CN1895547A

CN1895547A - Medicine for treating diabetes and its preparation

Info

Publication number: CN1895547A
Application number: CNA2006100914412A
Authority: CN
Inventors: 魏四清
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-06-16
Filing date: 2006-06-16
Publication date: 2007-01-17
Anticipated expiration: 2026-06-16
Also published as: CN1895547B

Abstract

A medicine for treating diabetes B and its complications is prepared from gliquidone and 21 Chinese-medicinal materials including ginseng, astragalus root, rehmannia root, red sage root, etc. Its preparing process is also disclosed.

Description

A kind of medicine and preparation method for the treatment of diabetes

Technical field:

The present invention relates to a kind of Jiangtang capsule, this capsule can be used to treat type 2 diabetes mellitus and complication thereof, also relates to this capsular preparation method.

Background technology:

At present, along with the raising of people's living standard and the prolongation of human longevity, diabetes prevalence has the trend of increasing.According to statistics, the prevalence in cities such as China Beijing has reached 1%-2%, and the people's prevalence more than 50 years old is 10%.China has diabetics 2,000 ten thousand people now; About 200,000,000 diabeticss in the whole world.Multiple acute and chronic complication easily takes place in diabetic duration principal, more becomes to increasing with the neural blood capillary of the peculiar general of diabetes, trunk chronic complicating diseases especially.Often can involve each organ of human body, cause many organ injuries such as the heart, brain, kidney, nerve and eye.Many complication, serious threat patient's health and lives.

For treatment of diabetes, types of drugs is various at present.Western medicine has the insulin secretion accelerating medicine, reduces or delays the medicine of carbohydrate absorption, and insulin sensitivity enhancing medicine etc. are multiple; Chinese medicine also has several, as SHENQI JIANGTANG sheet (granule), glycosuria spirit, blood sugar lowering drink, blood-sugar lowering tcm drug, YUQUAN WAN, JIANGTANGSHU, SHANHAI PILL etc., its function mostly is enriching yin and nourishing kidney, supplementing QI for promoting the production of body fluid, can improve the partial symptoms of diabetics, its advantage is that negative interaction is few, improves patient's subjective symptoms, and its blood sugar lowering effective percentage is lower.And the blood sugar reducing function of Western medicine is obvious, but its major part is taken the generation that will certainly quicken diabetic nephropathy for a long time from renal excretion.Diabetes pill is the model of Chinese and Western combination, but its Chinese medicine ingredients is single, mainly acts on supplementing QI and nourishing YIN, and is mainly good to deficiency of vital energy type of yin deficiency effect.And many diabeticss that experiment showed, of diabetics are just had the microangiopathies of many internal organs in early days, cause microcirculation disturbance thus.Learn the survey formula from hemorheology, diabetics has whole blood viscosity to increase, and erythrocyte deformability reduces, abnormal changes such as platelet aggregation enhancing.Therefore, the treatment diabetes add in early days with activating blood and removing stasis drug on the basis of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs and can improve effect, and effectively prevent and treat complication.Famous Traditional Chinese Medicine experts wishes that Chen Yuceng takes the lead in using activating blood and removing stasis drug treatment diabetes and obtains curative effect preferably, and use blood circulation promoting medicine to help the improvement of diabetic vascular lesion in early days, particularly improve the microcirculation in islets of langerhans zone, improve amount of blood supply, help secretion of insulin.

Through clinical verification for many years, the treatment by Chinese herbs diabetes, its few side effects, it is remarkable that it improves the certain effect in symptom aspect, but blood sugar reducing function then is inferior to Western medicine.Simple western medicine blood sugar lowering determined curative effect, its Liver and kidney toxicity, digestive tract side effects are many, have also just quickened the generation of diabetic nephropathy.Therefore, the inventor stablizes at Western medicine with Chinese medicine on the basis of blood glucose and prevents and treats complication, improves subjective symptoms, and then the two is learnt from other's strong points to offset one's weaknesses, and it is remarkable to obtain effect.

The objective of the invention is to, provide a kind of and have that tonifying QI to produce body fluid, yang invigorating quench the thirst, enriching yin and nourishing kidney, the treatment type 2 diabetes mellitus of blood circulation promoting and blood stasis dispelling function and the novel form of complication thereof, it can effectively improve polydipsia, polyuria, polyphagia, weak, become thin, symptom such as lumbago, visual deterioration, hyperhidrosis, acroesthesia, and can with in, Western medicine organically combines, in the performance, the Western medicine synergism, effectively reduce patient's blood glucose, glucose in urine and glycolated hemoglobin, prevent and treat and delay the generation of diabetes patient's complication.Also have drug safety, non-evident effect, small amount and special effect simultaneously, take characteristics easily.

