CN1899223A - Removable spring ring for treating angioma - Google Patents
Removable spring ring for treating angioma Download PDFInfo
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- CN1899223A CN1899223A CN 200610029280 CN200610029280A CN1899223A CN 1899223 A CN1899223 A CN 1899223A CN 200610029280 CN200610029280 CN 200610029280 CN 200610029280 A CN200610029280 A CN 200610029280A CN 1899223 A CN1899223 A CN 1899223A
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- turn
- angiomatous
- treatment
- medicine
- spring ring
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Abstract
The removable spring ring for treating angioma belongs to the field of angioma treating technology and medical equipment technology. The removable spring ring for treating angioma includes one spring ring with one coating of biodegradable polymer, hydro gel or medicine for efficient embolism, and one conveying duct connected to the spring ring via insulating polymer adhesive. The polymer coating in the spring ring can speed the formation of coagulated tissue inside the angioma to embolize and has controllable degrading speed; the hydro gel can expand in blood or moisture condition for dealing with giant aneurysm; and the medicine for efficient embolism can raise the treatment effect.
Description
Technical field
Belonging to technical field of medical instruments, exactly is a kind of angiomatous technology of treatment that relates to.
Background technology
Electrolysis is taken off the turn medical treatment device and is used for the treatment of encephalic angioma, and the hemangioma length of this thin-walled communicates on cerebral arteries and with it, in case hemangioma is broken, the patient faces life danger.When turn medical treatment device treatment encephalic angioma was freed in electricity consumption, the doctor delivered to special platinum turn in the hemangioma with a special conduit, and the logical 1mA of conduit causes platinum turn electrolytically detaching conduit, and retains in the hemangioma to the 2mA unidirectional current then.After the shared volume of one or more platinum turns reached the certain proportion of whole hemangioma volume, the flow velocity of blood in hemangioma reduced gradually, formed entity at last in hemangioma and sealed hemangioma, prevented that with this hemangioma from breaking.
First limitation that the turn design is taken off in the GDC of boston, u.s.a scientific ﹠ technical corporation (Guglielmi Detachable Coil) Gao Lemi electrolysis at present is that the time instability is taken off in electrolysis.The GDC electrolysis is taken off the turn design because of adopting the electric welding technology to connect platinum turn and delivery conduit.After the electric welding cooling, the part of welding can't be very even.And sometimes uneven weld can produce more high-tension electrolysis activity, and after reason was cooling, the weld metal composition was inhomogeneous caused.In addition, weld the electric current of being quoted and cause not specification ground electrolysis situation unavoidablely.This electric welding technology causes the platinum turn to be not easy control from the delivery conduit electrolytically detaching time, and scope can be from the shortest 30 seconds to the longest 15 minutes.This electric welding technology causes the platinum turn to be not easy control from the delivery conduit electrolytically detaching time, and scope can be from the shortest 30 seconds to the longest 15 minutes.
It is to guarantee very angiomatous thromboembolism that second limitation of turn design taken off in the GDC electrolysis.Though a hemangioma on average needs to fill with four to six GDC turns.Because hemangioma mainly is that the thrombosis between the turn also is because of blood stasis forms by the turn space filling, turn itself does not have the thrombosis generation that tangible biological nature is filled to facilitate favourable hemangioma.
Turn is taken off in the GDC electrolysis, and to design the 3rd limitation be the hemangioma that is not suitable for treating wide mouthful of neck, such as the tumor chamber: tumor neck≤4: 1, can't stablize the tortuous hemangioma chamber of overflowing easily because of turn, cause parent artery to stop up.
Turn is taken off in the GDC electrolysis, and to design the 4th limitation be to be not suitable for treating huge hemangioma.Can produce tangible occupy-place effect behind the giant aneurysm tumor intracavity filling turn, the compressing of gravity easily causes the parent artery obturation, especially for the hemangioma of the anterior communicating artery and middle cerebral artery 1-2 section.
In view of turn design limitation is taken off in above GDC electrolysis, need the even more ideal treatment of invention with taking off the turn medical treatment device to overcome these limitations.
