CN1927188A - Voltage endurance vitamin E microcapsule and its preparing process - Google Patents
Voltage endurance vitamin E microcapsule and its preparing process Download PDFInfo
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- CN1927188A CN1927188A CNA2006100950692A CN200610095069A CN1927188A CN 1927188 A CN1927188 A CN 1927188A CN A2006100950692 A CNA2006100950692 A CN A2006100950692A CN 200610095069 A CN200610095069 A CN 200610095069A CN 1927188 A CN1927188 A CN 1927188A
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Abstract
The invention relates to pressure resistant vitamin E capsules, wherein the constituents include (by weight percent) vitamin E oil 50-70%, capsule material 1-25%, auxiliary capsule material 5-30%, octenylsuccinate starch 10-30%, flow aid 0.5-2%. The invention also relates to the process for preparing the capsules.
Description
Technical field
The present invention relates to a kind of voltage endurance vitamin E microcapsule and preparation method thereof.
Technical background
Vitamin E has another name called tocopherol, runs concurrently for a kind of common drug and supports health product, has become maximum, the great main vitamins kind of volume of production and marketing of purposes on the international market at present.The most outstanding chemical property of vitamin E is an antioxidation, and it can strengthen the antioxidation of cell, has to utilize the integrity of keeping various cell membrane; Participate in many-sided metabolic process of some whole cell tissue; Effects such as the vigor of maintenance membrane bound enzyme and receptor; In addition it also have anti-aging effects, blood coagulation resisting function, enhancing immunity, improvement end slightly blood circulation, prevent arteriosclerosis, keep erythrocyte, leukocyte, brain cell, epithelial integrity, thus the normal function of maintenance muscle, neural blood vessel and hemopoietic system etc.
Be golden yellow or faint yellow thickness oily liquids under the vitamin E room temperature, transportation and use metering are inconvenient, and because of its oxidisability instability, having developed content inside and outside the native land one after another is 20%～70% vitamin E microcapsule powder, but when it directly applies to tablet, the easily broken capsule because the mechanical strength of its capsule is not high, content step-down during stability study shows vitamin E oxidation deterioration behind its broken capsule.
Summary of the invention
Technical problem to be solved by this invention provides a kind of voltage endurance vitamin E microcapsule and preparation method thereof, by with common emulsifying such as vitamin E oil, mictocystis material, fluidizer, homogenizing, spray drying is made the mobile powder of microencapsulation, can be dispersed in the cold water, the significant mechanical strength that improves microcapsule of new prescription can be directly used in tabletting, and this product can be used in medicine and the food.
The composition of the voltage endurance vitamin E microcapsule that the present invention relates to is such: the percentage by weight between its component and the component is: vitamin E oil 50%～70%, capsule material 1%～25%, auxiliary capsule material 5%～30%, octenyl succinate starch 10%～30%, fluidizer 0.5%～2%.
In the said components of the present invention:
1, vitamin E is a Main Ingredients and Appearance, the vitamin E powder of selling on the market mostly is greatly and contains vitamin E 50%～70%, vitamin E powder integrated cost in this content range is lower, and the later stage uses interpolation also comparatively convenient, contains vitamin E 50%～70% so vitamin E microcapsule of the present invention also is decided to be.
2, gelatin is the capsule material, a kind of in also available arabic gum, alginate, chitosan, the casein or more than 2 kinds.
3, dextrin prevents microcapsule adhesion in the spray-drying process for auxiliary capsule material, and available lactose, mannitol, sorbitol etc. are a kind of or more than 2 kinds.
4, octenyl succinate starch is the good emulsifying agent capsule material of holding concurrently, and can greatly strengthen the mechanical strength of microcapsule.
5, micropowder silica gel is a fluidizer, a kind of or mixing replacement more than 2 kinds such as available Pulvis Talci, magnesium stearate.The capsule material is selected: it is main capsule material that novel capsule material octenyl succinate starch is selected in this experiment for use, add a small amount of high score ascus material, the auxiliary capsule material of dextrin class and fluidizer, the emulsifying spray drying forms, select different prescriptions for use according to different oil content, optimize capsule material proportioning: octenyl succinate starch: high score ascus material: the dextrin class is assisted capsule material=(35～40): (5～10): (10～22).