Another object of the present invention provides the preparation method of this medicine.

Summary of the invention:

One medicine is formed

The component of medicine of the present invention comprises following crude drug kind, and the consumption of each crude drug is expressed as follows with weight portion:

The parasitic 60-70 Rhizoma Coptidis of Radix Ginseng 40-50 Radix Astragali 150-160 Radix Rehmanniae 50-60 50-60 Radix Ophiopogonis Rhizoma Cibotii 40-50 Rhizoma Polygonati Odorati 50-60 Rhizoma Atractylodis 50-60 Radix Scrophulariae 50-60 Rhizoma Anemarrhenae 24-30 Cortex Lycii 50-60 Fructus Corni 40-50 Rhizoma Polygonati 80-90 Fructus Ligustri Lucidi 50-60 Fructus Schisandrae Chinensis 24-30 pollen 120-130 Endothelium corneum 40-50 Radix Salviae Miltiorrhizae 80-90 Flos Carthami 40-50 Radix Puerariae 50-60 40-50.

Diabetics is become thin, hyperhidrosis, weak, cardiopalmus, and Chinese medical discrimination is a deficiency of both QI and YIN, and the flesh natural fibre line of meat is solid, lack of preservation of spirit; So with monarch drug Radix Ginseng, Radix Astragali tonifying QI to produce body fluid, yang invigorating quenches the thirst.

Diabetics has soreness of the waist and knees, weak breath weak more, diseases such as vexed insomnia, dryness of the mouth and throat, and Chinese medical discrimination is the kidney deficiency in both YIN and YANG, based on deficiency of the kidney yin, with the Radix Rehmanniae, Radix Ophiopogonis, Rhizoma Cibotii, medicine enriching yin and nourishing kidney such as parasitism, Fructus Corni, Rhizoma Polygonati are to support it.

Sugar patient's chronic complicating diseases refers to trunk, blood capillary and neuropathy.Coronary heart disease, hypertension, cerebrovascular, nephropathy, ocular complications, neuropathy are arranged.So live dead blood, the blood stasis that looses, qualcomm meridian with to its disease with Radix Salviae Miltiorrhizae, Flos Carthami.

Endothelium corneum, pollen, the Radix Astragali, the Radix Rehmanniae have the urine glucose lowering effect.Rhizoma Atractylodis are joined the Radix Scrophulariae blood sugar lowering, Radix Puerariae, Radix Salviae Miltiorrhizae, Endothelium corneum blood sugar lowering, microcirculation improvement.The hypoglycemic effect of Radix Ginseng is to improve the ability that body is removed interior free yl.Old friend's ginseng can not only be improved symptom by blood sugar lowering, but also can prevent and treat diabetic complication.

Two preparation methoies

By above component, medicine of the present invention can be made different dosage forms by usual way, is best with capsule wherein, and method is that medicine-feeding Radix Ginseng, the Radix Rehmanniae, Radix Scrophulariae, pollen, Endothelium corneum, Rhizoma Polygonati Odorati, Fructus Corni, Rhizoma Polygonati are pulverized and ground to the powder, and cross 120 mesh sieves.Other medicines decoct 3 times, and collecting decoction filters, and filtrate is condensed into cream.Above fine powder is blended in the cream, stirs evenly drying.Water medicine powder is broken into fine powder, and uniform mixing is promptly with it.

Encapsulated, every 0.4g.Every contains gliquidone sheet 5mg, according to the blood sugar regulating consumption.Sterilize with radiation sterilization.

Above capsule each oral dose of being grown up is equivalent to crude drug 4-8 gram approximately, divides every day and takes for 2-4 time, and generally logotype 30 days was 1 course of treatment.

The inventor used the positive at random analysis clinical observation of Drug therapy of the present invention and matched group in 1996 to hundreds of routine type 2 diabetes mellitus patients.The 367 routine statistical analysiss that the record of wherein selection data is more complete.Male's 206 examples wherein, women's 161 examples; The oldest person 75 years old, reckling 39 years old.

