CN1935174A - Animal medicament with expelling toxin bycooling, calming liver to brighten vision and its preparing method - Google Patents
Animal medicament with expelling toxin bycooling, calming liver to brighten vision and its preparing method Download PDFInfo
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- CN1935174A CN1935174A CN 200510015118 CN200510015118A CN1935174A CN 1935174 A CN1935174 A CN 1935174A CN 200510015118 CN200510015118 CN 200510015118 CN 200510015118 A CN200510015118 A CN 200510015118A CN 1935174 A CN1935174 A CN 1935174A
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- flos chrysanthemi
- chrysanthemi indici
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Abstract
The present invention relates to an animal medicine preparation wild chrysanthemum flower powder with the functions of clearing away heat and toxic material and calming the liver and improving acuity of sight for curing animal diseases. Said animal medicine preparation is made up by using Chinese medicinal material wild chrysanthemum flower through a certain preparation process. Said invention also provides the concrete steps of said preparation process.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, is a kind of heat-clearing and toxic substances removing of feedstock production, suppressing the hyperactive liver the make eye bright animal medicament and the method for making thereof of function with the Chinese crude drug Flos Chrysanthemi Indici particularly.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(the different name Herba Dendranthematis indici is come from " Japan hanako materia medica " to Flos Chrysanthemi Indici; FLOS CHRYSANTHEMI INDICI comes from " Jiangsu flora ") be one of heat-clearing and toxic substances removing medical material commonly used in the Chinese medicine for animals.Its pharmacological action of modern study: water decoction all has inhibitory action to antibacterials such as staphylococcus aureus, diphtheria corynebacterium, escherichia coli, and Orphan virus is also had inhibitory action.2000 editions veterinary drug allusion quotations record that its medical material is used for the treatment of poultry furuncle carbuncle, conjunctival congestion and swelling pain, disease such as have a dizzy spell.
In clinical use; because modern large-scale cultivation and intensive culture degree are more and more higher; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Flos Chrysanthemi Indici drug effect not bring into play fully; and take common decocting in water precipitate with ethanol to extract as " suppository of wild chrysanthemum flower " preparation of a Pharmacopoeia of the People's Republic of China of version in 2000; not only waste a large amount of ethanol, also lost the mass efficient composition simultaneously.At present do not retrieve the application of Herba Dendranthematis indici HUAJING powder on livestock and poultry pestilence as yet, the extractive technique of Flos Chrysanthemi Indici usually is the extractive technique of human medicine, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of heat-clearing and toxic substances removing that has to be provided, the suppressing the hyperactive liver Herba Dendranthematis indici HUAJING powder preparation of function such as make eye bright.Disease such as be used to cure mainly poultry furuncle carbuncle, conjunctival congestion and swelling pain, have a dizzy spell, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.Antibiotherapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of antibiotic that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Flos Chrysanthemi Indici nature and flavor toil, be slightly cold, can go into the heart, Liver Channel, staphylococcus aureus, diphtheria corynebacterium, escherichia coli etc. are had certain inhibitory action.And the present invention---Herba Dendranthematis indici HUAJING powder can comparatively fast be eliminated symptom for bacterial enteric infection disease, promotes body recovery.The side effect of Herba Dendranthematis indici HUAJING powder is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
Technical scheme of the present invention is: a kind of have make eye bright application and the method for making thereof of Herba Dendranthematis indici HUAJING powder on poultry of function of heat-clearing and toxic substances removing, suppressing the hyperactive liver.
The invention provides a kind of heat-clearing and toxic substances removing, suppressing the hyperactive liver function animal medicament that makes eye bright that has, it is characterized in that this medicament is is the medicament that raw material is made by Flos Chrysanthemi Indici.
Dose processing method: Flos Chrysanthemi Indici is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Flos Chrysanthemi Indici after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back respectively and merges, and it is 1.10-1.20g/cm that the merging rear filtrate is concentrated into relative density
3, 70 ℃ clear paste, spray drying promptly gets Herba Dendranthematis indici HUAJING powder, and yield is 14.0%-21%.
A kind of have a make eye bright method for making of animal medicament of function of heat-clearing and toxic substances removing, suppressing the hyperactive liver, comprise the Flos Chrysanthemi Indici medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Flos Chrysanthemi Indici after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and it is 1.10-1.20g/cm that the Flos Chrysanthemi Indici extracting solution is concentrated into relative density
3, 70 ℃ clear paste, spray drying promptly gets Herba Dendranthematis indici HUAJING powder (yield is 14.0%-21%).
