CN1942754A - Optical element and optical measurement device using the same - Google Patents
Optical element and optical measurement device using the same Download PDFInfo
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- CN1942754A CN1942754A CN 200680000139 CN200680000139A CN1942754A CN 1942754 A CN1942754 A CN 1942754A CN 200680000139 CN200680000139 CN 200680000139 CN 200680000139 A CN200680000139 A CN 200680000139A CN 1942754 A CN1942754 A CN 1942754A
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Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
It is possible to form a groove to be in contact with a sample without subjecting an optical element material to machining or etching and provide an optical element not lowering the optical measurement accuracy by light scattering by the groove. The optical element is formed by a light irradiation prism having a light emission surface from which light is emitted to irradiate the sample, a light reception prism having a light reception surface for receiving light fed back from the sample, and a light reduction unit arranged between the light irradiation prism and the light reception prism. By combination of the light irradiation prism and the light reception prism, a concave portion with which the sample is brought into contact is formed and the light emitted from the light emission surface is introduced to the light reception surface by direct proceeding through the sample in contact with the concave portion.
Description
Technical field
Thereby the present invention relates to a kind of be used for optical mode measure bio-tissue or solution equal samples measure sample glucose, cholesterol, urea or triglyceride etc. concentration optical element and used the optical detecting device of this optical element.
Background technology
Propose various optical elements and optical detecting device at present, be used for measuring the special component in bio-tissue or the solution.For example, in the open 01/58355A1 in the world, propose a kind of optical element that makes the bio-tissue contact have ditch portion, utilized the difference of the refractive index of ditch portion and bio-tissue to ask for the method for the information of biosome inside.
Here, Fig. 8 is the existing structural drawing with optical element of ditch portion that is proposed among the international open 01/58355A1.Arrow among Fig. 8 is represented from the path of the light of light source 44 ejaculations.The light (the arrow X among Fig. 8) of side surface part 42a of injecting the ditch portion 42 of optical element 41 passes behind the bio-tissue 48 from the side, and the 42b of portion penetrates.Utilize detecting device etc. that this emergent light is detected, just can obtain the information of bio-tissue.
Summary of the invention
The problem that the present invention attempts to solve
The ditch portion 42 of above-mentioned such existing optical element directly forms on the plane of optical element material therefor by machining such as plane lapping or ultrasonic machining or etching etc., but, the existing problem of these methods is, in formed ditch portion 42, produce damage easily, be difficult to obtain level and smooth machined surface, and be difficult to be processed into predetermined shape.
For example, ditch portion 42 shown in Figure 8 is to be the grinding stone rotation of V-shape by making machined surface, and it is pressed against is processed into V-shape on the plane of optical element material therefor.This method can cause machining precision and surfaceness directly to be subjected to the influence of the precision of grinding stone shape, and along with the wearing and tearing of grinding stone, the degree of depth of ditch portion 42 and shape can change, and surfaceness increases, and is difficult to accurately predetermined shape is processed in ditch portion 42.In addition, after the surfaceness that the degree of depth and the shape of ditch portion 32 changes, processes increased, actual light path will depart from designed path, and light on the surface of ditch portion 42 scattering takes place, and caused measuring precision and reduced.
Further, the light of coming from light source 44 irradiation all is directional light generally, but is not directional light completely.Therefore, the light (the arrow Z among Fig. 8) of the light (the arrow Y among Fig. 8) after the bottom surface of ditch portion 42 42c reflection, the reflection of the face beyond ditch portion 42 and do not inject the light (not shown) that bio-tissue 48 penetrates and wait these unnecessary light also can be detected simultaneously with above-mentioned smooth X after the internal reflection of plane of incidence 42a and optical element 42 causes measuring precise decreasing.
Therefore, the present invention has used for reference above-mentioned existing issue, and purpose is to provide a kind of by easy and easy method can either form, have again simultaneously the optical element of good mensuration precision and the optical detecting device that has used the high reliability of this optical element simply.
The problem solution
Optical element of the present invention possesses:
Light irradiation prism, it has light-emitting face, and the light that shines on the sample penetrates from this exit facet;
The light-receiving prism, it has light receiving surface, and the light that returns from above-mentioned sample is received by this light receiving surface;
Light intensity reduction portion is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism,
Above-mentioned light irradiation prism and above-mentioned light-receiving prism are combined, formed and the contacted recess of above-mentioned sample,
The light that penetrates from above-mentioned light-emitting face is injected above-mentioned light receiving surface advancing with the contacted above-mentioned sample cathetus of above-mentioned recess.
Here, " the light intensity reduction portion " among the present invention refers to the parts or the part of the function with the light quantity minimizing that makes the light that is passed.In addition, the light quantity that said among the present invention " dim light " refers to emergent light when light is mobile between more than or equal to 2 kinds of media reduces to some extent with respect to the light quantity of incident light, and the light quantity that promptly sees through reduces.For example, thereby this comprises following situation: (i) by changing the refractive index (reflectivity) between the medium the light quantity that minimizing sees through; And (ii) reduce the light quantity that sees through by light being tackled (for example reflection or absorption etc.).
In addition, optical detecting device of the present invention possesses:
Above-mentioned optical element of the present invention;
In order to make light shine above-mentioned sample and to the irradiant light source of above-mentioned light irradiation prism from above-mentioned light irradiation prism;
The photodetector that the light that turns back to above-mentioned light-receiving prism from above-mentioned sample is detected.