Preparation method:
1), preparation aqueous phase solution: 1～3 times the purified water of always measuring admittedly by above-mentioned microcapsule component is heated to 65～70 ℃, by proportioning capsule material, octenyl succinate starch, auxiliary capsule material and fluidizer is slowly added, and stirs it to be uniformly dispersed in 8～15 minutes.
2), preparation oil phase liquid: vitamin E oil is preheated to 65～70 ℃ by proportioning.
3), the emulsifying homogenizing: above-mentioned fluid is slowly added aqueous phase solution mutually, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, getting emulsion examines under a microscope, answer encapsulation complete and big or small about 10 μ m, as do not reach requirement, homogenizing is observed again;
4), spray drying: above-mentioned emulsion is added in the centrifugal spray dryer, is 180 ℃～190 ℃ in inlet temperature, 85～90 ℃ of air-out, the centrifugal energy nozzle rotating speed is under 20,000～30,000 conditions of changeing, and carries out spray drying;
5), check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
The voltage endurance vitamin E microcapsule outward appearance that makes is pure white, and flowability and compressibility are good, adds conventional adjuvant and can carry out tabletting or filled capsules.This product also has good water dispersible, can disperse rapidly at cold water, can be as the additive of food such as beverage, ice river in Henan Province icepro, cake and confection class in food.
The present invention is on old technology basis, adding novel adjuvant octenyl succinate starch forms through emulsifying, homogenizing, spray drying, the new octenyl succinate starch that adds has first-class film property and good emulsibility, can improve the mechanical strength of microcapsule greatly, be enough to satisfy the tabletting requirement, and fuel load can be up to 70%, encapsulation rate height, good fluidity.
The specific embodiment
Embodiment 1:
Vitamin E 50%
Gelatin 5%
Dextrin 12%
Octenyl succinate starch 32%
Micropowder silica gel 1%
Purified water is 1.5 times of weight of solid amount always
Preparation method:
1, water: the purified water of recipe quantity is heated to 65～70 ℃, gelatin, octenyl succinate starch, dextrin and the micropowder silica gel of recipe quantity slowly added, stir and it was uniformly dispersed in 10 minutes.
2, oil phase: the vitamin E oil of recipe quantity is preheated to 65～70 ℃.
3, emulsifying homogenizing: oil phase is slowly added water, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, gets emulsion and examines under a microscope, and answers encapsulation complete and big or small about 10 μ m, as does not reach requirement, and homogenizing is observed again.
4, spray drying: emulsion is added in the centrifugal spray dryer, and inlet temperature is 180 ℃～190 ℃, 85～90 ℃ of air-out, and the centrifugal energy nozzle rotating speed is 20,000～30,000 commentaries on classics, opens Liquid spraying pump and carries out spray drying.
5, check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
Embodiment 2
Vitamin E 55%
Sodium caseinate 9%
Lactose 10%
Octenyl succinate starch 25%
Micropowder silica gel 1%
Purified water is 1.5 times of weight of solid amount always
Preparation method:
1, water: the purified water of recipe quantity is heated to 65～70 ℃, sodium caseinate, octenyl succinate starch, lactose and the micropowder silica gel of recipe quantity slowly added, stir and it was uniformly dispersed in 10 minutes.
2, oil phase: the vitamin E oil of recipe quantity is preheated to 65～70 ℃.
3, emulsifying homogenizing: oil phase is slowly added water, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, gets emulsion and examines under a microscope, and answers encapsulation complete and big or small about 10 μ m, as does not reach requirement, and homogenizing is observed again.
4, spray drying: emulsion is added in the centrifugal spray dryer, and inlet temperature is 180 ℃～190 ℃, 85～90 ℃ of air-out, and the centrifugal energy nozzle rotating speed is 20,000～30,000 commentaries on classics, opens Liquid spraying pump and carries out spray drying.
5, check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
Embodiment 3
Vitamin E 60%
Chitosan 6%
Lactose 12%
Octenyl succinate starch 20.8%
Micropowder silica gel 1.2%
Purified water is 1.5 times of weight of solid amount always
Preparation method:
1, water: the purified water of recipe quantity is heated to 65～70 ℃, chitosan, octenyl succinate starch, lactose and the micropowder silica gel of recipe quantity slowly added, stir and it was uniformly dispersed in 10 minutes.