Have heat-clearing and toxic substances removing, suppressing the hyperactive liver make eye bright function animal medicament and a method for making thereof according to described, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by experiment this medicine is used for the treatment of infectious bronchitis of chicken, and experimental result is as follows:
The experiment medicine: Herba Dendranthematis indici HUAJING powder, control drug are that the Flos Chrysanthemi Indici decoction pieces is made the Flos Chrysanthemi Indici powder after crushed.
Laboratory animal: 430 AA mixing meat young birds, available from Tianjin side's big fowl industry company limited, be transported in this laboratory pouity dwelling place and raise in cages, Routine Management is fed to complete feed to 14 age in days, and colibacillosis does not take place on inspection, can be shown test and use chicken.Wherein 80 are used for doing trial test, all the other 350 tests are divided into 7 groups with healthy chicken, wherein 1,2,3 group is respectively the high, medium and low treatment group of counteracting toxic substances Herba Dendranthematis indici HUAJING powder, 4 groups is Flos Chrysanthemi Indici powder matched group, 5 groups of negative matched groups (counteracting toxic substances is not treated matched group), 6 groups of positive matched groups (not counteracting toxic substances do not treat normal healthy controls group), safe matched group (being used in healthy test chicken) according to 10 times of Herba Dendranthematis indici HUAJING powder recommended dose.
Seed culture of viruses: chicken colon bacillus reference culture (O
78Serotype) (by the TanJin Agricultural College animal science is that Microbiological Lab provides.)
Experimental technique: except that positive controls and safe matched group, every chicken muscle is injected 1.2 hundred million escherichia coli.Behind the counteracting toxic substances 4 hours, chickling performance lassitude, stop eating, necking down, close one's eyes, lie still on the ground, face downwards and symptom such as bradykinesia.Be diagnosed as colibacillosis with the bacteriology checking method, after this medication was at once used five days continuously, observed therapeutic effect.
Experimental session, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.
Chicken number * 100 before effective percentage (%)=treatment back survival chicken number/dispensing
Morbidity chicken number in sickness rate (%)=treatment/dispensing back chicken number * 100
Laying rate (%)=test chicken egg number every day/50 * 100
After the drug withdrawal three days, the administration experimental chicken did not have tangible clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing, and sx, anti-mistake chicken are effective in the therapeutic process.
The grouping of table 1 experimental chicken
| Group | Test chicken number (only) | Colon bacillus number (hundred million) | Medicine | Usage | Consumption (g/ plumage) | The beginning administration time | The medication natural law (my god) |
| 1 group 2 groups 3 groups 4 groups 5 groups 6 groups 7 groups | 50 50 50 50 50 50 50 | 1.2 1.2 1.2 1.2 1.2 - | Dosage group mother chrysanthemum fine powder low dose group mother chrysanthemum powder soluble powder in the mother chrysanthemum fine powder high dose group mother chrysanthemum fine powder--mother chrysanthemum fine powder safe dose group | Drinking-water (1 time/day) drinking-water (1 time/day) drinking-water (1 time/day) drinking-water (1 time/day) drinking-water (1 time/day) | 0.5 0.25 0.125 2 - - 5 | Occur behind the artificial challenge at once medication of clinical symptoms the same the same-- | 5 5 5 5 - - 5 |
30-35h behind the counteracting toxic substances respectively organizes the full group of chicken and clinical symptoms occurs except that the normal healthy controls group, show as dyspnea, diarrhoea, and sick chicken is cutd open the visible perihepatitis of inspection, pericarditis, and organs such as lung, liver are separable to go out escherichia coli.
Experimental result sees the following form:
Table 2 Herba Dendranthematis indici HUAJING powder is to the therapeutic effect of infectious bronchitis of chicken
| Group | Mortality rate (%) | Cure rate (%) | Effective percentage (%) | Average weight gain (g) | The relative weight gain rate (%) |
| The safe control group of dosage group mother chrysanthemum fine powder low dose group Norfloxacin soluble powder group in the positive controls negative control group mother chrysanthemum fine powder high dose group mother chrysanthemum fine powder | 0 90 10 16 32 30 0 | — 0 80 78 68 68 | — 90 84 68 70 | 281.6 — 262.5 261.6 203.0 214.0 279.3 | 100 — 93.2 92.9 72.1 76.0 99.2 |
Find out that from experimental result each medication group is compared, Herba Dendranthematis indici HUAJING powder height, middle dosage group mortality rate are lower, are respectively 10%, 16%.Statistical analysis shows that Herba Dendranthematis indici HUAJING powder height, middle dosage group mortality rate extremely significantly are lower than the mortality rate (p＜0.01) of negative control group (infection matched group).Herba Dendranthematis indici HUAJING powder height, middle dosage group cure rate are higher, all above 75%.Above-mentioned two groups effective percentage is also higher, all above 80%.Cure rate, the effective percentage of Herba Dendranthematis indici HUAJING powder low dose group, Flos Chrysanthemi Indici powder group are relatively low.The rate of body weight gain of Herba Dendranthematis indici HUAJING powder height, the middle dosage group difference extremely significantly (p＜0.01) of comparing with negative control group.Herba Dendranthematis indici HUAJING powder low dose group, the weightening finish of norfloxacin soluble powder group all significantly are lower than Herba Dendranthematis indici HUAJING powder height, middle dosage group matched group (p＜0.05).By the safety experiment (10 times of amount recommendations are oral, logotype five days) to healthy chicken, the clinical manifestation of no abnormality seen between the operating period illustrates that said preparation does not have obvious influence to healthy chicken, and is safe in utilization simultaneously.