The effect of invention
By means of the present invention, can easily form optical element with recess, can obtain to suppress the optical element of the mensuration precise decreasing that unnecessary light caused such as reflected light of optical element inside.
In addition, by means of optical element of the present invention, can be easily and realize the optical detecting device of high reliability easily.
Description of drawings
Fig. 1 is the figure of structure of the optical detecting device of expression the 1st embodiment of the present invention.
Fig. 2 is that expression utilizes the optical detecting device of Fig. 1 to measure the performance plot of the wavelength characteristic of penetration-detection light quantity under the situation of the penetration-detection light quantity of pointing.
Fig. 3 is the figure of deformed configurations of the optical detecting device of expression the 1st embodiment of the present invention.
Fig. 4 is the figure of structure of the optical detecting device of expression the 2nd example of the present invention.
Fig. 5 is the figure of structure of the optical detecting device of expression the 3rd example of the present invention.
Fig. 6 is the figure of structure of the optical detecting device of expression the 4th example of the present invention.
Fig. 7 is the figure of structure of the optical detecting device of expression the 5th example of the present invention.
Fig. 8 is the structural drawing that has with the existing optical element of the contacted ditch of sample portion.
Embodiment
Optical element of the present invention possesses: light irradiation prism, and it has light-emitting face, and the light that shines on the sample penetrates from this exit facet; The light-receiving prism, it has light receiving surface, and the light that returns from above-mentioned sample is received by this light receiving surface; Light intensity reduction portion is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism, it is characterized in that,
Above-mentioned light irradiation prism and above-mentioned light-receiving prism are combined, and have formed and the contacted recess of above-mentioned sample, and the light that penetrates from above-mentioned light-emitting face is injected above-mentioned light receiving surface advancing with the contacted above-mentioned sample cathetus of above-mentioned recess.
By means of this structure, can reduce and pass light irradiation prism but do not pass the light quantity of injecting the light-receiving prism among the light of sample.That is, can reduce the light quantity of not passing sample among the light that has passed light irradiation prism and injecting the light-receiving prism.In addition, can suppress unnecessary light and arrive the photodetector that is described below, can suppress to measure the decline of precision effectively.
In addition, after each face of the light irradiation prism that constitutes recess and light-receiving prism processed,, therefore, after forming recess, do not need recess surface is smoothly processed by the recess that is combined to form of rayed element and light-receiving prism.Therefore, can easily form the recess of surface smoothing, can obtain not can be because of light in the scattering of recess and cause the optical element of optical detecting precise decreasing.
Above-mentioned recess can be by for example making up the machined surface of flat shape and constituting at an easy rate.In addition, also can utilize disclosed technology utilization to form above-mentioned recess by composite planes that a plurality of plane constituted such as stairsteppings.In addition, also can make up and form above-mentioned recess curved surface.
In addition, form, therefore, process with the bottom of high precision especially easily recess owing to above-mentioned recess makes up it after light irradiation prism and light-receiving prism are processed into reservation shape.
Above-mentioned light intensity reduction portion also can be arranged on the clearance portion between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
By means of this structure, because the refractive index of light irradiation prism and light-receiving prism is different with the refractive index of clearance portion, on each interface, reflected light can be produced, therefore, the light quantity of not passing sample among the light that passes light irradiation prism and injecting the light-receiving prism can be reduced.In addition, can suppress unnecessary light and arrive the photodetector that is described below, can suppress to measure the decline of precision effectively.
In addition, above-mentioned light intensity reduction portion also can be arranged on the light shielding part between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
By means of this structure, utilize the light shielding part be arranged between light irradiation prism and the light-receiving prism, can tackle the light that does not pass sample among the light that passes light irradiation prism and inject the light-receiving prism.In addition, can suppress unnecessary light and arrive the photodetector that is described below, can suppress to measure the decline of precision effectively.
Further, optical element of the present invention preferably possesses the spacer that is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
By means of this structure, thereby change distance between light irradiation prism and the light-receiving prism, can easily adjust locating of depth direction in the sample by the thickness that changes spacer.As enlarge distance between rayed element and the light receiving element, and then the recess that sample contacted is more deep, and its result just can measure the position of going deep into of sample.Otherwise if dwindle distance between rayed element and the light receiving element, then sample is difficult to go deep into recess, consequently can measure the skin section of sample.
In addition, spacer can use with above-mentioned light intensity reduction portion identical materials and constitute.For example, if the material that uses refractive index to be lower than light irradiation prism and light-receiving prism forms spacer, just can make this spacer possess identical effect with above-mentioned light intensity reduction portion.
Preferably, the above-mentioned light-emitting face of above-mentioned light irradiation prism is the 1st plane rake that contacts with above-mentioned sample, the above-mentioned light receiving surface of above-mentioned light-receiving prism is the 2nd plane rake that contacts with above-mentioned sample, above-mentioned the 1st rake and above-mentioned the 2nd rake be mutually in the face of forming above-mentioned recess, and above-mentioned recess with above-mentioned the 1st rake direction vertical with above-mentioned the 2nd rake on the section shape that roughly is in the shape of the letter V.
