CN201083738Y - Flood preventing detection device - Google Patents

Flood preventing detection device Download PDF

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Publication number
CN201083738Y
CN201083738Y CNU2007201142518U CN200720114251U CN201083738Y CN 201083738 Y CN201083738 Y CN 201083738Y CN U2007201142518 U CNU2007201142518 U CN U2007201142518U CN 200720114251 U CN200720114251 U CN 200720114251U CN 201083738 Y CN201083738 Y CN 201083738Y
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CN
China
Prior art keywords
reagent strip
sample
moisture element
detection device
control flow
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CNU2007201142518U
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Chinese (zh)
Inventor
胡林
胡海鹏
戴节林
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ABON Biopharm Hangzhou Co Ltd
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ABON Biopharm Hangzhou Co Ltd
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Abstract

The utility model relates to a flooding prevention detecting device which comprises a body and a detecting reagent strip, wherein, a water containing element which can contain residual liquid is arranged in the body. When a liquid sample is larger than the detecting requirement, the water containing element inside the detecting device can effectively resort residual liquid sample, thereby solving the problem of flooding generated during detecting.

Description

A kind of flood control flow detection device
Technical field
The utility model relates to a kind of pick-up unit, especially a kind of flood control flow detection device that is used for the tracer liquid sample.
Background technology
At present, the device One's name is legion that is used to detect, and also there is various ways to change in profile, wherein popular is the single stage method immune detection, this detection only need drip sample, the result that just can read positive or negatively later in several minutes is to show whether contain detected material in the sample.This detectable bar has the structure of more complicated, preferably be placed in certain appearance device proper, and be included in immunologic function test reagent bar in the different appearance devices, can reduce the false positive of reaction and improve the sensitivity that detects by the change of this body structure of appearance device.
The pick-up unit that contains reagent strip reacts by dripping sample to well usually.Reagent strip is that one or more materials with water-intake capacity are formed, as nitrocellulose filter, and glass, filter paper etc.Reagent strip contain can with the biochemical substances of detected material qualitative response.When the liquid sample of suitable volumes is added dropwise on the reagent strip, they can be by capillary action when the sample region of acceptance of reagent strip flows to detection zone, material in the liquid sample and the reaction of the biochemical substances on the reagent strip produce change color, thereby observe out testing result.If liquid sample flow velocity amount too fast or liquid sample is too much, material in then a part of excess liquid sample has little time to react with biochemical substances, directly wash away in the past from the surface of reagent strip, i.e. " mighty torrent " (flooding) phenomenon, cause testing result inaccurate, even can not read the result at all.And other a part of excess liquid can directly flow down from reagent strip, causes the pollution of reagent strip.
Flow velocity or absorption excess liquid for the controlling liquid sample; traditional liquid sample detection device is (as U.S. Pat 6; 146; 590 inventions disclosed) the sample region of acceptance has added an absorbent material again in addition; and need attach a cover of protecting this absorbent material; cause its production cost height, price is expensive.
In addition, US 5,354, introduced a kind of device that prevents mighty torrent in 692, and this device is by the absorbent material at sample region of acceptance stack different densities, and spatially carry out different settings, reach the purpose of slowing down sample flow.Yet this device has been brought a series of too loaded down with trivial details operations in the process of producing reagent strip, is unfavorable for producing.And this device can effectively reduce flow velocity when liquid sample is excessive, but when the liquid sample amount is suitable, because sample will pass through a plurality of suction zone before reaching surveyed area, may cause the reduction of sensitivity.
Summary of the invention
The utility model will solve the shortcoming that above-mentioned prior art exists, and provides a kind of simple in structure, and production cost is low, and can effectively solve the flood control flow detection device of mighty torrent phenomenon.
