CN1957928A - Controlled release preparation of clinical treating medication, and fabricating method - Google Patents
Controlled release preparation of clinical treating medication, and fabricating method Download PDFInfo
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Abstract
A slowly-releasing clinical medicine for durable blood concentration and decreasing the peaks and valleys of blood concentration is a solid disperser prepared from multiple chemically synthesized clinic medicines and the slowly-releasing aggregate. Its preparing process is also disclosed.
Description
[technical field] the present invention relates to multiple medicine and preparation method thereof, particularly slow releasing preparation of medicine and preparation method thereof.
[background technology]
The research and development of slow releasing preparation, the history surplus in the of existing so far 40 year, it is in environment provided, non-lentamente on request perseverance is captured release, the preparation that medication every day number of times and corresponding ordinary preparation reduce once more at least or prolong to some extent blanking time of medication.This preparation can make human body keep this kind blood drug level to reach the long time, do not descend quickly the ordinary preparation and do not resemble, thereby " peak valley " phenomenon that can avoid the ordinary preparation frequent drug administration to be occurred, safety, effectiveness or the adaptability of medicine are increased, thereby reduced the medication number of times, greatly facilitate the patient, particularly the patient of long-term prescription.Peroral dosage form commonly used has matrix tablet, micropore bag pellicle controlled release tablet, laser osmotic pumps, composite particles chamber capsule, label chamber capsule, Entogastric lingering preparation, controlled release suspensoid, drop pill etc.; External preparation has eye therapy system, oral cavity sticking tablet, indoor knot medicine device, transdermal clam medicine system etc.; Injection has water suspendible chaste tree, newborn thorn, liposome, microsphere etc.Tablet is with its taking convenience, and preparation technology is simple relatively, and quality is easy to advantage such as control becomes most widely used, the most sophisticated dosage form of technology of slow releasing preparation research and development.Capsule is also with its taking convenience, and preparation technology is simple relatively, and quality such as is easy to control at advantage becomes a wider dosage form of slow releasing preparation research and development application prospect.Film coating sustained-release and controlled release preparation packs the suitable clothing layer of one deck on the surface of label and piller, it is dissolved under certain condition or be partly dissolved and discharge medicine, can reach the sustained-release and controlled release effect.Its principle belongs to diffusion and discharges, and the energy is based on the osmotic pressure of film intracavity, or the stripping dispersal behavior coated slow release controlled release preparation of drug molecule in polymer is one of type of extensive use in the oral sustained release controlled release preparation.
Slow releasing preparation belongs to third generation preparation in the development process of pharmaceutics.In recent years, the research and development development of slow releasing preparation rapidly, the slow releasing preparation that with the Western medicine is material medicine has carried out a large amount of research at pharmacokinetics design principle, adjuvant and moulding process, biopharmaceutics characteristic aspects such as (comprising medicine inside and outside release rule and influence thereof), and existing many sophisticated kinds such as aminophylline slow releasing tablet, cefaclor slow releasing tablet, cefalexin slow releasing capsule etc. are widely used in clinically.Chinese medicine is more complicated in this regard, the Chinese medicine compound preparation active component is often indeterminate, thereby cause in its dissolubility, partition coefficient, the stability in Digestive system and the body and the logical suitable property of the combination rate of blood plasma, medicine pK value and biomembrane between relation etc. indeterminate, thereby increased the difficulty of preparation, but it is clinical that more existing at present sophisticated kinds are used for, as ZHENGQINGFENGTONGNING slow releasing tablet, aescine gel sustained-release preparation etc.
According to its preparation technology's difference, slow releasing preparation can be divided into piller, capsule, matrix tablet, coated pellets matrix tablet, film coating matrix tablet, Entogastric lingering floating type slow releasing tablet, the outstanding agent of slow release dry powder, oral sustained release membrane, sustained-release dropping pill etc.Used substrate comprises hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible sustained-release matrix material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble sustained-release matrix material is as ethyl cellulose, zein etc.Along with being on the increase of substrate kind, preparation technology's is ripe day by day perfect, and slow releasing agent is extensive day by day in the application of Chinese-western medicine preparation, therefore existing medicine is carried out modified form, produce more medicament slow release dosage form, will greatly enrich drug market, improve quality of medical care.
[summary of the invention]
The purpose of this invention is to provide slow releasing preparation of multiple medicine and preparation method thereof.