By means of this structure, after respectively the 1st rake and the 2nd rake being carried out optical grinding, the 1st rake and the 2nd rake are changed to relative position, form the recess of the V-shape of contact sample, therefore, obtain having smooth surface and the very high recess of optical accuracy at an easy rate.In addition, be under the situation of V-shape when recess shapes, sample is fixing easily, can stablize optical path length.
Further, optical element of the present invention preferably possesses covering, and this covering is covered with the part of above-mentioned recess and combines with above-mentioned light irradiation prism and above-mentioned light-receiving prism and forms sample preservation portion.This covering can and make top the opening wide of above-mentioned recess and the 1st the hiding and the 2nd hide and constitute of configuration by the side of the side that is covered with above-mentioned light irradiation prism for example, above-mentioned smooth outgoing prism.
By means of this structure, because the side of recess is surrounded by light irradiation prism, light-receiving prism and covering, therefore,, also can in recess, preserve firmly sample with sample preservation portion function even sample is a liquid condition, it can not spilt.
Further, optical element of the present invention preferably possesses adjustment unit, is used for adjusting the distance between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
By means of this structure, can change the distance of light irradiation prism and light-receiving prism easily and easily, can be easier and adjust locating of sample depth direction easily.If enlarge the distance between light irradiation prism and the light-receiving prism, the recess that sample contacted is more deep, and its result just can measure the position of going deep into of sample.Otherwise if dwindle distance between rayed element and the light receiving element, then sample is difficult to go deep into recess, consequently can measure the skin section of sample.
Optical detecting device of the present invention is characterised in that it possesses: above-mentioned optical element of the present invention; In order to make light shine above-mentioned sample and to the irradiant light source of above-mentioned light irradiation prism from above-mentioned light irradiation prism; The photodetector that the light that turns back to above-mentioned light-receiving prism from above-mentioned sample is detected.
By means of this structure,, can provide a kind of optical detecting device of high reliability with easy and easy method by using the optical element of the invention described above.
Optical detecting device of the present invention preferably possesses the beam splitter that is configured between above-mentioned light-receiving prism and the above-mentioned photodetector.
By means of this structure, can only will measure required light more effectively and send to photodetector, improve and measure precision.
Below, present invention will be described in detail with reference to the accompanying representational embodiment.But, in the following description, give identical symbol, sometimes omit its repeat specification for identical or suitable part.
In addition, what below Shuo Ming embodiment was represented is an example of the present invention, the present invention is not constituted qualification.
[the 1st embodiment]
Fig. 1 is the figure of structure that the optical detecting device (component concentration measuring device) of the optical element (measuring element) in the 1st embodiment of the present invention has been used in expression, and the arrow among the figure is represented light path.Optical element at first is described below.
As shown in Figure 1, optical element 12 with to the light irradiation prism 13 of illumination of sample light and the light-receiving prism 14 that is used for receiving the light that returns from sample be combined into one and constitute, formed the recess 15 that is used for contacting sample between light irradiation prism 13 and the light-receiving prism 14.In addition, in the present embodiment, formed between light irradiation prism 13 and the light-receiving prism 14 and be used for the light shielding part of between interception light as light intensity reduction portion 19.
Before light irradiation prism 13 and light-receiving prism 14 are coupled together, to carry out optical grinding respectively, therefore, can make the 1st rake 13a and the 2nd rake 14a become level and smooth at an easy rate the 1st plane rake 13a and the 2nd rake 14a.Therefore, can obtain having the recess 15 of high optical accuracy face at an easy rate.
In addition, the optical element 12 of present embodiment can be decomposed into light irradiation prism 13 and light-receiving prism 14, therefore, compares with existing nondecomposable optical element (with reference to Fig. 8), easily recess is cleaned.
The constituent material of light irradiation prism 13 and light-receiving prism 14 can use the well-known material in this field.
Under the situation that the material that absorption peak is positioned at mid infrared region is measured, can use silicon, germanium, SiC, adamas, ZnSe, ZnS or KrS etc.
Just as absorption peak is wave number 1033cm
1And 1080cm
1Glucose such, under the situation that the material that absorption peak is positioned at mid infrared region is measured, consider that its infrared wavelength is about 9～10 microns, transmissivity height and processability is good, physical strength is high, therefore preferred silicon or the germanium of using.
In addition, under the situation that the material that absorption peak is positioned near infrared region is measured, can use fused quartz, monocrystalline silicon, optical glass or transparent resin etc.
Light intensity reduction portion 19 in the present embodiment is for example membranaceous, sheet, tabular or bar-shaped light shielding part, it function that possesses be prevent to pass do not arrive among the light of light irradiation prism recess light---the light that does not promptly pass sample is injected the light-receiving prism.
Preferred absorbing film or the dielectric multilayer films such as metallic reflective coating, Cr or tusche such as Al, Cu or Ag of using in the light shielding part.Also can use the multilayer film that forms by metal level and dielectric layer.The film build method of light shielding part in this case uses well-known methods such as vacuum vapour deposition, sputtering method or CVD method to get final product.In addition, both can be on the surface of light irradiation prism 13 or light-receiving prism 14 direct film forming, also can on two prisms, after the film forming they be coupled together respectively.
