CN1887358A - Medical chitosan dressing and its application - Google Patents
Medical chitosan dressing and its application Download PDFInfo
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- CN1887358A CN1887358A CN 200610045441 CN200610045441A CN1887358A CN 1887358 A CN1887358 A CN 1887358A CN 200610045441 CN200610045441 CN 200610045441 CN 200610045441 A CN200610045441 A CN 200610045441A CN 1887358 A CN1887358 A CN 1887358A
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Abstract
The medical chitosan dressing is mixture of chitosan in 1 weight portion, Chinese medicine extract in 0.01-10 weight portions, chitosan derivative in 0.01-10 weight portions, and metal ion in 0.0001-0.05 weight portion. The Chinese medicine extract is bletilla tuber polysaccharide or natural indigo; and the chitosan derivative is one of hydroxypropyl chitin, hydroxypropyl chitosan, succinyl chitin, succinyl chitosan, carboxymethyl chitin and carboxymethyl chitosan. The medical chitosan dressing has the functions of promoting healing of the wound and stopping bleeding, inhibiting bacterial growth, and has excellent wound pasting performance.
Description
Technical field
The present invention relates to a kind of medical chitosan dressing, particularly relate to a kind of medical chitosan dressing and be applied to wound hemostasis, antibacterial and wound repair.
Background technology
Chitosan is a kind of natural polymer polycation polysaccharide, good biocompatibility, non-immunogenicity, have no side effect, have hemostasis, antibiotic, anti-infectious function simultaneously, and can promote wound healing, and being easy to form gel and making diaphragm, these have all given the superperformance of chitosan as bleeding-stopping dressing, antibacterial dressing, repair in trauma dressing.With the chitosan is feedstock production wound hemostasis material, the existing report of material antibiotic, that promote wound healing.Water-fast diaphragm or sponge are normally made chitosan in these researchs, carry out the effects such as hemostasis of wound.But it is, not ideal for bigger hemorrhage its haemostatic effect because the haemostatic effect of chitosan own is limited.Researcher is arranged with chitosan and the compound use of other hemorrhages again, improve haemostatic effect.The hemorrhage majority of compound use is thrombin or sodium alginate or collagen, the attaching of the water-fast chitosan diaphragm of these that make or sponge and skin histology is poor thus, therefore still await further improving and improve its haemostatic effect and with the attaching of skin histology.
Summary of the invention
The purpose of this invention is to provide a kind of medical chitosan dressing, and use it for wound hemostasis, antibacterial infection and wound repair, to remedy the above-mentioned deficiency of prior art.
A kind of medical chitosan dressing, it is characterized in that it contains chitosan and Chinese medicine extract or chitosan derivatives or metal ion, the part by weight of described chitosan and Chinese medicine extract is 100: 1～1000, and described Chinese medicine extract is a kind of in bletilla polysaccharide, the Indigo Naturalis; The part by weight of described chitosan and chitosan derivatives is 100: 1～1000, and described chitosan derivatives is a kind of in Chitofilmer, hydroxypropyl chitosan, succinyl-chitosan, succinyl chitin, carboxymethyl chitosan, the carboxymethyl chitin; The part by weight of described chitosan and metal ion is 100: 0.01～5, and described metal ion is a kind of in calcium ion, the zinc ion.
Described medical chitosan dressing at clinical trauma care and the hemostasis in repairing, antibacterial, antibiotic, promote the application in the wound healing.
Medical chitosan dressing of the present invention has the wound healing of promotion, hemostatic effect, can suppress the growth of antibacterial simultaneously, and good with the wound surface applicating property, preparation technology is simple, is a kind of medical dressing with DEVELOPMENT PROSPECT.