The present invention studies the medicine that uses clinically at present multiple by experiment, has carried out modified form, changes slow releasing preparation into from existing tablet, capsule, oral liquid etc.Utilize medicament slow release framework material hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible sustained-release matrix material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble sustained-release matrix material, be aided with other common drug adjuvant as substrate such as ethyl cellulose, zein and selected medicine material and make solid preparation, make the non-lentamente as requested constant release of medicine, safety, effectiveness or the adaptability of medicine are increased, thereby reduced the medication number of times, greatly facilitate the patient, particularly the patient's of long-term prescription use.
Wherein, selected medicine by following one or more medicines and its esters (as sodium salt, potassium salt, hydrochlorate, sulfate, hydrobromate, tartrate, fumarates etc.) one-tenth of derivant is grouped into: celecoxib (Celecoxib), Quetiapine (quetiapine), the complexing agent of amlodipine/benazepril (amlodipine/Benazepril), topiramate (topiramate), methylphenidate (Methylphenidate Hydrochloride), the complexing agent of metformin and glibenclamide (Metformin Hydrochloride and Glibenclamide Tablets), cefprozil (cefprozil), cefdinir (Cefdinir), tizanidine hydrochloride (Tizanidine Hydrochloride), nitrofurantoin (Nitrofurantion), ranitidine (ranitidine), rosiglitazone adds metformin (rosiglitazone/Metformin Hydrochloride), neurosedyn (Thalidomide), Memantine hydrochloride (Akatinol), galantamine (Galanthamine), cilostazol (Cilostazol), amoxicillin (Amoxicillin), amoxicillin/dicloxacillin (Amoxicillin/dicloxacillin), amoxicillin/flucloxacillin (Amoxicillin/Flucloxacillin), CEFUROXIME AXETIL (cefuroxime axetil), Cefteram Pivoxil (Cefteram Pivoxil), erythromycin (Erythromycin), midecamycin (Midecamycin), acetylspiramycin (Acetylspiramycin), norfloxacin (norfloxacin), berberine (Berberine Hydrochloride), amitriptyline (Amintriptyline), doxepin (Doxepin Hydrochloride), oxazepam (Oxazepam), cinmetacin (Cinmetacin), benzydamine (Benzydamine), mefenamic acid (Mefenamic Acid), meclofenamic acid (Meclofenamic Acid), tolmetin (tolmetin), fenoprofen calcium (Fenoprofen), phenprobamate (Phenprobamate), tripterygium glycosides (Tripterysium Glucosides), tranilast (Tranilast), albuterol (Salbutamol), clorprenaline (Clorprenaline), hexoprenaline (Hexoprenaline), terbutaline (Terbutaline), tulobuterol (Tulobuterol Hydrochloride), clenbuterol (Clenbuterol Hydrochloride), procaterol (Procaterol), moracizine (Moricizine Hydrochloride), phenytoin Sodium (Phenytoin Sodium), mexiletine (Mexiletine hydrochloride), tocainide (tocainide), aprindine (Aprindine), Propafenone (Propafenone Hydrochloride), oxprenolol (Oxprenolol), pindolol (pindolol), pentaerithrityl tetranitrate (Tetranitrate), perhexiline (perhexiline), nicorandil (Nicorandil), efloxate (Efloxatem), carbocromen (carbocromen), puerarin (Puerarin), troxerutin (Troxerutin), tolperisone (Tolperisone), pyritinol (Pyritinol), reserpine (Reserpine), hydralazine (Hydralazine), bendazol (DibazolHydrochloride), captopril (captopril), clofibrate (Clofibrate), propylene glycol alginate sodium sulfate (Alginric SodiumDiester), Glucuronic acid lactone (Glucurolactone), oleanolic acid (oleanolic acid), silymarin (silymarin), polygynax (Neomycin Sulfate), methylthiouracil (methylthiouracil), tolbutamide (tolbutamide).
Wherein said slow releasing preparation is made up of medicine and substrate as active component, its Chinese medicine: sustained-release matrix material=1: 0.10-1: 50.0.Described substrate comprises the medicament slow release framework material: hydrophilic gel medicament slow release framework material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible medicament slow release framework material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble drug sustained-release matrix material comprises as ethyl cellulose, zein etc. and other additional materials:
1, diluent (filler): for example Icing Sugar, gelatin, glycerol, arabic gum, starch, dextrin, lactose, glucose, mannitol, calcium sulfate, calcium hydrogen phosphate, tricalcium phosphate, gelatinized corn starch, syrup, maltose, gelatine size, cellulose, Kaolin, sodium chloride, modified starch (Sta-RX1500), microcrystalline Cellulose etc., wherein Icing Sugar has sucrose, maltose, dextrinose, dextrinose oligosaccharide, panose, cottonseed sugar, stachyose, oligofructose, fructose, inulin, protein sugar, stevioside, xylitol, maltose alcohol, sorbitol;
2, binding agent: for example water, ethanol, starch, gelatin, sucrose, glucose, dextran, syrup, lactose, arabic gum, sodium alginate, gelatine size, polyvinylpyrrolidone, Polyethylene Glycol, methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, maltose, sucrose dextrin copolymer;
3, disintegrating agent: for example starch (corn and potato starch), cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, pectin, carboxymethyl cellulose, microcrystalline Cellulose, tween 80, sodium laurylsulfate, stearyl alcohol sodium sulfonate, kaolin.