In addition, above-mentioned light shielding part also can use for example aluminium foil or Cu sheet metal etc. except using the plate that material constituted by above-mentioned film.Both can be on light irradiation prism 13 or light-receiving prism 14 directly paste sheet metal, both are glued together after also can on two prisms, pasting sheet metal respectively.
Further, above-mentioned light shielding part also can use the plate that the material by above-mentioned film or above-mentioned plate constitutes.
Utilization has the optical detecting device that the optical element 12 of the present embodiment of structure as mentioned above just can be produced present embodiment.The optical detecting device of present embodiment possesses: optical element 12, send light light source 11, the light that returns from sample via light-receiving prism 14 is carried out the beam splitter 16 of beam split and the photodetector 17 that the light that passes beam splitter 16 is detected.Utilize the high optical element of above-mentioned optical accuracy 12 just can improve the mensuration precision, obtain high reliability.
In addition, light intensity reduction portion 19 has prevented that the above-mentioned light that does not pass sample from injecting the light-receiving prism, and the unnecessary light that light that therefore, do not pass sample, reflects from the face that forms recess and light source send can not arrive photodetector 17.Therefore, improved the S/N ratio of optical detecting device.
Here, light source 11 is so long as comprise light as the absorbing wavelength of the mensuration composition of determination object, and its optional scope is not special to be limited.
For example, if the light of mid infrared region can use and for example SiC be sintered into bar-shaped Ge Luoba light source (a Globar light source), CO
2Laser instrument, tungsten lamp, infrared pulse light source or QCL light source etc.
Have under the situation that the material of strong absorption peak measures in mid infrared region such to glucose, preferably use for example Ge Luoba light source, infrared pulse light source or QCL light source.
In addition, under the situation that the material that absorption peak is positioned near infrared region is measured, can use for example halogen light source, semiconductor laser or LED etc.As everyone knows, also there is absorption peak not only in mid infrared region in glucose near infrared region, preferably uses used Distributed Feedback Laser of for example LED optical communication or DBR laser instrument.
Can use for example optical grating element or optical filter element etc. in the beam splitter 16.In addition, also can use FT-IR or laser instrument beam split etc.In addition, the position of beam splitter is not particularly limited.
In addition, can use the well-known material in this field in the photodetector 17.For example, thermoelectric pickup or thermoelectric pile, thermistor, MCT detecting device (quantum type detecting device a kind of---HgCdTe detecting device) have been used in mid infrared region.Used sensor array of for example InGaAs detecting device, photodiode, PbS detecting device, InSb detecting device, InAs detecting device or these detecting devices etc. near infrared region.
Illustrate that then the optical detecting device that utilizes in the invention described above carries out the assay method of component concentration measuring.The situation that the bio-tissue of finger is measured is described here.
At first, finger 18 pressing pasters are come to the recess 15 of optical element 12.At this moment, as shown in Figure 1, applying light can make finger 18 be absorbed in recess 15.Then, make irradiate light to finger 18 be absorbed in part after, the light that penetrates from light source 11 arrives the light irradiation prism 13 of optical element 12, and the light that arrives light irradiation prism 13 can arrive recess 15 or the light shielding part 19 that is located at optical element 12.
Then, the light of arrival light intensity reduction portion 19 is absorbed or reflects, so that it does not inject light-receiving prism 14.The light refractive index difference owing to light irradiation prism 13 and finger 18 from recess 15 ejaculations time that arrives recess 15 reflects, and passes finger 18.
On the other hand, the light that passes finger 18 is injected light-receiving prism 14.Because light advances along above-mentioned path, light-receiving prism 14 just can receive the most of light that advances at finger 18 cathetuss at an easy rate, and the light that passes light-receiving prism 14 then arrives photodetector 17 via beam splitter 16.According to photodetector 17 detected light, just can calculate for example parameter of bio-tissue such as concentration of glucose.
The not special restriction of the transmission distance of light in finger 18 can be set at for example about 1～2mm.In addition, by the 1st rake and the not special restriction of the formed angle of the 2nd rake, can be set at for example 90 degree in the recess 15.
Here, light is with respect to as the decisions such as refractive index by shape, light irradiation prism 13 and the light-receiving prism 14 of recess 15 of the incident angle of the finger 18 of sample.The refractive index of light irradiation prism 13 and light-receiving prism 14 is preferably greater than the refractive index of sample.When measuring, preferably make the light that passes sample arrive photodetector 17 as much as possible, therefore, preferably not only will consider the refractive index of optical element 12, and the refractive index that will consider sample is set the shape of recess 15 and the light incident angle with respect to finger 18.
In addition, beam splitter 16 for example can only make constituent concentration detect necessary transmittance to go over.Calculate constituent concentration according to photodetector 17 detected photometries.That is, heterogeneity can make the light of specific wavelength be absorbed and reduce, and this dim light amount depends on constituent concentration, so constituent concentration can calculate according to the dim light amount.
Then, in Fig. 2, express result's the example that the optical detecting device that utilizes the invention described above is measured the bio-tissue of finger 18.Transverse axis is represented wavelength, and the longitudinal axis is represented the arbitrary value of detected light quantity.In addition, A represents to point 18 signatures and comes to recess measurement result before, and B represents to point 18 measurement results of giving as security when coming to recess.
