CN1943818A - A low frequency/small Power focusing ultrasonic therapeutic apparatus - Google Patents
A low frequency/small Power focusing ultrasonic therapeutic apparatus Download PDFInfo
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- CN1943818A CN1943818A CNA2005101059906A CN200510105990A CN1943818A CN 1943818 A CN1943818 A CN 1943818A CN A2005101059906 A CNA2005101059906 A CN A2005101059906A CN 200510105990 A CN200510105990 A CN 200510105990A CN 1943818 A CN1943818 A CN 1943818A
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Abstract
The invention comprises ultrasonic transducer, low-frequency power source, and the control circuit described above is connected ultrasonic transducer, the described ultrasonic transducer includes a sound head, which was set side of a focusing concave mirror. Through the focusing concave mirror, the low-frequency ultrasonic generated by ultrasonic transducer focuses and biological effects generated in focal area was restricted to certain position, not only focus the ultrasonic beam (targeted), reduce the required energy by two energy level change of one factor and the use of combinative micro vesicle, thus reduce injury risk of brain tissue, but also provides us a non-invasive, targeted thrombolytic, blood-brain barrier (BBB) opening and gene transfection of nerve cells therapy device, especially as a barrier to the blood-brain transmission of drugs and macromolecular in the central nervous system, and an important mean to enter the brain tissue.
Description
Technical field
The present invention relates to a kind of disease treatment apparatus, is a kind of low frequency/small Power focusing ultrasonic therapeutic apparatus specifically.
Technical background
Ultrasonic technique is applied to medical domain nearly half a century, is mainly used in the clinical diagnosis of breasts such as the heart, kidney, liver, abdominal distention device.Yet ultrasonic technique is applied to the research of central nervous system disease, and is actually rare as the research of the cerebral tumor and cerebrovascular disease therapy, and certain breakthrough is only just arranged in recent years.This except penetrate with ultrasound wave that the skull transmittance is low, outside the Pass high impedance has, its key issue also with high-energy ultrasonic relevant to the detrimental effect of cerebral tissue, therefore be the bottleneck that high energy is assembled the treatment of ultrasonic (HIFU) noinvasive intracranial disease always.In recent years along with further investigation and exploitation to hyperacoustic biological effect, people have recognized that hyperacoustic various biological effect is expected to breakthrough effect is played in the treatment of many intracranial diseases within the specific limits.Kudo in 1989 etc. find that external therapeutic ultrasound (ETUS) can increase the thrombolytic effect of streptokinase (blood vessel outside the cranium) in the thrombolytic experiment of Canis familiaris L. femoral artery segments; Nineteen ninety-five Vykhodtseva experimentation finds that first ETUS can open blood brain barrier, and very little to brain tissue impairment; Ali (2002) and Hynynen (2003) (wait by Ultrastructural observation, confirm HIFU open BBB momently, mainly be tight connection broadening between capillary endothelial cell and surface of cell membrane occur of short duration aperture (＜5um), and recover fully in a short time, this phenomenon has been considered to present plasmid DNA molecule and has entered optimal mode and the most promising approach in the born of the same parents by cell membrane.At the tumor vasa vasorum, utilize targeted microbubble to arrive tumor locus after, by low-yield low frequency ultrasound radiation, " shock " ripple that microbubble ruptures is produced directly destroys the integrity of blood capillary, the promotion blood vessel embolism; Simultaneously medicine, the genophore that carries can be entered into tumor locus by the blood vessel wall of breakage again.This research group (2003) is used low-frequency ultrasonic waves combining ultrasonic microbubble contrast agent radiation rat calvarium portion and is observed ultrasonic biological effect to brain recently, has confirmed that also low frequency ultrasound has the good tissue penetrance, can see through skull; Can cause of short duration cerebral microvascular gap edema at the ultrasonic of certain energy through cranium and microvesicle associating.The cavitation effect that ultrasonic-mediated microbubble contrast agent produces can make high molecular weight protein obviously improve or the like by the transfection and the expression rate of cell membrane and gene, further expands and has deepened hyperacoustic application.
