CN1905882A - 血管内膜增厚抑制剂 - Google Patents
血管内膜增厚抑制剂 Download PDFInfo
- Publication number
- CN1905882A CN1905882A CNA2005800017340A CN200580001734A CN1905882A CN 1905882 A CN1905882 A CN 1905882A CN A2005800017340 A CNA2005800017340 A CN A2005800017340A CN 200580001734 A CN200580001734 A CN 200580001734A CN 1905882 A CN1905882 A CN 1905882A
- Authority
- CN
- China
- Prior art keywords
- hydrogen atom
- intimal hyperplasia
- hyperplasia inhibitor
- halogen atom
- pharmacology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (5)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004032551 | 2004-02-09 | ||
JP032551/2004 | 2004-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1905882A true CN1905882A (zh) | 2007-01-31 |
CN100506230C CN100506230C (zh) | 2009-07-01 |
Family
ID=34836093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005800017340A Expired - Fee Related CN100506230C (zh) | 2004-02-09 | 2005-02-02 | 血管内膜增厚抑制剂 |
Country Status (13)
Country | Link |
---|---|
US (2) | US20070161642A1 (zh) |
EP (1) | EP1714654A4 (zh) |
JP (1) | JP4783152B2 (zh) |
KR (1) | KR20070029133A (zh) |
CN (1) | CN100506230C (zh) |
AU (1) | AU2005210326B2 (zh) |
BR (1) | BRPI0507518A8 (zh) |
CA (1) | CA2553915C (zh) |
HK (1) | HK1098377A1 (zh) |
IL (1) | IL176795A (zh) |
RU (1) | RU2339381C2 (zh) |
TW (1) | TWI357409B (zh) |
WO (1) | WO2005074938A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723362B2 (en) * | 2004-01-08 | 2010-05-25 | Syngenta Crop Protection, Inc. | Pesticidal heterocyclic dihaloallyl compounds |
EP1604988A1 (en) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
AU2008219166B2 (en) * | 2007-02-16 | 2013-05-16 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors |
FR2948939B1 (fr) * | 2009-08-05 | 2013-03-22 | Pf Medicament | Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA27031A1 (uk) * | 1990-04-25 | 2000-02-28 | Ніссан Кемікал Індастріз Лтд | Похідhі 3(2h)піридазиhоhу або їх фармацевтичhо прийhятhі солі, що мають протитромботичhу, позитивhу іhотропhу, судиhорозширювальhу дію й аhтиалергічhу активhість та фармацевтичhа композиція hа їх осhові |
JP3666042B2 (ja) * | 1994-01-25 | 2005-06-29 | 日産化学工業株式会社 | ピリダジノン誘導体 |
ATE192741T1 (de) * | 1994-01-25 | 2000-05-15 | Nissan Chemical Ind Ltd | Pyridazinon-derivate |
TW338037B (en) * | 1995-10-05 | 1998-08-11 | Otsuka Pharma Co Ltd | Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition |
JP2964029B2 (ja) * | 1995-10-05 | 1999-10-18 | 大塚製薬株式会社 | カルボスチリル誘導体 |
KR100559192B1 (ko) * | 1997-08-28 | 2006-03-13 | 닛산 가가쿠 고교 가부시키 가이샤 | 혈관신생 촉진제 및 혈관신생 작용증강제 |
AU5445699A (en) * | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Remedies for spinal canal stenosis |
EP1157694A4 (en) * | 1998-12-07 | 2002-08-28 | Nissan Chemical Ind Ltd | REMEDIES OF THE ERECTIONAL DISORDER |
JP2001131088A (ja) * | 1999-11-02 | 2001-05-15 | Kyurin:Kk | シンドロームx症候群治療剤 |
CA2304906A1 (en) * | 2000-04-07 | 2001-10-07 | 1411198 Ontario Limited | 13-hode, a regulator of vascular biocompatibility and an inhibitor of cell hyperplasia |
-
2005
- 2005-02-02 WO PCT/JP2005/001518 patent/WO2005074938A1/ja active Application Filing
- 2005-02-02 AU AU2005210326A patent/AU2005210326B2/en not_active Ceased
- 2005-02-02 JP JP2005517709A patent/JP4783152B2/ja not_active Expired - Fee Related
- 2005-02-02 KR KR1020067014583A patent/KR20070029133A/ko not_active Application Discontinuation
- 2005-02-02 BR BRPI0507518A patent/BRPI0507518A8/pt active Search and Examination
- 2005-02-02 EP EP05709638A patent/EP1714654A4/en not_active Withdrawn
- 2005-02-02 CA CA2553915A patent/CA2553915C/en not_active Expired - Fee Related
- 2005-02-02 US US10/585,949 patent/US20070161642A1/en not_active Abandoned
- 2005-02-02 RU RU2006132389/15A patent/RU2339381C2/ru not_active IP Right Cessation
- 2005-02-02 CN CNB2005800017340A patent/CN100506230C/zh not_active Expired - Fee Related
- 2005-02-03 TW TW094103407A patent/TWI357409B/zh not_active IP Right Cessation