By these results as can be known, give as security armrest refer to 18 o'clock frequency spectrum with give as security armrest and refer to that frequency spectrum before 18 is compared and alter a great deal.This be because, the major part of the light that light source 11 sends is pointed blood constituent such as water, glucose, neutral fat and the cholesterol in 18 and constituted the various of finger 18 becomes branch to absorb, light quantity reduces.For example, 1.4 microns light is reduced in a large number, and the absorption spectrum of this and water is suitable, has moisture in the expression biosome.
In addition, Fig. 3 is the figure of deformed configurations of the optical detecting device of expression present embodiment.This distortion is to be used for measuring the constituent concentration of solution or liquid equal samples liquid, except possessing the light source identical with Fig. 1 11, optical element 12, light irradiation prism 13, light-receiving prism 14, recess 15, beam splitter 16 and photodetector 17, optical element 12 further has the 1st and measures covering 20a and the 2nd mensuration covering 20b.
The 1st mensuration hides 20a and the 2nd mensuration covering 20b opens wide the top of recess 15, and the while is covered with light irradiation prism 13 and light-receiving prism 14 again.
That is, recess 15 is measured by the 1st rake 13a, the 2nd rake 14a, the 1st and is hidden 20a and the 2nd mensuration covering 20b encirclement, has the sample preservation portion function of preserving sample liquid 21.Therefore, sample liquid 21 can be kept in the recess 15, can not spill.
By means of this structure, only need so the structure of Fig. 1 to be appended this mensuration in this distortion and hide, just can measure the composition of sample liquid at an easy rate.
[the 2nd embodiment]
Fig. 4 is the figure that the structure of the optical detecting device (component concentration measuring device) in the 2nd embodiment of the present invention of optical element of the present invention (measuring element) has been used in expression, and the arrow among the figure is represented light path.Optical element at first is described below.
As shown in Figure 4, optical element 12 with to the light irradiation prism 13 of illumination of sample light and the light-receiving prism 14 that is used for receiving the light that returns from sample be combined into one and constitute, formed the recess 15 of the shape that roughly is in the shape of the letter V that is used for contacting sample between light irradiation prism 13 and the light-receiving prism 14.In addition, in the present embodiment, be provided with light intensity reduction portion 19 between light irradiation prism 13 and the light-receiving prism 14, it has stipulated the distance between light irradiation prism 13 and the light-receiving prism 14, and has reduced the light quantity of injecting light-receiving prism 14 among the light that passes light irradiation prism 13 but do not pass sample.
This light intensity reduction portion 19 is made of less than the refractive index materials (for example glass or plastics etc.) of for example light irradiation prism 13 and light-receiving prism 14 refractive index, and its function is to utilize the variation of refractive index (being reflectivity) to reduce the light quantity of injecting light-receiving prism 14 among the light that passes light irradiation prism 13 but do not pass sample.
The thickness (width) of light intensity reduction portion 19 is that the distance between light irradiation prism 13 and the light-receiving prism 14 is not particularly limited, but under the situation of measuring biological example soma, if light path is long, then the absorption of water is excessive, therefore preferably smaller or equal to 3mm.
In the present embodiment, light intensity reduction portion 19 has rectangular shape, and recess 15 is the shape that roughly is in the shape of the letter V by being combined to form of light irradiation prism 13, light-receiving prism 14 and light intensity reduction portion 19.In addition, the 2nd plane rake 14a that contacts sample in the 1st plane rake 13a and the light-receiving prism 14 of contact sample in the light irradiation prism 13 disposes in opposite directions, constitute the side surface part of recess 15 respectively, the upper surface of light intensity reduction portion 19 constitutes the bottom surface sections of recess 15 between the lower end of the lower end of the 1st rake 13a and the 2nd rake 14a.
Therefore, the thickness (width) of change light intensity reduction portion 19 just can change the light path of the light that passes recess 15 at an easy rate.That is, if increase the thickness of light intensity reduction portion 19, then the distance between light irradiation prism 13 and the light-receiving prism 14 increases, and bio-tissue is deep into recess 15, can measure the bio-tissue than the position, deep.In addition, if reduce the thickness of light intensity reduction portion 19, then the distance between light irradiation prism 13 and the light-receiving prism 14 is dwindled, and can measure the bio-tissue than the top layer.In this manner, make the effect of light intensity reduction portion 19 performance spacers,, just can measure bio-tissue with the mensuration degree of depth of expectation by the thickness of this light intensity reduction portion 19 of suitable setting.
Here, the tissue of finger 18 comprises the corium 18b and the subcutaneous fat 18c of the most surperficial epidermis 18a, its underpart.For example, when measuring concentration of glucose, preferably measure the corium 18b between epidermis 18a and the subcutaneous fat 18c, and preferably make more light pass this part.
If what use is the absorbing wavelength of the glucose of wavelength 1600nm for example, then the distance setting that passed in finger 18 of light is to get final product about 1～2mm.As surpassing 3mm, the uptake of water can increase.In addition, the recess 15 formed angles that roughly are in the shape of the letter V (the 1st rake and the formed angle of the 2nd rake) be set at 90 the degree～120 the degree get final product.
