201197744 Y CN 201197744Y
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Abstract
The utility model discloses a bandicoot cranial nuclear mass lesion instrument which comprises a power circuit, a switching circuit and an output circuit. The output terminal of the power circuit is connected with the switching circuit, and the output terminal of the switching circuit is connected with the output circuit. The switching circuit of the utility model is structured as follows: one end of a potentiometer R2 is connected with a pin 4 at the output terminal of a bridge rectifier D1, and the other end thereof is connected with one end of a potentiometer R3, an adjustable terminal thereof is connected with a terminal 1 of a switch S1, the other end of the potentiometer R3 is grounded, and an adjustable terminal thereof is connected with a terminal 4 of the switch S1 and one end of a resistor R4; a terminal 7 of the switch S1 is connected with an electrode R5 and an ammeter MuA of the output circuit through a resistor R1, and the other end of the resistor R4 is connected with the ammeter MuA of the output circuit. Compared with the prior similar instrument, the utility model adopts the high voltage lesion animal cranial nerve nuclear mass, has the advantages of simple structure, reduced cost, and safety and reliability, can adjust the current of the lesion animal cranial nerve nuclear mass by adopting coarse adjustment and fine adjustment, and can be popularized and used in medical animal physiology experiments.
Description
Technical field
This utility model belongs to pharmacological evaluation technique with the apparatus field, is specifically related to experimental rat brain nuclear group location damage instrument.
Background technology
In medical science and neural biological Experiment of Zoology, stimulate or damage a certain central nuclei and often be used to study its function, after the research of cranial nuclei cell function finishes, calibrate the location to nerve nucleus, the nerve nucleus that writes down is carefully run function locate in conjunction with cranial nerve maincenter collection of illustrative plates.Simultaneously according to the experiment needs, also can to before a certain specific brain regions nerve nucleus damage and the metergasis after the damage contrast, analyze the influence of a certain specific brain regions nerve nucleus function, thereby disclose the profoundness of this nerve nucleus.
The patent No. is 02262240.3, denomination of invention is the Chinese utility model patent of " mark of cranial nuclei tissue positioned, damage instrument ", have the mark of nerve nucleus tissue positioned and two kinds of functions of damage, can satisfy the needs of medical science and neurobiology zoopery scientific experiments science.This instrument uses the alternating current of 220V to become the 100V unidirectional current through AC/DC changeover switch conversion, potentiometer adjust blood pressure, is used to damage the cranial nerve of laboratory animal, and the major defect of this instrument is a complex structure, the production cost height, and selling price is expensive.
Summary of the invention
Technical problem to be solved in the utility model is to overcome the shortcoming of the mark of above-mentioned cranial nuclei tissue positioned, damage instrument, provide a kind of reasonable in design, simple in structure, volume is little, easy to carry, stable performance, safe and reliable, a rat brain nuclear group location damage instrument that product cost is low.
Solving the problems of the technologies described above the technical scheme that is adopted is: it comprises power circuit, on-off circuit, output circuit, the output termination on-off circuit of power circuit, the output termination output circuit of on-off circuit.On-off circuit of the present utility model is: outfan 4 feet of the termination bridge rectifier D 1 of potentiometer R2, the end of another termination potentiometer R3,1 terminals of adjustable termination switch S 1, one end of the other end ground connection of potentiometer R3,4 terminals of adjustable termination switch S 1 and resistance R 4,7 terminals of switch S 1 meet the electrode R5 and the ammeter μ A of output circuit, the ammeter μ A of another termination output circuit of resistance R 4 by resistance R 1.
This utility model is compared with the mark of existing cranial nuclei tissue positioned, damage instrument, adopted high-tension electricity damage animal brain nerve nucleus, apparatus structure is simple, reduced production cost, experiment safety is reliable, and adopting coarse adjustment, fine setting to adjust to the electric current of damage animal brain nerve nucleus, ammeter shows the size of damaging electric current exactly.The utlity model has reasonable in design, simple in structure, volume is little, easy to carry, stable performance, safe and reliable, advantage such as product cost is low, can satisfy zooperal needs in the medical research work, can in the medical faunae Physiological Experiment, extensively promote the use of.