4, lubricant: for example stearic acid, calcium stearate, magnesium stearate, zinc stearate, hydrogenated vegetable oil, polyoxyethylene monostearate, light mineral oil, liquid paraffin, boric acid, sodium chloride, sodium benzoate, sodium acetate, enuatrol, sodium laurylsulfate (magnesium), single Laurel sucrose acid ester, adipic acid, fumaric acid, three triacetins, Polyethylene Glycol
1500～20000
5, fluidizer: for example starch, purified talc, differential silica gel, pyrolytic silicon dioxide, hydrated sodium aluminosilicate.
Wherein said preparation type comprises slow releasing tablet, slow-release pill preparation, slow release capsule preparation etc.
By the preparation method of following slow releasing preparation provided by the present invention, can further understand the present invention, but following description not a limitation of the invention:
1, the preparation method of slow releasing tablet
With the medicine is primary raw material, according to certain ratio, adds medicament slow release framework material and additional materials as substrate, is prepared from through specific technology, apparatus processing again.Specific as follows:
(1) prescription: medicine+substrate;
Medicine: be foregoing medicine and its esters (as sodium salt, potassium salt, hydrochlorate, sulfate, hydrobromate, tartrate, fumarate etc.) derivant.
Substrate: include the medicament slow release framework material: hydrophilic gel medicament slow release framework material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible medicament slow release framework material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble drug sustained-release matrix material is as one or more composition and additional materials of ethyl cellulose, zein etc., its Chinese medicine: sustained-release matrix material=1: 0.10-1: 50.0.
(2) preparation technology: concrete implementation step is as follows:
Method one: according to certain ratio with medicine, erodible sustained-release matrix material, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc. and the additives mix homogeneously of milling, direct compression or dry granulation behind the adding lubricant, tabletting or elder generation add typical binders granulation, drying behind the adding lubricant, add the lubricant tabletting again.
Method two: according to certain ratio with medicine, erodible sustained-release matrix material, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and additives mill jointly mix after, again with hydrophilic gel sustained-release matrix material, as mixing such as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomers, direct compression or dry granulation behind the adding lubricant, tabletting or elder generation add typical binders granulation, drying behind the adding lubricant, add the lubricant tabletting again.
Method three: according to certain ratio with medicine, additives and water-insoluble sustained-release matrix material, alcoholic solution mix homogeneously as ethyl cellulose, zein etc., add hydrophilic gel sustained-release matrix material, as mixing granulations such as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomers, dry, add lubricant, tabletting gets finished product.
Method four: according to certain ratio with water-soluble components in medicine, the described additives and water-insoluble sustained-release matrix material, alcoholic solution mix homogeneously or dissolving as ethyl cellulose, zein etc., vacuum drying, pulverize, add hydrophilic gel sustained-release matrix material, as mixing such as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomers, add the lubricant tabletting again behind adding lubricant direct compression or the dry granulation and get finished product.
Method five: with medicine, water-insoluble sustained-release matrix material, even with additives and mix lubricant as ethyl cellulose, zein etc., tabletting gets finished product according to certain ratio.
2, the preparation method of slow releasing capsule
With the medicine is primary raw material, according to certain ratio, adds medicament slow release framework material and additional materials as substrate, is prepared from through specific technology, apparatus processing again.Specific as follows:
(1) prescription: medicine+substrate;
Medicine: be foregoing medicine and its esters (as sodium salt, potassium salt, hydrochlorate, sulfate, hydrobromate, tartrate, fumarate etc.) derivant.
Substrate: include the medicament slow release framework material: hydrophilic gel medicament slow release framework material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible medicament slow release framework material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble drug sustained-release matrix material is as one or more composition and additional materials of ethyl cellulose, zein etc., its Chinese medicine: sustained-release matrix material=1: 0.10-1: 50.0.
(2) preparation technology: concrete implementation step is as follows:
Method one: according to certain ratio with medicine, erodible sustained-release matrix material, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc. and the additives mix homogeneously of milling, dry method or wet method are made slow-release pill or granule, add or do not add additives, be packed in the hard capsule.
