CN1954862B - Syrup for treating headache - Google Patents
Syrup for treating headache Download PDFInfo
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- CN1954862B CN1954862B CN2005100157210A CN200510015721A CN1954862B CN 1954862 B CN1954862 B CN 1954862B CN 2005100157210 A CN2005100157210 A CN 2005100157210A CN 200510015721 A CN200510015721 A CN 200510015721A CN 1954862 B CN1954862 B CN 1954862B
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- 206010019233 Headaches Diseases 0.000 title claims abstract description 17
- 231100000869 headache Toxicity 0.000 title claims abstract description 17
- 239000006188 syrup Substances 0.000 title claims abstract description 17
- 235000020357 syrup Nutrition 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- 239000000284 extract Substances 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 239000012567 medical material Substances 0.000 claims description 33
- 238000000605 extraction Methods 0.000 claims description 31
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 22
- 239000012141 concentrate Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000010992 reflux Methods 0.000 claims description 11
- 241000218176 Corydalis Species 0.000 claims description 8
- 241000217407 Margaritifera Species 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 8
- 229920005989 resin Polymers 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000010828 elution Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 2
- 239000003480 eluent Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 244000236658 Paeonia lactiflora Species 0.000 abstract description 5
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract description 5
- 241000405414 Rehmannia Species 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000008504 concentrate Nutrition 0.000 description 8
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000009188 angelicae sinensis extract Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 3
- 238000012869 ethanol precipitation Methods 0.000 description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000002137 ultrasound extraction Methods 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940095559 cafergot Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- -1 leave standstill Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of syrup for treating headache is proportionally prepared from 11 Chinese-medicinal materials including Chinese angelica root, Chuan-xiong rhizome, white peony root, prepared rehmannia root, etc.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of syrup of treating headache and preparation method thereof.
Background technology
Headache is a kind of commonly encountered diseases, though there is the part Chinese and western drugs to use, effect is all not satisfactory, and especially to the medicine of the headache due to hyperactivity of liver-YANG of treatment blood deficiency, blood stasis type, the curative effect of medicine and drug effect speed influence the key factor of patients ' life quality especially.The Western medicine that existing treatment commonly used is had a headache has cafergot, and it is a kind of vasodilation, and it is sick only to be suitable for cerebral artery ischemia property expectorant.Its mechanism of action of flunarizine capsule of producing in 1988 is optionally to suppress calcium to get into cell, shrinks to reduce venous.The Chinese patent medicine of the treatment of report headache at present has ZHENGTIAN WAN; It is the Chinese medicine and western medicine side of closing, and its mechanism is blood circulation promoting and blood stasis dispelling, and is furnished with the analgesic of Western medicine; This medicine only is suitable for headache due to invasion of exogenous pathogens and so on, to the headache of the internal injury type of traditional Chinese medical science appellation, blood deficiency and blood stasis headache due to hyperactivity of liver-YANG poor effect then.
The Chinese medicine of treatment headache at present is a lot, and syrup takes by weighing to measure to have substituted, and dosage is adjusted and accurately easily, and through regulating taste, taking convenience, being easy to is medical producer and patient's acceptance.
Summary of the invention
The syrup that the object of the invention has been to provide a kind of brand-new treatment to have a headache.
Another object of the present invention is to provide the method for preparing of this syrup.
The syrup of treatment headache of the present invention, its prescription is (in a weight percentage):
Radix Angelicae Sinensis 4～9% Rhizoma Chuanxiongs 4～9% Radix Paeoniae Albas 2～8% Radix Rehmanniaes Preparata 2～8% Ramulus Uncariae Cum Unciss 10～15% Caulis Spatholobis 10～15% Spica Prunellaes 10～15% Semen Cassiaes 10～15% Concha Margaritiferas 10～15% Rhizoma Corydalis 4～9% Herba Asaris 0.5～2%.