Utilize the optical detecting device of present embodiment, can either obtain and the identical effect of above-mentioned the 1st embodiment, can utilize photodetector 17 to detect to pass most of light of the corium 18b of finger 18 again.In addition, in optical element 12, configuration can be brought into play the light intensity reduction portion 19 of the spacer effect between light irradiation prism 13 and the light-receiving prism 14, the distance that changes between light irradiation prism 13 and the light-receiving prism 14 makes the mensuration degree of depth reach optimization with respect to individuality, just can increase and pass the light quantity of specific part in the finger 18, increase in the photodetector 17 signal intensity based on this light produced.Therefore, utilize the optical detecting device of present embodiment, can increase the S/N ratio of detected light, realize high-precision component concentration measuring.
[the 3rd embodiment]
Fig. 5 is the figure that the structure of the optical detecting device (component concentration measuring device) in the 3rd embodiment of the present invention of optical element of the present invention (measuring element) has been used in expression, and the arrow among the figure is represented light path.Optical element at first is described below.In addition, omit its explanation for part identical in the optical detecting device of the 3rd embodiment with the 2nd embodiment.
The light intensity reduction portion 29 of present embodiment also has the effect of spacer.The part relative with the light intensity reduction described later portion 29 below the recess 25 in light irradiation prism 23 and light-receiving prism 24 be by the closer to below just big more plane rake 23b and the 24b of distance between light irradiation prism 23 and the light-receiving prism 24 constitute.The section on the vertical direction of rake 23b and 24b be trapezoidal light intensity reduction portion 29 with and rake 23b and the contacted state configuration of 24b between light irradiation prism 23 and light-receiving prism 24.
Be provided with the adjustment unit that is used for adjusting the distance between light irradiation prism 23 and the light-receiving prism 24 on the side of light irradiation prism 23 and light-receiving prism 24 and the bottom surface.
This adjustment unit is by being used at the move up moving meter of light intensity reduction portion 29 of upper and lower---screw 21, be used for keeping the maintaining part 26 of screw 21 and be arranged on maintaining part 26 and the slit of light irradiation prism 23 and maintaining part 26 and light-receiving prism 24 in deformable deformation element 27 and 28 constitute.
Screw 21 is configured in the below of light intensity reduction portion 29, utilizes screw 21 that light intensity is reduced portion 29 and pushes downwards, light intensity will be reduced portion 29 and push the top to.At this moment, just can must be shorter if the passing amount is little with the distance setting between light irradiation prism 23 and the light-receiving prism 24; The passing amount is big just can must be longer with the distance setting between light irradiation prism 23 and the light-receiving prism 24.The displacement elasticity that moves that deformation element 27 and 28 will be accompanied by light irradiation prism 23 and light-receiving prism 24 absorbs.
Though do not show among the figure, preferably fastening with screw from the side surface part of light irradiation prism 23 and light-receiving prism 24, so that light irradiation prism 23 and light-receiving prism 24 after moving are no longer mobile.In addition, also can use bonding agent to fix.
In addition, in the present embodiment, in moving meter, used screw 21, but moving meter is not limited to this.
Deformation element 27 and 28 can use for example rubber-like material or elasticity material.Do not limit for the rubber-like material is special, can use for example acrylic rubber, urethane rubber, silicon rubber, fluororubber, styrene-butadiene rubber, butadiene rubber, isoprene rubber, nitrile rubber, neoprene or butyl rubber etc.
Though there is no particular limitation for the material of formation maintaining part 26, preferably uses plastics or metal etc.Metal preference such as aluminium or stainless steel etc.
[the 4th embodiment]
Fig. 6 is the figure that the structure of the optical detecting device (component concentration measuring device) in the 4th embodiment of the present invention of optical element of the present invention (measuring element) has been used in expression, and the arrow among the figure is represented light path.Optical element at first is described below.In addition, omit its explanation for part identical in the optical detecting device of the 4th embodiment with the 1st embodiment.
The optical detecting device of present embodiment is combined across spacer 39 by light irradiation prism 13 and light-receiving prism 14, except possessing by the formed light intensity reduction of the clearance portion portion 19 between light irradiation prism 13 and the light-receiving prism 14, other parts are identical with the 1st embodiment.
In the present embodiment, the optical index of clearance portion is littler than the refractive index of light irradiation prism 13 and light-receiving prism 14, therefore, can reduce the light quantity of not passing sample among the light that has passed light irradiation prism 13 and injecting light-receiving prism 14.In addition, the unnecessary light that can suppress not need to detect arrives, and can suppress to measure the decline of precision effectively.
[the 5th embodiment]
Fig. 7 is the figure that the structure of the optical detecting device (component concentration measuring device) in the 5th embodiment of the present invention of optical element of the present invention (measuring element) has been used in expression, and the arrow among the figure is represented light path.Optical element at first is described below.In addition, omit its explanation for part identical in the optical detecting device of the 5th embodiment with the 2nd embodiment.
The optical detecting device of present embodiment is combined across spacer 39 by light irradiation prism 13 and light-receiving prism 14, is provided with the light intensity reduction portion 19 that is made of membranaceous light shielding part between spacer 39 and the light irradiation prism 13 and between spacer 39 and the light-receiving prism 14.
Therefore, the thickness (width) of change spacer 39 just can change the light path of the light that passes recess 15 at an easy rate.That is, if increase the thickness of spacer 39, then the distance between light irradiation prism 13 and the light-receiving prism 14 increases, and bio-tissue is deep into recess 15, can measure the more bio-tissue of position, deep.In addition, if reduce the thickness of spacer 19, then the distance between light irradiation prism 13 and the light-receiving prism 14 is dwindled, and can measure the bio-tissue than the top layer.In this manner, by the thickness of suitable setting spacer 39, just can measure bio-tissue with the mensuration degree of depth of expectation.
