CN1853467A - Method of controlling acarian and device for use in the same - Google Patents
Method of controlling acarian and device for use in the same Download PDFInfo
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- CN1853467A CN1853467A CNA2006100798337A CN200610079833A CN1853467A CN 1853467 A CN1853467 A CN 1853467A CN A2006100798337 A CNA2006100798337 A CN A2006100798337A CN 200610079833 A CN200610079833 A CN 200610079833A CN 1853467 A CN1853467 A CN 1853467A
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Abstract
A method of pest control characterized in that a gaseous compound having a structure represented by the formula (I) (.....indicates a single bond or double bond) is caused to be present in a concentration of 0.001 to 20,000 microg/L in a space where pest repellence is intended; and a pest control agent containing a compound represented by the formula (I) as an active ingredient.
Description
Technical field
The present invention relates to the method for Pest Control, the pest-controlling agent of device of Shi Yonging and inclusion compound for this reason, described method comprises with having wherein
The compound steam that is the following formula (I) of singly-bound or two keys is full of the space of not expecting that insect exists for a long time with specific concentrations, produces the environment that insect dislikes thus, forces insect to leave this space and also prevents new invasion simultaneously.
Background technology
Well-known insect causes the infringement to agricultural product, and the people is produced uncomfortable feeling and the infringement of sucking blood, mediation serious disease such as Japanese Type B encephalitis, malaria, dysentery, the plague etc., and the disease in the mediation domestic animal.Recently the enhancing of food import amount and birdman's globalization has strengthened the danger of insect invasion.Combine with global warming and indoor higher mean temperature, think that insect can spend winter.In addition, the possibility that is sent to zones of different for the specific agricultural product insect in specific region becomes big, torrid zone insect such as anopheles (malaria mosquito), beginning such as West Nile fever mosquito (West Nile Fevermosquito) occurs at the beach in zone, temperate zone.In addition, insect about domestic species, because conventional pesticide control causes losing by the ability of the indivedual number of pest of food chain natural equilibrium in the nature, along with recent trend is used the trend of low-level agricultural chemicals and do not had agricultural chemicals to be popular in family expenses insect repellants field, excessive breeding has become and can not suppress, and the possibility that insect may seriously grow is very high.Predict that because the high fecundity of no natural enemy environment and they, external source species insect is in case land, at short notice explosion type ground increase and infringement human, domestic animal and agricultural product, method that therefore need this situation of processing.
Routinely, will have the reagent of insecticidal action, as organic phosphate (organophosphate), carbamates etc. are widely used as pest-controlling agent.Yet these are relevant with the infringement problem to people and domestic animal.Although occurred many hypotoxic pyrethroid reagent in recent years,, can not eliminate about the healthy of people and domestic animal and to the consideration of the influence of environment as long as their effectiveness expression mechanism is based on biocidal activity.
On the other hand, cicada not based on insecticidal activity and based on the pest-controlling agent of dispel effect.The expellent of the no biocidal activity of expectation provides high security and insect controllability simultaneously.As showing to broad variety insect such as mosquito ant, horse botfly, the conventional reagent of the expeling effect of cockroach etc., known DEET (N, N-diethyl-m-tolazamide (tolamide)).Yet, because DEET volatilization in the short period of time in air is difficult to keep for a long time its dispel effect.Although terpenoid such as menthol, right-terpane-3, the known dispel effects that have mosquito such as 8-glycol, terpenoid such as linalool, the known dispel effect that has cockroach such as geraniol, they not necessarily keep actual effect [referring to Masato NOMURA etc., Nippon Nogeikagaku kaishi 67 volumes, 693-700 page or leaf (1993)] from the aspect in " long-acting period " and " effectively a small amount of ".
The inventor has been found that the compound with following array structure has the mite of driving property, and proposes to contain the acarina pest control agent (Acarina control agent) (referring to JP-A-10-316507) of this compound.
With the known organophosphorus ester of routine-, pyrethroid-compare with the miticide of carbamate type and other type, this acarina pest control agent has more advantage, because (1) it has lower acaricidal activity, can drive away acarina pest and do not stay the acarina pest corpse in environment, this corpse is potential anaphylactogen, and (2) acarina pest is not easy to obtain resistance, (3) it is to people and domestic animal high safety, or the like.
The open farnesyl acetone of above-mentioned publication can be used to control acarina pest.Yet its unexposed acarina pest control agent can be used to drive away the insect except acarina pest and not wish can obtain dispel effect especially significantly in the space that insect exists by farnesyl acetone is remained on the valid density scope.
Summary of the invention
The inventor furthers investigate and finds, by making the gaseous state farnesyl acetone with 0.001-20, the specific concentrations of 000 μ g/L is present in the insect that can control especially effectively in the space that is intended to disinfest except acarina pest, farnesyl acetone not only in addition, and the compound (below be also referred to as compound (I)) with formula (I) can be realized this effect when being used
Wherein
Be singly-bound or two key, and can realize that by the reagent (for example liquefied compound (I) or its dilution) that evaporation intensifier continuous evaporation comprises formula (I) compound effect is kept for a long time, finish the present invention thus.
Therefore, the invention provides the method for effective Pest Control, it is included in the concentration that keeps compound (I) in the space that is intended to disinfest for a long time in driving away the valid density scope, effectively obtain the method and apparatus of this valid density, and inclusion compound (I) is as the pest-controlling agent of active ingredient.Therefore, the invention provides following.
[1] a kind of method of Pest Control, it comprises with 0.001-20, and the gaseous compound that the concentration of 000 μ g/L will have formula (I) remains in the space that is intended to disinfest,
Wherein
Be singly-bound or two key,
[2] method of above-mentioned [1], wherein above-mentioned concentration are to evaporate the compound with formula (I) by the evaporation intensifier to obtain.
[3] method of above-mentioned [1] or [2], wherein above-mentioned concentration are to evaporate the compound with formula (I) by the disengagement area expanding unit to obtain.
[4] method of above-mentioned [2] or [3], wherein evaporating intensifier is heater.
[5] method of above-mentioned [2] or [3], wherein evaporating intensifier is blowning installation.
[6] a kind of device of Pest Control, it comprises the reagent storage device that contains (I) compound that has formula
Wherein
It is the device of the evaporation of singly-bound or two key and enhancing compound with formula (I).
[7] device of above-mentioned [6], it comprises be used to the to have formula disengagement area expanding unit of compound of (I) in addition.
[8] device of above-mentioned [6] or [7], wherein evaporating intensifier is heater.
[9] device of above-mentioned [6] or [7], wherein evaporating intensifier is blowning installation.
[10] a kind of pest-controlling agent, its comprise have following formula (I) compound as active ingredient,
Wherein
Be singly-bound or two key.
Detailed Description Of The Invention
Compound (I) is a compound known, and as synthesis example such as vitamin E and vitamin K
2The raw material of side chain by extensive chemosynthesis.When
When being two key, compound (I) comprise multiple based on the geometric isomer (cis, trans) of the different connection site of two keys.Being used for compound of the present invention (I) can be any of these geometric isomers, the perhaps mixture of two or more in these geometric isomers, wherein specifically restriction of blending ratio.
Depend on evaporation conditions, ambient environmental conditions etc., " gaseous state " of gaseous compound of the present invention (I) comprises the mist attitude.
The concentration of gaseous compound in the space that is intended to disinfest (I) is not less than 0.001 μ g/L at least, preferably is not less than 0.01 μ g/L, is no more than 20,000 μ g/L at the most, preferably is no more than 2,000 μ g/L.When concentration during less than 0.001 μ g/L, do not find pest controling effect, when it surpassed 20,000 μ g/L, the smell that compound (I) produces became and makes us strong and impracticable offensively.
The space that is intended to disinfest is about size, and aspects such as shape do not have any concrete restriction, because can adjust the consumption of compound (I) and using method so that can obtain above-mentioned concentration.
