CN1850229A - Nushengjin preparation and new preparing method - Google Patents
Nushengjin preparation and new preparing method Download PDFInfo
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- CN1850229A CN1850229A CN 200610057278 CN200610057278A CN1850229A CN 1850229 A CN1850229 A CN 1850229A CN 200610057278 CN200610057278 CN 200610057278 CN 200610057278 A CN200610057278 A CN 200610057278A CN 1850229 A CN1850229 A CN 1850229A
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Abstract
The present invention relates to a Chinese medicine composition for effectively curing the diseases of irregular menstruation, premenstrual abdominal pain, postmenstrual lumbago, dizziness, vexation, palpitation due to fright and insomnia, etc. and its preparation process. It can be made into granule preparation and tablet preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of irregular menstruation that is used for, the obstacle of passing through, under the purple black vaginal discharge of menses, cold uterus, puerperal anemia, premenstrual abdominal pain, dizzy vexed through the back pain in the lumbar region, the prescription and the preparation technology thereof of the sleeplessness of palpitating with fear.
Background technology:
Irregular menstruation, the obstacle of passing through, under the purple black vaginal discharge of menses, cold uterus, puerperal anemia, premenstrual abdominal pain, dizzy vexed through the back pain in the lumbar region, the palpitation with fear sleeplessness is to see that symptom, the traditional Chinese medical science often take to nourish blood clinical more, regulating menstruation, the means of cold relieving are treated it, and evident in efficacy.It is that it represents medicine that the woman wins Jindan.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, tablet, its pill that makes can be used for curing mainly irregular menstruation, the obstacle of passing through, under the purple black vaginal discharge of menses, cold uterus, puerperal anemia, premenstrual abdominal pain, through after pain in the lumbar region, dizzy vexed, the palpitation with fear sleeplessness.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
49.5～112.5 parts of 49.5～112.5 parts of Radix Paeoniae Rubra of 528～1200 parts of Radix Angelicae Sinensis of Rhizoma Cyperi (vinegar system)
49.5～112.5 parts of 49.5～112.5 parts of Rhizoma Chuanxiongs of 49.5～112.5 parts of Radixs Angelicae Dahuricae of the Radix Paeoniae Alba
49.5～112.5 parts of 49.5～112.5 parts of Radix Polygalaes of 33～75 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng Rubra (Jiao) (system)
82.5～187.5 parts of 82.5～187.5 parts of Radix Achyranthis Bidentataes of 82.5～187.5 portions of Cortex Cinnamomis of Cortex Moutan
148.5～337.5 parts of 132～300 parts of Radix Rehmanniae Preparata of 82.5～187.5 portions of Radix Cynanchi Atratis of Poria
16.5～37.5 parts of 247.5～562.5 parts of Olibanums of 66～150 portions of Radix Glycyrrhizaes of Rhizoma Ligustici (system) (system)
16.5～37.5 parts of 16.5～37.5 parts of Myrrha (processed) of 16.5～37.5 parts of Cinnabaris of Lignum Aquilariae Resinatum
16.5～37.5 parts of Rhizoma Corydalis (vinegar system) 16.5～37.5 parts of Halloysitum Rubrums of 49.5～112.5 parts of succinums (forging)
16.5～37.5 parts of Kaolins (forging).
Preferably:
75 parts of 75 parts of Radix Paeoniae Rubra of 800 parts of Radix Angelicae Sinensis of Rhizoma Cyperi (vinegar system)
75 parts of 75 parts of Rhizoma Chuanxiongs of 75 parts of Radixs Angelicae Dahuricae of the Radix Paeoniae Alba
75 parts of 75 parts of Radix Polygalaes of 50 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng Rubra (Jiao) (system)
125 parts of 125 parts of Radix Achyranthis Bidentataes of 125 portions of Cortex Cinnamomis of Cortex Moutan
225 parts of 200 parts of Radix Rehmanniae Preparata of 125 portions of Radix Cynanchi Atratis of Poria
25 parts of 375 parts of Olibanums of 100 portions of Radix Glycyrrhizaes of Rhizoma Ligustici (system) (system)
25 parts of 25 parts of Myrrha (processed) of 25 parts of Cinnabaris of Lignum Aquilariae Resinatum
25 parts of Rhizoma Corydalis (vinegar system) 25 parts of Halloysitum Rubrums of 75 parts of succinums (forging)
25 parts of Kaolins (forging).