Method two: according to certain ratio with medicine and additives mill jointly mix after, make slow-release pill or granule with dry method or wet method, the erodible sustained-release matrix material of reuse, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and/or hydrophilic gel sustained-release matrix material, as solution such as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomers is that coating material is to ball pericardium clothing, add or do not add additives, be packed in the hard capsule.
Method three: according to certain ratio with medicine, erodible sustained-release matrix material, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc. and the additives mix homogeneously of milling, dry method or wet method are made slow-release pill or granule, the erodible sustained-release matrix material of reuse, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and/or hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, solution such as carbomer are that coating material is to ball pericardium clothing, add or do not add additives, be packed in the hard capsule
Method four: according to certain ratio with water-soluble components in medicine, the described additives and water-insoluble sustained-release matrix material, alcoholic solution mix homogeneously or dissolving as ethyl cellulose, zein etc., vacuum drying, pulverize, add hydrophilic gel sustained-release matrix material, as mixing such as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomers, dry method or wet method are made slow-release pill or granule, add or do not add additives, be packed in the hard capsule.
Method five: according to certain ratio with medicine, water-soluble components in the described additives and water-insoluble sustained-release matrix material, as ethyl cellulose, the alcoholic solution mix homogeneously or the dissolving of zein etc., vacuum drying, pulverize, add hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, mixing such as carbomer, dry method or wet method are made slow-release pill or granule, the erodible sustained-release matrix material of reuse, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and/or hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, solution such as carbomer are that coating material is to ball pericardium clothing, add or do not add additives, be packed in the hard capsule.
3, the preparation method of sustained-release dropping pill
With the medicine is primary raw material, according to certain ratio, adds medicament slow release framework material and additional materials as substrate, is prepared from through specific technology, apparatus processing again.Specific as follows:
(1) prescription: medicine+substrate;
Medicine: be foregoing medicine and its esters (as sodium salt, potassium salt, hydrochlorate, sulfate, hydrobromate, tartrate, fumarate etc.) derivant.
Substrate: include the medicament slow release framework material: hydrophilic gel medicament slow release framework material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible medicament slow release framework material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble drug sustained-release matrix material is as one or more composition and drop pill additional materials of ethyl cellulose, zein etc., if any Polyethylene Glycol
(2000,4000,6000,8000,10000,20000), polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, polyoxyethylene monostearate, polyethers etc., its Chinese medicine: sustained-release matrix material=1: 0.10-1: 50.0.
(2) preparation technology: concrete implementation step is as follows:
Drop pill can improve the dissolution of insoluble drug, so be the better dosage form of preparation insoluble drug sustained-release preparation.
Method one: according to certain ratio with medicine, erodible sustained-release matrix material, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc. and the drop pill additives mix homogeneously of milling, adopt water-bath, oil bath or other mode of heating, mixed material is heated to fusion, stir, insert on the drop pill machine with suitable speed, splash in 40 →-40 ℃ the condensing agent.Condensing agent can be any one or a few in liquid paraffin, methyl-silicone oil, the vegetable oil, and type to be shrunk to takes out, and removes the surface condensation agent, dry.
Method two: according to certain ratio with medicine, erodible sustained-release matrix material, as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and hydrophilic gel sustained-release matrix material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc. and the drop pill additives mix homogeneously of milling, adopt water-bath, oil bath or other mode of heating, mixed material is heated to fusion, stir, insert on the drop pill machine with suitable speed, splash in 40 →-40 ℃ the condensing agent.Condensing agent can be any one or a few in liquid paraffin, methyl-silicone oil, the vegetable oil, type to be shrunk to, take out, remove the surface condensation agent, dry, reuse erodible sustained-release matrix material as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc. and/or hydrophilic gel sustained-release matrix material, is that coating material is to ball pericardium clothing as solution such as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomers.
The medicament slow release preparation that [beneficial effect] is involved in the present invention utilizes the sustained-release matrix material to comprise hydrophilic gel medicament slow release framework material, as hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer etc.; Erodible medicament slow release framework material is as stearic acid, hexadecanol, octadecanol, Polyethylene Glycol etc.; Water-insoluble drug sustained-release matrix material is made solid dispersion as ethyl cellulose, zein etc. for substrate and medicine material, makes medicine medicine after administration can be on request slowly continue to discharge keeping effective blood concentration, thereby reaches long-acting.