The reagent of inclusion compound in this context (I) is meant the unification compound and the dilution by obtaining with thinner diluted compounds (I) of compound (I), or comprising the reagent of other carrier, described carrier not only comprises liquid but also comprises solid.As thinner, can use any inorganic or organic diluent, as long as it does not apply adverse effect to compound (I).As thinner, can use solvent, fragrance retention agent, humectant etc.Among these, preferably have high security as those of cosmetic raw materials, for example can mention alcohols such as ethanol, isopropyl alcohol etc., ketone such as acetone etc., ester class (low boiling) is as ethyl acetate etc.; Silicone oil, polyethylene glycol, polypropylene glycol, jojoba oil, saualane, atoleine, rapeseed oil, cottonseed oil, tung oil, camellia oil, other vegetable oil (high boiling point oil) etc.Additive such as emulsifier etc. can also be added the thinner of compound (I) and mixture is used as water-dispersible agents.As additive, for example, can mention alkylbenzenesulfonate, alpha-olefins sulfonate, paraffin sulfonate contains four ammonium salts of chain alkyl, aliphatic series one or diglycollic amide, (gathering) glycol ester or the ether of fatty acid, the glyceride of mono fatty acid, the sorbitan ester of fatty acid, polyethylene glycol oxide sorbitan fatty acid ester, alkyl phenyl polyethylene oxides ether, N-alkyl betaine type or sulfo group betaine type surfactant etc.Among these, preferably have high security as those of cosmetic raw materials, as sulfosuccinic acid monooctyl ester sodium, Tween-20 etc.In addition, as required, the reagent of inclusion compound (I) can comprise auxiliary agent in addition, stabilizing agent, thickener, colouring agent, spices etc.
The liquid reagent of compound that comprises formula (I) as the evaporation capacity is with the method for the concentration that obtains gaseous compound (I) in the aforesaid space that is intended to disinfest, can use anyly can realize the method for purpose and do not have concrete restriction.Below particularly with show this method exemplaryly and realize the device of this method.
A kind of method, it comprises the reagent that will contain compound (I) and is placed in the container with porous wall, described container such as biscuiting pottery, sintering metal etc. ooze out at container outer surface at the reagent of inclusion compound (I) compound (I) are evaporated from about whole outer surface.The container that has porous wall in this method is equivalent to the storage device of the reagent of inclusion compound in apparatus of the present invention (I), and is a kind of disengagement area expanding unit.The storage device of the reagent of inclusion compound (I) is not limited to said vesse and not specifically restriction, as long as it can store the reagent of inclusion compound (I) until evaporation.For example, device can be a storage device, the reagent that is specially inclusion compound (I) is kept in container such as glass or the plastic bottle etc., reagent is assigned in the container that closes, when using, the part of container is cut, or uncap and content is transferred in disengagement area expanding unit or the container, depending on its embodiment, the disengagement area expanding unit of explained later can also be a storage device.
As distinct methods, can mention a kind of method, this method comprises cloth, a rope or a spongiform end with disengagement area expanding unit of wide surface area are immersed in the storage device of reagent of inclusion compound (I), make the disengagement area expanding unit absorb the reagent of inclusion compound (I) by capillarity thus, perhaps that the reagent of inclusion compound (I) is without interruption to the disengagement area expanding unit from the storage device of the reagent of inclusion compound (I), reagent is absorbed, can mentions surface evaporation compound (I) from the disengagement area expanding unit.The example that is used for the disengagement area expanding unit of this method comprises native fiber such as paper pulp, cotton, hemp etc.; Synthetic fibers such as polyester etc.; Paper, fabric, knitting, felt of producing by glass fibre and nonwoven etc.; Spongiotic article, it is the loose structure of being made by synthetic resin or glass; With other rope, knitting, doughnut fabric or the like by synthetic resin or glass production.These are specifically restriction not, as long as they can expand the evaporation of reagents area of inclusion compound (I).Although be difficult to provide the concrete numeral that it evaporates required wide surface area, because the condition of the material of its basis such as disengagement area expanding unit etc. changes, surface area is wide more, may promote effective evaporation more.The surface area of measuring the surface area of porous mass and fiber product is difficulty very, but 50cm at least
2, preferably be not less than 100cm
2Surface area be actual.In the situation of wide surface area, be included in the concentration of the compound (I) in the reagent by reduction, the concentration of the compound in the space that is intended to disinfest (I) can be adjusted to belongs in the above-mentioned scope, in the situation of little surface area, be included in the concentration of the compound (I) in the reagent by enhancing, the concentration of the compound in the space (I) can be adjusted to and belong in the above-mentioned scope.
As the distinct methods of the purpose that realizes mentioning in the aforementioned paragraphs, can mention a kind of method, it comprises and will contain the reagent coating of compound (I) or be sprayed on the disengagement area expanding unit with wide surface area.In this case, the disengagement area expanding unit is equivalent to the storage device of the reagent of inclusion compound (I).As the example of this coating or sprayer unit, can mention brush, sprayer is directly sprayed from bottle container, uses dropper to drip, and uses watering can spraying etc.
On the disengagement area expanding unit, can carry out one or many coating and spraying, and can be suitably in conjunction with coating and spraying.For repeatedly coating or spraying, calculate interval between each coating and the spraying based on the actual measurement of compound (I) extinction time or its theory hypothesis, preferably before the interval stops period or when it stops, implement coating or spray.Recommendation should the collateral use handbook, and it describes this method.
As mentioned above, also can promote the evaporation of compound (I) by the surface area that strengthens the disengagement area expanding unit.Because compound (I) has high boiling point, more preferably use the evaporation intensifier to come forced evaporation compound (I).Therefore, in another embodiment of the invention, preferably, explain this device now by using evaporation intensifier warp or obtaining above-mentioned concentration without disengagement area expanding unit forced evaporation compound (I).
Because, can use any device as long as it can forced evaporation compound (I) and concrete restrain evaporation intensifier.Compound (I) can be intended to evaporate separately or when evaporation is included in other material in the reagent that contains compound (I) with compound (I), compound (I) can be evaporated.
As this device, can mention heater and blowning installation.For example, when heater is used as the intensifier of evaporation compound (I), as an embodiment that realizes the object of the invention, can mention the equipment (the preferred temperature control equipment of equipment in addition) that uses the equipment heater, the reagent that will be included in the inclusion compound (I) of device inside by heater and temperature control equipment is heated to proper temperature, and inner surface and outer surface and/or outer surface evaporation compound (I) from installing.In another embodiment, operative installations, wherein this device combines with the above-mentioned disengagement area expanding unit with wide surface area, one end of disengagement area expanding unit is immersed in the holder that comprises the reagent that contains compound (I) so that absorb by capillarity, perhaps give the disengagement area expanding unit so that absorb with the reagent of inclusion compound (I) is without interruption, by heater and temperature control equipment the storage device or the disengagement area expanding unit of the reagent of inclusion compound (I) is heated to proper temperature, with forced evaporation compound (I).As above-mentioned heater, can mention by heating wires such as nichrome wire etc. and give birth to heat, low energy light source such as indicator lamp etc.As the said temperature control device, bimetallic is a most convenient, but can use by with thermocouple, and the temperature of detections such as thermistor input CPU control is supplied to the device of the electric power of heating wire.
When blowning installation is used as the evaporation intensifier, can mention that use blows to the device that the evaporation of reagents area expanding unit that absorbs inclusion compound (I) comes forced evaporation compound (I) by blowning installation with air.As this blowning installation, can mention fan such as propeller type fan, sirocco fans etc. have the pump (for example being used for air is sparging into the pump of water tank when breeding goldfish) of film and valve etc.As different embodiments, can mention device, it combines heater and blowning installation are paired, in the disengagement area expanding unit reagent of inclusion compound (I) is heated to proper temperature with forced evaporation compound (I) by sending hot-air.
The flash-point of compound (I) is low to moderate about 110 ℃ and high to about 160 ℃, and the heating-up temperature of heater is preferably and is not less than the temperature that is lower than 10 ℃ of flash-points.Need suitably adjust this temperature according to the character of the thinner that uses together etc.For example, it is 50-110 ℃, preferred 60-100 ℃.In addition, the wind speed of blowning installation is preferably 0.001-5m/ second, and air capacity is preferably 0.001-10L/ second.
Regularly be coated with or be sprayed at by the reagent with inclusion compound (I) and be placed on the indoor article, can make gaseous compound (I) with 0.001-20, the concentration of 000 μ g/L is present in the space that is intended to disinfest.As these article, for example can mention carpet, Couch cushion (tatami mat), bed clothes, stuffed toy, cylindrical fireworks, vase is decorated statue, artificial flower and be placed on other indoor article usually.In one embodiment of the invention, can mention a kind of method, its reagent that comprises inclusion compound (I) adds in floor wax or other buffing compound dipping disposable type of mop, reusable mop etc., and coating window still, threshold, screen windows etc. are according to this method, can prevent the invasion of insect, and by from wide surface area evaporation compound (I) and the room or be full of the steam of compound (I) near coating surface can be with pest repelling.The article of having used the reagent of inclusion compound (I) are equivalent to be used for the storage device and the disengagement area expanding unit of the reagent of inclusion compound (I).