Description of drawings
Fig. 1 is an electrical principle block diagram of the present utility model.
Fig. 2 is an electronic circuit schematic diagram of the present utility model.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is further described, but this utility model is not limited to these embodiment.
Fig. 1 is an electrical principle block diagram of the present utility model, referring to Fig. 1.In Fig. 1, this utility model is to be connected and composed by power circuit, on-off circuit, output circuit, and power circuit becomes the 410V dc source with the 220V alternating current, for this utility model provides working power, the output termination on-off circuit of power circuit, the output termination output circuit of on-off circuit.
In Fig. 2, the power circuit of present embodiment is connected and composed by socket J1, switch S 2, transformator T1, bridge rectifier D 1, capacitor C 1, capacitor C 2.Socket J1 connects the 220V alternating current power supply, 1 foot of socket J1 connects the primary end of transformator T1,2 feet of socket J2 connect the primary other end of transformator T1 by switch S 2,1 foot of the secondary termination bridge rectifier D 1 of transformator T1,2 feet of secondary another termination bridge rectifier D 1 of transformator T1,4 feet of bridge rectifier D 1 connect an end and the on-off circuit of capacitor C 1 and capacitor C 2, the other end ground connection of 3 feet of bridge rectifier D 1 and the other end of capacitor C 1 and capacitor C 2, capacitor C 1, capacitor C 2 are filter capacitor.Open switch S 2, the 220V alternating current boosts through transformator T1, is rectified into the unidirectional current of 410V again through bridge rectifier D 1, for this utility model provides dc source.
The on-off circuit of present embodiment is connected and composed by switch S 1, resistance R 1, potentiometer R2, potentiometer R3, resistance R 4.The end of outfan 4 feet of the termination bridge rectifier D 1 of potentiometer R2, another termination potentiometer R3,1 terminals of adjustable termination switch S 1, one end of the other end ground connection of potentiometer R3,4 terminals of adjustable termination switch S 1 and resistance R 4, the end of 7 terminals connecting resistance R1 of switch S 1, another termination output circuit of resistance R 1, another termination output circuit of resistance R 4.Adjust the resistance sizes of potentiometer R2, potentiometer R3, can determine to damage the size of experimental rat brain nuclear group electric current and the length of time.
The output circuit of present embodiment is connected and composed by electrode R5, ammeter μ A.The end of the other end of the terminating resistor R1 of electrode R5 and ammeter μ A, other end ground connection, the other end of the other end connecting resistance R4 of ammeter μ A.The high voltage direct current of electrode R5 and 410V can be damaged experimental rat cranial nuclei cell after connecting, and ammeter μ A is used to measure the size of damage brain nuclear group electric current.
A this brain nuclear damage instrument, have reasonable in design, simple in structure, volume is little, easy to carry, stable performance, safe and reliable, advantage such as product cost is low, can regulate the size of electric current and the size that the length of time is determined damage experimental rat nuclear group as required, can be used for the labelling location behind the rat location and experimental design need be damaged one-sided or a bilateral nuclear group block nerves path, also can be used for other animal location and labelling.
Operation principle of the present utility model is as follows:
The 220V alternating current is boosted through switch S 2, transformator T1 by socket J1 input, and bridge rectifier D 1 is rectified into the dc high-voltage of 410V, arrives potentiometer R2 again after capacitor C 1 and capacitor C 2 filtering, and potentiometer R2 is the coarse adjustment potentiometer.When 4 terminals of switch S 1 and 1 terminals overlap joint, the dc high-voltage of 410V is from the end input of potentiometer R2, potentiometer R2 carries out coarse regulation to the size of current of flowing through, through 1 terminals of switch S 1,4 terminals, resistance R 4, ammeter μ A to electrode R5, electrode R5 damage experimental rat cranial nuclei cell, ammeter μ A measures the size of damage brain nuclear group electric current.When 4 terminals of switch S 1 and 7 terminals overlap joint, the straight high-pressure spray electricity of 410V is from the end input of potentiometer R2, potentiometer R2 carries out coarse regulation to the size of current of flowing through, through potentiometer R3, potentiometer R3 carries out inching to the size of current of flowing through, again through 4 terminals of switch S 1,7 terminals, resistance R 1, to electrode R5, electrode R5 damage experimental rat cranial nuclei cell, ammeter μ A measures the size of damage brain nuclear group electric current.