Compare with conventional formulation, medication preparation becomes to have its special advantages behind the slow releasing preparation: (1) reduces administration number of times, improves patient's compliance of taking medicine; (2) reduce the blood concentration peak valley phenomenon, improve drug effect and drug safety: (3) reduce the accumulated dose of medication, so that minimum dose reaches greatest treatment efficacy; (4) after medicine is made slowly released and controlled-drug delivery system with suitable carrier, the absorption of medicine and the main character decision that distributes by carrier, therefore select the appropriate carriers material according to clinical requirement, not only can conduct drugs to the particular target organ, can also improve the physicochemical property and the pharmacologically active of medicine to a certain extent, have broad clinical application prospect.
[specific implementation method]
By following concrete embodiment, can further understand the present invention, but following example not a limitation of the invention.
The preparation of embodiment 1-amoxicillin slow release sheet
Method: get amoxicillin 375 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 375mg/ sheet.Through drug release determination, meet the requirements.
The capsular preparation of embodiment 2-amoxicillin slow release
Method: get amoxicillin 187.5 grams, hydroxypropyl methylcellulose 50 grams, lactose 10 grams, ethyl cellulose 15 grams, carbomer 2 grams, calcium hydrogen phosphate 50 grams respectively, cross 80 mesh sieves respectively, put the mixer mixing, add concentration and be 60% ethanol water as wetting agent and stir and make soft material, cross 16 mesh sieves and granulate, 60 ℃ of dryings of granule 1 hour, 16 mesh sieve granulate add magnesium stearate 0.5 gram and Pulvis Talci 0.5 gram, mixing again, encapsulated, containing medication amount is the 187.5mg/ grain.Through drug release determination, meet the requirements.
The preparation of embodiment 3-Amoxicillin Sodium sustained-release dropping pill
Method: get respectively, stearic acid 11 gram, polyethylene glycol 6000 20 grams, carbomer 1 gram, mix homogeneously, add Amoxicillin Sodium raw material powder 18 grams again, fully mix, adopt electrically heated mode with the supplementary material mixture heated that makes to molten condition, adopt homemade special drilling pill machine, regulate its water dropper temperature and make it remain on 90 ℃ (error＜2%); With the methyl-silicone oil is condensing agent, the refrigeration control system of regulating the drop pill machine makes the temperature of condensing agent remain on 20 →-15 ℃ (error＜5%), according to the given method of the front preparation technology system of dripping, wait to take out behind the type of being shrunk to again, remove the surface condensation agent, dry, make the drop pill that contains medicine 18mg/ grain, carry out the mensuration of rounding rate (%), the ball method of double differences different (%), dissolution and hardness then, the rounding rate is 82% as a result, the ball method of double differences is different from 10%, and hardness is qualified.Through dissolution determination, meet the requirements.
The preparation of embodiment 4-celecoxib slow releasing tablet
Method: get celecoxib 200 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 200mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 5-quetiapine fumarate slow releasing tablet
Method: get quetiapine fumarate 25 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 25mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 6-amlodipine/benazepril slow releasing tablet
Method: get amlodipine 5 grams, benazepril 20 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 25mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 7-topiramate slow releasing tablet
Method: get topiramate 100 grams, hydroxypropyl cellulose 50 grams, lactose 50 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 8-methylphenidate hydrochloride slow releasing tablet
Method: get methylphenidate hydrochloride 10 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of the composite slow release sheet of embodiment 9-metformin and glibenclamide
Method: get metformin 250 grams, glibenclamide 2.5 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation, adding magnesium stearate mixes, tabletting gets finished product, and containing medication amount is the 252.5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 10-cefprozil slow releasing tablet
Method: get cefprozil 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 11-cefdinir slow releasing tablet
Method: get cefdinir 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 12-tizanidine hydrochloride slow releasing tablet
Method: get tizanidine hydrochloride 1 gram, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 1mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 13-nitrofurantoin slow releasing tablet
Method: get nitrofurantoin 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 14-ranitidine slow releasing tablet
Method: get amoxicillin 150 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 150mg/ sheet.Through drug release determination, meet the requirements.