The therapeutic ultrasound technology mainly is by direct ultrasonic in the blood vessel and the ultrasonic two kinds of methods of percutaneous.The effect of two kinds of methods is all relevant with the acoustical power in ultransonic frequency, burnt territory and radiated time etc.As: the experiment of intravascular ultrasound thrombolytic can successfully obtain revascularization, and the low frequency that mostly is 20～45kHZ of its use is high-strength ultrasonic.But the method has certain damage to blood vessel wall, and has relatively high expectations, and still can not reach at present as the technology of the generator of microminiaturized, corner.And find in the ultransonic experimentation of percutaneous, though, can obtain different therapeutic effect by changing ultransonic parameter setting, but it is ultrasonic to use high frequency or high strength to assemble mostly in former experiments and design, the energy that is produced is big, and focus is too little, and active area efficient is low.And mainly be to utilize hyperacoustic building up principle, act on a certain target area in the body, make the hurried rising of temperature in the target area, arrive therapeutic purposes by heat effect.Although a large amount of external and zooperal results shows that HIFU can promote fibrinous dissolving preferably, for clinical application provides a new therapy that has a extensive future, but the utilization of high-frequency ultrasonic in intracranial disease is subjected to great restriction, wherein biggest obstacle is absorption and the impedance of skull to sound wave, it is very limited that HIFU passes the transmittance of skull, thereby limited its utilization in cerebrovascular disease.Use the zoopery of HIFU to find to cause brain tissue impairment easily and cause hematoblastic gathering and fibrinous deposition on the other hand, thereby cause the obturation of blood vessel.Therefore the ultrasonic therapeutic instrument that does not still have real practical application central nervous system disease at present both at home and abroad.
Summary of the invention
The present invention has overcome above-mentioned shortcoming, proposes strong, little to the injury of human low frequency/small Power sonicator of a kind of penetrance.
The present invention solves the technical scheme that its technical problem takes: comprise ultrasonic transducer, low frequency power source, described control circuit links to each other with described ultrasonic transducer, and described ultrasonic transducer comprises sound head, and described sound head is arranged on a side of a focusing concave mirror.
Also can be provided with a water filling sacculus on the described sound head.
Described low frequency power source can comprise power circuit, regulating and controlling circuit, power oscillating circuit, described power circuit links to each other with the regulating and controlling circuit with described power oscillating circuit respectively, the outfan of described regulating and controlling circuit links to each other with described power oscillating circuit, the described ultrasonic transducer of the connection of described power oscillating circuit.
Described ultrasonic transducer also can comprise feedback circuit, and the outfan of described power oscillating circuit links to each other with described sound head, and described feedback circuit outfan links to each other with described power oscillating circuit.
Described power oscillator can comprise a variable resistance, an electric capacity and two audions.
The burnt territory of described focusing area can be three times of wavelength.
The output of described low-frequency oscillatory network can be 20～500Hz.
Described sound head diameter can be 40～80mm, focuses on burnt territory, back area and can be 0.5cm
2
Described sound head output can be 0.2～2W/CM
2, corresponding focus point power can be 1～22W/CM
2
The present invention includes ultrasonic transducer, low frequency power source, described control circuit links to each other with described ultrasonic transducer, and described ultrasonic transducer comprises sound head, and described sound head is arranged on a side of a focusing concave mirror.Pass through focusing concave mirror, the low frequency excusing from death ripple of described ultrasonic transducer generating is focused on, and the biological effect that produces at Jiao Yuchu is limited to a certain position, not only ultrasonic beam is assembled (having targeting), and two energy levels passing through a factor change and the use of associating microvesicle, reduce the required energy of ultrasound wave, thereby lowered the risk of brain tissue impairment, also provide a kind of noninvasive for us, the thromboembolism of targeting, the therapy equipment of the gene transfection of blood brain barrier (BBB) opening and neurocyte, especially a kind of transmission medicine of central nervous system or macromolecular substances be can become and blood brain barrier, the important means that enters cerebral tissue crossed over; Also realize simultaneously ultrasonic blood brain barrier or open, the auxiliary microinvasion intracranial hematoma of bloodtumorbarrier (BTB) or the further treatment of improving and enriching intracranial disease of thrombolytic treatment technology that can mediate with microvesicle.
Description of drawings
Fig. 1 is a medium and low frequency power source block diagram of the present invention
Fig. 2 is power oscillating circuit schematic diagram among the present invention
Fig. 3 is a sound head part-structure sketch map of the present invention
The specific embodiment
Comprise low frequency power source and the ultrasonic transducer that links to each other with described low frequency power source among the present invention, described low frequency power source comprises power circuit, regulating and controlling circuit, power oscillating circuit, ultrasonic transducer as shown in fig. 1.