2, oil phase: the vitamin E oil of recipe quantity is preheated to 65～70 ℃.
3, emulsifying homogenizing: oil phase is slowly added water, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, gets emulsion and examines under a microscope, and answers encapsulation complete and big or small about 10 μ m, as does not reach requirement, and homogenizing is observed again.
4, spray drying: emulsion is added in the centrifugal spray dryer, and inlet temperature is 180 ℃～190 ℃, 85～90 ℃ of air-out, and the centrifugal energy nozzle rotating speed is 20,000～30,000 commentaries on classics, opens Liquid spraying pump and carries out spray drying.
5, check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
Embodiment 4
Vitamin E 65%
Arabic gum 5%
Lactose 8%
Octenyl succinate starch 20.5%
Micropowder silica gel 1.5%
Purified water is 2 times of weight of solid amount always
Preparation method:
1, water: the purified water of recipe quantity is heated to 65～70 ℃, arabic gum, octenyl succinate starch, lactose and the micropowder silica gel of recipe quantity slowly added, stir and it was uniformly dispersed in 10 minutes.
2, oil phase: the vitamin E oil of recipe quantity is preheated to 65～70 ℃.
3, emulsifying homogenizing: oil phase is slowly added water, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, gets emulsion and examines under a microscope, and answers encapsulation complete and big or small about 10 μ m, as does not reach requirement, and homogenizing is observed again.
4, spray drying: emulsion is added in the centrifugal spray dryer, and inlet temperature is 180 ℃～190 ℃, 85～90 ℃ of air-out, and the centrifugal energy nozzle rotating speed is 20,000～30,000 commentaries on classics, opens Liquid spraying pump and carries out spray drying.
Annotate: spray dryer also can be selected jet-propelled spray dryer for use.
5, check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
Embodiment 5
Vitamin E 70%
Arabic gum 2%
Dextrin 6.5%
Octenyl succinate starch 20%
Magnesium stearate 1.5%
Purified water is 2.5 times of weight of solid amount always
Preparation method:
1, water: the purified water of recipe quantity is heated to 65～70 ℃, arabic gum, octenyl succinate starch, dextrin and the magnesium stearate of recipe quantity slowly added, stir and it was uniformly dispersed in 10 minutes.
2, oil phase: the vitamin E oil of recipe quantity is preheated to 65～70 ℃.
3, emulsifying homogenizing: oil phase is slowly added water, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, gets emulsion and examines under a microscope, and answers encapsulation complete and big or small about 10 μ m, as does not reach requirement, and homogenizing is observed again.
4, spray drying: emulsion is added in the centrifugal spray dryer, and inlet temperature is 180 ℃～190 ℃, 85～90 ℃ of air-out, and the centrifugal energy nozzle rotating speed is 20,000～30,000 commentaries on classics, opens Liquid spraying pump and carries out spray drying.
Annotate: spray dryer also can be selected jet-propelled spray dryer for use.
5, check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
Embodiment 6: the chewable tablet of voltage endurance vitamin E microcapsule (microcapsule that embodiment 4 makes) preparation
Voltage endurance vitamin E microcapsule 50%
Mannitol 45%
Maltodextrin 4%
Sweeting agent is an amount of
Magnesium stearate 1%
With above-mentioned supplementary material mix homogeneously, direct compression.
Experimental result:
| Outward appearance | The encapsulation rate | Bulk density (g/MI) | Moisture | Ash | Content | |
| Embodiment 1 | White powder | 100.0 ％ | 4.9 | 2. 0％ | 0.4 ％ | 49.5％ |
| Embodiment 2 | White powder | 100.0 ％ | 4.8 | 2. 0％ | 0.5 ％ | 55.7％ |
| Embodiment 3 | White powder | 98.3 ％ | 4.8 | 1. 8％ | 0.5 ％ | 60.2％ |
| Embodiment 4 | White powder | 97.8 ％ | 4.7 | 1. 8％ | 0.6 ％ | 64.6％ |
| Embodiment 5 | White powder | 94.3 ％ | 4.6 | 1. 8％ | 0.6 ％ | 70.1％ |
| Common microcapsule | Off-white powder | 97.0 ％ | 4.3 | 2. 5％ | 2.1 ％ | 50.2％ |
Stability test is analyzed
The voltage endurance vitamin E microcapsule and the usual vitamin E microcapsule of embodiment 1,3,5 preparation gained are distinguished tabletting under the same conditions, be put in the accelerated test case, temperature is 40 ℃, and humidity is 75%, respectively at 1,2,3, the sampling in June, observe its outward appearance, capsule breaking rate, content; Obtain a result as following table.