The reagent of inclusion compound (I) can adopt any dosage form, as tablet, and pill, capsule, emulsifiable paste, ointment, aerosol, powder, liquid, emulsion, suspension etc.Can will comprise the reagent of the compound (I) that is used for the inventive method as the pest-controlling agent (being designated hereinafter simply as reagent of the present invention) of inclusion compound (I) as active component.Although reagent of the present invention can use separately, it can use simultaneously with other pest-controlling agent.In addition, can add effective other component of pest control so that unitary agent to be provided.
For the ease of the use of reagent of the present invention, except compound (I), preferably add solvent, carrier, emulsifier, stabilizing agent etc. to be providing preparation, and be processed into dilution etc. as required and use preparation.When needs, can add or,, keep material, paint, carrier, spices or colouring agent etc. as antioxidant in conjunction with other component.Preferably make spices or colouring agent play indicant, the timing that this indicant notice is replaced the article that use reagent Pest Control of the present invention.For example, have than the more lower boiling spices of compound (I) the preferred adding, when using beginning, and the fragrance that the article of its insect out of hand have before compound (I) disappears, the perhaps clear variation that shows fragrance.
In compound (I), contain those quilt oxidations gradually in air of two keys.In order to prevent this point, preferably add or use antioxidant simultaneously.As antioxidant, for example, use the antioxidant such as the vitamin E of phenols type, butylated hydroxytoluene, Irganox 1010, Irganox 1076 etc.; The antioxidant of polyphenol type such as tannic acid, gallic acid (gellic acid) etc.Its consumption is preferably the 0.001-10wt% with respect to compound (I), more preferably 0.1-5wt%.
As the control of insect composition that except compound (I), can add, for example can mention compound such as diethyl toluamide with anthelmintic action, 2,3,4, two (Δ 2-the butylene)-tetrahydrofurfurals of 5-, two-n-pro-pyl pyridinedicarboxylic acid ester, the di-n-butyl succinate, 2-ethoxy octyl group thioether, 2-tertiary butyl-4-hydroxy anisole, 3-tert-butyl group 4-BHA, 1-acetenyl-2-methyl-pentenyl 2,2,3, the 3-4-methyl cyclopropane carboxylic acid ester, N-hexyl-3,4-dichloro maleimide etc.Can use the pest-controlling agent that comprises these components simultaneously with reagent of the present invention.
As above-mentioned solvent, can use any solvent, as long as it does not apply adverse effect to compound (I).As this solvent, for example can mention alcohols such as ethanol, isopropyl alcohol etc.; Silicone oil, polyethylene glycol, polypropylene glycol, jojoba oil, saualane, atoleine; Rapeseed oil, cottonseed oil, tung oil, camellia oil, other plant wet goods.Its consumption is preferably the 10-99wt% of whole preparation, more preferably 50-95wt%.
As above-mentioned carrier, can use any carrier, as long as it does not apply adverse effect to compound (I).As this carrier, for example can mention silica, active carbon, porous calcium phosphate zirconium, Woelm Alumina, diatomite, perlite, vermiculite, zeolite, galleon earth, wood powder, wood chip etc.
As mentioned emulsifier, can use any emulsifier, as long as it does not apply adverse effect to compound (I).As this emulsifier, for example can mention alkylbenzenesulfonate, alpha-olefins sulfonate, paraffin sulfonate contains four ammonium salts of chain alkyl, aliphatic series one or diglycollic amide, (gathering) glycol ester or the ether of fatty acid, the glyceride of mono fatty acid, the sorbitan ester of fatty acid, the polyethylene glycol oxide sorbitan fatty acid ester, alkyl phenyl polyethylene oxides ether etc.Its consumption is preferably the 5-90wt% of whole preparation, more preferably 10-50wt%.
As the aforementioned stable agent, can use any stabilizing agent, as long as it does not apply adverse effect to compound (I).As this stabilizing agent, for example can mention polyvinyl alcohol, gelatin, carboxymethyl cellulose, polyvinylpyrrolidone, polyethylene glycol (polyethylene glycol), polyethylene glycol (macrogol), Acacia, starch etc.
As the above-mentioned material of keeping, can use any material of keeping, as long as it does not apply adverse effect to compound (I), and comprise thermoplastic resin, wax, gel, various capsules etc.
The reagent of inclusion compound (I) can be solid.As adding, for example can mention thermoplastic resin, wax, gel, microcapsules, porous inorganic particulate etc. to produce the material of keeping of solid.
The reagent that comprises the compound (I) that is used for the inventive method can be the shaping solid.The shaping solid can be taked particle, ball, and rod, sheet, piece, thin slice, any form in the sponge etc., and can be used as the closet dusting flour, underground dusting flour etc., or as upholstery, as the ornamental decoration statue of closet, vase, calendar, tapestry, candle etc.In addition, formed product can be used for allowing compound (I) container of evaporation easily in indoor critical positions.By adopting the form of formed product, to compare with using as aforesaid liquid, compound (I) can evaporate over a long time.
About thermoplastic resin, the use with resin of remarkable high molding temperature cause the evaporation of compound (I) etc. and on the compound of kneading during the molding (I) or its dilution significant white cigarette generate.Therefore, preferably use molding temperature, preferably be no more than 160 ℃, more preferably no more than 140 ℃ thermoplastic resin less than 200 ℃.Contrast therewith has the use of significantly hanging down the resin of molding temperature, because the high viscosity of resin causes limited use.Therefore, preferably use molding temperature to be not less than 50 ℃ resin.As preferred thermoplastic resin, for example can mention low-melting-point resin such as soft propene acid resin, comprise (methyl) acrylate-copolymer, the soft propene acid resin, it is produced the nucleocapsid structure of partly being made up of rubber part and animi resin to have, ethylene-vinyl yl acetate copolymer resins, poly-(trans-isoprene) resin, thermoplastic elastomer (TPE) by preparations such as block polymerization styrene-butadiene or isoprene, poly--6-caprolactone, poly--D, the L-decalactone, poly-two oxine ketone (polydioxinone), polyurethane resin etc.Preferably by experience set one from resin, do not have seepage compound (I) but upper limit amount and in scope, select the highest energy to determine that the amount of compound (I) of adding thermoplastic resin is to extend the expiration date.For example, when the soft propene acid resin was used as thermoplastic resin, the amount that adds compound (I) was preferably 10-50wt%.
As wax, for example can mention higher alcohol, candelilla wax, rice wax, carbawax, Japan tallow, cera flava, microwax, Tissuemat E, stearic acid, paraffin, vaseline, spermaceti, tallow etc.Preferably by experience set one from wax, do not have seepage compound (I) but upper limit amount and in scope, select the highest energy to determine that the amount of compound (I) of these waxes of adding is to extend the expiration date.For example, when stearic acid was used as wax, the amount of the compound of adding (I) was preferably 10-60wt%.
As gel, the gel that preferably can become oil-base gel is used to comprise a large amount of compounds (I).For example, with gelling composition such as odium stearate, aluminum stearate, 2 ethyl hexanoic acid aluminium, dibenzylidene sorbitols etc. add compound (I), and use a small amount of alcohol or water to prepare gel products.The amount that adds the compound (I) of this gel is preferably 10-60wt%.
As above-mentioned paint, can use any paint, as long as it does not apply adverse effect to compound (I).As this paint, for example can mention varnish; Enamel paint; The acetylcellulose lacquer; Ethyl cellulose lacquer; Alkyd resin enamel and varnish; Vinylite enamel paint and varnish such as vinyl chloride, vinyl acetate-methacrylate, styrene-butadiene etc.; Pigment oiliness paste paint etc.When compound (I) being added these paint, do not having the upper limit amount of the adhesion of painting after the drying and in scope, selecting the highest energy to determine that an amount is to extend the expiration date but preferably set one by experience.When for example it being added varnish, the amount that adds the compound (I) in the paint is preferably 1-10%.
As above-mentioned spices, can use any natural perfume material and synthetic perfume, need only the anthelminthic effect that it does not apply adverse effect to compound (I) and does not suppress compound (I).When reagent of the present invention is used for the living space, the spices of special preferred heights safety.As natural perfume material, for example can mention bergamot oil, peppermint oil, lemongrass oil, eucalyptus oil, Japan's pitch, the lemongrass wet goods as synthetic perfume, for example can be mentioned terpenoid spices such as linalool, lynalyl acetate, geraniol, nerolidol, citral etc.
Porous inorganic particulate is meant by the porous particle of the preparation of dissolubility or insoluble inorganic powder hardly to have the particle mean size of 1 μ m-10mm, more preferably 2 μ m-5mm, and the BET surface area is not less than 50m
2/ g more preferably is not less than 100m
2/ g.