Summary of the invention
It is even to the invention provides a kind of coupling part, and the time of freeing is stable, and favourable thrombosis can be stablized crumpled a kind of angiomatous turn that takes off that is used for the treatment of.
The technical scheme that the present invention takes:
A kind of taken off turn that is used for the treatment of encephalic angioma comprises metal turn and the delivery conduit that is attached thereto by the thing that links to each other, and its formation is: the thing that links to each other is insulation macromolecular material adhesive; Turn covers a coating; Coating is by biological degradation polyalcohol, or gel aqueous fluid, or can efficiently form the medicine formation of effect of embolization.Insulation macromolecular material adhesive is: acrylic acid, epoxy, polyurethane.Biological degradation polyalcohol is by polyglycolic acid (polyglycolic acid), polylactic acid (polylactic acid), polyglycolic acid/copolymer of poly lactic acid (polyglycolic/poly-L-lactic acid copolymers) and polycaprolactone (polycaprolactones) constitute.Gel aqueous fluid is a protein gel, collagen, albumin, hematochrome, Fibrinogen, fibrin, elastin laminin, keratin, casein.The medicine that can efficiently form effect of embolization is auspicious fado-ReFacto (Wyeth, Wei Si pharmacy); Ban Nifen-BeneFIX (Wyeth, Wei Si pharmacy); Alpha 9SD coagulation factor IX-AlphaNine SD Coagulation Factor IX (AlphaTherapeutic Corporation, Alpha Therapeutic Corp.).Its medicine can be directly to be coated on the turn or to be coated in coating (biological degradation polyalcohol or hydrogel) on the turn, and then becomes medicine and be coated with turn.
The structure of turn can comprise sphere, and oval or a series of difformities are formed.The metal building material of turn comprises, rustless steel, and platinum, rhodium, rhenium, palladium, tungsten, or the alloy of its metal, the length of turn can be from 2cm to 30cm.
Good effect behind enforcement the present invention is:
The present invention removes the electric welding design, adopts insulation macromolecular material adhesive technology, thereby has avoided the defective of electric welding technology, and then more effectively controls the platinum turn from the delivery conduit electrolytically detaching time.The advantage of macromolecular material adhesive technology provides more uniform connecting area, thereby turn can be broken away from from delivery guidewire in hemangioma faster; The turn of coating polymer can quicken the formation of grumeleuse tissue in the hemangioma, this advantage and then more effectively guarantee very angiomatous thromboembolism.Biological degradation polyalcohol can be regenerated and as the support of cell growth, and can control the speed of degradation by changing its molecular structure or different high molecular composition; The advantage of hydrogel uniqueness is in the environment of blood or humidity, its self expansion ability, the hydrogel material that the water yield is filled part can hold and be equivalent to 400% to 5000% moisture content (calculating by weight), increase on the respective diameters about 50% to 500%, usually about 50% to 250%, so the hydrogel of self expansion can tackle the problem of wide neck or giant aneurysm effectively.In addition, the present invention is also the turn that is covered with polymer (biological degradation polyalcohol or hydrogel), coats the medicine that improves effect of embolization, and then becomes medicine and be coated with turn.Medicine may be the outside that is coated in polymer, and inside or both all are.The ideal medicine polymer of putting must stick on the turn securely; Have the ability medicine is stayed in the coating, and then reach essential therapeutic dose, can under certain control, be released in medicine in the aneurysm simultaneously.
