CN201133891Y - Macromole permeability experiment researching device for nerve retina - Google Patents
Macromole permeability experiment researching device for nerve retina Download PDFInfo
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- CN201133891Y CN201133891Y CNU2007202011612U CN200720201161U CN201133891Y CN 201133891 Y CN201133891 Y CN 201133891Y CN U2007202011612 U CNU2007202011612 U CN U2007202011612U CN 200720201161 U CN200720201161 U CN 200720201161U CN 201133891 Y CN201133891 Y CN 201133891Y
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- neural retina
- groove
- interlayer
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Abstract
A giant molecule permeability experimental research device used for the neural retina comprises a permeable tank and a base, which are positioned in an open container; wherein, the permeable tank in the shape of a funnel is positioned on the base; the base is a container, the bottom of which is provided with an interlayer, an outlet is arranged from the sidewall of the base to a cavity in the interlayer, the upper layer of the interlayer is a base surface, which is provided with a throughhole, a circle of shallow groove is arranged on the periphery of the upper surface of the throughhole, the diameter of the shallow groove corresponds to the outer diameter of a leaky pipe on the lower part of the permeable tank, and the diameter of the throughhole corresponds to the inner diameter of the leaky pipe. The permeable tank and the base are made of non-magnetic metallic material, and a magnetic rotor is arranged in the open container. The giant molecule permeability experimental research device has the advantages of ingenious combination, reasonable structure, simplicity, practicability, low cost and convenient operation. The giant molecule permeability experimental research device can be used for the experiment in researching the permeability of drugs with different molecular weights passing through the neural retina and resolves the problem that the neural retina cannot easily fixed, and the problem of determining the permeability of different molecular substances on the neural retina.
Description
(1) technical field
The utility model relates to a kind of experimental provision of ophthalmology medical science, particularly studies the experimental provision of retina permeability.
(2) background technology
The ocular nerve retinal tissue is different from the semi-permeable diaphragm of general meaning, mainly constitute by interconnect (plexiform layers) between three layers of neurocyte nuclear (stratum nucleare) and neurocyte axon, the ophthalmology researchist is perplexed in its permeability research for many years, the transparent performance test of the fixing and different molecular material of neural retina on neural retina is the difficult problem of scientific research always, and following difficult point is specifically arranged:
1, soft texture is frangible, is difficult for fixing.
2, neural retina is a biological membrane, after external standing time is long, and the downright bad disintegration of cell meeting, retina loses integrality, and amphiblestroid penetrating characteristic also can change.
3, in penetrating experimentation, in order to keep amphiblestroid biologically active, need in penetrating liquid, add certain ion and potential of hydrogen stabilizing agent, keep normal physiology potential of hydrogen of cells in vitro and ion concentration.
4, in the penetrating experimentation, need the molecule of research transparent performance should in penetrating liquid, keep equally distributed concentration.
(3) utility model content
The purpose of this utility model provides a kind of penetrating test research device of big molecule that is used for neural retina, solve the technical matters that neural retina is difficult for fixing and being not easy to measure the transparent performance of different molecular material on neural retina.
For achieving the above object, the utility model adopts following technical scheme:
This penetrating test research device of big molecule that is used for neural retina is characterized in that: comprise a penetrating groove 1 and a base 2 that places open-top receptacle 10, penetrating groove 1 places on the base 2; Penetrating groove 1 is an infundibulate; Base 2 is that a bottom has interlayer, sidewall 7 to interlayer internal cavity 3 to have the container of outlet 6, the upper strata of interlayer is a seat surface 11, through hole 5 is arranged on the seat surface, through hole 5 upper surface peripheries have a circle shallow slot 4, the fistulae external diameter of the diameter of shallow slot 4 and penetrating groove 1 bottom is corresponding, and the diameter of through hole 5 is corresponding with the fistulae internal diameter.
The top of above-mentioned penetrating groove 1 can be cylindrical groove, square tube shape groove or cone barrel groove.
The material of an above-mentioned penetrating groove 1 and a base 2 is non-magnetic metal materials.
When experiment, neural retina 8 is placed on the through hole 5 of base 2, be sealed on the shallow slot 4 with the edge of bonding agent neural retina 8, gently be pressed on the neural retina 8 with penetrating groove, the fistulae of penetrating groove just in time embeds in the shallow slot 4 on the base 2, penetrating groove and base are inserted in the open-top receptacle 10, place a magnetic stirrer or magnet rotor 9 again 10 li of open-top receptacles, in open-top receptacle 10, add the penetrating liquid of 40ml for 1 li with penetrating groove, penetrating inside groove adds 1ml liquid, keep liquid level in the liquid level of 1 li of penetrating groove and the open-top receptacle 10 at same surface level, can reduce the influence of influent pressure like this, just can test the permeability of neural retina 8 then.
Compared with prior art the utlity model has following characteristics and beneficial effect:
The combination of the penetrating groove of the utility model and base is ingenious, and salable crimping, and penetrating smoothness have rational in infrastructurely, simple and practical, with low cost, operate easy characteristics.On base, designed shallow slot, the neural retina that takes off can gently be pressed the embedding shallow slot with gravity by the penetrating groove in top, use the cyanoacrylate adhesive closed edge, this processing can guarantee effectively that the liquid that can not in the penetrating groove in top overflows, disturbs penetrating experiment measuring from the neural retina edge.The material of penetrating groove and base is the non-magnetic stainless steel of 1Cr18Ni9Ti, can in penetrating groove, place magnet rotor like this and at the uniform velocity rotate stirring, can guarantee in penetrating process, the concentration of solute is equally distributed in the penetrating groove, increase the operability of experimental arrangement, improved the accuracy of experimental data.