The specific embodiment
Embodiment 1: the preparation of medical chitosan dressing A
(1) preparation of bletilla polysaccharide: take by weighing Chinese medicine Pseudobulbus Bletillae (Rhizoma Bletillae) 50g, porphyrize, (chief editor is cloudy strong by " modernization of cmm and clinical practice ", the traditional Chinese medical science Ancient Books Publishing House, nineteen ninety-five) method described in " preparation of Rhizoma Bletillae gel " in (2) the 120th page, the preparation bletilla polysaccharide, bletilla polysaccharide powder 6g.The quality of the described Chinese medicine Pseudobulbus Bletillae (Rhizoma Bletillae) of present embodiment meets a Pharmacopoeia of the People's Republic of China 67-68 page or leaf " Pseudobulbus Bletillae (Rhizoma Bletillae) " following described quality standard in 2005.
(2) preparation of chitosan Pseudobulbus Bletillae (Rhizoma Bletillae) glue: take by weighing chitosan powder 4g, put in the clean beaker of 500ml, the add 1% aqueous acetic acid 150ml of (V/V, down with), stirring and dissolving, the chitosan aqueous acetic acid.Take by weighing above-mentioned bletilla polysaccharide powder 0.5 g, place the clean beaker of another 100ml, add 1% aqueous acetic acid 50ml, stirring and dissolving gets the bletilla polysaccharide aqueous acetic acid.Above-mentioned chitosan aqueous acetic acid and above-mentioned bletilla polysaccharide aqueous acetic acid are merged, stir, get chitosan Pseudobulbus Bletillae (Rhizoma Bletillae) glue.
(3) preparation of membrane-like chitosan dressing A: get above-mentioned chitosan Pseudobulbus Bletillae (Rhizoma Bletillae) glue 60ml, average is on the square clean glass plate of 20cm * 20cm to the length of side two horizontal positioned, wipes off with Glass rod, and natural drying gets membrane-like chitosan dressing A.
(4) preparation of spongy chitosan dressing A: get above-mentioned chitosan Pseudobulbus Bletillae (Rhizoma Bletillae) glue 80ml, in 4 specifications of going into horizontal positioned rustless steel pallet mould that is 5cm * 5cm * 5mm, to full, place-20 ℃ of refrigerator and cooled to freeze 24h, place-56 ℃ of freezer dryer vacuum lyophilization 48h, get spongy chitosan dressing A.
(5) preparation of powdery chitosan dressing A: take by weighing above-mentioned chitosan powder 5g, take by weighing above-mentioned bletilla polysaccharide powder 0.2g, place the mortar porphyrize, and mix homogeneously, get powdery chitosan dressing A.
In the present embodiment, chitosan dressing A contains chitosan and bletilla polysaccharide, and the part by weight of chitosan and bletilla polysaccharide can be 100: 1～and 1000.Bletilla polysaccharide also is called Rhizoma Bletillae gel.Chitosan dressing A can be membrane-like, spongy and powdery.In the present embodiment, bletilla polysaccharide can change the Indigo Naturalis powder into, also can reach same effect.
Embodiment 2: the preparation of medical chitosan dressing B
(1) preparation of chitosan Chitofilmer glue: take by weighing chitosan powder 4.0g, put in the clean beaker of 500ml, add 1% aqueous acetic acid 150ml, stirring and dissolving gets the chitosan aqueous acetic acid.Take by weighing Chitofilmer powder 1.0g, put in the clean beaker of another 100ml, add 1% aqueous acetic acid 50ml, stirring and dissolving gets the Chitofilmer aqueous acetic acid.Chitosan aqueous acetic acid and Chitofilmer aqueous acetic acid are merged, stir, get chitosan Chitofilmer glue.
(2) preparation of membranaceous chitosan dressing B: get above-mentioned chitosan Chitofilmer glue 60ml, prepare membranaceous chitosan dressing B by the step of embodiment 1 they (3), membranaceous chitosan dressing B.
(3) preparation of spongy chitosan dressing B: get above-mentioned chitosan Chitofilmer glue 80ml, prepare spongy chitosan dressing B by the step of embodiment 1 they (4), spongy chitosan dressing B.