1, the tablet appearance relative analysis of four kinds of different VE microcapsule preparations:
| Time | The tablet (outward appearance) of pressure resistant type VE microcapsule 1 preparation | The tablet (outward appearance) of pressure resistant type VE microcapsule 3 preparations | The tablet (outward appearance) of pressure resistant type VE microcapsule 5 preparations | The tablet (outward appearance) of common VE microcapsule preparation |
| 0 month | Smooth pure white | Smooth pure white | Smooth pure white | Smooth, unilateral have a skin dark stain |
| January | No change | No change | No change | Smooth, unilateral have a skin dark stain |
| February | No change | No change | No change | Smooth, unilateral have a skin dark stain |
| March | No change | No change | No change | More smooth, hardness reduces |
| June | No change | No change | No change | More smooth, hardness further reduces |
2, the tablet microscopic examination of four kinds of different VE microcapsule preparations is (with 3.14mm
2Counting) capsule breaking rate relative analysis down:
| Time | The tablet (capsule breaking rate) of pressure resistant type VE microcapsule 1 preparation | The tablet (capsule breaking rate) of pressure resistant type VE microcapsule 3 preparations | The tablet (capsule breaking rate) of pressure resistant type VE microcapsule 5 preparations | The tablet (capsule breaking rate) of common VE microcapsule preparation |
| 0 month | Broken capsule 1% | Broken capsule 1% | Broken capsule 5% | Broken capsule 41% |
| January | Broken capsule 2% | Broken capsule 3% | Broken capsule 5% | Broken capsule 45% |
| February | Broken capsule 1% | Broken capsule 2% | Broken capsule 6% | Broken capsule 47% |
| March | Broken capsule 1% | Broken capsule 3% | Broken capsule 5% | Broken capsule 44% |
| June | Broken capsule 2% | Broken capsule 3% | Broken capsule 6% | Broken capsule 45% |
3, the tablet content relative analysis of four kinds of different VE microcapsule preparations:
| Time | The tablet (sign content) of pressure resistant type VE microcapsule 1 preparation | The tablet (sign content) of pressure resistant type VE microcapsule 3 preparations | The tablet (sign content) of pressure resistant type VE microcapsule 5 preparations | The tablet (sign content) of common VE microcapsule preparation |
| 0 month | 98.5％ | 99.5％ | 98.6％ | 97.4％ |
| January | 98.6％ | 99.5％ | 98.4％ | 97.0％ |
| February | 98.3％ | 99.3％ | 98.4％ | 96.0％ |
| March | 98.3％ | 99.3％ | 98.2％ | 95.5％ |
| June | 98.2％ | 99.0％ | 98.0％ | 93.2％ |
Conclusion: the tablet accelerated test of voltage endurance vitamin E microcapsule preparation was not seen significant change in 6 months, and the tablet accelerated test of usual vitamin E microcapsule preparation is after 6 months, the integrity of outward appearance, capsule and content have all produced bigger variation, illustrate that the voltage endurance vitamin E microcapsule that this experiment makes can satisfy the tabletting requirement fully.
Claims (10)
1, a kind of voltage endurance vitamin E microcapsule, it is characterized in that: the percentage by weight between its component and the component is: vitamin E oil 50%～70%, capsule material 1%～25%, auxiliary capsule material 5%～30%, octenyl succinate starch 10%～30%, fluidizer 0.5%～2%.
2, a kind of voltage endurance vitamin E microcapsule according to claim 1 is characterized in that: the capsule material is a kind of in gelatin, arabic gum, alginate, chitosan, the casein or more than 2 kinds.
