CN1961958B - 改善伤口愈合的方法 - Google Patents
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- CN1961958B CN1961958B CN2006101318021A CN200610131802A CN1961958B CN 1961958 B CN1961958 B CN 1961958B CN 2006101318021 A CN2006101318021 A CN 2006101318021A CN 200610131802 A CN200610131802 A CN 200610131802A CN 1961958 B CN1961958 B CN 1961958B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Manufacture Of Motors, Generators (AREA)
Abstract
Description
基因型 | 愈合天数 | 愈合模式 | 坏死组织 | 纤维蛋白沉积 |
野生型 | 8,7±2,4 | 正常愈合 | 无 | 无 |
tPA-/- | 9,0±2,4 | 明显正常愈合 | 无 | 无 |
uPA-/- | 11,0±1,7(7/8的小鼠在第11天愈合) | 愈合部位含有褶皱表面,并有鹅卵石状组织沉积 | 无 | 在愈合部位存在斑点状的纤维蛋白沉积 |
Plg-/- | -(0/8的小鼠在第144天愈合) | 鼓膜被白色组织所覆盖,该组织厚且不透明 | 从第16天起,坏死组织开始清晰可见 | 大面积的纤维蛋白沉积,从而完全覆盖鼓膜表面 |
穿孔后的时间(天数):纤溶酶原缺陷型小鼠:野生型小鼠: | 42/240/18 | 86/1410/14 | 110/610/10 | 361/610/10 | 728/3024/24 | 1440/1212/12 |
穿孔后的时间(天数): | 4 | 8 | 11 |
plg-/-小鼠:野生型小鼠:注射了plg的plg-/-小鼠: | 0/30/30/3 | 0/32/32/3 | 0/33/33/3 |
穿孔后的时间(天数): | 4 | 6 | 8 | 12 |
tPA+/+小鼠:tPA-/-小鼠: | 0/200/24 | 5/144/16 | 9/1410/16 | 6/68/8 |
穿孔后的时间(天数): | 4 | 8 | 16 | 30 |
野生型小鼠:uPA-/-小鼠: | 0/120/16 | 5/85/12 | 8/87/8 | 6/63/4 |
实验组: | 对照(PBS) | 1mg/ml Plg | 10mg/ml Plg |
愈合时间(天数) | 8.1±0.5 | 7.4±0.6 | 6.8±0.5 |
Claims (8)
Applications Claiming Priority (2)
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US31764301P | 2001-09-06 | 2001-09-06 | |
US60/317,643 | 2001-09-06 |
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CNB02822230XA Division CN1289145C (zh) | 2001-09-06 | 2002-09-06 | 纤溶酶原在制备促进哺乳动物鼓膜穿孔愈合的局部药物组合物中的应用 |
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CN1961958A CN1961958A (zh) | 2007-05-16 |
CN1961958B true CN1961958B (zh) | 2011-05-18 |
Family
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CNB02822230XA Expired - Fee Related CN1289145C (zh) | 2001-09-06 | 2002-09-06 | 纤溶酶原在制备促进哺乳动物鼓膜穿孔愈合的局部药物组合物中的应用 |
CN2006101318021A Expired - Fee Related CN1961958B (zh) | 2001-09-06 | 2002-09-06 | 改善伤口愈合的方法 |
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CNB02822230XA Expired - Fee Related CN1289145C (zh) | 2001-09-06 | 2002-09-06 | 纤溶酶原在制备促进哺乳动物鼓膜穿孔愈合的局部药物组合物中的应用 |
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US (3) | US7067492B2 (zh) |
EP (2) | EP1427440B1 (zh) |
CN (2) | CN1289145C (zh) |
AT (2) | ATE348631T1 (zh) |
AU (1) | AU2002361878A1 (zh) |
DE (1) | DE60216939T2 (zh) |
DK (2) | DK1790354T3 (zh) |
ES (2) | ES2387797T3 (zh) |
WO (1) | WO2003020297A2 (zh) |
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US7067492B2 (en) * | 2001-09-06 | 2006-06-27 | Omnio Ab | Method of promoting healing of a tympanic membrane perforation |
CA2613548A1 (en) * | 2005-06-30 | 2007-01-11 | Anthrogenesis Corporation | Repair of tympanic membrane using placenta derived collagen biofabric |
BRPI0708865A8 (pt) * | 2006-03-14 | 2019-01-22 | Univ Oregon Health & Science | métodos para produzir uma resposta imune à tuberculose |
WO2008021391A1 (en) | 2006-08-15 | 2008-02-21 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
JP5566106B2 (ja) * | 2006-08-28 | 2014-08-06 | オムニオ・ヒーラー・アクチボラゲット | 歯周病の阻止および治療、歯周創傷の治癒の改善および口腔衛生の促進を目的とする新規薬物 |
DK2056864T3 (en) * | 2006-08-28 | 2014-03-10 | Omnio Healer Ab | CANDIDATES AGAINST INFECTION |
US8071135B2 (en) | 2006-10-04 | 2011-12-06 | Anthrogenesis Corporation | Placental tissue compositions |
WO2008057162A2 (en) | 2006-10-06 | 2008-05-15 | Anthrogenesis Corporation | Native (telopeptide) placental collagen compositions |
WO2008146224A2 (en) | 2007-05-25 | 2008-12-04 | Compex Medical S.A. | Wound healing electrode set |
GB2450747A (en) * | 2007-07-06 | 2009-01-07 | Univ Sheffield | Treatment of sensorineural hearing loss |