Porous inorganic particulate comprises silica; Metal oxide such as aluminium oxide, zinc oxide, magnesia, titanium oxide, zirconia etc.; Metal hydroxides such as aluminium hydroxide, magnesium hydroxide etc.; Metal silicate such as calcium silicates, magnesium silicate, alumina silicate etc.; Metal carbonate such as calcium carbonate, magnesium carbonate etc.; Metal sulfate such as calcium sulphate, magnesium sulfate etc.; Clay mineral if you would take off stone, talcum, pyrophyllite, zeolite etc.; Or the like.
By using the sol-gel process of metal alkoxide etc., use the ion-exchange of soluble metallic salt etc. can synthesizing porous inorganic particle, perhaps can same as before or behind purifying, use naturally occurring particle.When synthetic or naturally occurring inorganic material itself have been porosu solid basically, by such as pulverizing, the method for screening etc. can suitably be adjusted to this porosu solid wieldy size, and as the carrier of adsorption compound (I).When this method is not directly utilized; can will synthesize or naturally occurring inorganic material is suspended in the solvent such as water etc.; and granulate by spray drying process; or in rotating the comminutor of slurry or powder simultaneously, drying granulates into the expectation granularity; or the like, adjust size, when needs; sintering etc. are to guarantee the stability of particle, and described particle is then as carrier.As improving one's methods, can will be used as carrier by handle interlayer clay mineral at interval with four ammonium salts with expansion; Can improve the inorganic powder adhesive granulation bonding what compound (I) is introduced immediately inorganic carrier simultaneously will be by organic polymer material preparation with compound (I); The organic polymer material as adhesive of inclusion compound (I) can be mixed with these inorganic powders, mixture of powders can be granulated together.
Reagent preparation of the present invention can be become any formulation by known method, aerosol for example, finish, fumigant, thin slice, powder, microcapsules, water-dispersible reagent etc.By spraying, coating, dipping, be coated with the shop wait operation with the agent administration of the present invention of these formulations in various materials such as woven cloth, looped fabric, wet type nonwoven (paper), dry type nonwoven, plywood, synthetic resin sheet, synthetic resin board, timber etc.
When the active compound component (I) with reagent of the present invention adds various resins and is processed into such as fiber film, sheet, the mechanograph of plate etc., these mechanographs are used as the raw material of producing the indoor life article that insect perches, described article such as various construction material, Couch cushion, bed clothes, carpet, cotton-wool etc., and with the assembly of mechanograph as Pest Control, above-mentioned mechanograph, the various assemblies of life article and performance pest control effect are also included among the present invention.
When forming preparation, the content of compound in the reagent of the present invention (I) is preferably 0.1-99wt%, more preferably 5-99wt%.The concrete amount of the reagent of the present invention that uses of restriction, as long as express the pest control effect, but preference such as its are per unit area 1m
2Be used for spraying, coating, dipping is coated with the about 0.01-10g of target object that operation is waited in the shop, more preferably from about 0.1-3g compound (I).
In addition, when compound (I) being added various resins and is processed into such as fiber, film, when sheet, the mechanograph of plate etc., the content of compound in the mechanograph (I) is preferably about 1-60wt%, more preferably from about 10-50wt%.
In addition, reagent of the present invention can form microcapsules.As microcapsules, use by interfacial polymerization, in-situ polymerization, the bag quilt is solidified in submergence, core solvation (core salvation), the microcapsules in conjunction with preparation of physics and machinery production method or these known methods.As the wall material of microcapsules, for example, can mention polyester, polyamide, polyurethane, polyureas, epoxy resin, polystyrene resin, vinyl-vinyl acetate copolymer, polylactic resin, acrylic resin, celluosic resin, sodium alginate, Acacia, polyvinyl alcohol, gelatin, albumin etc., preferred polylactic resin.
Although specifically do not limit the particle mean size of microcapsules, be preferably 10 μ m-1mm, more preferably 20 μ m-500 μ m.Its reason is when microcapsule granule is too fine, and inner compound (I) discharges at short notice, oxidation, and the term of validity of microcapsules shortens.On the other hand, when microcapsule granule is too coarse, the difficulty that becomes in the mechanograph etc. of kneading, the kind of object that can comprise particle is limited.For example, when using adhesive with microcapsules and fiber product adhesion, microcapsules are clearly thought allogenic material and are manually removed, or deliberately crushed to be infected with fiber product.
Be used to obtain the preferred every 1m of amount of the microcapsules of the above-mentioned concentration that disinfests
2The space that is intended to drive away is no less than 3g as indoor grade, more preferably is no less than 5g.Compound (I) is limited in from the release of microcapsules extremely low-level, even a large amount of the use do not go wrong in living environment yet.Yet consider economic aspect and extremely sensitive and dislike those of smell of compound (I), preferred every 1m to smell
2Be no more than 100g, more preferably no more than 50g.
By reagent of the present invention and above-mentioned thermoplastic resin are kneaded molding then, the band that can obtain to have the insect controllability, film, sheet, fiber or other mechanograph.By processing these mechanographs, the closet that can obtain to have the insect controllability is coated with the shop material, places material, clothing is coated with the shop, and the rearmounted material of furniture is coated with the shop under the Couch cushion, pedal, the blanket sheet, automotive interior material, bedding, mattress, animal pests control agent band (neck ring), the pet animals clothing, pet animals is coated with shop etc.In addition, by using adhesive reagent of the present invention and fiber product are adhered to, the fiber product of broad range can have the insect controllability, and it can be processed into controlled fiber product of insect such as bed clothes, kotatsu coverlet etc. then.Reagent of the present invention can be added paint, paste and spray, it can be used as the adhesive of paint or construction material, or is sprayed on the pet garden and equipment of pet and animal, or be sprayed on the animal body, can force attached to the insect on pet garden and the animal body thus and leave.
The target insect of the method for Pest Control and controlling agent of the present invention is to belong to Insecta (Insecta), arachnids (Arachnida), chilopoda (Chilopoda), in conjunction with guiding principle (Symphyla), Diplopoda (Diplopoda), the Pauropodra guiding principle, those of Gastropoda (Gastropoda) or Hirudinea (Hirudinea).They for example comprise,
The insect that belongs to Insecta as
Belong to Isoptera (Isoptera) as Rhinotermitidae (Rhinotermitidae), the insect of Termitidae (Termitidae) etc.,
Belong to orthoptera (Orthoptera) as Blattellidae, Blattidae (Blattidae), locust section (Acrididae) ， Zhong Si section (Tettigoniidae), Gryllidea (Gryllidae), the insect of Gryllotalpidae (Gryllotalpidae) etc.,
Belong to Semiptera (Hemiptera) as Aphidiadae (Aphididae), Delphacidae (Delphacidae), Cicadellidae (Cicadellidae), Typhlocybidae, Pentatomiddae (Pentatomidae), Cydnidae (Cydnidae), tortoise Chinese toon section (Plataspidae), Acanthosomatidae (Acanthosomatidae), Coreidae (Coreidae), Lygaeidae (Lygaeidae), Meridae, Pseudococcidae (Pseudococcidae), a red-spotted lizard section (Coccidae), Diaspidiae, Aleyrodidae (Aleyrodidae), the insect of Psyllidae (Psyllidae) etc.
Belong to coleoptera (Coleoptera) as Dermestidae (Dermestidae), Scarabaeidae (Scarabaeidae), Coccinellidae (Coccinellidae), Cerambycidae (Cerambycidae), Chrysomelidia, Scolytidae (Scolytidae), Curculionidae (Curculionidae), Curculionidae (Rhynchophoridae), the insect of Bruchidae (Bruchidae) etc.
Belong to Hymenoptera (Hymenoptera) as Formicidae (Formicidae), swaflies (Tenthredinidae), Vespidae (Vespidae), Siricidae (Siricidae), the insect of cynipidae (Cynipidae) etc.,
Belong to diptera (Diptera) as Dulicidae (Culicidae), Nuscidae (Musci dae), Cecidomyiidae (Cecidomyiidae), Chloropidae (Chloropidae), Tephritidae (Tephritidae), Agromyzidae (Agromyzidae), Chironomidae (Chironomidae), the insect of Anthomyiidae (Anthomyiidae) etc.
