CN1857650A - Compound Chinese medicine preparation with function of clearing away heat and toxic matter, softening dry feces, dissipating mass, etc and its preparing process - Google Patents
Compound Chinese medicine preparation with function of clearing away heat and toxic matter, softening dry feces, dissipating mass, etc and its preparing process Download PDFInfo
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- CN1857650A CN1857650A CN 200610065609 CN200610065609A CN1857650A CN 1857650 A CN1857650 A CN 1857650A CN 200610065609 CN200610065609 CN 200610065609 CN 200610065609 A CN200610065609 A CN 200610065609A CN 1857650 A CN1857650 A CN 1857650A
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Abstract
The medicine preparation for auxiliary treatment one women's chronic pelvic inflammation caused by accumulated damp-heat and Qi stagnation and blood stasis is prepared with honeysuckle, skullcap root, dandelion, Chinese violet, Chinese honeylocust spine and other seven kinds of Chinese medicinal materials. It has the functions of clearing away heat and toxic material, softening dry feces, dissipating mass, promoting blood circulation to disperse blood clots, and activating Qi to relieve pain. It has obvious clinical effect.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of heat-clearing and toxic substances removing, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, compound Chinese medicinal preparation of promoting the circulation of QI to relieve pain and preparation method thereof is specifically related to a kind of women's chronic pelvic inflammatory disease card that is used for and belongs to damp-heat accumulation, pharmaceutical preparation of the auxiliary treatment of people who gets stagnation of vital energy and blood stasis and preparation method thereof.
Background technology:
Chronic pelvic inflammatory disease is meant the chronic inflammatory disease that women's internal genitalia and connective tissue on every side thereof, pelvic peritoneum take place.Normal for childbirth, miscarriage and operation on pelvis or because of menstrual phase cloth note health infect due to or fail thoroughly treatment for acute pelvic inflammatory disease, or patient's body constitution is relatively poor, due to the course of disease is delayed, but but also NAI medical history.
For the then general treatment measures that adopt of chronic pelvic inflammatory disease, the antibiotic therapy of whole body, Chinese traditional treatment, naturopathy etc. combine more.If the state of an illness is more serious, the patient's concurrent chronic salpingitis of possibility and the hydrosalpinx that have, therefore infertile, such patient will adopt operative treatment.
By theoretical research and clinical practice for many years, in line with the principle for the treatment of both the principal and secondary aspects of a disease, we develop the Jinji blood stasis removing side of treatment chronic pelvic inflammatory disease, and full side is aided with the blood circulation promoting and dispersing pathogen accumulation medicine based on heat and toxic materials clearing away medicine such as Flos Lonicerae, Radix Scutellariae, Herba Taraxacis.Effect with heat-clearing and toxic substances removing, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Clinical efficacy is remarkable, has brought Gospel for numerous female patients.
Summary of the invention:
The invention provides a kind of heat-clearing and toxic substances removing, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, compound Chinese medicinal preparation of promoting the circulation of QI to relieve pain and preparation method thereof.
Compound Chinese medicinal preparation of the present invention is characterized in that, is made by the raw material of Chinese medicine of following weight ratio:
50～300 parts of 67～400 parts of Herba Taraxacis of 67～400 parts of Radix Scutellariaes of Flos Lonicerae
50～300 parts of 50～300 parts of Radix Paeoniae Rubra of 34～200 parts of Spina Gleditsiaes of Herba Violae
34～200 parts of 34～200 parts of Rhizoma Chuanxiongs of 67～400 parts of rhizoma sparganic of Caulis Spatholobi
34～200 parts of 34～200 parts of Rhizoma Corydalis of Rhizoma Cyperi (vinegar system) (vinegar system)
34～200 parts of Semen Vaccariae (stir-fry)
Preferably:
100 parts of 150 parts of Herba Violaes of 200 parts of Herba Taraxacis of 200 parts of Radix Scutellariaes of Flos Lonicerae
100 parts of 200 parts of rhizoma sparganic of 150 portions of Caulis Spatholobis of 150 parts of Radix Paeoniae Rubra of Spina Gleditsiae
100 parts of 100 parts of Rhizoma Corydalis of 100 portions of Rhizoma Cyperis of Rhizoma Chuanxiong (vinegar system) (vinegar system)
100 parts of Semen Vaccariae (stir-fry)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, chewable tablet.
Pharmaceutical preparation of the present invention, the solid preparation of its oral administration can contain excipient commonly used, as filler, binding agent, disintegrating agent, lubricant, correctives.If tablet can carry out coating to tablet in case of necessity.Wherein filler can be selected a kind of or concentrated in starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, pregelatinized Starch, mannitol, sorbitol, xylitol, calcium hydrogen phosphate, calcium phosphate, the micropowder silica gel.