-
2006
- 2006-07-11 IL IL176795A patent/IL176795A/en not_active IP Right Cessation
-
2007
- 2007-05-09 HK HK07104940.6A patent/HK1098377A1/xx not_active IP Right Cessation
-
2009
- 2009-01-14 US US12/353,646 patent/US20090155187A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2005210326A1 (en) | 2005-08-18 |
IL176795A (en) | 2013-01-31 |
US20090155187A1 (en) | 2009-06-18 |
RU2339381C2 (ru) | 2008-11-27 |
CA2553915C (en) | 2010-06-01 |
BRPI0507518A8 (pt) | 2015-12-01 |
US20070161642A1 (en) | 2007-07-12 |
BRPI0507518A (pt) | 2007-07-03 |
RU2006132389A (ru) | 2008-03-20 |
WO2005074938A1 (ja) | 2005-08-18 |
JPWO2005074938A1 (ja) | 2007-09-13 |
AU2005210326B2 (en) | 2009-10-22 |
HK1098377A1 (en) | 2007-07-20 |
KR20070029133A (ko) | 2007-03-13 |
TWI357409B (en) | 2012-02-01 |
CA2553915A1 (en) | 2005-08-18 |
EP1714654A1 (en) | 2006-10-25 |
CN100506230C (zh) | 2009-07-01 |
JP4783152B2 (ja) | 2011-09-28 |
IL176795A0 (en) | 2006-10-31 |
EP1714654A4 (en) | 2011-02-16 |
TW200530218A (en) | 2005-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Morgan et al. | Effects of interstrain renal transplantation on NaCl-induced hypertension in Dahl rats. | |
JP5190086B2 (ja) | 動脈硬化及び高血圧症の予防及び治療のための医薬 | |
KR100386229B1 (ko) | 히드록시카르바졸화합물의평활근유주및증식의억제 | |
US20110136865A1 (en) | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists | |
CN106304835A (zh) | sGC刺激剂 | |
US4444778A (en) | Method and composition for treating atherosclerosis | |
JPS62215527A (ja) | アルツハイマー病治療薬 | |
EA003142B1 (ru) | Лекарственное средство, обладающее антидепрессивным действием, его применение и способ лечения | |
KR20040032141A (ko) | 제약 복합제제 | |
EP1358177B1 (en) | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | |
EP0783303B1 (en) | Use of aromatic halides for treating mammalian cell proliferation | |
CZ287958B6 (cs) | Farmaceutický přípravek pro inhibici migrace buněk vaskulárního hladkého svalstva | |
CN1905882A (zh) | 血管内膜增厚抑制剂 | |
WO1997021439A1 (fr) | Medicament destine au traitement des troubles obsessifs compulsifs, de l'apnee du sommeil, des dysfonctions sexuelles, de l'emese et du mal des transports | |
EP1092431B1 (en) | Lasofoxifene compositions | |
CN1930123B (zh) | 用于预防或治疗伴有神经障碍的膀胱过度活动症的医药组合物 | |
AU779152B2 (en) | Prophylactic use of N-methyl-D-aspartate (NMDA) antagonists | |
EP0398326A2 (en) | Serotonin antagonist | |
BE1009060A3 (fr) | Compositions pharmaceutiques et procede permettant leur preparation. | |
EA007952B1 (ru) | Применение ирбесартана для изготовления лекарств, которые пригодны для предупреждения или лечения лёгочной артериальной гипертензии | |
MX2010006520A (es) | Metodo y composicion para el tratamiento de una condicion mediada por alfa-adrenoceptor. | |
SK227092A3 (en) | Pharmaceutical agent against the high blood pressure | |
US20050143441A1 (en) | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity | |
WO2000002556A1 (fr) | Utilisation d'une composition pharmaceutique contenant, en association, un antagoniste des recepteurs at1 de l'angiotensine ii et l'indomethacine pour la fabrication d'un medicament pour traiter les glomerulonephrites chroniques | |
AU2006261296B2 (en) | Pharmaceutical composition comprising a 1-(3-chlorophenyl)-3-alkylpiperazine for treating apetite disorder |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1098377 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1098377 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: TAISHO PHARMACEUTICAL CO., LTD. Effective date: 20150422 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150422 Address after: Tokyo, Japan Patentee after: Nissan Chemical Industries Co., Ltd. Address before: Tokyo, Japan Patentee before: Nissan Chemical Industries Co., Ltd. Patentee before: Taisho Pharmaceutical Co., Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090701 Termination date: 20180202 |
|
CF01 | Termination of patent right due to non-payment of annual fee |