Belong to Lepidoptera (Lepidoptera) as Yponomeutidae (Yponomeutidae), Noctuidae (Noctuidae), rain moth section (Tineidae), lyonetid section (Lyonetiidae), Gracilariidae (Gracillariidae), leaf miner section (Phyllocnistidae), Sphingidae (Sphingidae), Aegeriidae (Sesiidae), Tortricidae (Tortricidae), Pyralidae (Pyralidae), Lymantriidae (Lymantriidae), Sphingidae (Sphingidae), Papilionidae (Papilionidae), the insect of Lycaenidae (Lycaenidae) etc., or the like;
The insect that belongs to arachnids as
The insect that belongs to Araneina (Araneidea for example, Ji spider section (Theridiidae), canopy spider section (Linyphiidae), joint plate spider section (Liphistiidae), wolf spider section (Lycosidae), crab spider section (Thomisidae) etc.),
The insect that belongs to Scorpionida (Scorpionida) (for example Butnus etc.),
Or the like;
The insect that belongs to Gastropoda such as mucus Limacidae (Philomycidae) etc.;
The insect that belongs to Hirudinea;
Or the like.
More specifically, for example can mention following.
I. Insecta
Rhinotermitidae (Rhinotermitidae)
Eastern subterranean termite (Reticulitermes speratus), coptotermes formosanus (Coptotermes formosanus) etc.
·Blattellidae
Groton bug (Blattella germanica), Blattella lituricollis etc.
Blattidae (Blattidae)
Peroplaneta fluligginosa (Periplaneta fuliginosa), American cockroach (Periplaneta americana) etc.
Locust section (Acrididae)
Mecostethus magister, Patanga japonica (l.Bol.) (Patanga japonica) etc.
Aphidiadae (Aphididae)
Acyrthosiphum pisim (Acyrthosiphon pisum), Aphis pomonella, cabbage aphid (Brevicorynebrassicae) etc.
Delphacidae (Delphacidae)
Small brown rice planthopper (Laodelphax stratella) etc.
Cicadellidae (Cicadellidae)
Recilia oryzae, Orientus ishidae etc.
Chinese toon section (Pentatomidae)
Blue or green smelly tortoise worm (Nezara antennata), Lagynotomus elongatus etc.
Pseudococcidae (Pseudococcidae)
Geococcus oryzae, citrus mealy bug (Planococcus citri) etc.
Aleyrodidae (Aleyrodidae)
Trialeurodes packardi, trialeurodes vaporariorum (Trialeurodes vaporariorum) etc.
Wood louse (Psyllidae)
Apple psylla (Psylla mali), pear sucker (Psylla pyrisuga forst) etc.
Dermestidae (Dermestidae)
Ji Yuan dermestids (Anthrenus verbasci), Ji dermestids (Attagenusjaponicus) etc.
Scarabaeidae (Scarabaeidae)
Rhomborrhina japonica, black gill scarab beetle (Holotrichia kiotoensis) is relaxed and is spent the cockchafer (Cetoniine beetles) etc. of diving
Coccinellidae (Coccinellidae)
Epilachna boisduvali, ladybug of eggplant 28 stars (Epilachna vigintioctopunctata) etc.
Cerambycidae (Cerambycidae)
Longicorn beetle (Anoplophora malasiaca), sea-tangle longicorn (Oberea japonica), prionid (Prionus insularis) etc.
Chrysomelidae (Chrysomelidae)
Aulacophora femoralis (Aulacophora femoralis), Galerucella grisescens, rice root chrysomelid (Donacia provosti Fairmaire) etc.
Scolytidae (Scolytidae)
Scolytus japonicus Chapuis, vertical pit cutting pin small moth (Tomicus piniperda), Xyleborus sobrinus etc.
Formicidae (Formicidae)
Japan hunchbacked ant (Camponotus japonicus), Camponotus kiusiuensis, Japanese brown ant (Formica japonica) etc.
Swaflies (Tenthredinidae)
Allantus albicinctus, Caliroa matsumotonis etc.
Vespidae (Vespidae)
Wasp spot wasp (Vespa mandarinia), wasp (Vespa simillima) etc.
Dulicidae (Culicidae)
Northern house (Culex pipiens), Culex tritaeniorhynchus (Culex tritaeniorhynchus Giles) etc.
Nuscidae (Muscidae)
Housefly (Musca domestica), Musca bezzii, false stable fly (Muscina stabulans) etc.
Cecidomyiidae (Cecidomyiidae)
Contarinia okadai Miyoshi, Contarinia mali etc.
Chloropidae (Chloropidae)
Ricestem-fly (Chlorops oryzae), Meromyza nigriventris etc.
Tephritidae (Tephritidae)
Dacus tsuneonis, Zeugodacus cucurbitae, Dacus depressus etc.
Agromyzidae (Agromyzidae)
Agromyza oryzae, L.brassicae etc.
Chironomidae (Chironomidae)
Chironomus oryzae etc.
Yponomeutidae (Yponomeutidae)
Diamond-back moth (Plutella xylostella), Yponomeuta malinellus etc.
Noctuidae (Noctuidae)
Autographa nigrisigna, Sesamia uiferens etc.
Rain moth section (Tineidae)
Nemapogon granellus, Tinea translucens etc.
Lyonetid section (Lyonetiidae)
Peach leaf miner (Lyonetia clerkella) etc.
Gracilariidae (Gracillariidae)
Caloptilia zachrysa, Acrocercops astaurota etc.
·Phyllocnistidae
Citrus leaf-miner (Phyllocnistis citrella), Phyllocnistis toparca etc.
Sphingidae (Sphingidae)
Unfilled corner hawkmoth (Acosmeryx castanea), peach horn worm (Marumbagaschkewitschii) etc.
Aegeriidae (Sesiidae)
Synanthedon hector, grape clearwing moth (Paranthrene regalis) etc.
Tortricidae (Tortricidae)
Archips breviplicanus, Cornicacoecia lafauryana etc.
Pyralidae (Pyralidae)
Peach eats into wild snout moth's larva (Conogethes punctiferalis), striped rice borer (Chilo suppressalis) etc.
Lymantriidae (Lymantriidae)
Gypsymoth (Lymantria dispar), Calliteara pseudabietis etc.
Sphingidae (Sphingidae)
Peach horn worm (Marumba gaschkewitschii) etc.
Lycaenidae (Lycaenidae)
Imported cabbageworm (Pieris rapae), yellow line white butterfly (Colias erate) etc.
Papilionidae (Papilionidae)
Papilio xuthus Linnaeus (Papilio xuthus), black swallowtail butterfly (Papilio protenor) etc.
II. arachnids
·Araneidea
Big abdomen epeira (Araneus ventricosus), Gooch sour jujube spider (Gasteracantha kuhlii) etc.
Ji spider section (Theridiidae)
Da Ji spider (Achaearanea tepidariorum), Achaearanea culcivora etc.
Canopy spider section (Linyphiidae)
Ware spider (Linyphia) etc.
Joint plate spider section (Liphistiidae)
Carrhotus xanthogramma etc.
Wolf spider section (Lycosidae)
Lycosa coelestis, Lycosa ishikariana etc.
Crab spider section (Thomisidae)
Xysticus audax, tender leaf spider (Oxytate striatipes), three prominent flower spiders (Misumenopstricuspidatus) etc.
III. wide abdomen guiding principle (Latigastra)
Emperor scorpion (Pandinus imperator) etc.
IV. chilopoda
Scolopendpa Subspinipes Mutilans L. KOCH (Scolopendra subspinipes multidens Newport), Bothropolysrugosus, Thereuonema tuberculata, Pleurogeophilus etc.
V. in conjunction with guiding principle
Hanseniella, Scutigerella nodicerca, Symphylella vulgaris etc.
VI. Diplopoda
Parafontaria laminata, Ji Malu order (Julida), Diplomaragna, Tokyosomatakakuwai Verhoeff etc.
The VII.Pauropodra guiding principle
Pauropodra etc.
VIII. Gastropoda
Limax marginatus, slug (Incilaria), yellow slug (Limax flavus) etc.
IX. Hirudinea
Hirudo japonica (Hirudo nipponia), Erpobdella lineata etc.
Be applicable to the insect of broad range as implied above, reagent of the present invention is effective to protect agricultural product, preserves cereal etc. and avoids various insects, the safety and the health of bettering people's living environment etc., or the like.
Embodiment
Explain the present invention in detail by reference the following example, it is restrictive that described embodiment should not be considered to.