3, a kind of voltage endurance vitamin E microcapsule according to claim 1 is characterized in that: auxiliary capsule material comprises a kind of in dextrin, lactose, mannitol, the sorbitol or more than 2 kinds.
4, a kind of voltage endurance vitamin E microcapsule according to claim 1 is characterized in that: fluidizer is a kind of in micropowder silica gel, Pulvis Talci, the magnesium stearate or more than 2 kinds.
5, a kind of preparation a kind of voltage endurance vitamin E microcapsule preparation method as claimed in claim 1 is characterized in that:
1), preparation aqueous phase solution: 1～3 times the purified water of always measuring admittedly by above-mentioned microcapsule component is heated to 65～70 ℃, by proportioning capsule material, octenyl succinate starch, auxiliary capsule material and fluidizer is slowly added, and stirs it to be uniformly dispersed in 8～15 minutes.
2), preparation oil phase liquid: vitamin E oil is preheated to 65～70 ℃ by proportioning.
3), the emulsifying homogenizing: above-mentioned fluid is slowly added aqueous phase solution mutually, stirring and emulsifying 30～40 minutes, homogenizing is 3 times under 40～45Mpa pressure, getting emulsion examines under a microscope, answer encapsulation complete and big or small about 10 μ m, as do not reach requirement, homogenizing is observed again;
4), spray drying: above-mentioned emulsion is added in the centrifugal spray dryer, is 180 ℃～190 ℃ in inlet temperature, 85～90 ℃ of air-out, the centrifugal energy nozzle rotating speed is under 20,000～30,000 conditions of changeing, and carries out spray drying;
5), check: finished product is carried out outward appearance, encapsulation rate, bulk density, moisture, ash, content check, qualified back packing.
6, a kind of voltage endurance vitamin E microcapsule according to claim 1, it is characterized in that: the percentage by weight between its component and the component is: vitamin E 50%, gelatin 5%, dextrin 12%, octenyl succinate starch 32%, micropowder silica gel 1%.
7, a kind of voltage endurance vitamin E microcapsule according to claim 1, it is characterized in that: the percentage by weight between its component and the component is: vitamin E 55%, sodium caseinate 9%, lactose 10%, octenyl succinate starch 25%, micropowder silica gel 1%.
8, a kind of voltage endurance vitamin E microcapsule according to claim 1, it is characterized in that: the percentage by weight between its component and the component is: vitamin E 60%, chitosan 6%, lactose 12%, octenyl succinate starch 20.8%, micropowder silica gel 1.2%.
9, a kind of voltage endurance vitamin E microcapsule according to claim 1, it is characterized in that: the percentage by weight between its component and the component is: vitamin E 65%, arabic gum 5%, lactose 8%, octenyl succinate starch 20.5%, micropowder silica gel 1.5%.
10, a kind of voltage endurance vitamin E microcapsule according to claim 1, it is characterized in that: the percentage by weight between its component and the component is: vitamin E 70%, arabic gum 2%, dextrin 6.5%, octenyl succinate starch 20%, magnesium stearate 1.5%.