The utility model relates to a kind of flood control flow detection device, comprises body and the detectable bar that is positioned at body interior in the device, and reagent strip comprises sample region of acceptance and surveyed area, is provided with the moisture element that can hold unnecessary sample in the body.When liquid sample when detecting demand, the moisture element of pick-up unit inboard can effectively must be detained the excess liquid sample, solves the mighty torrent phenomenon that produces in detecting.
The utility model can also be further perfect by following manner:
Moisture element can be fixed on inner body wall, and is positioned at the top of reagent strip.In the process of application of sample, sample flows and passes through reagent strip usually, and excessive liquid sample, the top of the reagent strip that concentrates on are usually carried out in reagent strip both sides and reagent strip top.Moisture element is set in the pick-up unit body, can effectively must solves of the influence of mighty torrent phenomenon testing result.
In a preferred scheme, pick-up unit also comprises the well that is in liquid communication with the sample region of acceptance of reagent strip, and moisture element is positioned at the downstream of well.In the process that drips sample, sample flows to surveyed area from the sample region of acceptance and flows on the detectable bar, so sample contacts the sample region of acceptance at first.Moisture element is arranged on the downstream of well, can be when dripping sample, must absorb excessive sample rapidly.
In a preferred scheme, moisture element is made up of at least one rectangular recess.If liquid surface area increases, then the liquid surface free energy increases, and surface tension coefficient also increases thereupon so, the corresponding increase of surface tension.And this rectangular recess has increased the surface area of liquid to a certain extent, and more liquid is contained by rectangular recess, plays moisture effect.
In a more preferred scheme, moisture element comprises 2 rectangular recess.
In the more preferred scheme, an end opening of groove, the direction that the direction of opening flows in face of sample.
In another scheme, moisture element comprises at least one rhombus groove.
In another scheme, moisture element comprises at least one circular groove.
In another scheme, moisture element comprises at least one cellular groove.
In a preferred scheme, the distance of moisture element and reagent strip is between the 0.5mm-1.5mm.When moisture element was positioned at the top of reagent strip, the distance between moisture element and the reagent strip had determined the amount that moisture element can be moisture to a certain extent, and distance is too big between the two, and then the surface tension of water is big inadequately, and moisture element is difficult to contain moisture; Distance is too little between the two, and then when sample just dripped, liquid sample is not absorbed by the sample region of acceptance on the reagent strip was just kept here liquid by moisture element, has so also reduced the sensitivity that detects.
Better, in the body of closure, the distance of moisture element and reagent strip is 1mm.
In a more preferred scheme, moisture element be positioned at reagent strip the sample region of acceptance directly over, comprise that group leader's square groove forms, the width of rectangular recess is suitable with the width of reagent strip.It is identical with the width of reagent strip that moisture element is set, make moisture element be fixed on directly over the reagent strip just, when unnecessary sample is positioned on the reagent strip, can accurately must be absorbed by moisture element, can prevent effectively that so excessive liquid sample from washing away the raw material on the reagent strip, avoids occurring bad testing results such as false positive.
The beneficial effect that the utility model is obtained is: this device has increased moisture element, when liquid sample is too much, can prevent too fast " mighty torrent " phenomenon that causes of sample eroding velocity, makes testing result more accurate, and sensitivity is improved.In addition, this apparatus structure is simple, and production cost is low, and safe and reliable, realizes than being easier in practice.
Description of drawings
Fig. 1 is the prior art principle schematic.
Fig. 2 is the utility model know-why synoptic diagram.
Fig. 3 is the synoptic diagram of the moisture element of the utility model one embodiment.
Fig. 4 is the synoptic diagram of the moisture element of another embodiment of the utility model.
Fig. 5 is the synoptic diagram of the moisture element of another embodiment of the utility model.
Fig. 6 is the synoptic diagram of the moisture element of another embodiment of the utility model.
Fig. 7 is the front schematic view of the inboard part of the utility model body;
Fig. 8 is the front schematic view of the inboard another part of the utility model body;
Fig. 9 is the exploded perspective synoptic diagram of the whole device of the utility model, wherein arrow direction express liquid flow direction;
Figure 10 is the schematic perspective view of installation of the utility model reagent strip and body.
