CN1971245A - A measuring device for weak light photons - Google Patents
A measuring device for weak light photons Download PDFInfo
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- CN1971245A CN1971245A CN 200610165033 CN200610165033A CN1971245A CN 1971245 A CN1971245 A CN 1971245A CN 200610165033 CN200610165033 CN 200610165033 CN 200610165033 A CN200610165033 A CN 200610165033A CN 1971245 A CN1971245 A CN 1971245A
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- photomultiplier
- circuit
- pulse
- optical fibre
- liquid
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
A weak light photon measuring apparatus belongs to the photon measuring technical field of biochemical immunization analyzer. It comprises minitype darkroom, liquid-core optical fibre, photomultiplier, amplifying circuit, pulse-generating circuit and SCM circuit. The photomultiplier, amplifying circuit, pulse-generating circuit and SCM circuit are sealed in the metal case to shield effectively. The connection between the minitype darkroom and the liquid-core optical fibre, the liquid-core optical fibre and the photomultiplier sleeve, the photomultiplier sleeve and the sealed case of the amplifying circuit are screwed joint. The advantages of the apparatus are following: the loss of light emitted by immunizing agent can be decreased, the collection efficiency of photomultiplier is increased, the interference of external field to weak electrical signals is diminished, the counting accuracy of the weak light photon is improved, and the measuring requirements of the weak light photon can be fulfilled completely.
Description
Technical field
The invention belongs to biochemical immunity analysis instrument photon survey technical field, a kind of measuring device for weak light photons particularly is provided, be applicable to the low light level photon detection of the full-automatic biochemical immunity analysis instrument of biochemiluminescence.
Technical background
Present biochemical immune analysis method is to add specific luminescence reagent when antigen and antibody are carried out immune response, by the quantity and then the counter concentration of releasing antibody of the mensuration photon that sends.Since light intensity that immunoreagent sent very a little less than, therefore just need the transmitting device of the low light of a kind of loss and highly sensitive low light level measurement mechanism to cooperate, measuring method is carried out the measurement of photon numbers to it accurately in addition.
Summary of the invention
The object of the invention provides a kind of measuring device for weak light photons, loss in the transmission course of the low light level is little, photoelectric conversion part highly sensitive, the performance height of pulse generation and metering circuit, the photon numbers of the low light level that the immune response of can farthest reducing is sent has higher measuring accuracy.
Of the present inventionly form by miniature darkroom (promptly placing the device of luminescence reagent), liquid-core optical fibre, photomultiplier, amplifying circuit and pulse-generating circuit, single chip circuit.Photomultiplier, amplifying circuit and pulse-generating circuit, single chip circuit all are sealed in the wire chamber shell, effectively shield, and have improved the ability of opposing external disturbance.Whole device a miniature darkroom arranged foremost, can effectively satisfy the placement of biochemical immune response container, and prevent low light level loss and the influence of extraneous light measuring.Miniature darkroom is connected with liquid-core optical fibre by screwed part, guaranteed that the coupling part can not produce the phenomenon of light leak, the low light level that immunoreagent produced is transferred to the photomultiplier place by liquid-core optical fibre, photomultiplier is sealed in the lighttight tubular container, and it adopts engage thread equally with being connected of liquid-core optical fibre.The low light level is converted into faint current signal through photomultiplier, this low current signal is converted into voltage signal through oversampling circuit, again through amplifying and comparator circuit, the TTL pulse that produces and export a standard, follow-up single chip circuit obtains this pulse, and counted number of pulses sent to host computer by serial ports, can understand the photon number of the low light level that immune response sends more accurately by the shown counted number of pulses of host computer.Between miniature darkroom and photomultiplier, adopt optical fiber to carry out transmitting optical signal, the loss of the light that is caused than common light source and the direct-connected mode of photomultiplier reduces greatly, and the lens of suitable size have been placed in the end of optical fiber, light is converged, and the assurance low light level that light source sent is as much as possible to arrive the photomultiplier place by Optical Fiber Transmission.
The present invention has selected liquid-core optical fibre for use according to the wavelength coverage of the low light level to be measured.Voltage amplifier circuit of the present invention and pulse-generating circuit all are placed in the inside of photomultiplier sealed tube container, have dwindled the length of connecting line.The single-chip microcomputer pulse-scaling circuit is also by as among the airtight betal can, its with pulse-generating circuit between be connected with shielding line, these measures all help electrostatic screening, reduce the influence of external environment to signal, as far as possible little minimizing loss, thereby the degree of accuracy of raising low light level photon survey.