Choosing prescription proportioning is (in a weight percentage):
Radix Angelicae Sinensis 6.75% Rhizoma Chuanxiong 6.75% Radix Paeoniae Alba 5.4% Radix Rehmanniae Preparata 5.4% Ramulus Uncariae Cum Uncis 13.5% Caulis Spatholobi 13.5% Spica Prunellae 13.5% Semen Cassiae 13.5% Concha Margaritifera 13.5% Rhizoma Corydalis 6.75% Herba Asari 1.34%.
Said medicine prescription proportioning is the weight proportion of institute's uses crude drug, need process and water processed solution said medical material is further if be made into syrup.
Can select that wherein independent the or mixed extraction of Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong medical material is processed into extract method for distilling wherein and be selected from (but being not limited to this): decoction and alcohol sedimentation technique, ultrasonic extraction, supercritical extraction etc.
Method for optimizing is that the Radix Paeoniae Alba is extracted separately, with all the other medical material water extraction, concentrates the back ethanol precipitation, reclaims ethanol, gets drug extract; Perhaps all medical material Direct Water are extracted, concentrated the back ethanol precipitation, reclaim ethanol, get drug extract.
For the ease of understanding, existing method for distilling with the Radix Paeoniae Alba, Rhizoma Chuanxiong and Radix Angelicae Sinensis three flavor medical materials is described below for example, but is not limited to this.
Radix Paeoniae Alba ultrasonic extraction: get white Peony Root, pulverize, add the water supersound extraction, concentrate Radix Paeoniae Alba extract.
Radix Paeoniae Alba alcohol extraction is followed the example of: get white Peony Root, pulverize, add alcohol reflux, concentrate and reclaim ethanol, continue to concentrate Radix Paeoniae Alba extract.
The Radix Angelicae Sinensis supercritical extraction: get the Radix Angelicae Sinensis medical material, felicity condition adopts down carbon dioxide supercritical fluid extraction, filter Radix Angelicae Sinensis extract.
The Radix Angelicae Sinensis water extraction adds resin method: get the decocting in water ferment precipitate heating dissolved in distilled water of Radix Angelicae Sinensis, with calcium hydroxide saturated solution adjust pH, place the sucking filtration that spends the night; Filtrating is transferred pH5-6 with sulphuric acid, and ice is deposited and spent the night sucking filtration; Filtrating is through the exchange of zwitterion hybrid resin, and exchange liquid is concentrated into certain volume, adds ethanol precipitation; Ice is deposited the sucking filtration that spends the night, with pure hypostasis wave in ethanol and concentrate Radix Angelicae Sinensis extract.
Radix Angelicae Sinensis distillation and extraction method: take by weighing Radix Angelicae Sinensis powder in flask; With the distilled water lixiviate that refluxes, then under certain condition with raw material and immersion, distilling under reduced pressure; Get the Radix Angelicae Sinensis distillate; Add an amount of NaCl standing demix then, spill funnel Radix Angelicae Sinensis volatile oil is isolated with dividing, concentrate Radix Angelicae Sinensis extract.
Rhizoma Chuanxiong ethanol adds resin method: get the Rhizoma Chuanxiong decoction pieces, pulverize, ethanol is reflux, extract, in Suo Shi reflux, extract, device, sucking filtration; Sucking filtration liquid is evaporated to dried, adds suitable quantity of water again, and heating makes dissolving; Filter, filtrating is added on the macroporous resin column of having handled well, uses earlier water elution; The reuse ethanol elution, reclaim ethanol after, continue to concentrate Rhizoma Chuanxiong extract.
The Rhizoma Chuanxiong ethanol extraction method: get the Rhizoma Chuanxiong medical material, suitably pulverize, add the ethanol extraction several times, merge extractive liquid, filters, and reclaims ethanol, concentrate Rhizoma Chuanxiong extract.