Description of reference numerals: body 100, moisture element 11 contains water unit 10; Upper plate 1, rectangular recess 17, retaining muscle 12, well 13, testing result watch window 14, bail 15, pore 16; Reagent strip 2, sample region of acceptance 21, label position 22; Lower plate 3, pipe nail 31, seat groove 32, unnecessary sample A, normal sample B.
Embodiment
To the structure of pick-up unit, parts or this employed technical term are described further below.
Detect
Detect the expression chemical examination or test a kind of material or whether material exists, such as, but be not limited to this, the metabolin of chemical substance, organic compound, mineral compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymkeric substance.In addition, detect the quantity of expression test substances or material.Furtherly, immune detection, chemical detection, enzyme detection etc. are also represented in chemical examination.
Body
The body 100 of indication in the utility model is meant the external device (ED) that contains reagent strip 2.Body 100 can be a boxlike, also can be bar type.Body 100 can be the device of a sealing, also can be a decomposable device.Body 100 can comprise upper plate 1 and lower plate 3.
Upper plate 1 is the cover plate that is in the top in the pick-up unit body, it is generally acknowledged to include well 13 and testing result observation window 14 on the upper plate 1.Can also there be numerous parts upper plate 1 inboard, such as retaining muscle 12, moisture element 11, bail 15, pore 16 parts such as grade.Retaining muscle 12 generally is positioned at the below of testing result watch window 14, label 22 positions in correspondence and the reagent strip 2, it mainly acts on is to make sample when arriving reagent strip label 22 places, can carry out sufficient mixing, then with the velocity flow of the homogeneous other end to reagent strip 2.Bail 15 generally is positioned at the top of testing result watch window 14, is used for fixing reagent strip 2.Pore 16 is to be positioned near upper plate 1 periphery, and its effect is to match with the pipe of lower plate 3 nail 31 to make pick-up unit be in accurate closure state.
Lower plate 3 is the cover plates that are in the below in the pick-up unit body, and this lower plate 3 can be held support reagent strip 2, makes reagent strip 2 be in stationary state in device, is convenient to detect.Lower plate can also comprise moisture element 11, and when too much liquid sample entered well 13, the liquid of a part can flow along the both sides and the bottom of reagent strip 2, and a moisture element 11 is set on lower plate 3, can be detained too much liquid sample.Lower plate 3 can also comprise some pipe nails 31, cooperates the occlusion detection device with the pore 16 of upper plate.
Moisture element
Moisture element 11 is meant the effectively element of stagnant liquid sample body of pick-up unit inside.Moisture element can contain water unit by one or more and form, the water unit that contains in the utility model is meant the functional structure that can be detained unnecessary sample in the moisture element, this structure does not comprise that delay itself is present in the sample in the moisture element, definite must saying, the state of this moisture element in being detained unnecessary sample process is never to contain sample to the process that contains sample.
Utilize the action principle of the moisture element 11 of this spline structure to be: because this water unit 10 that contains, for example little groove or aperture, have huge surface energy, when the flow of liquid that is in free-flowing is crossed these grooves or aperture, the surface tension that liquid has touch contain water unit in, have huge surface energy to make these liquid filling in moisture element 11 and can not freedom flow forward owing to containing water unit.When this moisture element 11 that contains water unit 10 is applied to pick-up unit, a preferred mode is, when excess liquid flows forward from the reagent strip surface, thereby this moisture element 11 can absorb the excess liquid sample effectively controls unnecessary liquid sample does not directly flow to reagent strip by capillary action other parts, can effectively prevent the mighty torrent phenomenon like this.This moisture element is to the delay of liquid, and the principle of its dependence is the surface tension of liquid itself and the combination of the surface energy that moisture element has.When any rotating body, the liquid sample in the moisture element is difficult for splashing, and the strength of this combination is higher than the gravitional force that liquid itself has, thereby can firmly must be close to moisture element internal.