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be capsule, granule, tablet, powder.
The above new technology of the present invention may further comprise the steps:
(1) gets Radix Rehmanniae Preparata, Radix Polygalae, Radix Achyranthis Bidentatae, Rhizoma Corydalis, Radix Paeoniae Rubra, Cortex Moutan, Radix Ginseng Rubra, Poria medical material, soaked 30～90 minutes reheat reflux, extract, 2～6 times with 50～95% ethanol earlier, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get the Radix Paeoniae Alba, licorice medicinal materials, decoct with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get Cinnabaris, succinum, Kaolin, Halloysitum Rubrum, Olibanum, Myrrha and directly beat powder and be used as medicine, standby;
(4) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(2) preparation method of tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets tablet.
Filler described in granule, the preparation tablets is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, analgesic test
1.1 hot plate causes the pain method and gets (20 ± 2) g female mice, places the super constant temperature of 501 types [(55 ± 0.5) ℃] water-bath.Measure the threshold of pain on the hot plate, the screening threshold of pain is 30 of 10～30s mices, divides 3 groups at random, gastric infusion.Behind the medicine 30,60,120min surveys the threshold of pain respectively, the results are shown in Table 1.The result shows that the extractum group has significant analgesia role.
Table 1 pair mice hot plate cause the pain influence (x ± s, n=10)
| Group | Dosage (g/kg) | Threshold of pain time expand t/s behind the medicine | ||
| 30min | 60min | 120min | ||
| Normal saline Hyndarin extractum group | - 0.03 0.14 | 3.65±3.21 8.9 1±7.33 6.24±3.58 | 3.80±3.45 18.76±13.10 * 11.81±6.48 * | 4.73±4.27 15.86±15.13 9.79±3.47 * |
Annotate: compare with normal saline,
*P＜0.05
1.2 writhing method
Get 30 of (20 ± 2) g mices, male and female half and half are divided into 3 groups, gastric infusion at random.45min behind the medicine, every Mus is the ip0.6% glacial acetic acid solution respectively.Observe take place in the mice 15min turn round the body number of times.The results are shown in Table 2.The extractum group is turned round the body frequency to ip glacial acetic acid induced mice and is obviously reduced as seen from Table 2.
The influence of writhing response due to the table 2 pair mice glacial acetic acid (x ± s, n=10)
| Group | Dosage (g/kg) | Turn round the body frequency |
| Normal saline Hyndarin group extractum group | - 0.03 0.14 | 30.4±4.7 16.1±3.5 * 17.4±5.7 * |
Annotate: compare P＜0.05 with normal saline
2, to the influence of rat kind dysmenorrhea model
Get body weight and be 30 of the SD rats of 140～160g, female, evenly be divided into 3 groups, each Mus subcutaneous injection every day diethylstilbestrol injection 0.1mg/ only irritates stomach distilled water, extractum respectively simultaneously, aspirin 0.2g/kg, the administration capacity is 3.0ml/100g, once a day, connects and gives 3d, 1h after the last administration, each Mus lumbar injection oxytocin 2IU/ only turns round the body number of animals, with x in the 30min after the observed and recorded administration
2Statistical analysis is carried out in check, the results are shown in Table 3.
The influence of table 3 pair rat dysmenorrhea model
| Group | Dosage (g/kg) | Number of animals (only) | Turn round body number of animals (only) |
| Distilled water aspirin extractum group | - 0.2 0.07 | 10 10 10 | 9 2 *2 * |
Annotate: compare with the distilled water group,
*P＜0.05
By table 3 as seen, medicine has analgesic activity to the rat kind dysmenorrhea pain that oxytocin causes.