Described power circuit comprises a transformation rectification circuit that is used for alternating current power supply is converted into low-voltage direct output, comprise that also the output with described transformation rectification circuit links to each other, be used for the output of described transformation rectification circuit is converted into the DC-stabilized circuit of the stable dc power supply of three groups of different electric pressures.Described regulating and controlling circuit comprises the gear control circuit that is used to control ultrasound wave output intensity (being power), is used to control the ultrasound wave output time control circuit of action time, and respectively with described gear control circuit gear display circuit that links to each other and the time display circuit that links to each other with time control circuit.Described power oscillating circuit is used to produce the oscillator signal of required frequency, frequency of oscillation is 500Hz in the present embodiment, and output to the sound head input of the ultrasonic transducer that links to each other with described power oscillating circuit, produce the ultrasound wave of corresponding 500Hz, receive feedback signal at feedback end and transfer back in the described power oscillator by described ultrasonic transducer.Three outfans of described D.C. regulated power supply are according to the job demand of different circuit, be connected respectively in described power oscillator, gear control circuit, the time control circuit, and the power end that links to each other with described gear control circuit also links to each other with time control circuit with described power oscillator simultaneously.
Described power oscillating circuit as shown in Figure 2, by comprising crystal oscillator X1, capacitor C 1, C2, the amplifying circuit that oscillating circuit that variable resistance R1 constitutes and two-stage audion constitute constitutes, the two ends of described crystal oscillator X1 respectively with described capacitor C 1, the C2 series connection, described variable resistance R1 connects with another resistance R 2 afterwards and described capacitor C 1, C2 and crystal oscillator X1 be in parallel the other end of described capacitor C 2 with by Q1, the equivalent base stage of the two-stage audion that Q2 constitutes links to each other, the equal set electrode is through passing through resistance R 4 respectively, export behind the R5, described equivalent emitter stage is through inductance L 1, ground connection behind the L2, the other end of the other end of described resistance R 5 and inductance L 1 is parallel with another capacitor C that plays filter action 4.Described variable-resistance adjusting is used for adjusting different output frequencies according to different needs.
As shown in Figure 3, sound head 1 in the described ultrasonic transducer is fixedly installed on a side that focuses on crystal concave mirror 5, piezoelectric patches 2 in the described sound head links to each other with power oscillating circuit in the described low frequency power source by lead 3, and described sound head and focusing concave mirror 5 together are arranged in the water filling sacculus 6.Described sound head diameter is 60mm, and piezoelectric patches produces frequency on sound head under the control of power oscillating circuit be that 500Hz, wavelength are the ultrasound wave of 1.6mm, and described ultrasound wave forms area 0.5cm by the focusing of described focusing concave mirror 5
2The burnt territory 4 of focusing, focuses on burnt territory by this thrombosis position in skull is shone, thereby edge of a body of water is seen the non-invasive treatment of intracranial disease.Adjustment control ultrasonic power by described gear control circuit is 0.2～2W/CM
2, make focus point power reach 1～22W/CM
2Lower power can reduce ultrasound wave to brain tissue injury.Described sound head places the water filling sacculus, is used to reduce the injury that temperature that ultrasound wave produces causes local skin.
Among the present invention, utilize low-frequency ultrasonic waves, supersonic frequency is controlled between 20～500kHz, ultrasonic frequency is low more, and is strong more to the penetrance of skull, few more at the ultrasound wave of skull boundary reflection.Simultaneously by improving ultrasound emission and accumulation mode, with accurate gathering and the suitable burnt territory acoustical power that reaches intracranial.
The present invention is respectively 1,2,4 and 8W/cm in conjunction with mensuration 1MHZ ultrasound wave such as foreign scholar BLINC in intensity
2The time tissue absorb temperature behind the ultrasonic heat energy and raise and be respectively 1.3 ℃, 2.1 ℃, 3.6 ℃ and 6.5 ℃.Ultrasonic frequency is low more, and is strong more to the penetrance of skull, few more at the ultrasound wave of skull boundary reflection, and most of intensity that adopts is controlled at 3W/cm usually
2In, therefore, be used for hydrotropy, cell membrane is penetrating and the acoustical power in the burnt territory of the gathering ultrasound wave of open blood brain barrier is low, mainly is to utilize the ultrasonic cavitation effect, acoustic horn effect, rather than heat effect.Although local temperature has certain rising, being unlikely to has the infringement of burning to tissue.For reduce of the injury of the temperature of rising as far as possible, when operating, we can may play certain cooling effect between ultrasonic probe and scalp at interval with the water filling sacculus to local skin.Behrens etc.
5Ultrasound wave (2W/cm with 185KHz
2) the blood brain barrier prolonged exposure of rat after 90 minutes, there is not to find to have the sign of infringement or thermal burn, this has illustrated that also the utilization that the hydrotropy of low frequency/small Power ETUS acts on the cerebrovascular aspect is safely and effectively.