Moisture element 11 can be positioned at any one position of pick-up unit body interior, comprises body 100 inwalls and reagent strip 2 peripheries, such as the inboard of body upper plate 1 and the inboard of body lower plate 3.Moisture element 11 can be positioned at lower plate 3, better, be the both sides of these region of acceptance 21 correspondence positions of reagent galley proof in the lower plate, in the liquid sample process of flowing, after some liquid arrives the sample region of acceptance 21 of reagent strip 2, if liquid sample is excessive, part liquid can be along 2 liang of side flow of reagent strip, the both sides of these region of acceptance 21 correspondence positions of reagent galley proof are provided with moisture element 11 in lower plate, can be flowing in the excess liquid sample of reagent strip both sides, to a certain extent solution owing to liquid in too fast " mighty torrent " phenomenon that produces of reagent strip two side flow.Preferably, moisture element 11 can also be positioned at body 100 inwalls, the top of reagent strip 2.When sample solution is added drop-wise on the reagent strip 2, sample can flow along the sample region of acceptance 21 of reagent strip, a part of in addition unnecessary sample then is positioned at the top of reagent strip 2, there is not the resistance flow velocity bigger, therefore moisture element 11 is arranged on the top of reagent strip 2, can effectively must be detained unnecessary sample.Better, moisture element 11 can also be arranged in these region of acceptance 21 correspondence positions of lower plate reagent galley proof under, in this position moisture element 11 is set, also can be detained the unnecessary liquid sample that a part flows in the reagent strip both sides.Preferably, pick-up unit also comprises the well that is in liquid communication with the sample region of acceptance 21 of reagent strip, and moisture element 11 can also be positioned at the downstream of well 13.The downstream is to judge that according to the direction of liquid flow moisture element 11 is positioned at the downstream of well 13, and the liquid through well arrival reagent strip sample region of acceptance 21 can better be absorbed by moisture element 11.Better, body also comprises testing result watch window 14, moisture element 11 can be between the testing result watch window 14 and well 13 of upper plate.In common pick-up unit, the detection reaction of reagent strip 2 zone usually with body 100 on testing result watch window 14 be corresponding, equally, well 13 correspondences be sample region of acceptance 21 on the reagent strip, thereby between corresponding to sample region of acceptance 21 and detection reaction zone, moisture element 11 is set, can better must get unnecessary sample obstruction after the detection reaction zone, can not exert an influence testing result with producing " mighty torrent ".Better, also being provided with retaining muscle 12 in the body, moisture element 11 can be between retaining muscle 12 and well 13.Retaining muscle 12 is arranged on an arrester on body 100 inwalls, and corresponding to the marked region on the reagent strip 2 22, the effect of retaining muscle 12 is that label and sample are evenly mixed, and helps result's consistance.Between retaining muscle 12 and well 13, moisture element 11 is set, is based on the consideration that label is not washed away by unnecessary sample.Because in the time of excessive application of sample, most liquid can accumulate in the top in reagent strip sample collection zone 21, this position 1 of upper plate corresponding and pick-up unit is the position between retaining muscle 12 and the well 13, so choosing this position, moisture element 11 is set is a preferable selection, can be detained excessive liquid sample to the full extent, make that " mighty torrent " phenomenon is alleviated, the accuracy and the sensitivity of detection are improved.