Reference example 1: the measurement of farnesyl acetone concentration in the air
Farnesyl acetone (1mL) is placed in the 50mL sample bottle, and big magnetic stirring bar that can rotary air is also placed in wherein.Under agitation bottleneck is placed on deeply in 130 ℃ the oil bath, and heats 1 hour with farnesyl acetone saturated with vapor sample bottle inside., with gastight syringe get in 5mL sample bottle gas, use the gas chromatography of band fid detector, measure the concentration of farnesyl acetone by absolute calibration method thereafter.As a result, find in this 5mL gas, to comprise 20,000 μ g/L farnesyl acetones.This sample gas comprises white smoke a little, has overpowering odor, causes cough when a large amount of suction, causes people's discomfort sensation.
Farnesyl acetone (1mL) is placed in the 50mL sample bottle, and big magnetic stirring bar that can rotary air is also placed in wherein.Under agitation bottleneck is placed on deeply in 60 ℃ the water-bath, and heats 1 hour to be full of sample bottle inside with the farnesyl acetone steam., with gastight syringe get in 5mL sample bottle gas, use the gas chromatography of band fid detector, measure the concentration of farnesyl acetone by absolute calibration method thereafter.As a result, find in this 5mL gas, to comprise 20 μ g/L farnesyl acetones.Almost simultaneously, gas (5mL) in the sample thief bottle again, with propeller installation in the 10L beaker, the beaker that gas is added sealing, with with 2,000 times of gas dilutions, obtain to contain the gas of 0.01 μ g/L farnesyl acetone with the air in the propeller agitation beaker 10 minutes thus.With syringe sampling diluent gas (200mL), with propeller installation in the 2L flask, gas is added the flask that seals, and the air in the usefulness propeller agitation beaker obtained to contain the gas of 0.001 μ g/L farnesyl acetone thus with 10 times of further diluent gas in 10 minutes.This sample gas noticeable gas of almost having no talent.
Embodiment 1 and 2 and comparative example 1
20 purpose flexible cord nets are cut into 15 * 16cm, be folded into two, opening both sides (longitudinal side and horizontal side) is folding to produce bag.Prepare four such bags.Farnesyl acetone (blending ratio: suitable-trans/suitable-trans and anti--cis/anti--trans=15/50/35) is dissolved in the ethanol in the solution that is immersed in a kind of acquisition with one of each gauze bag about 10 seconds with 0.2wt% and 1wt%.From solution, take out bag, at room temperature air-dry 30 minutes gauze bags to provide farnesyl acetone to handle.Will be with the gauze bag of farnesyl acetone 0.2wt% solution-treated as embodiment 1, will be with the gauze bag of farnesyl acetone 1wt% solution-treated as embodiment 2.In addition, DEET is dissolved in the ethanol with 1wt%, with in the same way with the gauze bag of the solution-treated that obtains as a comparative example 1.In EXPERIMENTAL EXAMPLE 1 assessment embodiment 1 and 2 and the gauze bag of comparative example 1 to the dispel effect of the female northern house (culexpipiens) that grows up, use untreated gauze bag in contrast.
EXPERIMENTAL EXAMPLE 1
50-70 only sprouted wings 10-15 days and have the height active female adult northern house of sucking blood and be released in 4 adult breeding cages (in each of 30 * 40 * 30cm).From embodiment 1, embodiment 2 with a mouse, and the opening of each silk screen bag of comparative example 1 and contrast is put into and be fixing as the blood source.The silk screen bag is placed in the cage that discharges northern house.As the result who sucks blood, calculate the quantity of the test northern house with expansion belly at specified time interval beginning to test the back, with this quantity divided by the quantity of test northern house with the calculating rate (%) of sucking blood.Test is carried out remaining on the indoor of 23-24 ℃ of temperature.Result of the test is displayed in Table 1.
Table 1
| Cage number | The silk screen bag of the fixedly mouse of placing | Reagent treatment (concentration of treatment) | The quantity of test insect (mosquito) | The time rate of sucking blood (%) later | ||
| After 2 hours | After 6 hours | After 18 hours | ||||
| 1 | Embodiment 1 | Farnesyl acetone (0.2%) | 54 | 0 | 0 | 5.6 |
| 2 | Embodiment 2 | Farnesyl acetone (1%) | 64 | 0 | 0 | 0 |
| 3 | Comparative example 1 | DEET (1％) | 52 | 0 | 25.0 | 38.5 |
| 4 | Contrast | - | 59 | 30.5 | 86.4 | 91.5 |
Embodiment 3 and 4
The farnesyl acetone (blending ratio: suitable-cis/suitable-trans and anti--cis/anti--trans=15/50/35) and the mixture (weight ratio 99: 1) of vitamin E (antioxidant) are dissolved in the methyl alcohol with 0.06wt% and 0.3wt%.With the solution that obtains with 167g/l m
2Be coated on the thick scraps of paper of 0.26mm, and the air drying obtains coating 0.1g/m thus with evaporation methyl alcohol
2And 0.5g/m
2The scraps of paper of farnesyl acetone, and be used separately as embodiment 3 and embodiment 4.Use the untreated scraps of paper in contrast, in EXPERIMENTAL EXAMPLE 2-4, be evaluated at same day preparation the farnesyl acetone coating the scraps of paper and be 10-15 time/hour the unlimited placement in indoor 2 weeks and the free scraps of paper expeling performance by under 21-24 ℃ room temperature, being suspended on ventilation rate to the larva of Groton bug, Japanese hunchbacked ant and Ji Yuan dermestids.
EXPERIMENTAL EXAMPLE 2
Shelter case (long 8cm * wide 12.5cm * high 2cm for what one of each test specimen preparation had an inlet (wide 1cm * high 2cm), make by the undulatory cardboard of white) and the embodiment 3 of a test day preparation and 4 product, embodiment 3 and 4 unlimited placement and the product in unfettered 2 weeks and the contrast scraps of paper are attached to internal ground with it.At square tinplate container (floor area 1m
2, dark 17cm) on concentric circles, place 5 kinds and shelter case, opening is towards the center.In the tinplate container, feed and drinking water are placed on central authorities.In container, discharge 25 male or 25 female Groton bugs, calculate the quantity of cockroach in each incubation zone in time in the past.The result of the test of male Groton bug is displayed in Table 2, and the result of the test of female Groton bug is represented in table 3.Test is 23-24 ℃ indoor carrying out in the maintenance temperature.
Table 2
| Incubation zone | Handle the amount (g/m of the farnesyl acetone of usefulness 2) | The cockroach number (cockroach) that exists | |||
| Test initial | After 1 hour | After 4 hours | After 24 hours | ||
| Shelter outside the case | - | 25 | 0 | 3 | 0 |
| Embodiment 3 (product of test day preparation) hide (housing) shelters case | 0.1 | 0 | 0 | 0 | 0 |
| Embodiment 3 (opening wide the product in placement and unfettered 2 weeks) hides and shelters case | 0.1 | 0 | 2 | 4 | 1 |
| Embodiment 4 (product of test day preparation) hides and shelters case | 0.5 | 0 | 0 | 0 | 0 |
| Embodiment 4 (opening wide the product in placement and unfettered 2 weeks) hides and shelters case | 0.5 | 0 | 0 | 0 | 0 |
| The contrast scraps of paper are hidden and are sheltered case | 0 | 0 | 23 | 18 | 24 |
Table 3
| Incubation zone | Handle the amount (g/m of the farnesyl acetone of usefulness 2) | The cockroach number (cockroach) that exists | |||
| Test initial | After 1 hour | After 4 hours | After 24 hours | ||
| Shelter outside the case | - | 25 | 4 | 8 | 0 |
| Embodiment 3 (product of test day preparation) hides and shelters case | 0.1 | 0 | 0 | 0 | 0 |
| Embodiment 3 (opening wide the product in placement and unfettered 2 weeks) hides and shelters case | 0.1 | 0 | 5 | 3 | 2 |
| Embodiment 4 (product of test day preparation) hides and shelters case | 0.5 | 0 | 0 | 0 | 0 |
| Embodiment 4 (opening wide the product in placement and unfettered 2 weeks) hides and shelters case | 0.5 | 0 | 0 | 0 | 0 |
| The contrast scraps of paper are hidden and are sheltered case | 0 | 0 | 16 | 14 | 23 |
EXPERIMENTAL EXAMPLE 3
Sunny in early summer day daytime, select a mound (mound) to show the Japanese hunchbacked ant that enlivens outdoor activity, will be at embodiment 3 and the thin slice of embodiment 4 and the circle that the contrast scraps of paper are cut into the 10cm diameter of test preparation on the same day, the concentric circles that is placed on about 50cm diameter is divided on the point of three equal parts, inlet is placed on about 1g Icing Sugar the central authorities of each test film towards the Japanese hunchbacked anthill of central authorities.The continuous repeated test in position by changing thin slice 3 times, wherein with the seizure of transparent pressure sensitive bonding sheet after 1 hour the ant that accumulates on the test film on the sugar.The count results of catching ant is displayed in Table 4.