WO2009093970A1 (en) * | 2008-01-22 | 2009-07-30 | Omnio Healer Ab | Method of improving wound healing |
SI2996709T1 (sl) | 2013-05-15 | 2020-09-30 | The Board Of Trustees Of The Leland Stanford Junior University | Modulacija aktivnosti heparin vezavnega epidermalnega rastnega faktorja za celjenje bobniča |
TWI801331B (zh) * | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
TW201722464A (zh) * | 2015-11-10 | 2017-07-01 | 波麥堤克生化科學有限公司 | 用於傷口癒合之纖維蛋白溶酶原給藥方案 |
JP6793748B2 (ja) | 2015-12-18 | 2020-12-02 | タレンゲン インターナショナル リミテッドTalengen International Limited | 放射性および化学的損傷を予防及び治療するための方法 |
DK3395353T3 (da) | 2015-12-18 | 2024-03-11 | Talengen Int Ltd | Plasminogen til anvendelse til behandling eller forebyggelse af diabetes-mellitus-nerveskade |
WO2017101868A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
WO2017101870A1 (zh) * | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
ES2961967T3 (es) | 2015-12-18 | 2024-03-14 | Talengen Int Ltd | Plasminógeno para su uso en el tratamiento de la angiocardiopatía diabética |
TWI623321B (zh) | 2015-12-18 | 2018-05-11 | Talengen Institute Of Life Sciences Co Ltd | Method for preventing and treating cervical erosion |
TWI674903B (zh) * | 2016-09-26 | 2019-10-21 | 國立陽明大學 | 製備改良豬血漿纖連蛋白以增強傷口癒合之應用 |
TW201822812A (zh) | 2016-12-15 | 2018-07-01 | 深圳瑞健生命科學硏究院有限公司 | 一種預防和治療肥胖症的方法 |
CN108210912A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 一种使胰高血糖素、胰岛素恢复正常平衡的方法 |
TWI677348B (zh) * | 2016-12-15 | 2019-11-21 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種改善心臟病變的方法 |
CN108210910A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗***性硬化症的药物及其用途 |
CA3046671C (en) | 2016-12-15 | 2023-08-08 | Talengen International Limited | Method for preventing and treating pulmonary fibrosis |
US11207387B2 (en) | 2016-12-15 | 2021-12-28 | Talengen International Limited | Method and drug for preventing and treating obesity |
WO2018107706A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种使胰高血糖素、胰岛素恢复正常平衡的方法 |
US11938172B2 (en) | 2017-06-19 | 2024-03-26 | Talengen International Limited | Method for regulating and controlling GLP-1/GLP-1R and drug |
EP4251195A1 (en) * | 2020-11-25 | 2023-10-04 | Grifols Worldwide Operations Limited | Wound healing |
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- 2002-09-06 CN CN2006101318021A patent/CN1961958B/zh not_active Expired - Fee Related
- 2002-09-06 EP EP06126236A patent/EP1790354B1/en not_active Expired - Lifetime
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- 2002-09-06 AU AU2002361878A patent/AU2002361878A1/en not_active Abandoned
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US6043407A (en) * | 1997-07-29 | 2000-03-28 | Warner-Lambert Company | Debridement pad |
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EP1790354A2 (en) | 2007-05-30 |
EP1427440B1 (en) | 2006-12-20 |
WO2003020297A3 (en) | 2003-10-09 |
DE60216939T2 (de) | 2007-10-04 |
ATE348631T1 (de) | 2007-01-15 |
WO2003020297A2 (en) | 2003-03-13 |
DK1790354T3 (da) | 2012-07-23 |
ATE552842T1 (de) | 2012-04-15 |
US8637010B2 (en) | 2014-01-28 |
US20030147879A1 (en) | 2003-08-07 |
DK1427440T3 (da) | 2007-04-30 |
CN1289145C (zh) | 2006-12-13 |
ES2387797T3 (es) | 2012-10-01 |
CN1961958A (zh) | 2007-05-16 |
US8679482B2 (en) | 2014-03-25 |
ES2279001T3 (es) | 2007-08-16 |
EP1790354A3 (en) | 2007-10-24 |
US20080090751A1 (en) | 2008-04-17 |
US7067492B2 (en) | 2006-06-27 |
US20070041962A1 (en) | 2007-02-22 |
CN1585649A (zh) | 2005-02-23 |
AU2002361878A1 (en) | 2003-03-18 |
WO2003020297A8 (en) | 2004-07-08 |
EP1790354B1 (en) | 2012-04-11 |
EP1427440A2 (en) | 2004-06-16 |
DE60216939D1 (de) | 2007-02-01 |
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