Moisture element 11 comprises and contains water unit 10, the shape that contains water unit 10 can be a rectangular recess 17, also can form by the groove of circle, can also form by the groove of rhombus, can also be by cellular groove, can also be that other rules or irregular groove are formed, can also be difform combination, and its shape is unrestricted.This quantity that contains water unit 10 can be one, also can be two, and is perhaps a plurality of.A preferred mode is, moisture element 11 is made up of at least one rectangular recess 17, this moisture element 11 that water unit 10 is formed that contains by rectangular recess 17, can sample flow through the time be detained liquid by tiny aperture, sample can not flow freely.A better mode is, moisture element 11 is made up of 2 rectangular recess 17, such group leader's square groove 17, can make moisture surface area obtain enlarging, surface tension also becomes greatly, and the surface energy that has increases, and liquid receives that capillary traction can not flow freely, and can be held by this group leader's square groove 17, reach the purpose of being detained unnecessary sample.Better, an end opening of rectangular recess 17, the direction that the direction of opening flows in face of sample, when unnecessary sample existed, unnecessary sample is preferential must to enter inside grooves by the opening of rectangular recess 17, can be detained unnecessary sample faster and betterly.Another preferred mode is that moisture element 11 is made up of at least one circular groove, designs circular groove, and the hole between the groove, has also increased moisture surface area, thereby has improved moisture effect.Another preferred mode is, moisture element 11 is made up of the groove of a rhombus at least, and the rhombus groove intersects mutually, and the active volume that makes moisture element 11 can hold moisture maximizes the use, and can hold sample as much as possible.Same, moisture element 11 can also be made up of at least one cellular groove.Wherein than preferable, the rectangular recess 17 that moisture element 11 can be 2 projections, this moisture element can be by a horizontal muscle and three a semi-closed groove forming of muscle longitudinally, a not closed end and well 13 overlap joints, the other end is positioned at the below of retaining muscle 12, has 2 and contains water unit 10.Own with regard to rectangular recess 17, simple realization does not easily have loaded down with trivial details technological process on the structure, and the space that can hold sample is bigger, the surface area that the quantity that will contain water unit 10 is increased to the suitable moisture element 11 of increase of 2 energy farthest pins the excess liquid sample.The formal argument that contains water unit 10 in above-mentioned these moisture elements 11 can be various unrestricted.
When moisture element 11 was positioned at the top of reagent strip, the distance between moisture element 11 and the reagent strip 2 was one of factor of the moisture effect of influence.Moisture element 11 is positioned at the top of reagent strip 2, can be in the direct tops of contact of reagent strip 2, also can be and the have living space top of range difference of reagent strip 2.Distance in the utility model between moisture element 11 and the reagent strip 2, be meant between the two the poor of the useful space distance that exists, concrete must saying, when moisture element 11 is positioned at the top of reagent strip 2, can be separated by nearest position to moisture element 11 and reagent strip 2 as the benchmark of weighing, the distance between this position and the reagent strip 2 is exactly a useful space range difference between the two.In the pick-up unit of closure, be in the moisture element 11 in the body 100, and the distance between the reagent strip 2 is subjected to the standard of what and " mighty torrent " of sample can do suitable adjustment, fewer but effectively prevent mighty torrent again such as the sample that detect to require, the distance between so moisture element 11 and the reagent strip 2 can be smaller; Otherwise the sample size of requirement itself is many, can adjust the bigger distance of maintenance between moisture element 11 and the reagent strip 2, and these all are that those skilled in the art can implement according to the scheme that the utility model discloses.In a scheme, the distance between moisture element 11 and the reagent strip 2 can be between the 0.1mm-2.0mm.Preferably, the distance between moisture element 11 and the reagent strip 2 can be 0.1mm, 0.2mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1.1mm, 1.2mm, 1.3mm, 1.4mm, 1.5mm, 1.6mm, 1.7mm, 1.8mm, 1.9mm or 2.0mm.Better, the distance between moisture element 11 and the reagent strip 2 is 1mm.Distance between moisture element 11 and the reagent strip 2, be meant that moisture element 11 is away from that end distance of body height from reagent strip 2, be that moisture element 11 is near the position of reagent strip 2 and the distance between the reagent strip 2, this has determined the amount that moisture element 11 can be moisture to a certain extent, between the two the distance too conference cause the surface tension of water big inadequately, moisture effect is not obvious; But distance is too little between the two, and then when sample just dripped, liquid sample is not absorbed by the sample region of acceptance on the reagent strip 21 was just kept here liquid by moisture element 11, has so also reduced the sensitivity that detects.