Embodiment 15-rosiglitazone adds the preparation of metformin slow releasing tablet
Method: get rosiglitazone 250 grams respectively, metformin 2 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams, mix homogeneously, dry granulation, add magnesium stearate and mix, tabletting gets finished product, and containing medication amount is the 252mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 16-neurosedyn slow releasing tablet
Method: get neurosedyn 25 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 25mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 17-Memantine hydrochloride slow releasing tablet
Method: get Memantine hydrochloride 10 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 18-galantamine slow releasing tablet
Method: get amoxicillin 10 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 19-slow released cilostazol sheet
Method: get amoxicillin 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 20-amoxicillin/dicloxacillin slow releasing tablet
Method: get Amoxicillin Sodium 250 grams, dicloxacillin sodium 125 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation, adding magnesium stearate mixes, tabletting gets finished product, and containing medication amount is the 375mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 21-amoxicillin/flucloxacillin slow releasing tablet
Method: get amoxicillin 375 grams, flucloxacillin 125 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 375mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 22-CEFUROXIME AXETIL slow releasing tablet
Method: get CEFUROXIME AXETIL 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 23-Cefteram Pivoxil slow releasing tablet
Method: get Cefteram Pivoxil 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 24-erythromycin slow releasing tablet
Method: get erythromycin 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 25-midecamycin slow releasing tablet
Method: get midecamycin 200 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 200mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 26-acetylspiramycin slow releasing tablet
Method: get acetylspiramycin 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 27-norfloxacin slow releasing tablet
Method: get norfloxacin 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 28-berberine slow releasing tablet
Method: get berberine 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 29-amitriptyline slow releasing tablet
Method: get amitriptyline 50 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 30-doxepin slow releasing tablet
Method: get doxepin 25 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 25mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 31-oxazepam slow releasing tablet
Method: get oxazepam 30 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 30mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 32-cinmetacin slow releasing tablet
Method: get cinmetacin 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 33-benzydamine slow releasing tablet
Method: get benzydamine 50 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 34-mefenamic acid slow releasing tablet
Method: get mefenamic acid 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 35-meclofenamic acid slow releasing tablet
Method: get meclofenamic acid 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 36-tolmetin slow releasing tablet
Method: get tolmetin 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 37-fenoprofen sustained release tablet of calcium
Method: get fenoprofen calcium 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 38-phenprobamate slow releasing tablet
Method: get phenprobamate 200 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 200mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 39-tripterygium glycosides slow releasing tablet
Method: get tripterygium glycosides 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 40-tranilast slow releasing tablet
Method: get tranilast 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 41-albuterol slow releasing tablet
Method: get albuterol 1 gram, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 1mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 42-clorprenaline slow releasing tablet
Method: get clorprenaline 5 grams, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 43-hexoprenaline slow releasing tablet
Method: get hexoprenaline 1 gram, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 1mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 44-terbutaline slow releasing tablet
Method: get terbutaline 2.5 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 2.5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 45-tulobuterol slow releasing tablet
Method: get tulobuterol 0.5 gram, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 0.5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 46-clenbuterol slow releasing tablet
Method: get clenbuterol 2.5 grams, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 2.5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 47-procaterol slow releasing tablet
Method: get 25 milligrams of procaterols, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 25ug/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 48-moracizine slow releasing tablet
Method: get moracizine 50 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 49-phenytoin Sodium slow releasing tablet
Method: get phenytoin Sodium 50 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 50-mexiletine (Mexiletine hydrochloride) 300mg slow releasing tablet
Method: get mexiletine 300 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 300mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 51-tocainide slow releasing tablet
Method: get tocainide 200 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 200mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 52-aprindine slow releasing tablet
Method: get aprindine 50 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 53-Propafenone slow releasing tablet
Method: get Propafenone 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 54-oxprenolol slow releasing tablet
Method: get oxprenolol 80 grams, hydroxypropyl cellulose 50 grams, lactose 50 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 80mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 55-pindolol slow releasing tablet
Method: get pindolol 5 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 56-pentaerithrityl tetranitrate slow releasing tablet
Method: get pentaerithrityl tetranitrate 10 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 57-perhexiline slow releasing tablet
Method: get perhexiline 40 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 40mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 58-nicorandil slow releasing tablet
Method: get nicorandil 5 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 59-efloxate slow releasing tablet
Method: get efloxate 20 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 20mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 60-carbocromen slow releasing tablet
Method: difference card taking POLO gram in the Meng 75, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 restrain, Macrogol 4000 30 grams, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 75mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 61-puerarin sustained-release sheet
Method: get puerarin 375 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 375mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 62-troxerutin slow releasing tablet
Method: get troxerutin 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 63-tolperisone slow releasing tablet
Method: get tolperisone 50 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 64-pyritinol slow releasing tablet
Method: get pyritinol 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 65-reserpine slow releasing tablet
Method: get reserpine 0.5 gram, hydroxypropyl cellulose 50 grams, lactose 150 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 0.5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 66-hydralazine slow releasing tablet
Method: get hydralazine 10 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 67-bendazol slow releasing tablet
Method: get bendazol 10 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 68-captopril slow releasing tablet
Method: difference card taking Top profit 12.5 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 restrain, carbomer 1 restrains, Macrogol 4000 30 grams, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 12.5mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 69-clofibrate slow releasing tablet
Method: get amoxicillin 25 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 25mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 70-propylene glycol alginate sodium sulfate slow releasing tablet
Method: get propylene glycol alginate sodium sulfate 50 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 50mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 71-Glucuronic acid lactone slow releasing tablet
Method: get Glucuronic acid lactone 200 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 200mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 72-oleanolic acid slow releasing tablet
Method: even up pier fruit acid 10 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 10mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 73-silymarin slow releasing tablet
Method: water intaking flies silibin 35 grams, hydroxypropyl cellulose 50 grams, lactose 100 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 35mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 74-polygynax slow releasing tablet
Method: get polygynax 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 75-methylthiouracil slow releasing tablet
Method: get methylthiouracil 100 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 100mg/ sheet.Through drug release determination, meet the requirements.