Except that the independent extraction of above-mentioned medical material, all right mixed extraction of said Rhizoma Chuanxiong, Radix Angelicae Sinensis and the Radix Paeoniae Alba is mainly: the Radix Paeoniae Alba, Rhizoma Chuanxiong and the Radix Angelicae Sinensis medical material of learning from else's experience and pulverizing, and boiling water boils to be carried, filter, merging filtrate, and it is suitable concentrated to filtrate; In concentrated solution, add ethanol and carry out precipitate with ethanol, leave standstill, supernatant reclaims ethanol, is condensed into extractum, gets medicinal substances extract.
A kind of Chinese medicine of treating headache of the present invention, except that above-mentioned Chinese crude drug extract as the active component, also must add water and white sugar and just can process syrup.
A kind of Chinese medicine of treating headache of the present invention adds white sugar and water adjusted volume on the basis of said extracted, get final product.
All the time, motherland's medical science decocts use together with the Chinese medicine that uses, and thinks through the interaction between the medicine, can produce the effect of treatment disease.The present invention processes Chinese medicine that solution also carries out in line with such principle just.Extract the principle that Chinese medicine both can satisfy Chinese medicine decoction through suitably processing, can accomplish purpose easy to carry, wieldy again.
The specific embodiment
Below in conjunction with Comparative Examples and embodiment the present invention is further described, following this embodiment only is used to the present invention is described and the present invention is not limited.
Embodiment 1
Take off and state medical material: Radix Angelicae Sinensis 80g, Rhizoma Chuanxiong 80g, Radix Paeoniae Alba 80g, Radix Rehmanniae Preparata 80g, Ramulus Uncariae Cum Uncis 120g, Caulis Spatholobi 120g, Spica Prunellae 120g, Semen Cassiae 120g, Concha Margaritifera 120g, Rhizoma Corydalis 70g, Herba Asari 10g;
The extraction of the Radix Paeoniae Alba: get above-mentioned white Peony Root 80g, crushing screening adds the water supersound extraction 2 times; Make a living 10 times of dose of amount of water volume for the first time, supersonic frequency is 5MHz, the time is 50min; Be extracted as 8 times of crude drug amount the second time, and supersonic frequency is 5Mhz, and the time is 40min; Merge extractive liquid, concentrates, and gets Radix Paeoniae Alba extract.
The extraction of other medical material: above-mentioned other medical material mix homogeneously, extracting in water 2 times, for the first time amount of water is 8 times of crude drug; 2 hours extraction times, 6 times of the dose of making a living for the second time, 1.5 hours extraction times; Merge extractive liquid,, being concentrated into relative density is 1.10 (W/W), gets medicinal substances extract.
The preparation of syrup: get above-mentioned Radix Paeoniae Alba extract 5g, with other medicinal substances extract mix homogeneously of 0.46g; Add 20g white sugar, water dissolution continues to add adjusted volume to 100ml.
Embodiment 2
Take off and state medical material: Radix Angelicae Sinensis 80g, Rhizoma Chuanxiong 80g, Radix Paeoniae Alba 80g, Radix Rehmanniae Preparata 80g, Ramulus Uncariae Cum Uncis 120g, Caulis Spatholobi 120g, Spica Prunellae 120g, Semen Cassiae 120g, Concha Margaritifera 120g, Rhizoma Corydalis 70g, Herba Asari 10g;
The extraction of white Peony Root: get Radix Paeoniae Alba crude drug, pulverize, cross 120 mesh sieves, the alcohol reflux of adding 80% 2 times; Make a living for the first time 8 times of dose, 5 times of the doses of making a living for the second time extracted respectively 2 hours and 1 hour; Merge extractive liquid,, hold over night filters; Centrifugal (12000r/min) after-filtration reclaims ethanol, continues to concentrate to obtain Radix Paeoniae Alba extract.
The extraction of other medical material: above-mentioned other medical material mix homogeneously, extracting in water 2 times, for the first time amount of water is 8 times of crude drug; 2 hours extraction times, 6 times of the dose of making a living for the second time, 1.5 hours extraction times; Merge extractive liquid,, being concentrated into relative density is 1.10 (W/W), gets medicinal substances extract.