The material of moisture element 11 can be consistent with body 100, is plastics, also can be other hydrophobic or hydrophilic materials.The water unit 10 that contains in the moisture element 11 can be equally distributed, also can be irregular, and each contains can be contour between the water unit 10, also can be straggly.Moisture element 11 big or small unrestricted, better, the width of moisture element 11 is suitable with reagent strip 2, like this, has both saved starting material, can well cooperate the sample region of acceptance 21 on the reagent strip 2 again.When excessive liquid sample arrived sample region of acceptance 21, moisture element 11 can appropriately must be reacted, and can get liquid holdup wherein with unnecessary on the one hand, had also slowed down on the other hand because the sample flow that the excess liq sample causes is too fast.
Sample
The sample of the utility model indication refers to that those can be used for detecting, chemically examining or diagnose the material that whether has analyte of interest matter.Sample can be that for example, liquid sample, liquid sample can comprise blood, blood plasma, serum, urine, saliva and various juice, can also comprise that solid sample and semi-solid samples are through anticipating the liquid solution that the back forms.The sample of collecting can be used for methods such as immune detection, chemical detection, enzyme detection and detect whether there is analyte.
Reagent strip
Applying to reagent strip 2 of the present utility model can be usually said horizontal effluent reagent strip, and the concrete structure of these reagent strips and detection principle are persons skilled in the art technique known in the prior art.The general agents bar comprises sample collection zone and surveyed area, wherein comprises on the surveyed area detecting the necessary chemical substance that whether contains analyte.General commonly used reagent strip is the nitrocellulose filter reagent strip, and promptly surveyed area comprises nitrocellulose filter, and fixedly the specific bond molecule shows the result of detection on nitrocellulose filter; Can also be cellulose acetate membrane or nylon membrane or the like.The reagent strip that for example the following patent is described or contain the device of reagent strip: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; With US 6403383, the reagent strip described in these patents can be applied to accommodates one or more interested materials that detect in the reagent strip chamber 2 in the sample.
Analyte
Can analyze any analyte with apparatus and method of the present utility model.The example of the analyte of the enough apparatus and method stable detection of the present invention of energy comprises (but not only comprising) human chorionic gonadotrophin (hCG), lutropin (LH), ovarian stimulation element (FSH), hepatitis C virus (HCV), hepatitis B (HBV), hepatitis B surface antigen, the medicine of AIDS virus and any abuse.Analyte can detect in any liquid or liquefied sample, urine for example, saliva, saliva, blood, blood plasma, perhaps serum.The example of other analyte also has the acid of flesh ammonia acid anhydride, cholerythrin, nitrite, protein (nonspecific), blood, leucocyte, blood sugar, heavy metal and toxin, the bacterium composition is (for example, special protein and the sugar of the bacterium of particular type, colon bacillus 0157: H7 for example, staphylococcus aureus, salmonella, C.perfringens, campylobacter, listeria monocytogenes, enteritis vibrios, perhaps cured shape bacillus).Any other analyte of suitable lateral flow assay form can detect with this device.
Analyte can also be some haptens materials, and these haptens comprise drugs (as drug abuse)." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises ***e; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, Roche Pharmaceuticals, Nutley, NewJersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
Below in conjunction with concrete accompanying drawing examples of implementation of the present utility model are described in detail.These specific embodiment only are limited the enumerating under the utility model spirit, do not get rid of one of ordinary skill in the art prior art and the utility model in conjunction with and other specific embodiments of producing.