The preparation of embodiment 76-tolbutamide slow releasing tablet
Method: get tolbutamide 250 grams, hydroxypropyl cellulose 50 grams, lactose 10 grams, microcrystalline Cellulose 10 grams, carbomer 1 gram, Macrogol 4000 30 grams respectively, mix homogeneously, dry granulation adds magnesium stearate and mixes, tabletting gets finished product, and containing medication amount is the 250mg/ sheet.Through drug release determination, meet the requirements.
Claims (9)
1, the slow releasing preparation of multiple medicine is characterized in that: it contains substantially as the medicine of effective ingredient and slow release framework material, its Chinese medicine: sustained-release matrix material=1: 0.10-1: 50.0.
2, slow releasing preparation according to claim 1 is characterized in that: described sustained-release matrix material is one or more a combination in any of hydrophilic gel sustained-release matrix material, erodible sustained-release matrix material, water-insoluble sustained-release matrix material.
3. slow releasing preparation according to claim 1 is characterized in that: described medicine as active component is that the one-tenth by following one or more medicines and salt derivative thereof is grouped into: celecoxib, Quetiapine, amlodipine/benazepril, topiramate, methylphenidate, the complexing agent of metformin and glibenclamide, cefprozil, cefdinir, the tizanidine, nitrofurantoin, ranitidine, rosiglitazone adds metformin, neurosedyn, Memantine hydrochloride, galantamine, cilostazol, the amoxicillin, amoxicillin/dicloxacillin, amoxicillin/flucloxacillin, CEFUROXIME AXETIL, Cefteram Pivoxil, erythromycin, midecamycin, acetylspiramycin, norfloxacin, berberine, amitriptyline, doxepin, oxazepam, cinmetacin, benzydamine, mefenamic acid, meclofenamic acid, tolmetin, fenoprofen calcium, phenprobamate, tripterygium glycosides, tranilast, albuterol, clorprenaline, hexoprenaline, terbutaline, tulobuterol, clenbuterol, procaterol, moracizine, phenytoin Sodium, mexiletine, tocainide, aprindine, Propafenone, oxprenolol, pindolol, pentaerithrityl tetranitrate, perhexiline, nicorandil, efloxate, carbocromen, puerarin, troxerutin, tolperisone, pyritinol, reserpine, hydralazine, bendazol, captopril, clofibrate, propylene glycol alginate sodium sulfate, Glucuronic acid lactone, oleanolic acid, silymarin, polygynax, methylthiouracil, tolbutamide.
4, sustained-release matrix material according to claim 2 is characterized in that: described hydrophilic gel sustained-release matrix material is one or more a combination in any of hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, carbomer; Described erodible sustained-release matrix material is one or more the combination in any in stearic acid, hexadecanol, octadecanol, the Polyethylene Glycol; Described water-insoluble sustained-release matrix material is that ethyl cellulose is or/and zein.
5, slow releasing tablet according to claim 1 is characterized in that: be added with lubricant and filler, binding agent, disintegrating agent, lubricant, fluidizer in the described matrine slow-release tablet.
6, slow releasing preparation according to claim 1 is characterized in that: preparation type comprises slow releasing tablet, slow-release pill preparation, slow release capsule preparation.
7, the preparation method of slow releasing tablet according to claim 5, it is characterized in that: with medicine, sustained-release matrix material, the additives mix homogeneously of milling, direct compression or dry granulation behind the adding lubricant, tabletting or elder generation add typical binders granulation, drying behind the adding lubricant, add the lubricant tabletting again.