The 1st rake 13a and the 2nd rake 14a are being carried out respectively after optical grinding becomes even surface, light irradiation prism 13 and light-receiving prism 14 are clipped spacer 39 to be coupled together, make the 1st rake 13a relative, formed the side surface part that the recess 15 that light passes is arranged thus at an easy rate with the 2nd rake 14a.In addition, before light irradiation prism 13 and light-receiving prism 14 are coupled together, to carry out optical grinding respectively, therefore, can make the 1st rake 13a and the 2nd rake 14a become level and smooth at an easy rate the 1st plane rake 13a and the 2nd rake 14a.Therefore, can obtain having the recess 15 of high optical accuracy face at an easy rate.
The material of spacer 39 is not special to be limited, but preferably the physical strength height, absorb easily and see through the material of measuring used light and being difficult for reflecting.For example, preferably glass or plastics if use refractive index to be lower than the material of light irradiation prism 13 and light-receiving prism 14, just can make this spacer 39 possess function as above-mentioned light intensity reduction portion.
The thickness of spacer 39 (width) is that the distance between light irradiation prism 13 and the light-receiving prism 14 is not particularly limited, but under the situation of measuring biological example soma, if light path is long, then the absorption of water is excessive, therefore preferably smaller or equal to 3mm.
In addition, can adopt material in the above-mentioned embodiment as light intensity reduction portion 19.
The embodiment of the best of the present invention more than has been described, but the present invention is not limited to these embodiments, but can makes design alteration by the combination of various textural elements according to the scope that claims are recorded and narrated.
For example, recess 15,25 shape that roughly is in the shape of the letter V in the above-described embodiment, but also the 1st rake and the 2nd rake can be made curved surface, form the recess that roughly is the U word shape, perhaps the 1st rake and the 2nd rake are made stepped appearance, form the notch cuttype recess.
Be illustrated at the situation that with the finger is sample in the above-described embodiment, but sample is not limited thereto.Except finger, also can measure for example bio-tissues such as lip, forearm and ear.
In addition, in the distortion of the 1st embodiment, be illustrated, but the present invention is not limited to this, also can measures fluid at the sample liquid that remains static.For example, the runner that sample liquid is flowed into is connected to the recess 15 corresponding sides that hide 20a with the 1st mensuration, the runner that sample liquid is flowed out is connected to the recess 15 corresponding sides that hide 20b with the 2nd mensuration, with the runner of recess 15, also can measure the composition in the fluid thus at an easy rate as sample liquid.
Industrial usability
Optical element of the present invention and optical detecting device are fit to be applied to measure for example liquid, molten The device of the constituent concentration of liquid, fluid and organism tissue etc.
Claims
(according to the modification of the 19th of treaty)
1. (revise afterwards) a kind of optical element, it possesses:
Light irradiation prism, it has light-emitting face, and the light that shines on the sample penetrates from this exit facet;
The light-receiving prism, it has light receiving surface, and the light that returns from above-mentioned sample is received by this light receiving surface;
Light intensity reduction portion is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism,
Above-mentioned light intensity reduction portion is arranged on the light shielding part between above-mentioned light irradiation prism and the above-mentioned light-receiving prism,
Above-mentioned light irradiation prism and above-mentioned light-receiving prism are combined, and have formed and the contacted recess of above-mentioned sample, and the light that penetrates from above-mentioned light-emitting face is injected above-mentioned light receiving surface advancing with the contacted above-mentioned sample cathetus of above-mentioned recess.
2. (after revising) optical element as claimed in claim 1 also possesses the clearance portion that is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
3. (deletion)
4. optical element as claimed in claim 1, it further possesses the spacer that is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
5. optical element as claimed in claim 1,
The above-mentioned light-emitting face of above-mentioned light irradiation prism is the 1st plane rake that contacts with above-mentioned sample,
The above-mentioned light receiving surface of above-mentioned light-receiving prism is the 2nd plane rake that contacts with above-mentioned sample,
Above-mentioned the 1st rake and above-mentioned the 2nd rake be mutually in the face of forming above-mentioned recess, and above-mentioned recess with above-mentioned the 1st rake direction vertical with above-mentioned the 2nd rake on the section shape that roughly is in the shape of the letter V.
6. optical element as claimed in claim 1, it possesses covering, and this covering is covered with the part of above-mentioned recess and combines with above-mentioned light irradiation prism and above-mentioned light-receiving prism and forms sample preservation portion.
7. optical element as claimed in claim 1, it further possesses adjustment unit, is used for adjusting the distance between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
8. optical detecting device, it possesses:
Optical element as claimed in claim 1;
In order to make light shine above-mentioned sample and to the irradiant light source of above-mentioned light irradiation prism from above-mentioned light irradiation prism;
The photodetector that the light that turns back to above-mentioned light-receiving prism from above-mentioned sample is detected.
9. optical detecting device as claimed in claim 8, it possesses the beam splitter that is configured between above-mentioned light-receiving prism and the above-mentioned photodetector.