Embodiment 1
As shown in Figure 1, be to represent in the prior art flowing of sample on the reagent strip, in general, when sample arrived sample region of acceptance 21 on the reagent strip 2, liquid can infiltrate reagent strip inside, and the other end to reagent strip 2 shown in B flows; When having excessive sample A, sample region of acceptance 21 can't receive unnecessary sample at short notice, so unnecessary sample A just can't infiltrate sample region of acceptance 21, but directly flows to the other end along reagent strip 2 surfaces above reagent strip 2, flows shown in the A sample.Because unnecessary sample A does not receive resistance on the surface of reagent strip 2, thereby can " wash away " reagent strip 2, can influence the reaction of raw material and sample on the reagent strip 2 like this, make testing result insensitive not good even wrong result occurs with very fast speed.
This pick-up unit that the utility model adopts, as shown in Figures 2 and 3, moisture element 11 contains water unit by two and forms, and each contains water unit is rectangular recess.When unnecessary sample A flowed above reagent strip, there was surface tension in sample A, has certain surface energy in the water unit and contain, when sample A when containing water unit and contact, both interaction energies are detained unnecessary sample A in the moisture element 11.The unnecessary sample A that is trapped in wherein tightly presses close to groove, can not flow freely again, and like this, the unnecessary sample of reagent strip 2 tops just can overcome too fast " mighty torrent " phenomenon brought of flow velocity, has solved unnecessary sample " washing away " to reagent strip, plays moisture effect.
Embodiment 2
As shown in Figure 4, the groove by one group of circle of moisture element 11 is formed in the present embodiment as different from Example 1, and it is circular promptly containing water unit 10.
Embodiment 3
As shown in Figure 5, the groove by one group of rhombus of moisture element 11 is formed in the present embodiment as different from Example 1, and promptly containing water unit 10 is rhombuses.
Embodiment 4
As shown in Figure 6, as different from Example 1 being made up of one group of cellular groove of moisture element 11 in the present embodiment, it is cellular promptly containing water unit 10.
Embodiment 5
Moisture element 11 is group leader's square grooves 17 in the present embodiment, and promptly each rectangular recess 17 is one and contains water unit 10.
This pick-up unit that comprises moisture element 11 as shown in Figure 9, comprises body 100 and reagent strip 2, and body 100 comprises upper plate 1 and lower plate 3.As shown in Figure 8, upper plate 1 is provided with well 13, testing result watch window 14, retaining muscle 12, rectangular recess 17, bail 15, pore 16; As shown in Figure 7, the pipe nail 31 that lower plate 3 is provided with a groove 32 and can cooperates with bail, seat groove 32 can make reagent strip 2 be fixed on just on the lower plate 3.
As shown in Figure 9, the pick-up unit under decomposing state, can see moisture element 11 by a horizontal muscle and three longitudinally muscle form, form 2 rectangular recess 17.When the occlusion detection device, when carrying out the analyte detection, if drip excessive sample to well 13, sample arrives the sample region of acceptance 21 (arrow points among sample flow direction such as Fig. 9) of reagent strip earlier along well 13, because the excessive amount of sample region of acceptance 21 that surpassed of liquid sample at moment reception liquid, the top of then most of existence of remaining liquid and sample region of acceptance 21, fraction flows forward along seat groove 32 along the both sides of reagent strip 2 in addition.The excessive sample nothing in my way that is present in 21 tops, reagent strip sample region of acceptance, thereby can be with than on reagent strip 2, containing the zone flows that detects raw material in common pick-up unit in the bigger speed of the flowing velocity on the reagent strip 2, can destroy the drying of reagent strip 2 itself and the reaction of raw material like this, thus the result of influence reaction.In the present embodiment, because the upper plate 1 inboard rectangular recess 17 that exists, one end opening of rectangular recess 17, the direction that the direction of opening flows in face of sample, be present in the liquid of 21 tops, reagent strip sample region of acceptance owing to there is surface tension, unnecessary sample is preferential must to enter inside grooves by the opening of rectangular recess 17, in the rectangular recess 17 of moisture element 11 inside that liquid can be attached to, slow down the water cut of 21 tops, reagent strip sample region of acceptance, thereby improve " mighty torrent " phenomenon.