Table 4
| Test film | Handle the farnesyl acetone (g/m of usefulness 2) | The ant quantity (ant) of catching on the thin slice | ||
| Test for the first time | Test for the second time | Test for the third time | ||
| Embodiment 3 | 0.1 | 3 | 12 | 5 |
| Embodiment 4 | 0.5 | 1 | 3 | 0 |
| The contrast scraps of paper | 0 | 32 | 54 | 83 |
EXPERIMENTAL EXAMPLE 4
In carton (long 30cm * wide 30cm * dark 10cm), be placed on the embodiment 3 of test preparation on the same day and 4 the thin slice and the contrast scraps of paper, it has been cut into the circle of 7cm diameter, be divided into the point of three equal parts so that the center of circle appears at the circumference of circle that will have a 15cm diameter of identical central with box, and the castor suede circle of a 6cm diameter be placed on the central authorities of each test film.Then 30 Anthrenus verbasci larvas are released in the central authorities of box, pass by to calculate the quantity that is present in the Anthrenus verbasci larva on the wool blanket on each test film in time.The result is displayed in Table 5.Test is 23-24 ℃ indoor carrying out in the maintenance temperature.
Table 5
| Test film | Handle the farnesyl acetone (g/m of usefulness 2) | The quantity (larva) of Anthrenus verbasci larva on the test film on the wool blanket | ||
| After 0 hour | After 24 hours | After 48 hours | ||
| Embodiment 3 | 0.1 | 0 | 0 | 1 |
| Embodiment 4 | 0.5 | 0 | 0 | 0 |
| The contrast scraps of paper | 0 | 0 | 21 | 29 |
| Outside the scraps of paper | - | 30 | 9 | 0 |
Embodiment 5
Farnesyl acetone (blending ratio: suitable-cis/suitable-trans and anti--cis/anti--trans=15/50/35) is dissolved in the ethanol with 1wt%, and 20 * 10 * 10mm pine is immersed in the solution of acquisition 10 minutes.Thereafter the pine that will from solution, take out at room temperature air provided the pine of dipping farnesyl acetone with ethanol evaporation in dry 1 day.Based on flooding before and the weight differential of pine afterwards, absorb about 30mg farnesyl acetone.In EXPERIMENTAL EXAMPLE 5, use and only flood ethanol and air dried pine in the same way in contrast, assess the dispel effect of the pine of this farnesyl acetone dipping eastern subterranean termite.
EXPERIMENTAL EXAMPLE 5
(95 * 60 * 20mm) are divided into the 3 parts (size of 1 part: 30 * 60 * 20mm with the styrole container; The pine mounting portion of farnesyl acetone dipping, middle body, contrast pine mounting portion), make the hole that is used for the 5mm diameter that termite passes through at the low middle body of two partition walls, with the pine of water-moistened dipping farnesyl acetone or contrast pine and be placed on each two ends in two parts as the termite feed.50 eastern subterranean termite worker ants are released in middle body, the outside of container covers so that inner blackening with aluminium foil fully, remain on 23-24 ℃, in the quantity of the termite of given interval calculating in each part, whether the pine of observing the farnesyl acetone dipping is expellent.In each part of container, form the air vent of about 2mm diameter, supply water from top by being added drop-wise to pine at any time.Result of the test is displayed in Table 6.
Table 6
| Time goes over | The termite quantity of each part | ||
| The pine mounting portion of farnesyl acetone dipping | Middle body | Contrast pine mounting portion | |
| Test initial | 0 | 50 | 0 |
| 0.5 after hour | 5 | 38 | 7 |
| After 1 hour | 4 | 5 | 41 |
| After 2 hours | 5 | 8 | 37 |
| After 24 hours | 2 | 4 | 44 |
| After 48 hours | 3 | 0 | 47 |
EXPERIMENTAL EXAMPLE 6
Preparation three cover experimental systems, the quartz sand that wherein will allow to absorb suitable quantity of water is layered on the dish of 90mm diameter with the thickness of 1mm, on radial line, form the wide groove of 5mm dish is divided into two parts, with an amount of farnesyl acetone solution of the dipping of three 8mm diameters or plant the acetone soln of peptone and air dried circular filter is placed on a test portion, three untreated circular filters are placed on the contrast part.
In each experimental system, each discharges 10 coptotermes formosanus (Coptotermes formosanus) worker ant, and at 28 ℃, raises in the incubator of 70% humidity.Behind special time, calculate the quantity of the coptotermes formosanus in test portion and contrast part.The result is displayed in Table 7.Calculate expeling rate and lethality rate from following formula.
Expeling rate={ 1-(the ant quantity of the ant quantity/survival in the test portion) } * 100 (%)
Lethality rate=dead ant quantity/30 * 100 (%)
Table 7
| Reagent | After 1 day | After 4 days | ||||||
| Farnesyl acetone | Plant peptone | Farnesyl acetone | Plant peptone | |||||
| Concentration | 1％ | 5％ | 10％ | 50％ | 1％ | 5％ | 10％ | 50％ |
| Test portion | 4 | 0 | 11 | 4 | 0 | 1 | - | - |
| The contrast part | 25 | 28 | 19 | 25 | 29 | 26 | - | - |
| Dead | 1 | 2 | 0 | 1 | 1 | 3 | - | - |
| The expeling rate | 86％ | 100％ | 63％ | 86％ | 100％ | 96％ | - | - |
| Lethality rate | 3％ | 7％ | 0％ | 3％ | 3％ | 10％ | - | - |
Embodiment 6
With farnesyl acetone (blending ratio: suitable-cis/suitable-trans and anti--cis/anti--trans=15/50/35), the mixture of butylated hydroxytoluene (antioxidant) and propylene glycol monostearate (emulsifier) (weight ratio 88: 2: 10) adds in the entry with 1wt%, and the vigorous stirring mixture is to provide emulsion.In EXPERIMENTAL EXAMPLE 7, be evaluated at the expeling performance of this emulsion of soya bean (favabean) growing period to acyrthosiphum pisim.In addition, in EXPERIMENTAL EXAMPLE 8, be evaluated at this emulsion of growing period of sprouting broccoli to belonging to the control performance of lepidopterous various insects.
EXPERIMENTAL EXAMPLE 7
In the place that comprises contiguous place of no insecticide, build pillars (high 2m) at four jiaos of 2m * 4m zone, install around with pillar and pounce on worm net and ceiling with should zone and external discrete.To be divided into two equal portions with the patch in the solarium that pounces on the preparation of worm net and be used as test portion and contrast part (each 2m * 2m), wherein 4 soya bean seedling fixed races are implanted in two parts.Test portion and contrast part not separately are not released in about 500 acyrthosiphum pisims in the solarium.According to the growth of soya bean, with each 10-50mL/ root, 2 weeks, 1 time frequency was sprayed on the soya bean of test portion with the emulsion of embodiment 6.As a result, acyrthosiphum pisim survival on top cauline leaf of soya bean and the pod in growing period is contrasting partly, but throughout the growing season in test portion, on soya bean, do not observing acyrthosiphum pisim.In addition, in the soya bean growth drug-induced infringement does not appear at test portion.
EXPERIMENTAL EXAMPLE 8
In the place that comprises contiguous place of no insecticide, 10m * 20m zone is divided into two equal portions part and is used as test portion and the contrast part.The sprouting broccoli seedling is planted and cultivated in two parts with the fixed interval of about 60cm.Use sprayer with about 100mL/m the emulsion of embodiment 6
2, 2 weeks, 1 time frequency was sprayed at test portion.The result, in the contrast part, on the leaf of growing period, find by diamond-back moth sprouting broccoli, Autographa nigrisigna larva, the insect damage that cabbage caterpillar causes, but the leaf of sprouting broccoli does not have because the damage that these insects cause in test portion.In addition, in the sprouting broccoli growth drug-induced infringement does not appear at test portion.
Be clear that as result farnesyl acetone shows the control action to the insect of broad range from EXPERIMENTAL EXAMPLE 1-8.As showing in the result of EXPERIMENTAL EXAMPLE 1, the gauze bag that DEET handles reduces in time to the dispel effect of northern house, but the gauze bag that farnesyl acetone is handled is to the dispel effect of mosquito even remained on high level after after on-test 18 hours.As the result who tests embodiment 2 shows that with scraps of paper maintenance Groton bug control at least 2 weeks of effect that farnesyl acetone is handled, pest control effect of its explanation farnesyl acetone keeps for a long time.In addition, the result as experiment embodiment 7-8 shows that farnesyl acetone does not cause the drug-induced infringement to crop.