8, the preparation method of slow-release pill preparation according to claim 5, it is characterized in that: described sustained-release dropping pill is made up of active constituents of medicine that includes antibiotics and substrate, adopt water-bath, oil bath or other mode of heating, mixed material is heated to fusion, stir, insert on the drop pill machine, splash in 40 →-40 ℃ the condensing agent liquid paraffin, methyl-silicone oil, vegetable oil any one or a few with suitable speed, drying forms, and its mesostroma is by including Polyethylene Glycol
(2000,4000,6000,8000,10000,20000), one or more one-tenth in polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, polyoxyethylene monostearate, polyethers and the described sustained-release matrix material are grouped into.
9, the preparation method of slow release capsule preparation according to claim 5, it is characterized in that: with medicine, sustained-release matrix material, the additives mix homogeneously of milling, direct compression or dry granulation behind the adding lubricant, tabletting or elder generation add typical binders granulation, drying behind the adding lubricant, add the lubricant tabletting again.
Priority Applications (44)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510104989 CN1957928A (en) | 2005-09-26 | 2005-09-26 | Controlled release preparation of clinical treating medication, and fabricating method |
| CNA2006100986302A CN101011363A (en) | 2005-09-26 | 2006-07-10 | Slow release tablet of amoxicillin |
| CNA2006101530212A CN101002739A (en) | 2005-09-26 | 2006-09-20 | Slow release preparation of ranitidine |
| CNA2006101529111A CN101015531A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of dibazole |
| CNA200610152915XA CN101015535A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of perhexiline |
| CNA2006101529145A CN101015534A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of phenprobamate |
| CNA2006101530250A CN1994282A (en) | 2005-09-26 | 2006-09-20 | Sustained-release preparation of mexiletine |
| CNA2006101529107A CN101015530A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of doxepin |
| CNA2006101530195A CN101036632A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of cinmetacin |
| CNA2006101529130A CN101015533A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of norfloxacin |
| CNA2006101530180A CN101002738A (en) | 2005-09-26 | 2006-09-20 | Slow release preparation containing tolbutamide |
| CNA2006101530208A CN101006987A (en) | 2005-09-26 | 2006-09-20 | Slow release preparation of erythromycin |
| CNA2006101530231A CN101002740A (en) | 2005-09-26 | 2006-09-20 | Slow release preparation of compactin |
| CNA2006101530265A CN1994283A (en) | 2005-09-26 | 2006-09-20 | Sustained-release preparation of nicorandil |
| CNA2006101530227A CN101006988A (en) | 2005-09-26 | 2006-09-20 | Slow release preparation of puerarin |
| CNA2006101530161A CN101002736A (en) | 2005-09-26 | 2006-09-20 | Slow-release preparation containing polyheteroside of tripterygium wilfordii |
| CNA2006101530246A CN1994281A (en) | 2005-09-26 | 2006-09-20 | Sustained-release preparation of midecamycin |
| CNA2006101529126A CN101015532A (en) | 2005-09-26 | 2006-09-20 | Sustained release preparation of phenytoin sodiumslow release |
| CNA2006101530176A CN101002737A (en) | 2005-09-26 | 2006-09-20 | Slow release preparation of Kui-Liu-Ping |
| CNA200610153073XA CN101002751A (en) | 2005-09-26 | 2006-09-21 | Slow release preparation of amitriptyline |
| CNA2006101530725A CN101002750A (en) | 2005-09-26 | 2006-09-21 | Slow release preparation of pyrithione alcohol |
| CNA2006101530710A CN101002749A (en) | 2005-09-26 | 2006-09-21 | Slow release preparation of nitrofurantion |
| CNA2006101529588A CN101011368A (en) | 2005-09-26 | 2006-09-21 | Slow release tablet of troxerutin |
| CNA2006101530763A CN101002752A (en) | 2005-09-26 | 2006-09-21 | Slow release preparation of tropyone |
| CNA2006101529554A CN101011365A (en) | 2005-09-26 | 2006-09-21 | Slow release tablet of ampicillin |
| CNA2006101530689A CN101002746A (en) | 2005-09-26 | 2006-09-21 | Slow release preparation of cefuroxime axetil |
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| CNA2006101526147A CN101015529A (en) | 2005-09-26 | 2006-09-25 | Sustained release preparation of amoxillin and dicloxacillin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510104989 CN1957928A (en) | 2005-09-26 | 2005-09-26 | Controlled release preparation of clinical treating medication, and fabricating method |
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| Publication Number | Publication Date |
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| CN1957928A true CN1957928A (en) | 2007-05-09 |
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| CN 200510104989 Pending CN1957928A (en) | 2005-09-26 | 2005-09-26 | Controlled release preparation of clinical treating medication, and fabricating method |
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