Claims (10)

  1. One kind the flood control flow detection device, comprise body and the reagent strip that is positioned at body interior, wherein reagent strip comprises sample region of acceptance and surveyed area, surveyed area is provided with the chemical substance that can indicate whether to contain analyte, it is characterized in that, also be provided with the moisture element that holds unnecessary sample in the described body.
  2. 2. flood control flow detection device as claimed in claim 1 is characterized in that, described moisture element is fixed on inner body wall, and is positioned at the top of reagent strip.
  3. 3. flood control flow detection device as claimed in claim 2 is characterized in that wherein pick-up unit also is provided with well, and the sample region of acceptance of this well and reagent strip is in liquid communication, and described moisture element is positioned at the downstream of well.
  4. 4. flood control flow detection device as claimed in claim 1 is characterized in that, described moisture element comprises at least one rectangular recess.
  5. 5. flood control flow detection device as claimed in claim 4 is characterized in that, described moisture element is 2 rectangular recess.
  6. 6. as claim 4 or 5 described flood control flow detection devices, it is characterized in that described groove one end opening, the direction that the direction of opening flows in face of sample.
  7. 7. flood control flow detection device as claimed in claim 1 is characterized in that, described moisture element comprises at least one rhombus groove or circular groove or cellular groove.
  8. 8. flood control flow detection device as claimed in claim 1 or 2 is characterized in that, the distance of described moisture element and reagent strip is between 0.1mm one 2.0mm.
  9. 9. flood control flow detection device as claimed in claim 1 or 2 is characterized in that, the distance of described moisture element and reagent strip is 1mm.
  10. 10. flood control flow detection device as claimed in claim 1 or 2 is characterized in that, described moisture element be positioned at reagent strip the sample region of acceptance directly over, comprise that group leader's square groove forms, the width of moisture element is suitable with the width of reagent strip.
CNU2007201142518U 2007-09-04 2007-09-04 Flood preventing detection device Expired - Lifetime CN201083738Y (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069610A1 (en) * 2010-11-24 2012-05-31 Spd Swiss Precision Diagnostics Gmbh Assay device
CN103439483A (en) * 2013-08-23 2013-12-11 苏州凯恩医药科技有限公司 Novel urine test paper
CN104777298A (en) * 2010-04-26 2015-07-15 艾博生物医药(杭州)有限公司 Detection apparatus
CN107664702A (en) * 2016-07-27 2018-02-06 杭州博拓生物科技股份有限公司 The device of analyte in a kind of detection sample
CN108387718A (en) * 2017-12-22 2018-08-10 杭州博拓生物科技股份有限公司 The detection device of analyte in a kind of detection fluid sample
WO2023179215A1 (en) * 2022-03-24 2023-09-28 艾康生物技术(杭州)有限公司 Immunoassay device

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104777298A (en) * 2010-04-26 2015-07-15 艾博生物医药(杭州)有限公司 Detection apparatus
CN104777298B (en) * 2010-04-26 2017-10-31 艾博生物医药(杭州)有限公司 A kind of detection means
WO2012069610A1 (en) * 2010-11-24 2012-05-31 Spd Swiss Precision Diagnostics Gmbh Assay device
US9638704B2 (en) 2010-11-24 2017-05-02 Spd Swiss Precision Diagnostics Gmbh Assay device
CN103439483A (en) * 2013-08-23 2013-12-11 苏州凯恩医药科技有限公司 Novel urine test paper
CN107664702A (en) * 2016-07-27 2018-02-06 杭州博拓生物科技股份有限公司 The device of analyte in a kind of detection sample
CN108387718A (en) * 2017-12-22 2018-08-10 杭州博拓生物科技股份有限公司 The detection device of analyte in a kind of detection fluid sample
WO2023179215A1 (en) * 2022-03-24 2023-09-28 艾康生物技术(杭州)有限公司 Immunoassay device

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