The preparation of syrup: get above-mentioned Radix Paeoniae Alba extract 5g, with other medicinal substances extract mix homogeneously of 0.46g; Add 20g white sugar, water dissolution continues to add adjusted volume to 100ml.
Embodiment 3
Take off and state medical material: Radix Angelicae Sinensis 67.5g, Rhizoma Chuanxiong 67.5g, Radix Paeoniae Alba 54g, Radix Rehmanniae Preparata 54g, Ramulus Uncariae Cum Uncis 135g, Caulis Spatholobi 135g, Spica Prunellae 135g, Semen Cassiae 135g, Concha Margaritifera 135g, Rhizoma Corydalis 67.5g, Herba Asari 14.5g;
The extraction of Rhizoma Chuanxiong: get 67.5g Rhizoma Chuanxiong medical material, with 8 times of 70% alcohol reflux 3 times, for the first time be 2 hours for the second time, be 1.5 hours for the third time, merge extractive liquid, filters, and reclaims ethanol, continue to concentrate Rhizoma Chuanxiong extract.
The extraction of other medical material: above-mentioned other medical material mix homogeneously, extracting in water 2 times, for the first time amount of water is 8 times of crude drug; 2 hours extraction times, 6 times of the dose of making a living for the second time, 1.5 hours extraction times; Merge extractive liquid,, being concentrated into relative density is 1.10 (W/W), gets medicinal substances extract.
The preparation of syrup: get above-mentioned Rhizoma Chuanxiong extract 5g, with other medicinal substances extract mix homogeneously of 0.46g; Add 20g white sugar, water dissolution continues to add adjusted volume to 100ml.
Embodiment 4
Take off and state medical material: Radix Angelicae Sinensis 67.5g, Rhizoma Chuanxiong 67.5g, Radix Paeoniae Alba 54g, Radix Rehmanniae Preparata 54g, Ramulus Uncariae Cum Uncis 135g, Caulis Spatholobi 135g, Spica Prunellae 135g, Semen Cassiae 135g, Concha Margaritifera 135g, Rhizoma Corydalis 67.5g, Herba Asari 14.5g;
The extraction of Rhizoma Chuanxiong medical material: get Rhizoma Chuanxiong medical material 67.5g, pulverize slightly, with 95% ethanol in Suo Shi reflux, extract, dress and middle reflux, extract, 9 hours: the solvent consumption is 8-10 times.Extracting solution is taken out turbid device sucking filtration with Bu Shi, sucking filtration liquid concentrating under reduced pressure as for, add suitable quantity of water again; Heating makes dissolving, sucking filtration, and filtrating is added on the macroporous resin column of having handled well (ratio of dried cream and resin is 1: 15); Water elution, reuse 70% ethanol elution is collected eluent; Reclaim ethanol, continue to concentrate Rhizoma Chuanxiong extract.
The extraction of other medical material: above-mentioned other medical material mix homogeneously, extracting in water 2 times, for the first time amount of water is 8 times of crude drug; 2 hours extraction times, 6 times of the dose of making a living for the second time, 1.5 hours extraction times; Merge extractive liquid,, being concentrated into relative density is 1.10 (W/W), gets medicinal substances extract.
The preparation of syrup: get above-mentioned Rhizoma Chuanxiong extract 5g, with other medicinal substances extract mix homogeneously of 0.46g; Add 20g white sugar, water dissolution continues to add adjusted volume to 100ml.