More than low frequency/small Power focusing ultrasonic therapeutic apparatus provided by the present invention is described in detail, used specific case herein principle of the present invention and embodiment are set forth, the explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof; Simultaneously, for one of ordinary skill in the art, according to thought of the present invention, the part that all can change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.
Claims (9)
1. low frequency/small Power focusing ultrasonic therapeutic apparatus, it is characterized in that: comprise ultrasonic transducer, low frequency power source, described control circuit links to each other with described ultrasonic transducer, and described ultrasonic transducer comprises sound head, and described sound head is arranged on a side of a focusing concave mirror.
2. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 1 is characterized in that: also be provided with a water filling sacculus on the described sound head.
3. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 1 and 2, it is characterized in that: described low frequency power source comprises power circuit, regulating and controlling circuit, power oscillating circuit, described power circuit links to each other with the regulating and controlling circuit with described power oscillating circuit respectively, the outfan of described regulating and controlling circuit links to each other with described power oscillating circuit, the described ultrasonic transducer of the connection of described power oscillating circuit.
4. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 3, it is characterized in that: described ultrasonic transducer also comprises feedback circuit, the outfan of described power oscillating circuit links to each other with the sound head of described ultrasonic transducer, and described feedback circuit outfan links to each other with described power oscillating circuit.
5. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 3 is characterized in that: described power oscillator comprises a variable resistance, an electric capacity and two audions.
6. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 1 and 2 is characterized in that: the burnt territory of described focusing area is three times of wavelength.
7. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 3 is characterized in that: the output in described low frequency power source is 20～500Hz.
8. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 1 and 2 is characterized in that: described sound head diameter is 40～80mm, and focusing on burnt territory, back area is 0.2～0.8cm
2
9. low frequency/small Power focusing ultrasonic therapeutic apparatus according to claim 1 and 2 is characterized in that: described sound head output is 0.2～2W/CM
2, being directed to skull, corresponding focus point power is 1～22W/CM
2
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101059906A CN100542636C (en) | 2005-10-08 | 2005-10-08 | Low frequency/small Power focusing ultrasonic therapeutic apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101059906A CN100542636C (en) | 2005-10-08 | 2005-10-08 | Low frequency/small Power focusing ultrasonic therapeutic apparatus |
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| CN1943818A true CN1943818A (en) | 2007-04-11 |
| CN100542636C CN100542636C (en) | 2009-09-23 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102232857A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Nondestructive focused ultrasound coronary artery in-vitro thrombus dissolving system |
| CN102232856A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Double-frequency ultrasonic multi-dimensional focused cerebrovascular thrombolytic system |
| CN101670143B (en) * | 2008-09-11 | 2012-03-07 | 姚广权 | Medical infusion device |
| CN103505820A (en) * | 2012-06-27 | 2014-01-15 | 洛阳康立医疗器械有限公司 | Transcranial ultrasonic therapeutic apparatus |
| CN111112037A (en) * | 2020-01-20 | 2020-05-08 | 重庆医科大学 | Lens type multi-frequency focusing ultrasonic transducer, transduction system and method for determining axial length of acoustic focal region of lens type multi-frequency focusing ultrasonic transducer |
| CN115337077A (en) * | 2022-07-22 | 2022-11-15 | 广东博迈医疗科技股份有限公司 | Ultrasonic control circuit, electronic device and ultrasonic balloon catheter |
-
2005
- 2005-10-08 CN CNB2005101059906A patent/CN100542636C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670143B (en) * | 2008-09-11 | 2012-03-07 | 姚广权 | Medical infusion device |
| CN102232857A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Nondestructive focused ultrasound coronary artery in-vitro thrombus dissolving system |
| CN102232856A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Double-frequency ultrasonic multi-dimensional focused cerebrovascular thrombolytic system |
| CN103505820A (en) * | 2012-06-27 | 2014-01-15 | 洛阳康立医疗器械有限公司 | Transcranial ultrasonic therapeutic apparatus |
| CN111112037A (en) * | 2020-01-20 | 2020-05-08 | 重庆医科大学 | Lens type multi-frequency focusing ultrasonic transducer, transduction system and method for determining axial length of acoustic focal region of lens type multi-frequency focusing ultrasonic transducer |
| CN115337077A (en) * | 2022-07-22 | 2022-11-15 | 广东博迈医疗科技股份有限公司 | Ultrasonic control circuit, electronic device and ultrasonic balloon catheter |
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| Publication number | Publication date |
|---|---|
| CN100542636C (en) | 2009-09-23 |
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