(4) preparation of powdery chitosan dressing B: take by weighing above-mentioned chitosan powder 2g, take by weighing above-mentioned Chitofilmer powder 0.5g, place the mortar porphyrize, and mix homogeneously, get powdery chitosan dressing B.
In the present embodiment, chitosan dressing B contains chitosan and Chitofilmer, and the part by weight of chitosan and Chitofilmer can be 100: 1～and 1000.Chitofilmer can also change a kind of in hydroxypropyl chitosan, succinyl-chitosan, succinyl chitin, carboxymethyl chitosan, the carboxymethyl chitin into, all can reach same effect.
Embodiment 3: the preparation of medical chitosan dressing C
(1) preparation of chitosan-zn: take by weighing chitosan powder 10g, place the clean beaker of 250ml, add deionized water 150ml, stirring suspension, stirring slowly adds the 0.2g zinc acetate down, stirs 30min under the room temperature, filters, and gets solid content I.With solid content I 150ml deionized water wash 3 times, each 20 minutes, filter, get solid content II.Solid content II in 60～70 ℃ of dryings, is got the chitosan zinc powder.
(2) preparation of powdery chitosan dressing C: take by weighing above-mentioned chitosan zinc powder 4g, put in the mortar, porphyrize gets powdery chitosan dressing C.
(3) preparation of membranaceous chitosan dressing C: take by weighing above-mentioned chitosan zinc powder 2g, put in the 250ml beaker, add 2% aqueous acetic acid 100ml, stirring and dissolving, chitosan-zn colloid solution, prepare membranaceous chitosan dressing C by the step of embodiment 1 they (3), must membranaceous chitosan dressing C.
(4) preparation of spongy chitosan dressing C: take by weighing above-mentioned chitosan zinc powder 2g, put in the 250ml beaker, the aqueous acetic acid 100ml of adding 2%, stirring and dissolving, get chitosan-zn colloid solution, step by embodiment 1 they (4) prepares spongy chitosan dressing C, gets spongy chitosan dressing C.
In the present embodiment, used zinc acetate can change a kind of in zinc chloride, zinc nitrate, zinc gluconate, the zinc lactate into, all can arrive same effect.Chitosan dressing C contains chitosan and zinc, and the part by weight of chitosan and zinc can be 100: 0.01～and 5.
Press the method for embodiment 3, use a kind of in calcium chloride, calcium gluconate, the calcium lactate, the preparation chitosan calcium re-uses chitosan calcium and prepares chitosan dressing, in this chitosan dressing the part by weight of chitosan and calcium can be 100: 0.01～5, all can reach same effect.
Chitosan dressing A, chitosan dressing B, the chitosan dressing C of preparation among the embodiment 1 to embodiment 3 through high pressure steam sterilization or 60Co irradiation sterilization or epoxyethane fumigation sterilization, all can be obtained aseptic chitosan dressing.