Embodiment 5
Take off and state medical material: Radix Angelicae Sinensis 67.5g, Rhizoma Chuanxiong 67.5g, Radix Paeoniae Alba 54g, Radix Rehmanniae Preparata 54g, Ramulus Uncariae Cum Uncis 135g, Caulis Spatholobi 135g, Spica Prunellae 135g, Semen Cassiae 135g, Concha Margaritifera 135g, Rhizoma Corydalis 67.5g, Herba Asari 14.5g;
The extraction of Radix Angelicae Sinensis medical material: take by weighing Radix Angelicae Sinensis powder 67.5g in flask; Expand behind the 24h (room temperature) with the distilled water preimpregnation, the lixiviate that refluxes (but electricity consumption stir to help soak), then with raw material and immersion at (50-60) ℃; 0.09MPa under the condition; Distilling under reduced pressure, the flow velocity of distillate (2-3) mL/min, distillate be about stop four of lixiviating solution/a period of time the distillation.Add the NaCl standing demix be equivalent to distillate quality 10% then, concentrate Radix Angelicae Sinensis extract.
The extraction of other medical material: above-mentioned other medical material mix homogeneously, extracting in water 2 times, for the first time amount of water is 8 times of crude drug; 2 hours extraction times, 6 times of the dose of making a living for the second time, 1.5 hours extraction times; Merge extractive liquid,, being concentrated into relative density is 1.10 (W/W), gets medicinal substances extract.
The preparation of syrup: get above-mentioned medicinal substances extract 5g, with other medicinal substances extract mix homogeneously of 0.46g; Add 20g white sugar, water dissolution continues to add adjusted volume to 100ml.
Claims (1)
1. a method for preparing of treating the syrup of headache is characterized in that, comprises the steps:
A, take off and state medical material: Radix Angelicae Sinensis 67.5g, Rhizoma Chuanxiong 67.5g, Radix Paeoniae Alba 54g, Radix Rehmanniae Preparata 54g, Ramulus Uncariae Cum Uncis 135g, Caulis Spatholobi 135g, Spica Prunellae 135g, Semen Cassiae 135g, Concha Margaritifera 135g, Rhizoma Corydalis 67.5g, Herba Asari 14.5g;
The extraction of b, Rhizoma Chuanxiong medical material: get Rhizoma Chuanxiong medical material 67.5g, pulverize slightly, with 95% ethanol reflux, extract, 9 hours in Suo Shi reflux, extract, device: the solvent consumption is 8-10 times, and extracting solution is taken out turbid device sucking filtration with Bu Shi; Sucking filtration liquid is evaporated to dried, adds suitable quantity of water again, and heating makes dissolving, sucking filtration; The ratio that filtrating is added to the dried cream handled well and resin is on 1: 15 the macroporous resin column, water elution, reuse 70% ethanol elution; Collect eluent, reclaim ethanol, continue to concentrate Rhizoma Chuanxiong extract;
The extraction of c, other medical material: above-mentioned other medical material mix homogeneously, extracting in water 2 times, for the first time amount of water is 8 times of crude drug; 2 hours extraction times, 6 times of the dose of making a living for the second time, 1.5 hours extraction times; Merge extractive liquid,, being concentrated into relative density is 1.10W/W, gets medicinal substances extract;
The preparation of d, syrup: get above-mentioned Rhizoma Chuanxiong extract 5g, with other medicinal substances extract mix homogeneously of 0.46g; Add 20g white sugar, water dissolution continues to add adjusted volume to 100ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100157210A CN1954862B (en) | 2005-10-28 | 2005-10-28 | Syrup for treating headache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100157210A CN1954862B (en) | 2005-10-28 | 2005-10-28 | Syrup for treating headache |
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| Publication Number | Publication Date |
|---|---|
| CN1954862A CN1954862A (en) | 2007-05-02 |
| CN1954862B true CN1954862B (en) | 2012-03-28 |
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| CN2005100157210A Expired - Fee Related CN1954862B (en) | 2005-10-28 | 2005-10-28 | Syrup for treating headache |
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| CN107929395B (en) * | 2017-12-12 | 2020-08-14 | 眉山碧丛生物技术有限公司 | Preparation method and application of uncaria extract |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593634A (en) * | 2004-06-25 | 2005-03-16 | 张晴龙 | Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593634A (en) * | 2004-06-25 | 2005-03-16 | 张晴龙 | Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process |
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