Claims (9)
1. optical element, it possesses:
Light irradiation prism, it has light-emitting face, and the light that shines on the sample penetrates from this exit facet;
The light-receiving prism, it has light receiving surface, and the light that returns from above-mentioned sample is received by this light receiving surface;
Light intensity reduction portion is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism,
Above-mentioned light irradiation prism and above-mentioned light-receiving prism are combined, formed and the contacted recess of above-mentioned sample,
The light that penetrates from above-mentioned light-emitting face is injected above-mentioned light receiving surface advancing with the contacted above-mentioned sample cathetus of above-mentioned recess.
2. optical element as claimed in claim 1, above-mentioned light intensity reduction portion is arranged on the clearance portion between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
3. optical element as claimed in claim 1, above-mentioned light intensity reduction portion is arranged on the light shielding part between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
4. optical element as claimed in claim 1, it further possesses the spacer that is arranged between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
5. optical element as claimed in claim 1,
The above-mentioned light-emitting face of above-mentioned light irradiation prism is the 1st plane rake that contacts with above-mentioned sample,
The above-mentioned light receiving surface of above-mentioned light-receiving prism is the 2nd plane rake that contacts with above-mentioned sample,
Above-mentioned the 1st rake and above-mentioned the 2nd rake be mutually in the face of forming above-mentioned recess, and above-mentioned recess with above-mentioned the 1st rake direction vertical with above-mentioned the 2nd rake on the section shape that roughly is in the shape of the letter V.
6. optical element as claimed in claim 1, it possesses covering, and this covering is covered with the part of above-mentioned recess and combines with above-mentioned light irradiation prism and above-mentioned light-receiving prism and forms sample preservation portion.
7. optical element as claimed in claim 1, it further possesses adjustment unit, is used for adjusting the distance between above-mentioned light irradiation prism and the above-mentioned light-receiving prism.
8. optical detecting device, it possesses:
Optical element as claimed in claim 1;
In order to make light shine above-mentioned sample and to the irradiant light source of above-mentioned light irradiation prism from above-mentioned light irradiation prism;
The photodetector that the light that turns back to above-mentioned light-receiving prism from above-mentioned sample is detected.
9. optical detecting device as claimed in claim 8, it possesses the beam splitter that is configured between above-mentioned light-receiving prism and the above-mentioned photodetector.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP026576/2005 | 2005-02-02 | ||
| JP2005026576 | 2005-02-02 | ||
| JP034988/2005 | 2005-02-10 |
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| Publication Number | Publication Date |
|---|---|
| CN1942754A true CN1942754A (en) | 2007-04-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200680000139 Pending CN1942754A (en) | 2005-02-02 | 2006-02-01 | Optical element and optical measurement device using the same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101598662B (en) * | 2008-04-03 | 2012-12-19 | 克洛纳光学传感器公司 | Device for measuring the dispersion and/or absorption and/or refraction of a sample |
| CN103384493A (en) * | 2011-01-20 | 2013-11-06 | 日东电工株式会社 | A sensing device, a method of preparing a sensing device and a personal mobile sensing system |
| CN104161526A (en) * | 2014-08-25 | 2014-11-26 | 康泰医学***（秦皇岛）股份有限公司 | Lateral jetting type blood oxygen detection device |
| CN105388127A (en) * | 2015-10-30 | 2016-03-09 | 清华大学深圳研究生院 | Online detecting method and system for concentration of all ions of all-vanadium redox flow battery |
| US9289177B2 (en) | 2011-01-20 | 2016-03-22 | Nitto Denko Corporation | Sensing device, a method of preparing a sensing device and a personal mobile sensing system |
| CN103398947B (en) * | 2009-03-26 | 2016-03-23 | 浜松光子学株式会社 | Light irradiation device and light measurement device |
| CN106908149A (en) * | 2017-04-11 | 2017-06-30 | 上海电机学院 | A kind of robot object color identifying system and method |
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2006
- 2006-02-01 CN CN 200680000139 patent/CN1942754A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101598662B (en) * | 2008-04-03 | 2012-12-19 | 克洛纳光学传感器公司 | Device for measuring the dispersion and/or absorption and/or refraction of a sample |
| CN103398947B (en) * | 2009-03-26 | 2016-03-23 | 浜松光子学株式会社 | Light irradiation device and light measurement device |
| CN103384493A (en) * | 2011-01-20 | 2013-11-06 | 日东电工株式会社 | A sensing device, a method of preparing a sensing device and a personal mobile sensing system |
| US9289177B2 (en) | 2011-01-20 | 2016-03-22 | Nitto Denko Corporation | Sensing device, a method of preparing a sensing device and a personal mobile sensing system |
| CN104161526A (en) * | 2014-08-25 | 2014-11-26 | 康泰医学***（秦皇岛）股份有限公司 | Lateral jetting type blood oxygen detection device |
| CN105388127A (en) * | 2015-10-30 | 2016-03-09 | 清华大学深圳研究生院 | Online detecting method and system for concentration of all ions of all-vanadium redox flow battery |
| CN105388127B (en) * | 2015-10-30 | 2018-01-26 | 清华大学深圳研究生院 | A kind of online test method and system of each ion concentration of all-vanadium flow battery |
| CN106908149A (en) * | 2017-04-11 | 2017-06-30 | 上海电机学院 | A kind of robot object color identifying system and method |
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Open date: 20070404 |