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, granule particularly of the present invention and tablet formulation are a kind of good irregular menstruation, obstacles of passing through of being used for, under the purple black vaginal discharge of menses, cold uterus, puerperal anemia, premenstrual abdominal pain, through after pain in the lumbar region, dizzy vexed, the medicine of palpitation with fear sleeplessness, and change preparation technology, can obviously strengthen it and nourish blood, regulating menstruation, clinical efficacies such as cold relieving, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of granule of the present invention:
Prescription:
Rhizoma Cyperi (vinegar system) 1200g Radix Angelicae Sinensis 112.5g Radix Paeoniae Rubra 112.5g
Radix Paeoniae Alba 112.5g Radix Angelicae Dahuricae 112.5g Rhizoma Chuanxiong 112.5g
The Radix Ginseng Rubra 75g Rhizoma Atractylodis Macrocephalae (Jiao) 112.5g Radix Polygalae (system) 112.5g
Cortex Moutan 187.5g Cortex Cinnamomi 187.5g Radix Achyranthis Bidentatae 187.5g
Poria 187.5g Radix Cynanchi Atrati 300g Radix Rehmanniae Preparata 337.5g
Rhizoma Ligustici 150g Radix Glycyrrhizae (system) 562.5g Olibanum (system) 37.5g
Lignum Aquilariae Resinatum 37.5g Cinnabaris 37.5g Myrrha (processed) 37.5g
Rhizoma Corydalis (vinegar system) 112.5g succinum 37.5g Halloysitum Rubrum (forging) 37.5g
Kaolin (forging) 37.5g
Make 1000g
Preparation method:
(1) get Radix Rehmanniae Preparata, Radix Polygalae, Radix Achyranthis Bidentatae, Rhizoma Corydalis, Radix Paeoniae Rubra, Cortex Moutan, Radix Ginseng Rubra, Poria medical material, soaked 50 minutes earlier with 85% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get the Radix Paeoniae Alba, licorice medicinal materials, decoct with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get Cinnabaris, succinum, Kaolin, Halloysitum Rubrum, Olibanum, Myrrha and directly beat powder and be used as medicine, standby;
(4) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate;
(5) above active component is merged, add aspartame 5.0g, dextrin 225.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 2:
The preparation method of sheet of the present invention:
Prescription:
Rhizoma Cyperi (vinegar system) 528g Radix Angelicae Sinensis 49.5g Radix Paeoniae Rubra 49.5g
Radix Paeoniae Alba 49.5g Radix Angelicae Dahuricae 49.5g Rhizoma Chuanxiong 49.5g
The Radix Ginseng Rubra 33g Rhizoma Atractylodis Macrocephalae (Jiao) 49.5g Radix Polygalae (system) 49.5g
Cortex Moutan 82.5g Cortex Cinnamomi 82.5g Radix Achyranthis Bidentatae 82.5g
Poria 82.5g Radix Cynanchi Atrati 132g Radix Rehmanniae Preparata 148.5g
Rhizoma Ligustici 66g Radix Glycyrrhizae (system) 247.5g Olibanum (system) 16.5g
Lignum Aquilariae Resinatum 16.5g Cinnabaris 16.5g Myrrha (processed) 16.5g
Rhizoma Corydalis (vinegar system) 49.5g succinum 16.5g Halloysitum Rubrum (forging) 16.5g
Kaolin (forging) 16.5g
Make 1000
Preparation method:
(1) get Radix Rehmanniae Preparata, Radix Polygalae, Radix Achyranthis Bidentatae, Rhizoma Corydalis, Radix Paeoniae Rubra, Cortex Moutan, Radix Ginseng Rubra, Poria medical material, soaked 50 minutes earlier with 85% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get the Radix Paeoniae Alba, licorice medicinal materials, decoct with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get Cinnabaris, succinum, Kaolin, Halloysitum Rubrum, Olibanum, Myrrha and directly beat powder and be used as medicine, standby;
(4) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate;
(5) above active component is merged, add aspartame 3.0g, mannitol 160.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000.