The utility model has solved neural retina and has been difficult for fixing problem, and has solved the problem of measuring the transparent performance of different molecular material on neural retina.Can be used for studying of the transparent performance experiment of different molecular weight medicine by neural retina, significant for the research different pharmaceutical to the influence of ocular nerve retinal tissue.
(4) description of drawings
Below in conjunction with accompanying drawing the utility model is described in further details.
Fig. 1 is the schematic perspective view of penetrating groove.
Fig. 2 is the schematic perspective view of base.
The structural principle synoptic diagram of assembled state when Fig. 3 is the utility model use.
The penetrating groove of Reference numeral: 1-, 2-base, 3-interlayer internal cavity, 4-shallow slot, 5-through hole, 6-outlet, 7-sidewall, 8-neural retina, 9-magnet rotor, 10-open-top receptacle, 11-seat surface.
(5) embodiment
Embodiment is referring to Fig. 1-3, and as shown in Figure 1, penetrating groove 1 is an infundibulate.
Referring to Fig. 2, base 2 is that a bottom has interlayer, sidewall 7 to interlayer internal cavity 3 to have the container of outlet 6, and the upper strata of interlayer is a seat surface 11, and through hole 5 is arranged on the seat surface, and through hole 5 upper surface peripheries have a circle shallow slot 4.
Referring to Fig. 3, this penetrating test research device of big molecule that is used for neural retina comprises a penetrating groove 1 and a base 2 that places open-top receptacle 10, and penetrating groove 1 places on the base 2.The fistulae external diameter of penetrating groove 1 bottom and the diameter of shallow slot 4 adapt, and the diameter of fistulae internal diameter and through hole 5 adapts.The top of penetrating groove 1 can be cylindrical groove, square tube shape groove or cone barrel groove.
The material of penetrating groove 1 and base 2 is non-magnetic metal materials, can adopt the nonmagnetic stainless steel material of a kind of 1Cr18Ni9Ti by name.At the uniform velocity rotate stirring by magnetic stirrer or magnet rotor 9 in the open-top receptacle 10, guarantee that in experimentation the solute concentration in the open-top receptacle 10 is equally distributed.
In addition, this cover experimental provision also comprises neural retina awl that a bore is 8mm, by the rotation awl, can get the neural retina of 8mm diameter, guarantees effectively to cover shallow slot.
Claims (4)
1. penetrating test research device of big molecule that is used for neural retina, it is characterized in that: comprise a penetrating groove (1) and a base (2) that places open-top receptacle (10), penetrating groove (1) places on the base (2); Penetrating groove (1) is an infundibulate; Base (2) is that a bottom has interlayer, sidewall (7) to have the container of outlet (6) to interlayer internal cavity (3), the upper strata of interlayer is seat surface (11), through hole (5) is arranged on the seat surface, through hole (5) upper surface periphery has a circle shallow slot (4), the fistulae external diameter of the diameter of shallow slot (4) and penetrating groove (1) bottom is corresponding, and the diameter of through hole (5) is corresponding with the fistulae internal diameter.
2. the penetrating test research device of big molecule that is used for neural retina according to claim 1 is characterized in that: the top of described penetrating groove (1) is cylindrical groove, square tube shape groove or cone barrel groove.
3. the penetrating test research device of big molecule that is used for neural retina according to claim 1 is characterized in that: the material of a described penetrating groove (1) and a base (2) is non-magnetic metal material.
4. the penetrating test research device of big molecule that is used for neural retina according to claim 3 is characterized in that: rotor (9) is magnetic in the described open-top receptacle (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007202011612U CN201133891Y (en) | 2007-10-17 | 2007-10-17 | Macromole permeability experiment researching device for nerve retina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007202011612U CN201133891Y (en) | 2007-10-17 | 2007-10-17 | Macromole permeability experiment researching device for nerve retina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201133891Y true CN201133891Y (en) | 2008-10-15 |
Family
ID=40062160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007202011612U Expired - Fee Related CN201133891Y (en) | 2007-10-17 | 2007-10-17 | Macromole permeability experiment researching device for nerve retina |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201133891Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102967543A (en) * | 2012-10-31 | 2013-03-13 | 天津大学 | Method for measuring permeability coefficient of oral drug by using hollow fiber membrane |
| CN105466832A (en) * | 2015-11-25 | 2016-04-06 | 重庆医科大学附属永川医院 | Cartilage permeability detection device |
-
2007
- 2007-10-17 CN CNU2007202011612U patent/CN201133891Y/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102967543A (en) * | 2012-10-31 | 2013-03-13 | 天津大学 | Method for measuring permeability coefficient of oral drug by using hollow fiber membrane |
| CN105466832A (en) * | 2015-11-25 | 2016-04-06 | 重庆医科大学附属永川医院 | Cartilage permeability detection device |
| CN105466832B (en) * | 2015-11-25 | 2018-09-21 | 重庆医科大学附属永川医院 | Cartilage permeability detection device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081015 Termination date: 20111017 |