Wherein binding agent can be selected starch slurry, polyvinylpyrrolidone aqueous solution or alcoholic solution, HPMC, ethyl cellulose, pregelatinized Starch, sodium carboxymethyl cellulose solution etc., also can select water, Mel or water-honey liquor in the pill.
Wherein disintegrating agent can be selected one or more in carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, XLPE ketopyrrolidine, the cross-linking sodium carboxymethyl cellulose etc.Wherein lubricant can be selected magnesium stearate, Macrogol 4000 or 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
If desired, also can add an amount of correctives, as aspartame, flavoring orange essence, Mel, Borneolum Syntheticum, Herba Menthae essence etc.Also can contain an amount of aromatic or coloring agent.
The preparation method of compound medicinal formulation provided by the invention, can pass through following steps:
(1) above 12 flavors are given as one thinks fit cataclasmly, decoct with water secondary, add 10 times of water gagings for the first time, decoct 2 hours, add 6 times of water gagings for the second time, decocted 1 hour, and collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃);
(2) above-mentioned clear paste stirs and slowly adds ethanol down and make and contain the alcohol amount and reach 50%, fully stirs, and leaves standstill 24 hours, and the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃).
(3) above clear paste is after drying under reduced pressure or spray drying, or above clear paste directly mixes with other pharmaceutic adjuvants, is prepared into suitable oral formulations.
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The preparation method of capsule of the present invention:
Prescription:
Flos Lonicerae 200g Radix Scutellariae 200g Herba Taraxaci 150g Herba Violae 100g
Spina Gleditsiae 150g Radix Paeoniae Rubra 150g Caulis Spatholobi 200g rhizoma sparganic 100g
Rhizoma Chuanxiong 100g Rhizoma Cyperi (vinegar system) 100g Rhizoma Corydalis (vinegar system) 100g
Semen Vaccariae (stir-fry) 100g starch 120g
Make 1000
Preparation method:
More than 12 flavors, give as one thinks fit cataclasmly, decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, and added 6 times of water gagings for the second time, decocted collecting decoction 1 hour, filter, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), stirs slowly to add ethanol down and make and contain the alcohol amount and reach 50%, fully stirs, left standstill 24 hours, the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃), add starch, drying under reduced pressure is pulverized, encapsulated, make 1000, promptly.
Embodiment 2:
The preparation method of tablet of the present invention:
Flos Lonicerae 200g Radix Scutellariae 200g Herba Taraxaci 150g Herba Violae 100g
Spina Gleditsiae 150g Radix Paeoniae Rubra 150g Caulis Spatholobi 200g rhizoma sparganic 100g
Rhizoma Chuanxiong 100g Rhizoma Cyperi (vinegar system) 100g Rhizoma Corydalis (vinegar system) 100g
Semen Vaccariae (stir-fry) 100g microcrystalline Cellulose 150g
Make 1000
Preparation method:
More than 12 flavors, give as one thinks fit cataclasmly, decoct with water secondary, for the first time add 10 times of water gagings, decocted 2 hours, add 6 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), stirs slowly to add ethanol down and make and contain the alcohol amount and reach 50%, fully stirs, left standstill 24 hours, the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃), adds starch, drying under reduced pressure, pulverize, make soft material in right amount with ethanol, 12 mesh sieves are granulated, dry, 12 mesh sieve granulate, tabletting promptly gets 1000.
Embodiment 3:
The preparation method of coated tablet of the present invention:
Flos Lonicerae 200g Radix Scutellariae 200g Herba Taraxaci 150g Herba Violae 100g
Spina Gleditsiae 150g Radix Paeoniae Rubra 150g Caulis Spatholobi 200g rhizoma sparganic 100g
Rhizoma Chuanxiong 100g Rhizoma Cyperi (vinegar system) 100g Rhizoma Corydalis (vinegar system) 100g
Semen Vaccariae (stir-fry) 100g microcrystalline Cellulose 250g
Make 1000
Preparation method:
More than 12 flavors, give as one thinks fit cataclasmly, decoct with water secondary, for the first time add 10 times of water gagings, decocted 2 hours, add 6 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), stirs slowly to add ethanol down and make and contain the alcohol amount and reach 50%, fully stirs, left standstill 24 hours, the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃), drying under reduced pressure, pulverize, with the microcrystalline Cellulose mix homogeneously, make soft material in right amount with ethanol, 12 mesh sieves are granulated, dry, 12 mesh sieve granulate, tabletting promptly gets 1000.Carry out coating.