Description of drawings
Fig. 1 is the structural representation of measuring device for weak light photons.Wherein, miniature darkroom 1, screw fixing device 2, liquid-core optical fibre 3, photomultiplier sleeve 4, amplifying circuit and pulse-generating circuit annular seal space 5, cavity connecting thread 6, signal transmission shielding line 7, single chip circuit capsul 8, serial port connecting wire 9, computing machine 10
Embodiment
As shown in Figure 1, miniature darkroom 1 is connected with an end of liquid-core optical fibre 3 by screw fixing device 2, and an other end of liquid-core optical fibre 3 stretches into photomultiplier sleeve 4 inside, and fixes.Photomultiplier is fixed in the photomultiplier sleeve 4.Photomultiplier sleeve 4 is connected with annular seal space 5 by screw thread 6, and amplifying circuit and pulse-generating circuit are fixed in the annular seal space 5.The low light level that reagent sends in the miniature darkroom 1 is transferred to the photomultiplier place through liquid-core optical fibre 3, be converted into current signal through photomultiplier, this faint current signal is converted into voltage signal, amplify through amplifying circuit again, signal after the amplification is through relatively exporting the TTL pulse of a standard, this pulse is transferred to single chip circuit place in the capsul 8 by signal transmission shielding line 7, the single-chip microcomputer paired pulses is counted, and pass through serial port connecting wire 9, thereby obtain the low light level photon number that reagent place sends to the computing machine 10 transmission umber of pulses of counting.Each connecting portion has all adopted the connected mode of sealing, and circuit has also been done necessary processing, has reduced the loss in the low light level transmission course, has improved the antijamming capability of ultra-weak electronic signal, has guaranteed the accuracy of low light level photon counting.
Claims (2)
1. a measuring device for weak light photons is made up of miniature darkroom, liquid-core optical fibre, photomultiplier, amplifying circuit and pulse-generating circuit, single chip circuit; It is characterized in that photomultiplier, amplifying circuit and pulse-generating circuit, single chip circuit all are sealed in the wire chamber shell; Photomultiplier, amplifying circuit and pulse-generating circuit, single chip circuit all are sealed in the wire chamber shell, effectively shield, and have improved the ability of opposing external disturbance; Whole device a miniature darkroom arranged foremost, can effectively satisfy the placement of biochemical immune response container, and prevent low light level loss and the influence of extraneous light measuring; Between miniature darkroom and the liquid-core optical fibre, between liquid-core optical fibre and the photomultiplier sleeve, all adopt thread connecting mode between photomultiplier sleeve and the amplifying circuit annular seal space shell; Photomultiplier is sealed in the lighttight tubular container, and it adopts with liquid-core optical fibre and is threaded; The TTL pulse of the standard that pulse-generating circuit produced is transferred to by shielded conductor and counts in the single chip circuit, and the umber of pulse of being counted is sent to computing machine by serial communication mode.
According to the described device of claim 1, it is characterized in that 2, voltage amplifier circuit and pulse-generating circuit all are placed in the inside of photomultiplier sealed tube container, dwindled the length of connecting line; The single-chip microcomputer pulse-scaling circuit is also by as among the airtight betal can, its with pulse-generating circuit between be connected with shielding line, these measures all help electrostatic screening, reduce the influence of external environment to signal, as far as possible little minimizing loss, thereby the degree of accuracy of raising low light level photon survey.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610165033 CN1971245A (en) | 2006-12-12 | 2006-12-12 | A measuring device for weak light photons |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610165033 CN1971245A (en) | 2006-12-12 | 2006-12-12 | A measuring device for weak light photons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1971245A true CN1971245A (en) | 2007-05-30 |
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ID=38112168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610165033 Pending CN1971245A (en) | 2006-12-12 | 2006-12-12 | A measuring device for weak light photons |
Country Status (1)
| Country | Link |
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| CN (1) | CN1971245A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106482830A (en) * | 2016-09-29 | 2017-03-08 | 清华大学 | A kind of calibration system of the photon counter based on standard light source and method |
| CN107560830A (en) * | 2017-08-25 | 2018-01-09 | 北方夜视技术股份有限公司 | Large area microchannel template photomultiplier test device |
| CN108519372A (en) * | 2018-04-12 | 2018-09-11 | 厦门大学 | A kind of dinoflagellate bioluminescent detection device |
| CN109387502A (en) * | 2017-08-10 | 2019-02-26 | 株式会社理光 | Measuring device |
-
2006
- 2006-12-12 CN CN 200610165033 patent/CN1971245A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106482830A (en) * | 2016-09-29 | 2017-03-08 | 清华大学 | A kind of calibration system of the photon counter based on standard light source and method |
| CN109387502A (en) * | 2017-08-10 | 2019-02-26 | 株式会社理光 | Measuring device |
| CN107560830A (en) * | 2017-08-25 | 2018-01-09 | 北方夜视技术股份有限公司 | Large area microchannel template photomultiplier test device |
| CN108519372A (en) * | 2018-04-12 | 2018-09-11 | 厦门大学 | A kind of dinoflagellate bioluminescent detection device |
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