Description of drawings
Fig. 1 is turn and the bonding cross-sectional schematic of the thing that links to each other
Fig. 2 is turn seal coat sketch map
Fig. 3 is the full aneurysm sketch map of turn thromboembolism
Fig. 4 is for medicine is coated with the full aneurysm sketch map of turn thromboembolism
Fig. 5 is hydrogel coating turn expansion back sketch map
The specific embodiment
Now the invention will be further described in conjunction with the accompanying drawings
A kind of taken off turn that is used for the treatment of encephalic angioma, comprise metal turn 1 and the delivery guidewire 3 that is attached thereto by the thing 2 that links to each other, its structure is: the thing 2 that links to each other is insulation macromolecular material adhesive, and macromolecule adhesive is positioned over the zone between delivery guidewire and the turn.The length that connects may be as short as 0.5mm, and does not generally surpass 5cm length;
Can take off turn 1 and put into 7 li of hemangioma by arteries 6 via microtubular 5.When turn 1 from microtubular 5, expand successively long in, its can nature curls up and and then forms the aneurysm of a thromboembolism.Then, turn can and delivery guidewire 8 come by electrolytic separation.Can place one or more turns in the aneurysm.After the implanted aneurysm of turn, thromboembolism can produce from the spatial mechanism of the inherent charges of turn itself, or the cell effect that causes of turn and cause the formation of thrombosis, or uses both means, after the full hemangioma of turn thromboembolism; If coat the turn of medicine, along with polymer is demoted in aneurysm, medicine 9 can discharge in hemangioma.Medicine may be the outside that is coated in polymer, and inside or both all are.The situation of thromboembolism is along with medicine is released and improves from turn in the aneurysm.And, because turn device obstacle the outlet of most of aneurysm neck, therefore medicine can not flow into the arteries that adjoins and cause the formation of thrombosis.If be covered with hydrogel coating on the turn, the incipient stage after the intravasation tumor, its area coverage just with as turn the same, as Fig. 4.But after general 30-60 minute, hydrogel coating turn 10 expansion voluntarily comes, and angiomatous most area is filled up, and then be more suitable for treating wide neck or huge aneurysm.
Claims (5)
1, a kind ofly be used for the treatment of the angiomatous turn that takes off, comprise metal turn (1) and the delivery conduit (3) that is attached thereto by the thing that links to each other (2), it is characterized in that: the thing (2) that links to each other is insulation macromolecular material adhesive; Turn (1) covers a coating (4); Coating is by biological degradation polyalcohol, or gel aqueous fluid, or can efficiently form the medicine formation of effect of embolization.
2, a kind of angiomatous turn that takes off that is used for the treatment of according to claim 1, it is characterized in that: described insulation macromolecular material adhesive is: acrylic acid, epoxy, polyurethane.
3, a kind of angiomatous turn that takes off that is used for the treatment of according to claim 1, it is characterized in that: described biological degradation polyalcohol is by polyglycolic acid, polylactic acid, polyglycolic acid/copolymer of poly lactic acid and polycaprolactone constitute.
4, a kind of angiomatous turn that takes off that is used for the treatment of according to claim 1, it is characterized in that: described gel aqueous fluid is a protein gel, collagen, albumin, hematochrome, Fibrinogen, fibrin, elastin laminin, keratin, casein.
5, a kind of angiomatous turn that takes off that is used for the treatment of according to claim 1, it is characterized in that: the described medicine that can efficiently form effect of embolization is auspicious fado, Ban Nifen, Alpha 9SD coagulation factor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610029280 CN1899223A (en) | 2006-07-24 | 2006-07-24 | Removable spring ring for treating angioma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610029280 CN1899223A (en) | 2006-07-24 | 2006-07-24 | Removable spring ring for treating angioma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1899223A true CN1899223A (en) | 2007-01-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610029280 Pending CN1899223A (en) | 2006-07-24 | 2006-07-24 | Removable spring ring for treating angioma |
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| Country | Link |
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| CN (1) | CN1899223A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006286A (en) * | 2012-12-18 | 2013-04-03 | 邹旭华 | Developable sealed type woven body implantation material and conveying device |
| CN104739479A (en) * | 2013-12-31 | 2015-07-01 | 微创神通医疗科技（上海）有限公司 | Spring coil and production method thereof |
-
2006
- 2006-07-24 CN CN 200610029280 patent/CN1899223A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006286A (en) * | 2012-12-18 | 2013-04-03 | 邹旭华 | Developable sealed type woven body implantation material and conveying device |
| CN103006286B (en) * | 2012-12-18 | 2015-07-08 | 邹旭华 | Developable sealed type woven body implantation material and conveying device |
| CN104739479A (en) * | 2013-12-31 | 2015-07-01 | 微创神通医疗科技（上海）有限公司 | Spring coil and production method thereof |
| CN104739479B (en) * | 2013-12-31 | 2017-11-03 | 微创神通医疗科技（上海）有限公司 | A kind of turn and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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