Claims (8)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
49.5～112.5 parts of 49.5～112.5 parts of Radix Paeoniae Rubra of 528～1200 parts of Radix Angelicae Sinensis of Rhizoma Cyperi (vinegar system)
49.5～112.5 parts of 49.5～112.5 parts of Rhizoma Chuanxiongs of 49.5～112.5 parts of Radixs Angelicae Dahuricae of the Radix Paeoniae Alba
49.5～112.5 parts of 49.5～112.5 parts of Radix Polygalaes of 33～75 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng Rubra (Jiao) (system)
82.5～187.5 parts of 82.5～187.5 parts of Radix Achyranthis Bidentataes of 82.5～187.5 portions of Cortex Cinnamomis of Cortex Moutan
148.5～337.5 parts of 132～300 parts of Radix Rehmanniae Preparata of 82.5～187.5 portions of Radix Cynanchi Atratis of Poria
16.5～37.5 parts of 247.5～562.5 parts of Olibanums of 66～150 portions of Radix Glycyrrhizaes of Rhizoma Ligustici (system) (system)
16.5～37.5 parts of 16.5～37.5 parts of Myrrha (processed) of 16.5～37.5 parts of Cinnabaris of Lignum Aquilariae Resinatum
16.5～37.5 parts of Rhizoma Corydalis (vinegar system) 16.5～37.5 parts of Halloysitum Rubrums of 49.5～112.5 parts of succinums (forging)
16.5～37.5 parts of Kaolins (forging).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
75 parts of 75 parts of Radix Paeoniae Rubra of 800 parts of Radix Angelicae Sinensis of Rhizoma Cyperi (vinegar system)
75 parts of 75 parts of Rhizoma Chuanxiongs of 75 parts of Radixs Angelicae Dahuricae of the Radix Paeoniae Alba
75 parts of 75 parts of Radix Polygalaes of 50 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng Rubra (Jiao) (system)
125 parts of 125 parts of Radix Achyranthis Bidentataes of 125 portions of Cortex Cinnamomis of Cortex Moutan
225 parts of 200 parts of Radix Rehmanniae Preparata of 125 portions of Radix Cynanchi Atratis of Poria
25 parts of 375 parts of Olibanums of 100 portions of Radix Glycyrrhizaes of Rhizoma Ligustici (system) (system)
25 parts of 25 parts of Myrrha (processed) of 25 parts of Cinnabaris of Lignum Aquilariae Resinatum
25 parts of Rhizoma Corydalis (vinegar system) 25 parts of Halloysitum Rubrums of 75 parts of succinums (forging)
25 parts of Kaolins (forging).
3, claim 1 or any one Chinese medicine preparation of 2 are granule, tablet, capsule, powder.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
(1) gets Radix Rehmanniae Preparata, Radix Polygalae, Radix Achyranthis Bidentatae, Rhizoma Corydalis, Radix Paeoniae Rubra, Cortex Moutan, Radix Ginseng Rubra, Poria medical material, soaked 30～90 minutes reheat reflux, extract, 2～6 times with 50～95% ethanol earlier, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get the Radix Paeoniae Alba, licorice medicinal materials, decoct with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get Cinnabaris, succinum, Kaolin, Halloysitum Rubrum, Olibanum, Myrrha and directly beat powder and be used as medicine, standby;
(4) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets tablet.
7, the Chinese medicine preparation of claim 6 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
8, the preparation method of any one Chinese medicine preparation of claim 1～7 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
(1) gets Radix Rehmanniae Preparata, Radix Polygalae, Radix Achyranthis Bidentatae, Rhizoma Corydalis, Radix Paeoniae Rubra, Cortex Moutan, Radix Ginseng Rubra, Poria medical material, soaked 30～90 minutes reheat reflux, extract, 2～6 times with 50～95% ethanol earlier, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get the Radix Paeoniae Alba, licorice medicinal materials, decoct with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get Cinnabaris, succinum, Kaolin, Halloysitum Rubrum, Olibanum, Myrrha and directly beat powder and be used as medicine, standby;
(4) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610057278 CN1850229A (en) | 2006-03-10 | 2006-03-10 | Nushengjin preparation and new preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610057278 CN1850229A (en) | 2006-03-10 | 2006-03-10 | Nushengjin preparation and new preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1850229A true CN1850229A (en) | 2006-10-25 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610057278 Pending CN1850229A (en) | 2006-03-10 | 2006-03-10 | Nushengjin preparation and new preparing method |
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| CN (1) | CN1850229A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948903A (en) * | 2014-05-14 | 2014-07-30 | 张少林 | Traditional Chinese medicinal composition for treating gynaecological dysmenorrhea |
-
2006
- 2006-03-10 CN CN 200610057278 patent/CN1850229A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948903A (en) * | 2014-05-14 | 2014-07-30 | 张少林 | Traditional Chinese medicinal composition for treating gynaecological dysmenorrhea |
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