Selected patient all meets following diagnostic criteria: 1 fasting glucose is higher than 7.0mmol/L; The 2 glucose in urine positives; 3 have tangible clinical symptoms.

Therapeutic Method is, the patient takes medicine 8-16 grain of the present invention every day, divide 2-4 time oral, 1 month was 1 course of treatment.3 courses of treatment are observed in the treatment of this group case.Take cooperate during this medicine with keep on a diet, appropriate exercise, withdraw other all Chinese and Western hypoglycemic medicines.

After the treatment group was taken medicine of the present invention, according to the blood sugar regulating oral dose, matched group was with pure Chinese medicine, western medicine, also according to blood sugar regulating dosage.The treatment group to blood glucose and syndrome effective percentage all apparently higher than matched group.See accompanying drawing 1 for details.

After 3 years, follow up a case by regular visits to the 85 routine courses of disease the patient of 10-12 patient age between 48 years old-70 years old, the treatment group significantly reduces than matched group complication sickness rate.See accompanying drawing 2 for details.

From accompanying drawing as can be seen, because the collaborative treatment of Chinese and western medicines diabetes with the Western medicine blood sugar control, prevent or postponed the generation of complication effectively, and with the Chinese herb prevention complication, its effect are apparent.

The invention will be further described below in conjunction with embodiment.

Take by weighing following medicine:

Radix Ginseng 40 Radixs Astragali 150 Radix Rehmanniae 50 Rhizoma Cibotii, 40 Rhizoma Polygonati Odorati, 50 Radix Ophiopogonis 50 Rhizoma Atractylodis 50 Radix Scrophulariaes 50 Rhizoma Anemarrhenaes 24 Cortex Lycii 50 Fructus Corni 40 Rhizoma Polygonatis 80 Fructus Ligustri Lucidi 50 Fructus Schisandrae Chinensis 24 pollen 120 Endothelium corneum 40 Radix Salviae Miltiorrhizaes 80 Flos Carthamis 40 Radix Puerariaes 50 parasitic 60 Rhizoma Coptidis 40.

Each medicine is cleaned, sorts initial processing, and by above component, the pulverizing such as Radix Ginseng, the Radix Rehmanniae, Radix Scrophulariae, pollen, Endothelium corneum of will adding medicine to grind to the powder, through 120 mesh sieves.Other medicines decoct 3 times, and collecting decoction filters, and filtrate is condensed into cream.Above fine powder is blended in the cream, stirs evenly drying.Water medicine powder is broken into fine powder, and uniform mixing is promptly with it.

Claims

1, a kind of medicine for the treatment of diabetes, it consists of: Radix Ginseng 40-50, Radix Astragali 150-160, Radix Rehmanniae 50-60, Radix Ophiopogonis 50-60, Rhizoma Cibotii 40-50, Rhizoma Polygonati Odorati 50-60, Rhizoma Atractylodis 50-60, Radix Scrophulariae 50-60, Rhizoma Anemarrhenae 24-30, Cortex Lycii 50-60, Fructus Corni 40-50, Rhizoma Polygonati 80-90, Fructus Ligustri Lucidi 50-60, Fructus Schisandrae Chinensis 24-30, pollen 120130, Endothelium corneum 40-50, Radix Salviae Miltiorrhizae 80-90, Flos Carthami 40-50, Radix Puerariae 50-60, parasitic 60-70, Rhizoma Coptidis 40-50; And gliquidone.

2, the medicine of treatment diabetes as claimed in claim 1, its preparation method is as follows: Radix Ginseng, the Radix Rehmanniae, Radix Scrophulariae, pollen, Endothelium corneum, Rhizoma Polygonati Odorati, Fructus Corni, Rhizoma Polygonati, the common pulverizing are ground to the powder, cross 120 mesh sieves; Other medicines decoct 3 times, and collecting decoction filters, and filtrate is condensed into cream; Above fine powder is blended in the cream, stirs evenly drying; Gliquidone is ground into fine powder, with the cream uniform mixing that is blended into fine powder; Incapsulate then.

3, the medicine of treatment diabetes as claimed in claim 1 is characterized in that: every 0.4g of this capsule, and every contains gliquidone 5mg, according to the blood sugar regulating consumption, the radiation sterilization sterilization.

4, as the purposes of medicine in being used for the treatment of type 2 diabetes mellitus and complication thereof of claim 1 or 3 described treatment diabetes.