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| CN102090518A (en) * | 2011-01-12 | 2011-06-15 | 乐山市瑞和祥畜牧药业有限公司 | Origanum oil premix and preparation method thereof |
| CN102716087A (en) * | 2012-05-31 | 2012-10-10 | 浙江中同科技有限公司 | Vitamin powder and preparation method thereof |
| CN101703243B (en) * | 2009-08-10 | 2013-01-16 | 北京市金康普食品添加剂科技有限公司 | Vitamin e powder and preparation method thereof |
| CN105542234A (en) * | 2016-01-25 | 2016-05-04 | 中国农业科学院农产品加工研究所 | Degradable composite film for cold fresh meat |
| CN106262933A (en) * | 2016-11-08 | 2017-01-04 | 浙江工业大学 | A kind of preparation method of Vitamin E contained micro capsule |
| CN108888601A (en) * | 2018-08-02 | 2018-11-27 | 济源希健生物医药科技发展有限公司 | A kind of vitamin E selenium microcapsules tablet, preparation method and its usage |
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| US6020003A (en) * | 1998-02-23 | 2000-02-01 | Basf Corporation | Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin |
| EP0966889B1 (en) * | 1998-06-24 | 2007-05-02 | DSM IP Assets B.V. | Vitamin powders for beverage applications |
| EP1066761B1 (en) * | 1999-07-06 | 2004-09-29 | DSM IP Assets B.V. | Compositions containing fat-soluble substances in a carbohydrate matrix |
| CN1203843C (en) * | 2001-04-10 | 2005-06-01 | 中国科学院成都有机化学研究所 | Preparation method of high-content oil-soluble vitamin slow-releasing microcapsule powder |
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| CN101703243B (en) * | 2009-08-10 | 2013-01-16 | 北京市金康普食品添加剂科技有限公司 | Vitamin e powder and preparation method thereof |
| CN102090518A (en) * | 2011-01-12 | 2011-06-15 | 乐山市瑞和祥畜牧药业有限公司 | Origanum oil premix and preparation method thereof |
| CN102716087A (en) * | 2012-05-31 | 2012-10-10 | 浙江中同科技有限公司 | Vitamin powder and preparation method thereof |
| CN102716087B (en) * | 2012-05-31 | 2014-06-11 | 浙江中同科技有限公司 | Vitamin powder and preparation method thereof |
| CN105542234A (en) * | 2016-01-25 | 2016-05-04 | 中国农业科学院农产品加工研究所 | Degradable composite film for cold fresh meat |
| CN105542234B (en) * | 2016-01-25 | 2018-02-13 | 中国农业科学院农产品加工研究所 | Degradable composite membrane for cold fresh meat |
| CN106262933A (en) * | 2016-11-08 | 2017-01-04 | 浙江工业大学 | A kind of preparation method of Vitamin E contained micro capsule |
| CN108888601A (en) * | 2018-08-02 | 2018-11-27 | 济源希健生物医药科技发展有限公司 | A kind of vitamin E selenium microcapsules tablet, preparation method and its usage |
| CN109619536A (en) * | 2018-10-18 | 2019-04-16 | 山东海能生物工程有限公司 | A kind of 25-hydroxy-vitamin D3Microcapsule powder and preparation method thereof |
| CN112107555A (en) * | 2020-09-18 | 2020-12-22 | 万华化学集团股份有限公司 | Vitamin A acetate microcapsule and preparation method thereof |
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Effective date of registration: 20110714 Address after: 19, building 9, building B, Fortune Tower, No. 401121, Honghu East Road, Chongqing, Yubei District Co-patentee after: PKU International Healthcare Group Co., Ltd. Patentee after: PKUCare Southwest Synthetic Pharmaceutical Corp., Ltd. Address before: 401147 Chongqing city Yubei District Longxi Road No. 34 red Patentee before: Southwest Synthetic Pharmaceutical Corp. Ltd. |
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Free format text: FORMER OWNER: PKU INTERNATIONAL HEALTH CARE GROUP CO., LTD. Effective date: 20120203 |
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Effective date of registration: 20120203 Address after: 19, building 9, building B, Fortune Tower, No. 401121, Honghu East Road, Chongqing, Yubei District Patentee after: PKUCare Southwest Synthetic Pharmaceutical Corp., Ltd. Address before: 19, building 9, building B, Fortune Tower, No. 401121, Honghu East Road, Chongqing, Yubei District Co-patentee before: PKU International Healthcare Group Co., Ltd. Patentee before: PKUCare Southwest Synthetic Pharmaceutical Corp., Ltd. |
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Owner name: PEKING UNIVERSITY HEALTHCARE CO., LTD. Free format text: FORMER NAME: PKUCARE SOUTHWEST SYNTHETIC PHARMACEUTICALS CO., LTD. |
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Address after: 19, building 9, building B, Fortune Tower, No. 401121, Honghu East Road, Chongqing, Yubei District Patentee after: PKU HEALTHCARE CORP., LTD. Address before: 19, building 9, building B, Fortune Tower, No. 401121, Honghu East Road, Chongqing, Yubei District Patentee before: PKUCare Southwest Synthetic Pharmaceutical Corp., Ltd. |
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Inventor after: Zhao Hongwu Inventor after: Wang Haiyu Inventor after: Ran Jing Inventor before: Zhao Hongwu Inventor before: Wang Haiyu |
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