Above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Flos Chrysanthemi Indici, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
The invention has the beneficial effects as follows:, confirmed that Herba Dendranthematis indici HUAJING treated powder domestic animal, poultry colibacillosis have excellent curative, have played the effect that heat-clearing and toxic substances removing, suppressing the hyperactive liver make eye bright by zoopery.
Confirmed the purposes of Herba Dendranthematis indici HUAJING powder on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Flos Chrysanthemi Indici crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, tame avian infectious eqpidemic disease has excellent curative, has played the effect that heat-clearing and toxic substances removing, suppressing the hyperactive liver make eye bright.
The specific embodiment:
Embodiment 1: get Flos Chrysanthemi Indici medical material 100kg, with the Flos Chrysanthemi Indici raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, and with 10% hydrochloric acid adjusting pH to 3, extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% sodium hydroxide adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(70 ℃).Spray drying or vacuum decompression crushed after being dried promptly get Herba Dendranthematis indici HUAJING powder 17.2kg (yield is 17.2%).
Certain chicken house chicken group infected chicken Hakuri, symptoms such as spirit is depressed, white dysentery appear in most of chicken group, do not see obvious improvement with antibiotics treatment back effect.Adopt medicine of the present invention, 0.3g/ plumage/sky is freely drunk water, carry out five days by a definite date treatment after, most of sick fowl disease close friend changes, symptom disappears substantially, cure rate has reached 94%.
Embodiment 2: get Flos Chrysanthemi Indici medical material 100kg, with the Flos Chrysanthemi Indici raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, and with 10% lactic acid adjusting pH to 3, extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% sodium hydroxide adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(70 ℃).Spray drying or vacuum decompression crushed after being dried promptly get Herba Dendranthematis indici HUAJING powder 17.3kg (yield is 17.3%).Certain pig farm is because of immuning failure, and almost full group infects yellow scour of piglet, and state of an illness weight differs, and after taking measures to carry out urgent immunity, adds medicine of the present invention, 1g/kg feedstuff, mixed feeding, logotype 5 days in feedstuff.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (3)
1, a kind of have a make eye bright animal medicament of function of heat-clearing and toxic substances removing, suppressing the hyperactive liver, it is characterized in that being is the medicament that raw material is made by Flos Chrysanthemi Indici
Dose processing method: the Flos Chrysanthemi Indici medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Flos Chrysanthemi Indici after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Flos Chrysanthemi Indici extracting solution, and it is 1.10-1.20g/cm that the Flos Chrysanthemi Indici extracting solution is concentrated into relative density
3, 70 ℃ clear paste, spray drying promptly gets Herba Dendranthematis indici HUAJING powder.Yield is 14.0%-21%.
2, a kind of have a make eye bright method for making of animal medicament of function of heat-clearing and toxic substances removing, suppressing the hyperactive liver, comprise the Flos Chrysanthemi Indici medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Flos Chrysanthemi Indici after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Flos Chrysanthemi Indici extracting solution, and it is 1.10-1.20g/cm that the Flos Chrysanthemi Indici extracting solution is concentrated into relative density
3, 70 ℃ clear paste, spray drying promptly gets Herba Dendranthematis indici HUAJING powder.Yield is 14.0%-21%.
3, describedly have heat-clearing and toxic substances removing, suppressing the hyperactive liver make eye bright function animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949650A (en) * | 2012-11-16 | 2013-03-06 | 旌德县鸿雁养殖有限公司 | Traditional Chinese medicine for curing white diarrhea of young geese, preparation and using method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102949650A (en) * | 2012-11-16 | 2013-03-06 | 旌德县鸿雁养殖有限公司 | Traditional Chinese medicine for curing white diarrhea of young geese, preparation and using method |
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