Coating solution and coating operation are as follows:
1. coating fluid prescription:
Hypromellose 12g
Tween 80 10g
95% ethanol 400ml
Distilled water 550ml
2. coating solution preparation
(HPMC) uses water dissolution with hypromellose, and reuse 95% ethanol dilution is standby, and tween 80 merges with small amount of thermal water dissolution and HPMC liquid, stirs, and to stir evenly filtration standby with other material again.
3. coating operation
Tablet is placed in the pot, start air draft and dust exhaust apparatus, started coating pan with back about 40 ℃ of hot-air pre-heating 10min every 1 minute simultaneously, tablet is heated evenly, and sops up the fine powder that is adsorbed on the tablet.Open peristaltic pump, start coating pan, with the coating solution spray for preparing on the tablet that rotates.Regulate solution spray speed (5.0-15ml/min) and hot air drying temperature (75-85 ℃), make its even coating, keep the label drying, continuously spraying.Calculate the coating gain in weight and get final product, the about 10min of cold wind (room temperature) rolling at the 2-5% of label.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Flos Lonicerae 200g Radix Scutellariae 200g Herba Taraxaci 150g Herba Violae 100g
Spina Gleditsiae 150g Radix Paeoniae Rubra 150g Caulis Spatholobi 200g rhizoma sparganic 100g
Rhizoma Chuanxiong 100g Rhizoma Cyperi (vinegar system) 100g Rhizoma Corydalis (vinegar system) 100g
Semen Vaccariae (stir-fry) 100g
Cane sugar powder 300g Fructus Citri Limoniae essence 20g Mentholum 15g
Make 1000
Preparation method:
More than 12 flavors, give as one thinks fit cataclasmly, decoct with water secondary, for the first time add 10 times of water gagings, decocted 2 hours, add 6 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), stirs slowly to add ethanol down and make and contain the alcohol amount and reach 50%, fully stirs, left standstill 24 hours, the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃), drying under reduced pressure, pulverize, with cane sugar powder, the Fructus Citri Limoniae essence mix homogeneously is made soft material in right amount with ethanol, 12 mesh sieves are granulated, drying, 12 mesh sieve granulate add Mentholum, tabletting promptly gets 1000.
Embodiment 5:
The preparation method of granule of the present invention:
Flos Lonicerae 200g Radix Scutellariae 200g Herba Taraxaci 150g Herba Violae 100g
Spina Gleditsiae 150g Radix Paeoniae Rubra 150g Caulis Spatholobi 200g rhizoma sparganic 100g
Rhizoma Chuanxiong 100g Rhizoma Cyperi (vinegar system) 100g Rhizoma Corydalis (vinegar system) 100g
Semen Vaccariae (stir-fry) 100g dextrin 200g cane sugar powder 560g
Make 1000g
Preparation method:
More than 12 flavors, give as one thinks fit cataclasmly, decoct with water secondary, for the first time add 10 times of water gagings, decocted 2 hours, add 6 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), stir and slowly to add ethanol down and make and contain the alcohol amount and reach 50%, fully stir, left standstill 24 hours, the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃).It is an amount of to add sucrose, dextrin and ethanol, granulates, and drying is made 1000g, promptly.
Claims (6)
1. one kind has heat-clearing and toxic substances removing, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, the promoting the circulation of QI to relieve pain effect can be used for the women's chronic pelvic inflammatory disease card and belongs to damp-heat accumulation, the compound Chinese medicinal preparation of the auxiliary treatment of people who gets stagnation of vital energy and blood stasis, it is characterized in that, make by the raw material of Chinese medicine of following weight ratio:
50～300 parts of 67～400 parts of Herba Taraxacis of 67～400 parts of Radix Scutellariaes of Flos Lonicerae
50～300 parts of 50～300 parts of Radix Paeoniae Rubra of 34～200 parts of Spina Gleditsiaes of Herba Violae
34～200 parts of 34～200 parts of Rhizoma Chuanxiongs of 67～400 parts of rhizoma sparganic of Caulis Spatholobi
34～200 parts of 34～200 parts of Rhizoma Corydalis of Rhizoma Cyperi (vinegar system) (vinegar system)
34～200 parts of Semen Vaccariae (stir-fry)
2. the compound Chinese medicinal preparation of claim 1 is characterized in that, is preferably by the raw material of Chinese medicine of following weight ratio to make:
100 parts of 150 parts of Herba Violaes of 200 parts of Herba Taraxacis of 200 parts of Radix Scutellariaes of Flos Lonicerae
100 parts of 200 parts of rhizoma sparganic of 150 portions of Caulis Spatholobis of 150 parts of Radix Paeoniae Rubra of Spina Gleditsiae
100 parts of 100 parts of Rhizoma Corydalis of 100 portions of Rhizoma Cyperis of Rhizoma Chuanxiong (vinegar system) (vinegar system)
100 parts of Semen Vaccariae (stir-fry)
3. the compound Chinese medicinal preparation of claim 2 wherein also comprises the medicine acceptable carrier.