Embodiment 4 chitosan dressings are to the hemostasis of rat and the influence test of wound healing
Adopt the Wistar rat as experimental animal, 40 of rat, male and female hold concurrently half, body weight 250g ± 20.Test divides 4 groups: cotton cloth matched group, chitosan dressing A test group, chitosan dressing B test group, chitosan dressing C test group, 10 every group.Respectively with 30mg/Kg body weight lumbar injection 2% (percentage by weight, pentobarbital sodium anesthesia down together), the rat back is fixed on the operation frame up, the back is shaved off the hair of 1cm * 2cm area, and carry out skin degerming with the bromo geramine cotton balls with razor blade.Do the otch that 1.5cm is long, 2mm is dark with the disinfectant blade at unhairing position, back, have blood flow to go out.Each test group is carried out following processing: (1) cotton cloth control rats otch exposes; (2) chitosan dressing A rats in test groups sticks the aseptic membranaceous chitosan dressing A of 1cm * 2cm in incision; (3) chitosan dressing B rats in test groups sticks the aseptic membranaceous chitosan dressing B of 1cm * 2cm in incision; (4) chitosan dressing C rats in test groups sticks the aseptic membranaceous chitosan dressing C of 1cm * 2cm in incision.Observe every hemorrhage situation of rat wound surface in the operation, the record clotting time is to estimate the haemostatic effect of chitosan dressing to the scalpel edge wound.Postoperative is respectively organized rat all with the sterile gauze wrapping, and normal the raising observed rat wound healing situation every day, to estimate the influence of chitosan dressing to the rat wound healing.The results are shown in following table:
| Group | Number of animals (only/group) | Average clotting time (min) | Average wound healing natural law |
| Cotton cloth matched group chitosan dressing A test group chitosan dressing B test group chitosan dressing C test group | 10 10 10 10 | 4.5 2.2 2.5 1.9 | 5 days 1.5 days 1.5 days 2 days |
Above result of the test proves, the haemostatic effect of chitosan dressing and promote that wound healing effect obviously is better than cotton cloth, so chitosan dressing develops as a kind of novel bleeding-stopping dressing or wound healing dressing, has a extensive future.
The antibacterial tests of embodiment 5 chitosan dressings
(1) preparation of aseptic nutrient agar and aseptic double nutrient agar: press the method described in the preparation (appendix 89-appendix 90) of the culture medium under two (Chinese Pharmacopoeia Commission's volume) appendix XIH sterility tests of Pharmacopoeia of the People's Republic of China version in 2005 method item, prepare the 500ml triangular flask that nutrient agar 150ml places the band tampon in proportion.By this method, in proportion water is wherein reduced half again, prepare double nutrient agar 75ml3 part respectively; Place the 500ml triangular flask of 3 band tampons respectively.Nutrient agar and double nutrient agar be all in 121 ℃ of downforce steam sterilizations 25 minutes, aseptic nutrient agar and aseptic double nutrient agar.
(2) take by weighing aseptic chitosan dressing A powder 0.75g, aseptic chitosan dressing B powder 0.75g, aseptic chitosan dressing C powder 0.75g under the aseptic condition respectively, being placed on 150ml does not respectively have in the triangular flask of cingula tampon, each adds sterile distilled water 75ml, be mixed with 75ml 1% (percentage by weight respectively, chitosan dressing A solution down together), the chitosan dressing B solution of 75ml 1%, the chitosan dressing C solution of 75ml 1% place 45 ℃ of waters bath with thermostatic control standby.
(3) get long have 1 on colibacillary inclined-plane, 1 on the long inclined-plane that staphylococcus aureus arranged respectively, wash lawn with the 5ml physiological saline solution respectively under the aseptic condition, put in the test tube with cover.Get the test tube with cover of 15mm * 150mm specification respectively, respectively escherichia coli and staphylococcus aureus are diluted to 10 with normal saline
-7, standby.
(4) aseptic nutrient agar is heated to dissolves, fall 6 flat boards, be cooled to and solidify.3 parts of double Nutrient agars are heated to dissolve, respectively with the chitosan dressing A solution of 75ml 1%, the chitosan dressing B solution of 75ml 1%, the chitosan dressing C solution mix homogeneously of 75ml 1%, divide and be clipped to 6 flat boards, be cooled to and solidify, get 6 chitosan dressing A nutrient agar panels, 6 chitosan dressing B nutrient agar panels, 6 chitosan dressing C nutrient agar panels respectively.