Embodiment 7
Observe following dog: the dog of in kennel (disengagement area expanding unit), raising, kennel is inner with automiser spray (storage device) the 1% farnesyl acetone ethanolic solution of spraying weekly, with the dog of in kennel, raising, only spray weekly with ethanol in kennel inside, the behavior that compare them every day reached for 1 week in 30 minutes.The dog of raising in the kennel that farnesyl acetone is handled grabbed its health 2 times in 1 day, but the dog of raising in the kennel of no farnesyl acetone processing grabbed its health 13 times in 1 day.The concentration of farnesyl acetone is no more than 1 μ g/L (detection limit) in the kennel.The flea that deduction colonizes on the dog is driven away and reduces by farnesyl acetone.
Embodiment 8
Will be by dissolving farnesyl acetone (2g) and poly-acetate (10g, prepare by Cargill Dow LLC, number-average molecular weight 87,000, weight average molecular weight 163,300, D/L ratio 8/92) disperse phase that in carrene (100mL), obtains and the continuous phase mixing of (10.4g) forming by 4% polyvinyl alcohol water solution (1400mL) and surfactant (Q12S), the speed with 100rpm stirred 30 minutes on propeller agitator under 30 ℃.Progressively improve the pressure reducing horizontal in the reaction vessel, under the decompression that aspirator produces, stir the mixture 6 hours with the evaporation carrene.The suspension that obtains is passed through glass filter, wash product with water for several times, and freeze drying comprised the microcapsules of farnesyl acetone in 1 day with generation.The microcapsules that obtain are that particle mean size is the nearly rounded grain of 0.4mm, and are similar to grains of sand demonstration dry flow property.
Embodiment 9
Polyvinyl acetate (5g) and farnesyl acetone (10g) are dissolved in the methyl alcohol (300mL), and celelular silica powder (100g) is added solution.Remove methyl alcohol with rotary evaporator, after the methyl alcohol outflow stopped, at 40 ℃, the operation rotary evaporator was 1 hour under the 20mmHg, and the bag of preparation gathering is by the silica solid of polyvinyl acetate thus, and its inside and surface comprise farnesyl acetone.Collect this agglomerate and pulverizing, a small amount of talcum is adsorbed in its surface to produce the silica granule that keeps farnesyl acetone, its granularity is no more than 1mm.
Embodiment 10
Except peptone (10g) replacement farnesyl acetone (10g) is planted in use, by being similar to the operation of embodiment 9, obtain to keep the silica granule of planting peptone, its granularity is no more than 1mm.
Embodiment 11
The monodispersed average particulate diameter of dilute with water is that the silica granule (by NISSANCHEMICAL INDUSTRIES, the Snowtex OL of LTD. preparation) of 0.045 μ m is 17% slurry (600g) with the generation solid content.To wherein adding the polyvinyl alcohol as adhesive (PVA 117,2g is by KURARAY CO.LTD. preparation) that is dissolved in the water (20g), fully blend mixture.The slurry that obtains with spray dryer (L-8, by Ohkawarakakouki CO., Ltd. preparation) atomized drying is to produce the agglomerate of the about 20 μ m of granularity.With this 450 ℃ of following sintering 1 hour to remove adhesive, produce the porous agglomerate of making by silica (95g).To plant peptone (20g) and ethanol (80mL) solution and add pears shape flask, add above-mentioned porous agglomerate (80g).Be installed in pears shape flask on the rotary evaporator and under normal pressure the rotation 5 minutes.When raising pressure reducing horizontal and temperature gradually, keep the sand-like silica granule of planting peptone to produce by evaporative removal ethanol.
EXPERIMENTAL EXAMPLE 9
Microcapsules that will obtain in embodiment 8 or the silica granule that obtains in embodiment 9-11 and quartz sand mixed equably with 1: 7, and with dealing with sample.The glass plate of a cover 90mm diameter than main frame in, will handle sample and be layered on a side, quartz sand is layered on opposite side, thickness all is about 1mm, so that the groove that forms about 5mm in central authorities suitably absorbs water with generation processing section and unprocessed portion.In processing section and unprocessed portion, place 38 φ filter discs separately as feed, on dish, discharge 10 coptotermes formosanus worker ants, and at 28 ± 2 ℃ temperature, incubation in the incubator of 70% humidity.After preset time, the position of observer termite, whether they are at processing section and unprocessed portion.Repeat this test 3 times, calculate the expeling rate based on the integrated value of 3 observed results.Result of the test is displayed in Table 8.
Expeling rate={ 1-(quantity of ant/ant total quantity in the processing section) } * 100 (%)
Table 8
| Sample | Term day | ||
| After 1 day | After 2 days | After 4 days | |
| The microcapsules of embodiment 8 | 87％ | 83％ | 90％ |
| The silica granule of embodiment 9 | 100％ | 100％ | 100％ |
| The silica granule of embodiment 10 | 70％ | 73％ | 83％ |
| The silica granule of embodiment 11 | 100％ | 100％ | 100％ |
Embodiment 12
Farnesyl acetone (10g) and soft propene acid resin powder (100g, ProductName Parapet SA-N is by KURARAY CO.LTD. preparation) are mixed, mixture was at room temperature mixed 15 minutes.Mixture was kneaded 1 minute 125 ℃ of following fusions in two roller kneading machines, and at 135 ℃ and 50kg/cm
2Following extrusion molding is to provide the thick soft rubber sheet of 0.5mm (being equivalent to storage device and disengagement area expanding unit among the present invention).The refrigerator that this thin slice is cut into the wide band of 1cm and sticks to dwelling house down and ground-wall joint.As a result, stop to occur the indoor cockroach that comprises band.The room that comprises this band has the smell of farnesyl acetone, and it can smell after going out especially, but after being accustomed to it, smell is in the level of no any specific question.
Industrial usability
According to method of the present invention, by in the space that is intended to disinfest, the concentration of compound (I) being remained on specific concentration range, effective Control pests. In addition, reagent of the present invention can provide pest controling effect at various article.
The application is based on the patent application 31409/2002 and 34625/2002 that Japan submits to, and its content all is hereby expressly incorporated by reference.
Claims (2)
1. pest-controlling agent, its comprise have following formula (I) compound as active ingredient,
Wherein
Be singly-bound or two key,
Wherein said insect is not an acarina pest.
2. plant peptone and be used for the purposes of Pest Control, wherein said insect is not an acarina pest.
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| JP2002031409 | 2002-02-07 | ||
| JP200231409 | 2002-02-07 | ||
| JP200234625 | 2002-02-12 |
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| CNB038035596A Division CN100336449C (en) | 2002-02-07 | 2003-02-07 | Method of controlling pest and pest control agent |
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| CN1853467A true CN1853467A (en) | 2006-11-01 |
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| CN 200610079834 Pending CN1875708A (en) | 2002-02-07 | 2003-02-07 | Method of controlling acarian and device for use in the same |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104969997A (en) * | 2015-06-05 | 2015-10-14 | 陈东霖 | Disinfestation mat and applications thereof |
| CN108143763A (en) * | 2017-12-26 | 2018-06-12 | 重庆医学检验试剂研究所 | A kind of preparation that Dragonfly nymph is inhibited to sprout wings and method |
| CN109258578A (en) * | 2018-11-21 | 2019-01-25 | 北京阔野田园生物技术有限公司 | A kind of method of Larva Harmonia Axyridis indoor industrially raising |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101928709B (en) * | 2009-06-24 | 2012-05-23 | 中国农业科学院上海兽医研究所 | Gene sequence, recombinant expression and application of hyalomma asiaticum histamine binding protein (HaHBP) |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104969997A (en) * | 2015-06-05 | 2015-10-14 | 陈东霖 | Disinfestation mat and applications thereof |
| CN108143763A (en) * | 2017-12-26 | 2018-06-12 | 重庆医学检验试剂研究所 | A kind of preparation that Dragonfly nymph is inhibited to sprout wings and method |
| CN109258578A (en) * | 2018-11-21 | 2019-01-25 | 北京阔野田园生物技术有限公司 | A kind of method of Larva Harmonia Axyridis indoor industrially raising |
| CN109258578B (en) * | 2018-11-21 | 2023-12-05 | 北京阔野田园生物技术有限公司 | Indoor industrial breeding method for ladybug larvae |
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