4. the compound Chinese medicinal preparation of claim 2 is characterized in that it being oral formulations.
5. the preparation method of the compound Chinese medicinal preparation of claim 1 is characterized in that, through following steps,
(1) above 12 flavors are given as one thinks fit cataclasmly, decoct with water secondary, add 10 times of water gagings for the first time, decoct 2 hours, add 6 times of water gagings for the second time, decocted 1 hour, and collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃);
(2) above-mentioned clear paste stirs and slowly adds ethanol down and make and contain the alcohol amount and reach 50%, fully stirs, and leaves standstill 24 hours, and the leaching supernatant reclaims the clear paste of ethanol to relative density 1.30～1.35 (80 ℃).
(3) above clear paste is after drying under reduced pressure or spray drying, or above clear paste directly mixes with other pharmaceutic adjuvants, is prepared into suitable oral formulations.
The active constituents of medicine that makes of claim 5 and medicine acceptable auxiliary mixed tablet, capsule, granule, chewable tablet.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610065609 CN1857650A (en) | 2006-03-21 | 2006-03-21 | Compound Chinese medicine preparation with function of clearing away heat and toxic matter, softening dry feces, dissipating mass, etc and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610065609 CN1857650A (en) | 2006-03-21 | 2006-03-21 | Compound Chinese medicine preparation with function of clearing away heat and toxic matter, softening dry feces, dissipating mass, etc and its preparing process |
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| CN 200610065609 Pending CN1857650A (en) | 2006-03-21 | 2006-03-21 | Compound Chinese medicine preparation with function of clearing away heat and toxic matter, softening dry feces, dissipating mass, etc and its preparing process |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849999B (en) * | 2009-03-31 | 2012-05-23 | 江苏康缘药业股份有限公司 | Chinese medicinal composition for treating pelvic inflammation and preparation method thereof |
| CN102973731A (en) * | 2011-09-05 | 2013-03-20 | 王成光 | Pelvic inflammatory disease and dysmenorrheal treatment liquid agent and preparation method thereof |
| CN104352953A (en) * | 2014-10-11 | 2015-02-18 | 胥琴 | Traditional Chinese medicine composition for treating chronic annexitis |
| CN104587400A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine formula for treating chronic pelvic inflammation |
| CN104825669A (en) * | 2015-05-21 | 2015-08-12 | 薛建芳 | Traditional Chinese medicine for treating qi-stagnation and blood stasis type chronic pelvic inflammation and preparation method of traditional Chinese medicine |
| CN104873866A (en) * | 2015-06-17 | 2015-09-02 | 翔宇药业股份有限公司 | Dandelion and rhizoma smilacis glabrae medical preparation for treating pelvic inflammation and detection method thereof |
-
2006
- 2006-03-21 CN CN 200610065609 patent/CN1857650A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849999B (en) * | 2009-03-31 | 2012-05-23 | 江苏康缘药业股份有限公司 | Chinese medicinal composition for treating pelvic inflammation and preparation method thereof |
| CN102973731A (en) * | 2011-09-05 | 2013-03-20 | 王成光 | Pelvic inflammatory disease and dysmenorrheal treatment liquid agent and preparation method thereof |
| CN104352953A (en) * | 2014-10-11 | 2015-02-18 | 胥琴 | Traditional Chinese medicine composition for treating chronic annexitis |
| CN104352953B (en) * | 2014-10-11 | 2016-02-10 | 胥琴 | A kind of Chinese medicine composition for the treatment of chronic adnexitis |
| CN104587400A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine formula for treating chronic pelvic inflammation |
| CN104825669A (en) * | 2015-05-21 | 2015-08-12 | 薛建芳 | Traditional Chinese medicine for treating qi-stagnation and blood stasis type chronic pelvic inflammation and preparation method of traditional Chinese medicine |
| CN104873866A (en) * | 2015-06-17 | 2015-09-02 | 翔宇药业股份有限公司 | Dandelion and rhizoma smilacis glabrae medical preparation for treating pelvic inflammation and detection method thereof |
| CN104873866B (en) * | 2015-06-17 | 2018-05-15 | 翔宇药业股份有限公司 | A kind of Pu Ling basins inflammation health pharmaceutical preparation and its detection method for pelvic infecton |
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