(5) get 10 respectively
-5, 10
-6, 10
-7Three dilution each 0.2ml of escherichia coli normal saline suspension, each 0.2ml of staphylococcus aureus normal saline suspension, separate application is on corresponding flat board, and experimental technique sees the following form.
| Bacterial strain | Nutrient agar panel | Chitosan dressing A nutrient agar panel | Chitosan dressing A nutrient agar panel | Chitosan dressing A nutrient agar panel |
| Escherichia coli | Three dilution factors respectively are coated with 1 flat board | Three dilution factors respectively are coated with 1 flat board | Three dilution factors respectively are coated with 1 flat board | Three dilution factors respectively are coated with 1 flat board |
| Staphylococcus aureus | Three dilution factors respectively are coated with 1 flat board | Three dilution factors respectively are coated with 1 flat board | Three dilution factors respectively are coated with 1 flat board | Three dilution factors respectively are coated with 1 flat board |
With whole flat boards put in 35 ℃ of constant incubators cultivate 48h after, observe the growing state of escherichia coli and golden yellow glucose coccus.Experimental result shows, 3 are coated with colibacillary nutrient agar panel and overgrow with escherichia coli, 3 nutrient agar panels that are coated with staphylococcus aureus overgrow with staphylococcus aureus, and all chitosan dressing A nutrient agar panels, chitosan dressing B nutrient agar panel, all aseptic length of being born of chitosan dressing C nutrient agar panel.Experimental result shows that chitosan dressing A, chitosan dressing B, chitosan dressing C have the effect of bacteria growing inhibiting.
Claims (4)
1, a kind of medical chitosan dressing, it is characterized in that it contains chitosan and Chinese medicine extract or chitosan derivatives or metal ion, the part by weight of described chitosan and Chinese medicine extract is 100: 1～1000, and described Chinese medicine extract is a kind of in bletilla polysaccharide, the Indigo Naturalis; The part by weight of described chitosan and chitosan derivatives is 100: 1～1000, and described chitosan derivatives is a kind of in Chitofilmer, hydroxypropyl chitosan, succinyl-chitosan, succinyl chitin, carboxymethyl chitosan, the carboxymethyl chitin; The part by weight of described chitosan and metal ion is 100: 0.01～5, and described metal ion is a kind of in calcium ion, the zinc ion.
2, medical chitosan dressing as claimed in claim 1 is characterized in that described dressing is powdery, membranaceous or spongy.
3, the described medical chitosan dressing of claim 1 is at clinical trauma care with the application in the hemostasis in repairing, antibacterial, antibiotic, promotion face healing.
4, application as claimed in claim 4 is characterized in that described wound surface is abdominal operation, thoracic surgery, bone surgery, gynecilogical operation, department of stomatology surgical wound surface and skin ulcer, skin burn, skin scald, skin mechanical injury wound surface.
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| CN101209354B (en) * | 2007-12-25 | 2010-06-02 | 青岛博益特生物材料有限公司 | Medical blood-stopping healing agent for wound-surface and uses thereof |
| CN101927028A (en) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | Preparation method of chitosan/ acetalized poval medical dressing |
| CN101927027A (en) * | 2010-04-16 | 2010-12-29 | 哈尔滨工业大学 | Chitosan/carboxymethyl chitosan rapid hemostatic sponge and preparation method thereof |
| CN102813957A (en) * | 2012-09-14 | 2012-12-12 | 上海白衣缘生物工程有限公司 | Biological membrane which promotes healing and preparation method thereof |
| CN104497348A (en) * | 2014-12-31 | 2015-04-08 | 武汉奥绿新生物科技有限公司 | Softening technology and equipment for polysaccharides lyophilized sponge dressing |
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| CN101209354B (en) * | 2007-12-25 | 2010-06-02 | 青岛博益特生物材料有限公司 | Medical blood-stopping healing agent for wound-surface and uses thereof |
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Address after: 266071 No. 268 East Hongkong Road, Shandong, Qingdao Patentee after: QINGDAO BIOTEMED BIOLOGICAL MATERIAL CO., LTD. Address before: 266071 No. 268 East Hongkong Road, Shandong, Qingdao Patentee before: Qingdao Boyite Biological Material Co., Ltd. |