Claims (1)
1. instrument is damaged in a rat brain nuclear group location, comprise power circuit, on-off circuit, output circuit, the output termination on-off circuit of power circuit, the output termination output circuit of on-off circuit, it is characterized in that said on-off circuit is: outfan 4 feet of the termination bridge rectifier D 1 of potentiometer R2, the end of another termination potentiometer R3,1 terminals of adjustable termination switch S 1, the other end ground connection of potentiometer R3,4 terminals of adjustable termination switch S 1 and an end of resistance R 4,7 terminals of switch S 1 meet the electrode R5 and the ammeter μ A of output circuit, the ammeter μ A of another termination output circuit of resistance R 4 by resistance R 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200282436U CN201197744Y (en) | 2008-01-30 | 2008-01-30 | Locating and breaking instrument for brain nuclei of rat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200282436U CN201197744Y (en) | 2008-01-30 | 2008-01-30 | Locating and breaking instrument for brain nuclei of rat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201197744Y true CN201197744Y (en) | 2009-02-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008200282436U Expired - Fee Related CN201197744Y (en) | 2008-01-30 | 2008-01-30 | Locating and breaking instrument for brain nuclei of rat |
Country Status (1)
| Country | Link |
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| CN (1) | CN201197744Y (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108348772A (en) * | 2015-06-24 | 2018-07-31 | 美国密歇根州立大学试剂中心 | Histotripsy treatment system and method for treating brain tissue |
| US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
| US11364042B2 (en) | 2005-09-22 | 2022-06-21 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| US11432900B2 (en) | 2013-07-03 | 2022-09-06 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
| US11648424B2 (en) | 2018-11-28 | 2023-05-16 | Histosonics Inc. | Histotripsy systems and methods |
| US11813485B2 (en) | 2020-01-28 | 2023-11-14 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
-
2008
- 2008-01-30 CN CNU2008200282436U patent/CN201197744Y/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11364042B2 (en) | 2005-09-22 | 2022-06-21 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| US11701134B2 (en) | 2005-09-22 | 2023-07-18 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| US11432900B2 (en) | 2013-07-03 | 2022-09-06 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
| US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
| US11819712B2 (en) | 2013-08-22 | 2023-11-21 | The Regents Of The University Of Michigan | Histotripsy using very short ultrasound pulses |
| CN108348772A (en) * | 2015-06-24 | 2018-07-31 | 美国密歇根州立大学试剂中心 | Histotripsy treatment system and method for treating brain tissue |
| CN108348772B (en) * | 2015-06-24 | 2020-03-03 | 美国密歇根州立大学试剂中心 | Histotripsy therapy system and method for treating brain tissue |
| US11135454B2 (en) | 2015-06-24 | 2021-10-05 | The Regents Of The University Of Michigan | Histotripsy therapy systems and methods for the treatment of brain tissue |
| US11648424B2 (en) | 2018-11-28 | 2023-05-16 | Histosonics Inc. | Histotripsy systems and methods |
| US11813484B2 (en) | 2018-11-28 | 2023-11-14 | Histosonics, Inc. | Histotripsy systems and methods |
| US11980778B2 (en) | 2018-11-28 | 2024-05-14 | Histosonics, Inc. | Histotripsy systems and methods |
| US11813485B2 (en) | 2020-01-28 | 2023-11-14 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090225 Termination date: 20100130 |